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Korman Lab

Cell Processes in Fibrosis

The Korman lab focuses on scleroderma (SSc, systemic sclerosis) which is a multi-system disease characterized by fibrosis (scarring) of the skin and internal organs, autoimmunity with disease specific autoantibodies, and vascular disease. The lab’s basic science focus lays in the vascular and fibrotic parts of scleroderma and utilizes a variety of cell-based systems, mouse models, genetic/genomic approaches, and patient samples to better understand the pathways which contribute to scleroderma. Most work currently focuses on either (1) skin disease and (2) pulmonary hypertension. The lab is integrated with the scleroderma clinic and utilizes clinical data and patient bio-specimens to address fundamental questions about disease pathogenesis, heterogeneity, and to develop insights that will lead to new therapeutic approaches and increasingly personalized medicine.

Benjamin Korman, M.D.

Benjamin Korman, M.D.
Principal Investigator

Publications

Korman B. Evolving insights into the cellular and molecular pathogenesis of fibrosis in systemic sclerosis. Translational Research. 2019 Feb 23.

Korman B, Marangoni RG, Hinchcliff M, Carns M, Hoffman E, Shah S, Ramsey-Goldman R, Varga J. Elevated Levels of the Adipokine Adipsin are Associated with Pulmonary Arterial Hypertension in Systemic Sclerosis. Arthritis & Rheumatology. 2017 Oct;69(10):2062-2068.

Korman B, Marangoni RG, Lord G, Olefsky J, Tourtellotte W, Varga J. Adipocyte-specific Repression of PPAR-gamma by NCoR Contributes to Scleroderma Skin Fibrosis. Arthritis Res Ther. 2018 Jul 11;20(1)

Marangoni RG, Korman BD, Wei J, Wood TA, Graham LV, Whitfield ML, Scherer PE, Tourtellotte WG, Varga J. Myofibroblasts in murine cutaneous fibrosis originate from adiponectin-positive intradermal progenitors. Arthritis Rheumatol. 2015 Apr;67(4):1062-73.

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Contact Us

  Korman Lab
601 Elmwood Ave/Box 695
Rochester, NY 14642