Welcome to the Steiner Lab
Red blood cells comprise one in four cells in the human body. The average adult must produce ~2 million red blood cells per second to maintain a normal hematocrit.
The focus of the Steiner Lab is understanding the molecular mechanisms underlying the development of red blood cells in both normal and disease states. The maturation of a hematopoietic stem or progenitor cell to a functional red blood cell is a complex process that involves significant changes in gene expression during a time of rapid cell division. We are particularly interested in the role of chromatin structure and chromatin modifiers in this process, as appropriate chromatin structure is critical for red blood cell maturation and chromatin modifiers are potential therapeutic targets for inherited anemias.
We are located in the first floor of the MRB-X building.