Skip to main content
Explore URMC

SMD Logo

menu

News

20182017201620152014 Archive

URMC Student/Trainee Travel Awards 2018 Request for Applications

Tuesday, November 13, 2018

Two travel reimbursement awards of up to $1,000 will be given this funding cycle (one for clinical research and one for basic sciences research) to support a University of Rochester School of Medicine & Dentistry medical student, graduate student, postdoctoral trainee, clinical resident, and/or clinical fellow to attend important national or international meetings at which they will present their research and make professional connections.
 
Eligible applications for the current cycle are for travel between September 1, 2018 and February 28, 2019. Submission Deadline: Friday, December 14, 2018, 6:00 pm. For questions, email Amy Blatt, M.D. or call 585-275-4912.

View the full RFA.
 
 

Congratulations Eugene!

Monday, November 12, 2018

Eugene Kim

We celebrated the successful PhD defense by Eugene Kim last Friday. Working with Jianwen Que, Eugene has identified a significant progenitor cell population in the early foregut. She used a combination of xenopus and mouse models to demonstrate that the transcription factor Isl1 enriched in the unique progenitor population regulates the separation of the esophagus from the trachea. These findings provide important insights into the pathobiology of a relatively common birth defect esophageal atresia with/without trachea-esophageal fistula (EA/TEF). Her findings will be forthcoming in Developmental Cell. Eugene has a passion for studying developmental biology and stem cells in regeneration, and she plans for a future career in these areas!

Eugene Kim With Advisor Jianwen Que

Congratulations to the 4th Annual Immune Imaging Symposium Poster and Image Winners

Monday, November 12, 2018

Wish the four winners a hardy congratulations when you see them.

Image Winner McRaePoster Winner Amitrano

Poster Winner PrizantPoster Winner Schrock

New Issue of Opportunities to Explore

Monday, November 12, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into next month

Opportunities to Explore - November 12-16, 2018

Congratulations Fanju!

Thursday, November 8, 2018

Fanju Meng

On Thursday, Fanju Meng successfully defended his PhD thesis. Under mentorship of Dr. Benoit Biteau, Fanju’s studies focus on the regulatory network that coordinates stem cell proliferation and differentiation in the Drosophila intestinal epithelium. Using advanced fly genetics and cell biology methods, Fanju characterized the expression and role of several transcription factors in adult intestinal progenitors. His work significantly improves our understanding of the programs controlling stem cell function and establishes the fruit fly as a model to study these conserved, critical stem cell factors. His findings have been published in Cell Reports and Stem Cell Investigation. And there are additional papers in the pipeline! Fanju was a recipient of a NYSTEM training grant hosted by the Department of Biomedical Genetics, and the Goodman Doctoral Dissertation Fellowship from the University of Rochester. Fanju is now planning on continuing in his work in the field of stem cell and cancer biology using genetic model organisms – and we wish him the best of luck! You will be missed.

For further reading, please see:

Fanju Meng Successfully Defending His Ph.D. Thesis
Fanju Meng Successfully Defending His Ph.D. Thesis

GDSC Halloween Costume Contest!

Thursday, November 8, 2018

Last week GDSC held our Halloween Costume Contest. Our three GDSC student contestants can be seen below.

Derek Crowe as Bart Simpson

Derek Crowe as Bart Simpson

Anne Roskowski as Sailor Moon.

Anne Roskowski as Sailor Moon

Neal Shah as a Medical Garbed Squidward.

Neal Shah as a Medical Garbed Squidward

Derek Crowe earned a very close second place with 14 votes. While first place went to Anne Roskowski with 15 votes. Congrats Anne!”

Dumont Receives 2018 Outstanding Graduate Student Teacher Award

Tuesday, November 6, 2018

kielkopf lab door

 

Biochemistry professor Mark Dumont, Ph.D. is the recipient of the 2018 Outstanding Graduate Student Teacher Award. Established in 2013, this award is given to an outstanding graduate student teacher for record of excellence in classroom instruction. Mark was nominated by graduate students Brandon Davis, Ashwin Kumar and Matthew Raymonda.

This award was presented at the School of Medicine and Dentistry Convocation Ceremony, September 6, 2018.

The department would like to extend congratulations to Mark on this well- deserved honor.

New Issue of Opportunities to Explore

Friday, November 2, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into next month

Opportunities to Explore - November 5-9, 2018

GDSC Fall Retreat

Thursday, November 1, 2018

Our graduate program in Genetics, Development and Stem Cells (GDSC) celebrated another successful season of research and academic growth. On the afternoon of Friday October 26th 2018, the faculty, students and families of GDSC held our Fall Retreat at the Ellison Park Pavilion Lodge. Among our many reasons to celebrate was our Department’s recent faculty expansion including, Brian J. Altman, Stephano Spano Mello, and Patrick J. Murphy. Welcome! We also celebrated the faculty promotion of Benoit Biteau to Associate Professor. Finally, we celebrated the future research of faculty members Margot Mayer-Pröschel, Douglas Portman, Chris Pröschel, and Andy Samuelson each of whom obtained prominent research grants earlier this year. Our festivities included pumpkin carvings, board games and a cocktail hour. There were also three hotly contested rounds of Science Trivia. (The final scores for the first and second place teams were separated by a margin of half a point!) The winning team “Smooth ER” included members Derek Crow, Li Xie, Shen Zhou, Yungeng Pang, Mark Noble, Daxiang Na, and Andy Samuelson. Additionally, Jessie Hogestyn won our “Hidden Facts” contest testing one’s knowledge of eccentric or esoteric trivia regarding GDSC faculty and students. Photos of GDSC’s genetic festivities can be seen below.

GDSC Fall Retreat 2018

New Issue of Opportunities to Explore

Friday, October 26, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into next month

Opportunities to Explore - October 29-November 2, 2018

CMPP Graduate Student Published in Nature Communications

Wednesday, October 24, 2018

Edward Ayoub With PosterEdward Ayoub, a Graduate student in the Cellular and Molecular Pharmacology and Physiology PhD Program and member of Archibald Perkins Lab published in Nature Communications on 10/12/2018. More information can be found on the Nature Website.

Paper Title & Abstract

EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription

Edward Ayoub, Michael P. Wilson, Kathleen E. McGrath, Allison J. Li, Benjamin J. Frisch, James Palis, Laura M. Calvi, Yi Zhang & Archibald S. Perkins

Inv(3q26) and t(3:3)(q21;q26) are specific to poor-prognosis myeloid malignancies, and result in marked overexpression of EVI1, a zinc-finger transcription factor and myeloid-specific oncoprotein. Despite extensive study, the mechanism by which EVI1 contributes to myeloid malignancy remains unclear. Here we describe a new mouse model that mimics the transcriptional effects of 3q26 rearrangement. We show that EVI1 overexpression causes global distortion of hematopoiesis, with suppression of erythropoiesis and lymphopoiesis, and marked premalignant expansion of myelopoiesis that eventually results in leukemic transformation. We show that myeloid skewing is dependent on DNA binding by EVI1, which upregulates Spi1, encoding master myeloid regulator PU.1. We show that EVI1 binds to the −14 kb upstream regulatory element (−14kbURE) at Spi1; knockdown of Spi1dampens the myeloid skewing. Furthermore, deletion of the −14kbURE at Spi1 abrogates the effects of EVI1 on hematopoietic stem cells. These findings support a novel mechanism of leukemogenesis through EVI1 overexpression.

New Issue of Opportunities to Explore

Monday, October 22, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into next month

Opportunities to Explore - October 22-26, 2018

Former Tox Student Claire McCarthy, PhD Featured on NPR

Thursday, October 18, 2018

McCarthy

Early one morning in the spring of 2017, former Toxicology graduate student Claire McCarthy (Sime Lab) started her day as many don't: rolling dried rhinoceros dung into cigarettes and packing them into a machine that smoked them.

Although it might seem bizarre, McCarthy's purpose was serious: She wanted to know what happens when people breathe in dung smoke.

Dung smoke is no joke. Animal dung is used by millions globally for heating and cooking.

It's a dangerous practice. Burning biomass fuels (including animal dung as well as wood, charcoal, and plant matter) generates indoor air pollution, which caused 4 million deaths worldwide in 2012 according to the World Health Organization. Like cigarette smoke, biomass smoke has been linked to increased risk of lung diseases, such as chronic obstructive pulmonary disorder (COPD), lung cancer and respiratory infection.

Read More: Former Tox Student Claire McCarthy, PhD Featured on NPR

New Issue of Opportunities to Explore

Thursday, October 11, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into next month

Opportunities to Explore - October 15-19, 2018

New Issue of Opportunities to Explore

Friday, September 28, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into next month

Opportunities to Explore - October 1-5, 2018

CMPP Graduate Student Brandon Berry Wins Poster Award

Monday, September 24, 2018

The Wojtovich lab attended the Translational Research in Mitochondria, Aging, and Disease (TRiMaD) Symposium.  A yearly event that brings together approximately 150-200 scientists from the Northeast to discuss the role of mitochondria in aging and disease. 

8th Annual TRiMaD Website

Brandon Berry, Graduate Student in Wojtovich lab, was one of four recipients to win a poster award for his work entitled “Novel Optogenetic control of mitochondrial energetics rescues electron transport chain inhibition”

Adrian Moises Molina Vargas is awarded Graduate Alumni Convocation Award

Friday, September 14, 2018

Adrian (’18 University of Alcalá, Spain), one of three new 2018 recruits to the GDSC program was awarded the Graduate Alumni Convocation Award to recognize his promise for exceptional accomplishment in graduate studies. During his year of studying abroad at Tufts during 2017-2018, Adrian worked in the Mirkin lab to study the role of cdc13 mutations in genome instability.

In addition, Sarah Spahr (’18 Ohio State University) was nominated for the Irving Spar Fellowship and Tom O’Connor (’17 University of Buffalo) was nominated for the Newell Stannard Graduate Student Scholarship Award. Congratulations to all three!

Adrian Moises Molina Vargas Sarah Spahr Tom O'Connor

Adrian, Sarah & Tom

GDSC Team Participates in 6th annual Wilmot “Warrior Walk”

Friday, September 14, 2018

GDSC Team supports the 2017 Wilmot Cancer Warrior Walk
GDSC Team supports the 2017 Wilmot Cancer Warrior Walk

Students and faculty from Biomedical Genetics and the GDSC program attended the 6th Wilmot Cancer Institute Warrior Walk on Sunday. Aptly named the “NextGen Cancer Busters” to symbolize the graduate students and post-docs training to become cancer researchers, the GDSC team mingled with cancer survivors and family members, to support the fight against cancer. As one team member pointed out: “Meeting cancer survivors really helps put the work in the lab into perspective”.

In addition to the Cancer Survivor Walk, “NextGen Cancer Busters” also participated in the 10k and 5k events. Notably, Dalia Ghoneim (5k) and Adam Cornwall (10k) and placed 1st and 2nd in their group, and 2nd and 7th overall.  In addition, Scott Friedland and our new faculty addition, Brian Altman, both placed 4th in their age group for the 5k. Congratulations!!

Neuroscience Graduate Program Student Receives Award for SfN Trainee Professional Development

Tuesday, September 11, 2018

Photo of Emily WarnerEmily Warner was recently selected to receive a 2018 Trainee Professional Development Award (TPDA) from the Society for Neuroscience.  These are highly competitive awards and it is a great achievement for Emily.

The award comes with a complementary registration to the conference in San Diego and a monetary award of $1000.  Emily will present a poster at a poster session for other recipients and will be able to attend several Professional Development Workshops while at the conference.

Congratulations Emily!

New Issue of Opportunities to Explore

Monday, September 10, 2018

The latest issue of opportunities to explore is out(September 10-14), packed with events, information and resources starting from next week and well into next month

Opportunities to Explore - September 10-14, 2018

New Issue of Opportunities to Explore

Monday, September 3, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into next month

Opportunities to Explore - September 3-7, 2018

New Issue of Opportunities to Explore

Sunday, August 26, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into next month

Opportunities to Explore - August 27-31, 2018

Neuroscience Graduate Program Student Receive 3 Convocation Awards

Wednesday, August 22, 2018

Congratulations to our NGP students for again earning these honors at this year's School of Medicine and Dentistry Convocation Ceremony.

  • Kathryn Toffolo (1st year):  Merritt and Marjorie Cleveland Fellowship Award
    • This fellowship was established in 1991 from Mr. and Mrs. Merritt Cleveland and is awarded to a Ph.D. student entering graduate study through the Biomedical Sciences Program with interest in developing a neuroscience-related research career.
  • Monique Mendes (4th year): Outstanding Student Mentor Award
    • This award, established in 2015, recognizes a student mentor who guides, supports and promotes the training and career development of others.
  • Gregory Reilly (1st year): J. Newell Stannard Graduate Student Scholarship Award
    • This scholarship was established by Dr. Stannard, Professor Emeritus, to recognize one deserving incoming graduate student for their commendable academic achievements. Dr. Stannard developed the world’s first doctoral program in radiation biology at the School of Medicine and was a faculty member for almost 40 years before retiring in 1975. He taught and mentored hundreds of students who went on to become leaders and experts in the field of radiation health.

School of Medicine Names New Dean for Graduate Education

Tuesday, August 21, 2018

Photo of Richard Libby

Richard T. Libby, Ph.D.

Richard T. Libby Ph.D., professor of Ophthalmology and of Biomedical Genetics at the University of Rochester School of Medicine and Dentistry, and a member of the University’s Center for Visual Science, has been named Senior Associate Dean for Graduate Education and Postdoctoral Affairs (GEPA), pending approval of the University Board of Trustees. Beginning Sept. 1, Libby will direct the School of Medicine and Dentistry’s Ph.D., postdoctoral and master’s degree programs. He succeeds Edith M. Lord, Ph.D., who served a decade in the role and is shifting her focus to microbiology and immunology research.

An innovative researcher in the neurobiology of glaucoma, Libby arrived in Rochester in 2006 after postdoctoral and fellowship experiences that enlightened him on the power of model genetics systems in the study of eye disease. Years spent training at the Medical Research Council’s Institute for Hearing Research in Nottingham, England, and the Jackson Laboratory in Bar Harbor, Maine, formed the foundation for his current laboratory, which is focused on understanding the cell signaling pathways that lead to vision loss in glaucoma.

Libby is director of the Cell Biology of Disease Graduate Program, has served on numerous academic committees integral to research activities and graduate education, and is a respected mentor and teacher. He has published, as author or co-author, more than 60 peer-reviewed scientific articles and numerous reviews, book chapters and commentaries, and has presented internationally on a range of topics in eye and vision research.

“Rick understands that excellence in a research enterprise is essential to attracting the best and brightest talent and has articulated a vision for further improving the experience here, making it clear to the outside world that Rochester is the best place to learn and study,” said Mark Taubman, M.D., CEO of the Medical Center and Dean of the School of Medicine and Dentistry at the University of Rochester. “He is a passionate scientist whose experience in a clinical department will bring valuable insight to graduate programs in basic and clinical research—a true asset to his role in helping prepare future generations of scientists.”

“Complementing his expertise in leading graduate programs, and thorough understanding of their needs, Rick has developed a thoughtful approach to what it will take to continue moving them forward. It’s clear that he’s driven by a desire to develop our trainees and motivated to give them the best graduate/postdoctoral experience possible,” said Stephen Dewhurst, Ph.D., Vice Dean for Research at the School of Medicine and Dentistry and Associate Vice President for Health Sciences Research at the University of Rochester. “In addition, having developed his own career in a somewhat untraditional way, Rick brings an added dimension to understanding and supporting others who are exploring diverse career options.”

Libby received a doctorate degree in biology from Boston College in the field of neurodevelopment.  He was a postdoctoral fellow at the Medical Research Council’s Institute for Hearing Research in Nottingham England, and a postdoctoral fellow at the Jackson Laboratory in Bar Harbor, Maine. He joined the School of Medicine and Dentistry faculty as an assistant professor in 2006, was named associate professor in 2012, and professor in 2018.

“Rick is a great choice to succeed Edith Lord as the Senior Associate Dean for Graduate Education,” said Dirk Bohmann, Ph.D., Donald M. Foster, M.D. Professor of Biomedical Genetics and Senior Associate Dean for Basic Research, who led the search committee. “He realizes that research excellence and successful graduate and postdoctoral programs are mutually dependent. You cannot have one without the other. He will be a passionate advocate for the graduate students and postdocs.”

“Under Dr. Lord’s leadership, GEPA has greatly enhanced the support and training of URMC’s graduate students and postdoctoral fellows,” Libby said. “In fact, GEPA has helped lead the nation in providing enhanced educational opportunities to ready trainees for the numerous careers available to the modern-day scientist. I am excited to be a part of this team. I look forward to further developing GEPA’s missions of providing world-class training for our graduate students and postdoctoral fellows, and to helping our trainees continue their important work focused on understanding human health and disease.”

Lord’s four-decade career in Rochester is dotted with milestones and accomplishments. She joined the School of Medicine and Dentistry faculty as a senior instructor in 1976 and rose through the ranks to professor in 1994. In 10 years as Senior Associate Dean, she worked to improve the experience of graduate students and postdocs in and outside the lab, adding Postdoctoral Affairs to the Office for Graduate Education’s name, standardizing salaries and benefits, and advocating on behalf of trainees. She spearheaded a revamping of the fundamental basic science courses, incorporating more workshops and active learning components and emphasizing team-based science. She also fostered professional development initiatives and guided efforts to support students’ health and wellbeing. Her return to the research lab will include focusing on an NIH grant to study the immune response in tumors.

New Issue of Opportunities to Explore

Friday, August 17, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into next month

Opportunities to Explore - August 20-24, 2018

Ralph Jozefowicz Honored for Mentoring Next Generation of Leaders in Neurology

Tuesday, August 14, 2018

URMC neurologist Ralph Jozefowicz, M.D., has been awarded the American Academy of Neurology’s (AAN) Leading in Excellence through Mentorship award.  He received the recognition at the AAN’s 2018 annual meeting. 

Jozefowicz, a professor of Neurology and Medicine, is a nationally recognized leader and innovator in neurologic education and has received numerous awards and accolades from AAN, the American Neurological Association, the Fulbright Program, the Association of American Medical Colleges, and Jagiellonian University in Poland for his work in the field.

He currently serves as director for the second year medical student "Mind, Brain and Behavior" course and co-director of the third year Neurology Clerkship. He is also the Neurology Residency Program Director at the URMC.

You can read more about the award and perspectives from colleagues he has mentored over the years in Neurology Today.

MSTP Alum, Alan Kenny Headlines MSTP 18th Annual Retreat

Friday, August 10, 2018

2018 retreat photo

August 10, 2018 marked the Medical Scientist Training Program’s 18th Annual Retreat. The retreat was held at the Rochester Yacht Club, overlooking Lake Ontario and the Genesee River.

The Annual Retreat is an opportunity for the entire program to touch base and welcome incoming students. This year, the MSTP welcomed 8 new students: Catherine Beamish, Wash U., Zachary Christensen, UR 2nd year med. (Brigham Young U.), Ankit Dahal (U. Penn), Adam Geber (Columbia U.), Emily Isenstein (Cornell U.), Bryan Redmond (Xavier U.), Alison Roby (Penn St.), Matt Sipple (Cornell U.).

2018 MSTP Incoming Students
2018 MSTP Incoming Students

The Keynote this year (“Iterations of cross-talk direct differentiation in development”) was given by former URMC MSTP Student, Alan P. Kenny, MD, PhD, Assistant Professor, Pediatrics (Neonatology) at the University of Cincinnati Children’s Hospital, Cincinnati, OH. Dr. Kenny focuses his research on elucidating the molecular mechanisms controlling the earliest stages of respiratory and digestive organ development. Available evidence suggests that early lung, liver, and pancreas lineages develop from a pool of foregut progenitor cells in the ventral endoderm. They are induced by FGF and BMP signals emanating from the cardiogenic mesenchyme during early somite stages of development through a mechanism that is highly conserved among vertebrates.

Following the keynote, the morning science session concluded with several short-format research talks by Mark Kenney(M2, lab rotation, Summer 2018 - Edward Schwarz, PhD), Jonathan Gigas (G1, Vera Gorbunova, PhD), Karl Foley ( G2, Houhui Xia, PhD), Matthew Tanner (G3, Charles Thornton, MD), Colleen Schneider (G4, Bradford Mahon, PhD), and Evan McConnell, PhD (M3, Maiken Nedergaard, DMD, PhD).

After lunch, the program convened for a business meeting. Attendees of the Keystone MD/PhD Student Conference and the Class Council representative for American Physician Scientist Association (ASPA) reported on their trips to annual meetings and upcoming events. New Student Council members were elected at the end of the afternoon.

After closing the meeting, MD/PhD students met for conversation and drinks overlooking the water. Another successful year for the program!

New Issue of Opportunities to Explore

Friday, August 10, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into next month

Opportunities to Explore - August 13-17, 2018

NGP Student Monique Mendes Selected as a Neuroscience Scholars Program Fellow

Tuesday, August 7, 2018

Photo of Monique MendesMonique was selected by the Society for Neuroscience's Professional Development Committee and its Diversity in Neuroscience Subcommittee as a Neuroscience Scholars Program Fellow.  This program is designed to provide underrepresented graduate students in neuroscience with career development and networking opportunities to help them with success going into the future.

The program provides the following benefits:

  • A mentoring team consisting of a senior mentor and a member of the Diversity in Neuroscience Subcommittee.  The team will discuss a fellow's research, career plans, and overall experience.
  • Two years of complimentary SfN membership.
  • A travel award to attend the SfN annual meeting each fall during the two-year program.
  • Up to $1500 in enrichment funds to support allowed professional development activities.

Congratulations Monique!

New Issue of Opportunities To Explore - August 6-10, 2018

Friday, August 3, 2018

This weeks events in Opportunities To Explore:

  • Page-Turners for Teaching - discussion group for grad students, medical students, postdocs, and residents interested in exploring their teaching practice with like-minded colleagues!
  • Center for the Integration of Research, Teaching and Learning (CIRTL) Webinar - Faculty Advising: What You Need to Know and How to Do It Well
  • Postdoctoral Association (PDA) Monthly Meeting

That's Just this week, there are opportunities, information and events going into September in the latest issue of Opportunities To Explore!

Opportunities To Explore - August 6-10, 2018

New Issue of Opportunities to Explore

Friday, July 27, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into Summer, we also have an employment and internship opportunity advertised in this issue. Check it out!

Latest Issue of Opportunities to Explore - July 30-August 3, 2018

Edward Ayoub, CMPP graduate student in the laboratory of Dr. Archibald S. Perkins, was awarded an NRSA F31 beginning 8/1/18

Monday, July 23, 2018

Edward Ayoub - Recipient of a Two-Year Ruth L. Kirschstein National Research Service Award (NRSA)
Individual Predoctoral Fellowship (F31) August 1, 2018 – July 31, 2020

Thursday, July 19, 2018

Edward Ayoub, graduate student in the laboratory of Dr. Archibald S. Perkins was awarded a two-year Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship entitled, “Therapeutic Strategies for Anemia in 3q26 Rearranged Leukemia”.

Project Summary

According to the most recent NIH Cancer Statistics Review, leukemia, a cancer of blood cells, is the ninth most common type of cancer. Acute myeloid leukemia (AML) is an aggressive form of leukemia with high lethality (~75% of patients die 5 years after being diagnosed) characterized by anemia, and excessive proliferation of abnormal myeloid progenitor cells in the bone marrow (BM). Rearrangements of the chromosomal band 3q26 portend further reduction in survival, and lead to the overexpression of the oncogene Ecotropic Viral Integration Site 1 (EVI1). The severity of 3q26 rearranged AML, the lack of in-depth understanding of the role of EVI1 in leukemia, and the inadequate therapeutic strategies interested our lab and others to investigate EVI1 associated leukemogenesis. While previous groups used transplantation of BM virally transduced to overexpress EVI1, we are the first lab to recapitulate the effects of the 3q26 rearrangements in the mouse by establishing an inducible EVI1-overexpression model, which has provided us with new insights into the mechanisms by which EVI1 induces leukemia. We concluded using our in vivo and in vitro models that EVI1 causes myeloid expansion and blocks both erythropoiesis and lymphopoiesis. As an insight to the molecular mechanism, we previously documented that EVI1 binds to GACAAGATA, which overlaps with the binding site of the master regulator of erythropoiesis GATA-1. Additionally, our data indicate that EVI1 upregulates a previously published GATA-1 blocker, PU.1, and we showed that EVI1 binds to an enhancer upstream of PU.1 encoding gene (Spi-1). Thus, we hypothesize that EVI1 blocks erythroid differentiation by two mechanisms: 1) directly competing with GATA-1 for key genomic binding sites harboring EVI1/GATA-1 overlap motifs and 2) binding to Spi-1 enhancer and upregulating PU.1, which suppresses GATA1 function. We will investigate both hypothesized mechanisms using cutting edge techniques including ChIP-seq, ATAC-seq, and CRISPR under the training of my sponsor and collaborator. In order to translate the proposed mechanistic insights into clinical settings and therapeutic strategies, we will perform CRISPR library screening using an in vivo model to identify genes that reverse erythropoiesis blockage associated with EVI1-overexpression.  

In summary, this fellowship will focus on investigating erythropoiesis blockage and resulting anemia that might explain the increased lethality associated with 3q26 rearranged leukemia, and It will unveil new therapeutic strategies that reverse the leukemia-associated anemia.

New Issue of Opportunities to Explore

Monday, July 23, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into August, we also have an employment and internship opportunity advertised in this issue. Check it out!

Latest Issue of Opportunities to Explore 7/23-7/27

New Issue of Opportunities to Explore

Friday, July 13, 2018

This Week

Town hall meetings are being held to allow students to meet the candidates for Associate Dean for Graduate Education. 

  • Denise Hocking | Monday, July 16 | 2:00 – 3:00 PM | 1-7619 Adolf Auditorium
  • Richard Libby | Tuesday, July 17 | 11:30 – 12:30 PM | 1-9576 Ryan Case Method Room
  • Edwin van Wijngaarden | Wednesday, July 18 | 12:00 – 1:00 PM | 1-7619 Adolf Auditorium

Also this week:

  • A webinar on leveraging your PhD for career success
  • Page-Turners for Teaching a new bi-weekly  discussion group for grad students, medical students, postdocs, and residents interested in exploring their teaching practice with like-minded colleagues!
  • Pride Parade - Walk with the University of Rochester in the 2018 pride parade will send a positive message of support to the LGBTQ community.

For more information on this weeks events as well as many, many other opportunities, check out this weeks issue!

Opportunities To Explore - July 16-20, 2018

Isaac Fisher, 5th year graduate student in the lab of Alan V. Smrcka, won first place for his poster at the EB/ASPET meeting in San Diego

Monday, July 9, 2018

Group Photo-Isaac Fisher-Prize winning Poster from EB ASPET 2018

Congratulations to Isaac Fisher, a 5th year student in the laboratory of Dr. Alan V. Smrcka for receiving First Place in the Postbaccalaureate/Graduate Student category within the Division for Molecular Pharmacology!  We applaud your contributions to ASPET’s 2018 Student Competition.

The winners of the awards for the ASPET Student Poster Competition were announced at the Division Mixer on Tuesday, April 24 at EB 2018 in San Diego.

Poster Details

Title: Hydrogen Deuterium Exchange Mass Spectrometry Reveals Distinct Activation States of PCLb by G-Protein

Authors: Isaac Fisher, Meredith Jenkins, Greg Tall, John Burke, and Alan V. Smrcka

Isaac Fisher-Prize winning Poster from EB ASPET 2018

See Awards on ASPET website