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Korman Lab

Cell Processes in Fibrosis

The Korman lab focuses on scleroderma (SSc, systemic sclerosis) which is a multi-system disease characterized by fibrosis (scarring) of the skin and internal organs, autoimmunity with disease specific autoantibodies, and vascular disease. The lab’s basic science focus lays in the vascular and fibrotic parts of scleroderma and utilizes a variety of cell-based systems, mouse models, genetic/genomic approaches, and patient samples to better understand the pathways which contribute to scleroderma. Most work currently focuses on either (1) skin disease and (2) pulmonary hypertension. The lab is integrated with the scleroderma clinic and utilizes clinical data and patient bio-specimens to address fundamental questions about disease pathogenesis, heterogeneity, and to develop insights that will lead to new therapeutic approaches and increasingly personalized medicine.

Benjamin Korman, M.D.

Benjamin Korman, M.D.
Principal Investigator

Projects

pulmonary hypertension

Pulmonary Hypertension

Rheumatoid Arthritis

Rheumatoid Arthritis

Scleroderma and Fibrosis

Scleroderma and Fibrosis

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Publications

Marangoni RG, Datta P, Paine A, Duemmel S, Nuzzo M, Sherwood L, Varga J, Ritchlin C, Korman BD. Thy-1 plays a pathogenic role and is a potential biomarker for skin fibrosis in scleroderma. JCI insight; Vol 7(19). 2022 Jan 10.

Bell RD, White RJ, Garcia-Hernandez ML, Wu E, Rahimi H, Marangoni RG, Slattery P, Duemmel S, Nuzzo M, Huertas N, Yee M, O'Reilly MA, Morrell C, Ritchlin CT, Schwarz EM, Korman BD. TNF Induces Obliterative Pulmonary Vascular Disease in a Novel Model of Connective Tissue Disease Associated Pulmonary Arterial Hypertension (CTD-PAH). Arthritis & Rheumatol 2020 Oct;72(10):1759-1770

Korman B. Evolving insights into the cellular and molecular pathogenesis of fibrosis in systemic sclerosis. Translational Research. 2019 Feb 23.

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Contact Us

  Korman Lab
601 Elmwood Ave/Box 695
Rochester, NY 14642