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Pediatrics / Pediatric Cardiology Division / Current Research


Clinical Research

  • The Division participates as a sub-site for the Yale University Center of the National Heart, Lung, and Blood Institute-sponsored Pediatric Cardiac Genomics Consortium (PCGC), which is part of the Bench to Bassinet Program, which also includes the Cardiovascular Development Consortium and the Pediatric Heart Network. This international consortium has enrolled thousands of patients and their families in the "Congenital Heart Disease Genetic Network Study (CHD Genes)," a multicenter, prospective observational study designed to investigate relationships between genetic factors and phenotypic and clinical outcomes of patients with congenital heart disease. Now, in its 7th year, the CHD Genes study is beginning to study the role of mutations found in CHD patients in neurodevelopmental development of patients with CHD. Dr. George Porter is the site principal investigator for this study.
  • Dr. George Porter is recognized for his contributions to the landmark study called CHD Genes in a news release. Data from the study has identified new genes and pathways that are involved in heart and brain development and has appeared in the journals Nature and Science, among others.

Basic Science

Research Interests

Nader Atallah-Yunes, M.D.

  • Surgical outcomes in congenital heart disease

Gisella Beutner, Ph.D.

  • Mitochondrial energy generation in the heart in physiological and pathological conditions
  • Impact of the mitochondrial permeability transition pore on energy generation
  • Regulation of the permeability transition pore during cardiac development

Jill M. Cholette, M.D.

  • Blood cell utilization, modification and impact on inflammation and immune modulation
  • Clinical outcomes after blood transfusions in children with congenital heart disease status post cardiac surgery
  • Venous thrombosis prevention, as well as management, particularly in pediatric cardiac surgery and in association with central venous lines

Rajiv Devanagondi, M.D.

  • Long-term outcomes following transcatheter interventions for congenital heart disease
  • Impact of cardiac anatomy on cardiac surgery outcomes


Glenn Leonard, M.D.


  • Cardiac interventions

Cecilia C. Meagher, M.D.

  • Surgical outcomes in congenital heart disease

George A. Porter, Jr., M.D., Ph.D.

  • The genetics of congenital heart disease
  • The role in environmental factors in congenital heart disease
  • Fundamental mechanisms of cardiac development, including
    - Bioenergetics and mitochondrial biology
    - Oxidative stress
    - Hyperoxia and hypoxia
    - Calcium signaling

Jeffrey Vinocur, M.D.

  • Quality improvement, performance improvement and patient safety in many aspects of pediatric cardiology, including electrophysiology and cardiac surgery.

Fellowship Research

View research projects of current and past fellows.