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Ralph Jozefowicz Honored for Mentoring Next Generation of Leaders in Neurology

Tuesday, August 14, 2018

URMC neurologist Ralph Jozefowicz, M.D., has been awarded the American Academy of Neurology’s (AAN) Leading in Excellence through Mentorship award.  He received the recognition at the AAN’s 2018 annual meeting. 

Jozefowicz, a professor of Neurology and Medicine, is a nationally recognized leader and innovator in neurologic education and has received numerous awards and accolades from AAN, the American Neurological Association, the Fulbright Program, the Association of American Medical Colleges, and Jagiellonian University in Poland for his work in the field.

He currently serves as director for the second year medical student "Mind, Brain and Behavior" course and co-director of the third year Neurology Clerkship. He is also the Neurology Residency Program Director at the URMC.

You can read more about the award and perspectives from colleagues he has mentored over the years in Neurology Today.

MSTP Alum, Alan Kenny Headlines MSTP 18th Annual Retreat

Friday, August 10, 2018

2018 retreat photo

August 10, 2018 marked the Medical Scientist Training Program’s 18th Annual Retreat. The retreat was held at the Rochester Yacht Club, overlooking Lake Ontario and the Genesee River.

The Annual Retreat is an opportunity for the entire program to touch base and welcome incoming students. This year, the MSTP welcomed 8 new students: Catherine Beamish, Wash U., Zachary Christensen, UR 2nd year med. (Brigham Young U.), Ankit Dahal (U. Penn), Adam Geber (Columbia U.), Emily Isenstein (Cornell U.), Bryan Redmond (Xavier U.), Alison Roby (Penn St.), Matt Sipple (Cornell U.).

2018 MSTP Incoming Students
2018 MSTP Incoming Students

The Keynote this year (“Iterations of cross-talk direct differentiation in development”) was given by former URMC MSTP Student, Alan P. Kenny, MD, PhD, Assistant Professor, Pediatrics (Neonatology) at the University of Cincinnati Children’s Hospital, Cincinnati, OH. Dr. Kenny focuses his research on elucidating the molecular mechanisms controlling the earliest stages of respiratory and digestive organ development. Available evidence suggests that early lung, liver, and pancreas lineages develop from a pool of foregut progenitor cells in the ventral endoderm. They are induced by FGF and BMP signals emanating from the cardiogenic mesenchyme during early somite stages of development through a mechanism that is highly conserved among vertebrates.

Following the keynote, the morning science session concluded with several short-format research talks by Mark Kenney(M2, lab rotation, Summer 2018 - Edward Schwarz, PhD), Jonathan Gigas (G1, Vera Gorbunova, PhD), Karl Foley ( G2, Houhui Xia, PhD), Matthew Tanner (G3, Charles Thornton, MD), Colleen Schneider (G4, Bradford Mahon, PhD), and Evan McConnell, PhD (M3, Maiken Nedergaard, DMD, PhD).

After lunch, the program convened for a business meeting. Attendees of the Keystone MD/PhD Student Conference and the Class Council representative for American Physician Scientist Association (ASPA) reported on their trips to annual meetings and upcoming events. New Student Council members were elected at the end of the afternoon.

After closing the meeting, MD/PhD students met for conversation and drinks overlooking the water. Another successful year for the program!

NGP Student Monique Mendes Selected as a Neuroscience Scholars Program Fellow

Tuesday, August 7, 2018

Photo of Monique MendesMonique was selected by the Society for Neuroscience's Professional Development Committee and its Diversity in Neuroscience Subcommittee as a Neuroscience Scholars Program Fellow.  This program is designed to provide underrepresented graduate students in neuroscience with career development and networking opportunities to help them with success going into the future.

The program provides the following benefits:

  • A mentoring team consisting of a senior mentor and a member of the Diversity in Neuroscience Subcommittee.  The team will discuss a fellow's research, career plans, and overall experience.
  • Two years of complimentary SfN membership.
  • A travel award to attend the SfN annual meeting each fall during the two-year program.
  • Up to $1500 in enrighment funds to support allowed professional development activities.

Congratulations Monique!

New Issue of Opportunities To Explore - August 6-10, 2018

Friday, August 3, 2018

This weeks events in Opportunities To Explore:

  • Page-Turners for Teaching - discussion group for grad students, medical students, postdocs, and residents interested in exploring their teaching practice with like-minded colleagues!
  • Center for the Integration of Research, Teaching and Learning (CIRTL) Webinar - Faculty Advising: What You Need to Know and How to Do It Well
  • Postdoctoral Association (PDA) Monthly Meeting

That's Just this week, there are opportunities, information and events going into September in the latest issue of Opportunities To Explore!

Opportunities To Explore - August 6-10, 2018

New Issue of Opportunities to Explore

Friday, July 27, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into Summer, we also have an employment and internship opportunity advertised in this issue. Check it out!

Latest Issue of Opportunities to Explore - July 30-August 3, 2018

Edward Ayoub, CMPP graduate student in the laboratory of Dr. Archibald S. Perkins, was awarded an NRSA F31 beginning 8/1/18

Monday, July 23, 2018

Edward Ayoub - Recipient of a Two-Year Ruth L. Kirschstein National Research Service Award (NRSA)
Individual Predoctoral Fellowship (F31) August 1, 2018 – July 31, 2020

Thursday, July 19, 2018

Edward Ayoub, graduate student in the laboratory of Dr. Archibald S. Perkins was awarded a two-year Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship entitled, “Therapeutic Strategies for Anemia in 3q26 Rearranged Leukemia”.

Project Summary

According to the most recent NIH Cancer Statistics Review, leukemia, a cancer of blood cells, is the ninth most common type of cancer. Acute myeloid leukemia (AML) is an aggressive form of leukemia with high lethality (~75% of patients die 5 years after being diagnosed) characterized by anemia, and excessive proliferation of abnormal myeloid progenitor cells in the bone marrow (BM). Rearrangements of the chromosomal band 3q26 portend further reduction in survival, and lead to the overexpression of the oncogene Ecotropic Viral Integration Site 1 (EVI1). The severity of 3q26 rearranged AML, the lack of in-depth understanding of the role of EVI1 in leukemia, and the inadequate therapeutic strategies interested our lab and others to investigate EVI1 associated leukemogenesis. While previous groups used transplantation of BM virally transduced to overexpress EVI1, we are the first lab to recapitulate the effects of the 3q26 rearrangements in the mouse by establishing an inducible EVI1-overexpression model, which has provided us with new insights into the mechanisms by which EVI1 induces leukemia. We concluded using our in vivo and in vitro models that EVI1 causes myeloid expansion and blocks both erythropoiesis and lymphopoiesis. As an insight to the molecular mechanism, we previously documented that EVI1 binds to GACAAGATA, which overlaps with the binding site of the master regulator of erythropoiesis GATA-1. Additionally, our data indicate that EVI1 upregulates a previously published GATA-1 blocker, PU.1, and we showed that EVI1 binds to an enhancer upstream of PU.1 encoding gene (Spi-1). Thus, we hypothesize that EVI1 blocks erythroid differentiation by two mechanisms: 1) directly competing with GATA-1 for key genomic binding sites harboring EVI1/GATA-1 overlap motifs and 2) binding to Spi-1 enhancer and upregulating PU.1, which suppresses GATA1 function. We will investigate both hypothesized mechanisms using cutting edge techniques including ChIP-seq, ATAC-seq, and CRISPR under the training of my sponsor and collaborator. In order to translate the proposed mechanistic insights into clinical settings and therapeutic strategies, we will perform CRISPR library screening using an in vivo model to identify genes that reverse erythropoiesis blockage associated with EVI1-overexpression.  

In summary, this fellowship will focus on investigating erythropoiesis blockage and resulting anemia that might explain the increased lethality associated with 3q26 rearranged leukemia, and It will unveil new therapeutic strategies that reverse the leukemia-associated anemia.

New Issue of Opportunities to Explore

Monday, July 23, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into August, we also have an employment and internship opportunity advertised in this issue. Check it out!

Latest Issue of Opportunities to Explore 7/23-7/27

New Issue of Opportunities to Explore

Friday, July 13, 2018

This Week

Town hall meetings are being held to allow students to meet the candidates for Associate Dean for Graduate Education. 

  • Denise Hocking | Monday, July 16 | 2:00 – 3:00 PM | 1-7619 Adolf Auditorium
  • Richard Libby | Tuesday, July 17 | 11:30 – 12:30 PM | 1-9576 Ryan Case Method Room
  • Edwin van Wijngaarden | Wednesday, July 18 | 12:00 – 1:00 PM | 1-7619 Adolf Auditorium

Also this week:

  • A webinar on leveraging your PhD for career success
  • Page-Turners for Teaching a new bi-weekly  discussion group for grad students, medical students, postdocs, and residents interested in exploring their teaching practice with like-minded colleagues!
  • Pride Parade - Walk with the University of Rochester in the 2018 pride parade will send a positive message of support to the LGBTQ community.

For more information on this weeks events as well as many, many other opportunities, check out this weeks issue!

Opportunities To Explore - July 16-20, 2018

Isaac Fisher, 5th year graduate student in the lab of Alan V. Smrcka, won first place for his poster at the EB/ASPET meeting in San Diego

Monday, July 9, 2018

Group Photo-Isaac Fisher-Prize winning Poster from EB ASPET 2018

Congratulations to Isaac Fisher, a 5th year student in the laboratory of Dr. Alan V. Smrcka for receiving First Place in the Postbaccalaureate/Graduate Student category within the Division for Molecular Pharmacology!  We applaud your contributions to ASPET’s 2018 Student Competition.

The winners of the awards for the ASPET Student Poster Competition were announced at the Division Mixer on Tuesday, April 24 at EB 2018 in San Diego.

Poster Details

Title: Hydrogen Deuterium Exchange Mass Spectrometry Reveals Distinct Activation States of PCLb by G-Protein

Authors: Isaac Fisher, Meredith Jenkins, Greg Tall, John Burke, and Alan V. Smrcka

Isaac Fisher-Prize winning Poster from EB ASPET 2018

See Awards on ASPET website

New Issue of Opportunities to Explore

Thursday, July 5, 2018

The latest issue of opportunities to explore is out, packed with events, information and resources starting from next week and well into July, we also have an employment and internship opportunity advertised in this issue. Check it out

 

 

Read More: New Issue of Opportunities to Explore

MSTP Student Wins Research Award from American Heart Association

Thursday, June 21, 2018

Jonathan Bartko, MS has received a two-year Predoctoral Fellowship Award from the American Heart Association (AHA).

Bartko is an MD/PhD candidate currently in his second year of the Cell Biology of Disease (Pathology) Graduate Program as part of the Medical Scientist Training Program (MSTP) at the University of Rochester.

He currently works in the lab of Marc Halterman, M.D., Ph.D. which specializes in stroke and cardiac arrest research. Bartko’s current project is entitled, “BDNF-TrkB Regulation of ER-Dependent Death in the Peri-Ischemic Cortex.”

NGP Student Receives Ruth L. Kirschstein Predoctoral Individual National Research Service Award

Thursday, June 21, 2018

Photo of Rianne StowellRianne Stowell, a fourth year NGP graduate student, has been awarded a two year NIH Fellowship award (F31) for her project titled, “Noradrenergic modulation of microglial dynamics and synaptic plasticity”. Rianne works in the laboratory of Ania Majewska, Ph.D.

The purpose of the Kirschstein National Research Service Award program is to enable promising predoctoral students with potential to develop into a productive, independent research scientists, to obtain mentored research training while conducting dissertation research.

Well done Rianne!

Event Recap: Pathology Research Day 2018

Monday, June 18, 2018

The annual Pathology Research Day event at the University of Rochester Medical Center was held on Monday, June 11, 2018.

The day included more than 50 poster presentations in addition to 12 oral presentationsgiven by Pathology residents and fellows, and graduate students in the Cell Biology of Disease Ph.D. Program.

This year’s keynote speaker was Andrew Folpe, M.D. who is professor and consultant for Anatomic Pathology at Mayo Clinic. His engaging and informative talk was titled, “Phosphaturic Mesenchymal Tumors: What I Have Learned.” A video recording of the keynote is available online (note: UR login is required to view).

The graduate program gave out several awards at a special reception at the end of the day, per below.

View Event Photos

Graduate Program Awards

  •         Outstanding Academic Excellence by a First Year Student – David Villani, MS
  •         Outstanding Program Contribution – Sarah Catheline, MS
  •         Robert Mooney Thesis Award – Irena Lerman, Ph.D.

Travel Award for Oral Presentation

  •      Madison Doolittle, MS

Poster Presentation Travel Awards

  •         Robert Hoff, MS
  •         Allison Li, MS
  •         Xi Lin, MS
  •         Robert Maynard, MS

New Issue of Opportunities to Explore

Friday, June 15, 2018

This Week in Opportunities To Explore:

Monday

  • LinkedIn Workshop: Utilizing LinkedIn to Market Yourself in Today’s Job Search Environment
  • NextCorp SBIR Road Show (Postdoc Professional Development Opportunity)

Tuesday

  • Post-doc Only Grant Writing Workshops

Wednesday

  • Graduate Student Society Coffee Hour
  • GoToWebinar - Career Path: "Negotiating Your Way to a Job in Academia"
  • Webinar on Preparing Your Application to the NIGMS PRAT Program
  • Page-Turners For Teaching

Thursday

  • Ubiquitous Stress: Responsive Mentorship in the Higher Education Mental Health Crisis

Saturday

  • GSS Bristol Mountain Aerial Adventure Park

That's just this week, there are several other Opportunities in the current issue, check it out!

Opportunities To Explore - June 18-22, 2018

Biochemistry & Biophysics Students Going Places

Tuesday, June 12, 2018

By Dr. Joseph Wedekind

The Department of Biochemistry & Biophysics is pleased to announce the winners of the Sayeeda Zain Fall Travel awards: Debapratim Dutta, Sierra Fox and Hong Zhu.

The Sayeeda Zain Travel Award honors the distinguished career and charitable life of Dr. Sayeeda Zain. The award is given in recognition of research excellence to support travel and related expenses associated with attendance at a scientific conference or corporate internship to gain practical experience.

Debapratim (Dave) Dutta is presenting a poster and was invited to give a talk at the Annual RNA Society Meeting (Berkeley, CA). Sierra Fox presented a poster and was a Keystone Symposia Future of Science Fund Scholarship recipient at the Keystone Symposia in Chromatin Architecture and Chromatin Organization, and Gene Control in Development and Disease Symposia (Whistler, BC, Canada). Hong Zhu presented a poster at the III International Conference on Vaccines Research and Development (Washington, DC).

Debapratim (Dave) Dutta

Debapratim (Dave) Dutta

Sierra Fox

Sierra Fox

Hong Zhu

Hong Zhu

Neuroscience Grad Student Awarded NIH Diversity Fellowship

Tuesday, June 12, 2018

Photo of Monique MendesMonique S. Mendes, a neuroscience Ph.D. student, is the first University of Rochester Medical Center (URMC) graduate student to receive a prestigious diversity award from the National Institute of Neurological Disorders in Stroke (NINDS).  Mendes works in the laboratory of Ania Majewska, Ph.D. and studies the role that the brain’s immune cells play in development, learning, and diseases like Autism.

Mendes, originally from Kingston, Jamaica, received her undergraduate degree in Biology from the University of Florida. She came to URMC in search of a robust program that focused on glial biology and a collaborative environment.  She chose the Del Monte Institute for Neuroscience to complete her thesis work due in part to Majewska’s record of mentoring students and her lab’s reputation for conducting leading research in brain development. 

Mendes has been awarded a F99/K00 NIH Blueprint Diversity Specialized Predoctoral to Postdoctoral Advancement in Neuroscience (D-SPAN) fellowship from NINDS.  The award was created to provide outstanding young neuroscientists from diverse backgrounds a pathway to develop independent research careers.  Unlike traditional graduate student fellowships, this award provides research funding for 6 years, including dissertation research and mentored postdoctoral research career development.

Read the local Jamacian Observer newspaper article.

Read More: Neuroscience Grad Student Awarded NIH Diversity Fellowship

New Issue of Opportunities to Explore - June 11-15, 2018

Friday, June 8, 2018

This week is the PREP Symposium, the PDA monthly meeting, mid-week brings the Online Career Conference for PhDs and on Thursday students and alumni can learn about The Meliora Collective the University's online network for Alumni and Students in the morning and attend the National Research Mentoring Network (NRMN) Career Development Webinar- Submitting to Journals for Publication in the afternoon.

That's just this week, this issue contains events and opportunities covering June and July, click the link below to read more.

New Issue of Opportunities to Explore - June 11-15, 2018

GSS Annual Poster Session - Travel Award Winners Announced

Thursday, June 7, 2018

Congratulations to our most recent GSS poster session Travel Award Winners!

Lara Terry, 3rd year student in David Yule Lab: 2nd place – Title: Effects of Missense Mutations on Inositol 1,4,5-trisphosphate Receptor Mediated Calcium Release.

Si Chen, 4th year student in Chen Yan lab: 3rd place – Title: PDE10A Inhibition and Deficiency Attenuate Pathological Cardiac Remodeling

Latest Issue of Opportunities To Explore - June 4-8, 2018

Friday, June 1, 2018

The latest issue of Opportunities to Explore is out. Get all the latest updates on events, grants, reading resources and more.

Latest Issue of Opportunities To Explore - June 4-8, 2018

Fourth year NGP Graduate Student Publishes in Journal of Neuroscience

Tuesday, May 29, 2018

Fourth year NGP graduate student Patrick Miller-Rhodes (Gelbard lab) has recently published a single author review in Journal of Neuroscience (Journal Club, J Neurosci. 2018 38(19):4457– 4459) tackling the fascinating and timely topic of the heterogeneity of microglial mechanisms that contribute to normal brain functions such as synaptic plasticity. In this publication, Patrick highlights a recent study by NGP alumna Rebecca Lowery (Majewska lab; Glia 65(11):1744-1761), showing that microglial CX3CR1 loss does not affect multiple forms of plasticity, to make his point that the mechanisms microglia use to support neuronal function are likely diverse and differ based on brain region and developmental stage.

Congratulations Patrick and go NGP!

Latest Issue of Opportunities To Explore - May 28-June 1, 2018

Friday, May 25, 2018

The latest issue of Opportunities to Explore is out. Get all the latest updates on events, grants, reading resources and more.

Latest Issue of Opportunities To Explore - May 28-June 1, 2018

Outstanding Dissertations Honored

Wednesday, May 23, 2018

Each year, Arts, Sciences & Engineering and the School of Medicine and Dentistry recognize outstanding research and dissertations by PhD students.

Wishing our graduates well at the 2018 Commencement Dinner

Wednesday, May 23, 2018

The 2018 Ph.D.Commencement Dinner was held at the Daisy Flour Mill. Following introductions from Edith Lord, Senior Associate Dean for Graduate Education and Jennifer Stripay, representing the University of Rochester Alumni Council, Awards were presented to three graduating PhD students:

Vincent du Vigneaud Award: Anthony DiPiazza, Microbiology and Immunology, “Insights into CD4 T Cell-Mediated Immunity to Influenza Viruses.” The award is conferred by the Office of Graduate Education to a graduating student whose thesis is judged superior and unique in potential for stimulating and extending research in the field.

Wallace O. Fenn Award: Benjamin Plog, Pathology, “Novel Insight into Regulation of Glymphatic Flow with Implications for Traumatic Brain Injury.” The award is given annually to a graduating student judged to have performed especially meritorious research and who presented a Ph.D. thesis suitable to honor the name of Wallace Fenn, former professor and chair of physiology.

Marvel-Dare F. Nutting Award (recognizing an outstanding Biochemistry PhD): Amber Cutter, whose PhD dissertation was on “Molecular Characterization of Nucleosome Recognition by Linker Histone H1.0.” 

Commencement Dinner Photos

2018 Commencement Dinner

Latest Issue of Opportunities to Explore - May 21-25, 2018

Friday, May 18, 2018

This week holds professional development day, a URBEST Career Story from Sarah Goodwin, PhD and the CIRTL@UR Research Day along with workshops on Strategies for Effective Clinical Teaching and Learning and The Bottom Line: What You Need To Know About Interviewing.

There are many events, opportunities and resources in the latest issue, check it out!

Latest Issue of Opportunities to Explore - May 21-25, 2018

Catching Research Fever: UR CTSI’s Academic Research Track Turns Medical Students into Medical Researchers

Wednesday, May 16, 2018

By Susanne Pritchard Pallo

MSTP Students

The MSTP 2017 incoming class, with former UR CTSI Academic Research Track participants Samuel Weisenthal and Ian De Andrea-Lazarus (far right).

Over the past several decades, concerns have risen about the declining population of physician-scientists, with reports pointing to early career training and support as a possible solution. The UR CTSI Academic Research Track, which allows medical students to try their hands at research, has helped two University of Rochester School of Medicine and Dentistry students take the next step toward a research career: joining an MD-PhD program.  

The pair, Ian De Andrea-Lazarus and Samuel Weisenthal, joined the University of Rochester Medical Scientist Training Program after finishing their Academic Research Track projects. This is a move that a new study from the Association of American Medical Colleges suggests will help them stay in science. The study tracked MD-PhD program graduates over 50 years and showed that most stuck with their research careers. 

Ian and Sam explain what drove them to pursue a career as physician-scientists.

Why did you join the UR CTSI’s Academic Research Track?

Ian: I’ve always craved knowledge and enjoy the challenge of pushing the boundaries of existing human knowledge. I had several years of research experience before applying for medical school - as an undergraduate research assistant in the Linguistics Department at Gallaudet University and as a post-baccalaureate fellow at the National Cancer Institute. For two years, I worked in the Laboratory of Cancer Biology and Genetics at NCI, studying a non-selective cation channel found mainly in the peripheral nervous system that is involved in the transmission and modulation of pain.

Sam: Like Ian, I was inspired by my time as a post-baccalaureate trainee at the NIH, where I worked for a year in a computational radiology lab. I also had a great time doing a summer research project in health informatics at Rochester. I joined the Academic Research Track because I wanted to study the vast amount of data being collected through the electronic health record. In a single year, the University of Rochester Medical Center alone accrues more than two terabytes of non-image data (a lot). I was particularly interested in how this data could be used to predict – and hopefully help prevent – adverse health events in patients. 

How did your experience in the Academic Research Track drive you to join the University of Rochester Medical Scientist Training Program?

Ian: I had originally wanted to apply for the University of Rochester Medical Scientist Training Program but I was afraid that my application would not be competitive enough. The Academic Research Track was the bridge that allowed me to pursue my goal of becoming a physician-scientist and reinvigorated my interest in research. The program allowed me to obtain a master’s degree in Public Health along with the tools and drive I needed to apply for the MD-PhD program.

Sam: I had also previously considered an MD-PhD program, but did not have a cohesive story to tell in an application. The Academic Research Track year allowed me to obtain a master’s degree in Data Science from the Goergen Institute for Data Science at the University of Rochester, which provided a foundation for more advanced study. It also helped me discover the UR CTSI’s Translational Biomedical Science PhD Program, which was a good fit, and to fully engage in a research project in a great lab. 

What did you study during the Academic Research Track program?

Sam: We were initially interested in predicting readmission to the intensive care unit, which is a quality metric used by some hospitals. Ultimately, however, we decided to focus on predicting acute kidney injury, which is common, deadly, and sometimes completely preventable with simple interventions like fluid administration or medication review.  Insights from our studies could be used to hopefully develop a better predictive tool that could help prevent acute kidney injury in the future.

Ian: We explored the association between low levels of lead in the serum of 3- to 5-year-old children and their mental capacity to focus attention, remember instructions, and juggle multiple tasks. We used a well-characterized tool for assessing these mental executive functions in children, called the Stroop day-night task, but found that the tool may not be sensitive enough to detect lead’s effects on neurodevelopment.

What are you studying now?

Sam: I am pursuing a joint degree between the Translational Biomedical Science PhD Program and Computer Science Department, with Computer Science as a minor. This includes select coursework in computer science, biostatistics, and medicine. My research focus is a continuation of my Academic Research Track project with Martin Zand, Ph.D., co-director of the UR CTSI and professor of Nephrology and Public Health Sciences at the University of Rochester Medical Center. Our goal is to improve acute kidney injury prediction by reformulating the standard approach and performing more rigorous error analysis. Ultimately, we hope to squeeze maximal predictive value out of electronic health record data to assist physicians in making the best decisions for at-risk patients.

Ian: I am pursuing a doctoral degree in the UR CTSI’s Translational Biomedical Science PhD Program and working with John Foxe, Ph.D., Killian J. and Caroline F. Schmitt chair of Neuroscience, and Edward Freedman, Ph.D., associate professor of Neuroscience, on a mobile brain/body imaging (MoBI) study. We are interested in understanding how the brains of people with decreased cognitive function, like those with Alzheimer’s disease, handle the cognitive demands of multitasking while walking, which requires continuous processing of information about the environment and body position.

Read More: Catching Research Fever: UR CTSI’s Academic Research Track Turns Medical Students into Medical Researchers

Pharmacology Alumni Named Associate Dean

Friday, May 11, 2018

Jennifer Mathews in front of ACPHS LogoJennifer Mathews, PhD has been named the Associate Dean for the Albany College of Pharmacy and Health Sciences - Vermont Campus.

Dr. Mathews earned her doctorate in Pharmacology from the University of Rochester in 2007, her field(s) of interest as a student were Neuropharmacology, Opioid receptors, Pain, Tolerance, Antinociception

Her responsibilities will include execution of the pharmacy program; supervision of faculty; campus operations; and coordination of the development, implementation, and assessment of initiatives that support the programs on the Vermont Campus, which also include a Master’s program in Pharmaceutical Sciences.

Congratulations to Dr. Mathews!

Read More: Pharmacology Alumni Named Associate Dean

New Issue of Opportunities to Explore - May 14-18, 2018

Thursday, May 10, 2018

This week features a webinar on renting in New York City, the Graduate Student Society (GSS) Coffee Hour, a CV/Resume workshop and the 5th Annual Alumni Networking Event, the work week ends with the Pre-doctoral Organization for the Neurosciences (PONS) Luncheon Roundtable Series and the weekend brings commencement for Doctoral and Master Degree Students. Congratulations to all of our graduates!

Opportunities to Explore has Events and Grant, Travel Award, and Conference Information into June and beyond!

New Issue of Opportunities to Explore - May 14-18, 2018

Deborah Cory-Slechta Receives Lifetime Achievement Award in Graduate Education

Monday, May 7, 2018

As a faculty member at the School of Medicine and Dentistry, Deborah Cory-Slechta holds professorship positions in the departments of Environmental Medicine, Pediatrics, and Public Health Sciences. A former chair of the Department of Environmental Medicine and principal investigator of the department’s National Institute of Environmental Health Sciences Center, Cory-Slechta has been nationally and internationally recognized for her scientific contributions.

Considered one of the medical school’s most distinguished faculty members, Cory-Slechta served in leadership roles for several Ph.D. programs, where she also teaches key graduate courses. As the recipient of a Women’s Health and the Environment over the Entire Lifespan grant, she oversees a career development and mentoring initiative for junior faculty members.

Widely regarded for her research on the consequences of developmental exposures to environmental chemicals on brain development and behavior, she has examined the effects of exposures to metals, pesticides and air pollutants. That work—particularly her groundbreaking research on the biological effects of exposure to lead—has had important regulatory and policy implications.

After earning her undergraduate and master’s degree at Western Michigan University, she received her PhD at the University of Minnesota. Following a postdoctoral fellowship at Rochester, she joined the University in 1982.

Read More: Deborah Cory-Slechta Receives Lifetime Achievement Award in Graduate Education

Students Present 'Groundbreaking and Transformative' Research at Expo

Friday, May 4, 2018

At the annual Undergraduate Research Exposition, students presented projects on topics ranging from fluid dynamics, deforestation in Bolivia, and nomad cultures in Morocco, to prenatal depression, meteorites, and software that affects education. President’s Award winners Lauren Oey ’18 (left), Harrah Newman ’18, Yiyun Huang ’18, and Perry DeMarche ’18 were among the students honored at the event.

Pathology Graduate, Ben Plog, Ph.D., Receives 2018 Fenn Award

Wednesday, May 2, 2018

Ben PlogBen Plog, Ph.D. has been named the recipient of the distinguished Wallace O. Fenn Award. Named after the late University Physiology professor and chair, the award is given to a graduating student whose Ph.D. research and thesis honor the name and work of Dr. Fenn.

Plog was a medical science training program (MSTP) student who entered the Pathology graduate program in 2012 to work in the lab of Maiken Nedergaard, M.D., D.M.Sc. in the Center for Translational Neuromedicine and Neurosurgery. Having defended his thesis (titled Novel Insight into Regulation of Glymphatic Flow with Implications for Traumatic Brain Injury), Plog has returned to Medical School to continue his Medical School training and will be part of 2018 Ph.D. degree conferral.

Latest Rochester Medicine Explores the 'Spirit and Science' of Lynne Maquat

Tuesday, May 1, 2018

maquat

The magazine's new issue, now in an interactive, flip-book format, highlights the investigative work of the J. Lowell Orbison Endowed Chair, as well as the impressive efforts of our medical students, alumni and faculty—past and present.

Read More: Latest Rochester Medicine Explores the 'Spirit and Science' of Lynne Maquat

Neuroscience Graduate Student publishes paper with the Briggs lab

Friday, April 27, 2018

Neuroscience Graduate student Allison Murphy co-authored a paper with the Briggs lab while in a rotation with the lab.  Allison contributed an extensive amount of work toward the paper during her fall rotation, and the paper was accepted shortly after her joining the lab.

Postdoctoral fellow, Mike Hasse was the first author on the paper, "Morphological heterogeneity among corticogeniculate neurons in ferrets: quantification and comparison with a previous report in macaque monkeys."

Nice work Allison and Mike!!

Read More: Neuroscience Graduate Student publishes paper with the Briggs lab

The Center for the Integration of Research, Teaching and Learning (CIRTL) Events

Wednesday, April 25, 2018

One of the many sponsored programs within the Center for Professional Development in the School of Medicine & Dentistry is The Center for the Integration of Research, Teaching and Learning (CIRTL). CIRTL is an NSF-funded consortium of 42 PhD granting institutions around the country, whose aim it is to advance the teaching of STEM disciplines in higher education by preparing future faculty. CIRTL uses graduate and postdoc level research trainees as the leverage point to develop national Science, Technology, Engineering, and Mathematics (STEM) faculty committed to implementing and advancing effective teaching practices for diverse student audiences as part of successful professional careers. The goal of CIRTL is to improve the STEM learning of all students at every college and university, and thereby to increase the diversity in STEM fields and the STEM literacy of the nation.

CIRTL provides a number of online workshops, courses, and educational experiences throughout the year. Graduate students and postdocs interested in teaching are encouraged to participate in CIRTL events. For more information about CIRTL, please visit rochester.edu/college/cetl/cirtl/.

Upcoming CIRTL Events Include…

Center for the Integration of Research, Teaching and Learning (CIRTL) @ UR Research Day

Wednesday, May 23 | 9:00 am-5:00 pm | River Campus

Center for the Integration of Research, Teaching and Learning (CIRTL) @ UR will be hosting its annual Research Day and all trainees interested in participating are invited to attend. Kevin Kelly’s LinkedIn profile provides an overview of his work in eLearning. The day’s agenda will include examining teaching through a research lens, optimizing course design, using technology to assess learning in the classroom, using technology to engage diverse learners, and using technology to share course content.  Register for this event. Trainees with an interest in teaching are highly encouraged to attend. For a full overview of the days agenda and workshop descriptions, please contact Dr. Jenny Hadingham at jennifer.hadingham@rochester.edu or (585) 276-5998.

The Bugs in Your Gut Could Make You Weak in the Knees

Tuesday, April 24, 2018

A Prebiotic May Alter the Obese Microbiome and Protect Against Osteoarthritis

Diagram showing the gut microbiome of a person who is obese and has osteoarthritis of several major

The obese microbiome may be a

key driver of osteoarthritis and a

prebiotic supplement may turn

things around.

Bacteria in the gut, known as the gut microbiome, could be the culprit behind arthritis and joint pain that plagues people who are obese, according to a new study published today in JCI Insight.

Osteoarthritis, a common side effect of obesity, is the greatest cause of disability in the US, affecting 31 million people. Sometimes called “wear and tear” arthritis, osteoarthritis in people who are obese was long assumed to simply be a consequence of undue stress on joints. But researchers at the University of Rochester Medical Center provide the first evidence that bacteria in the gut – governed by diet – could be the key driving force behind osteoarthritis.   

The scientists found that obese mice had more harmful bacteria in their guts compared to lean mice, which caused inflammation throughout their bodies, leading to very rapid joint deterioration. While a common prebiotic supplement did not help the mice shed weight, it completely reversed the other symptoms, making the guts and joints of obese mice indistinguishable from lean mice.

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Brandon Berry Recipient of a two-year American Heart Association Predoctoral Fellowship & Professional Member of the AHA July 1, 2018 – June 30, 2020

Monday, April 23, 2018

Brandon Berry, graduate student in the laboratory of Dr. Andrew P. Wojtovich was awarded a two-year American Heart Association Predoctoral Fellowship entitled, “Optogenetic Control of Mitochondrial Function to Protect Against Ischemia Reperfusion Injury”.

Project Summary

Mitochondria are central mediators of cell death following the pathologic stress of ischemia reperfusion (IR) injury during heart attack or stroke. However, mitochondria can be targeted with specific interventions that inhibit cell death following IR. The mitochondrial protonmotive force (PMF) is coupled to ATP synthesis, and controls ion gradients and oxidative stress. Dissipation of the PMF in IR injury results in cellular damage and death. Interestingly, mild uncoupling of the PMF from ATP synthesis using low-dose protonophores protects against IR injury. It is unclear whether uncoupling triggers protective signaling, or if uncoupling itself is the effector of protection. Further, pharmacologic tools lack temporal and spatial control, obscuring when and where uncoupling is sufficient to protect against IR injury. Uncoupling mitochondria using optogenetics addresses the spatiotemporal challenge of using protonophores. Spatiotemporal control can determine if the mechanism of uncoupling confers protection before ischemia (preconditioning), during ischemia, during reperfusion, or after reperfusion (postconditioning). Overall, using our novel optogenetic tools, this project aims to test how precise, selective, reversible uncoupling is sufficient to elicit cellular responses that protect against IR injury.