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Weiguo Peng, B.Med., M.Surg.

Weiguo Peng, B.Med., M.Surg.

Contact

Fax (585) 276-2298
Administrative (585) 275-0550

About Me

Faculty Appointments

Associate - Department of Neurology (SMD)

Credentials

Post-doctoral Training & Residency

Post-Doctoral Fellow;
Department of Cell Biology and Anatomy;
New York Medical College;
Valhalla, NY 2000 - 2001

Resident, Department of Orthopedics;
2nd Affiliated Hospital;
Hunan Medical University;
Changsha, Hunan, China 1989 - 1992

Resident, Department of Surgery;
Affiliated Hospital;
Medical School of Yichun College;
Yichun, China 1985 - 1989

Education

Master of Surgery | Hunan Medical College. Surgery. 1992

MD | Jiangxi Medical College. Medicine. 1985

Publications

Journal Articles

Potentiating glymphatic drainage minimizes post-traumatic cerebral oedema.

Hussain R, Tithof J, Wang W, Cheetham-West A, Song W, Peng W, Sigurdsson B, Kim D, Sun Q, Peng S, Plá V, Kelley DH, Hirase H, Castorena-Gonzalez JA, Weikop P, Goldman SA, Davis MJ, Nedergaard M

Nature.. 2023 November 15 Epub 11/15/2023.

Age- and glaucoma-induced changes to the ocular glymphatic system.

Wang X, Delle C, Peng W, Plá V, Giannetto M, Kusk P, Sigurdsson B, Sakurai S, Sweeney A, Sun Q, Du T, Libby RT, Nedergaard M

Neurobiology of disease.. 2023 October 11 :106322. Epub 10/11/2023.

Distinct astrocytic modulatory roles in sensory transmission during sleep, wakefulness, and arousal states in freely moving mice.

Wang F, Wang W, Gu S, Qi D, Smith NA, Peng W, Dong W, Yuan J, Zhao B, Mao Y, Cao P, Lu QR, Shapiro LA, Yi SS, Wu E, Huang JH

Nature communications.. 2023 April 1714 (1):2186. Epub 04/17/2023.

Cerebrospinal fluid influx drives acute ischemic tissue swelling.

Mestre H, Du T, Sweeney AM, Liu G, Samson AJ, Peng W, Mortensen KN, Stæger FF, Bork PAR, Bashford L, Toro ER, Tithof J, Kelley DH, Thomas JH, Hjorth PG, Martens EA, Mehta RI, Solis O, Blinder P, Kleinfeld D, Hirase H, Mori Y, Nedergaard M

Science.. 2020 January 30 Epub 01/30/2020.

Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension.

Mestre H, Tithof J, Du T, Song W, Peng W, Sweeney AM, Olveda G, Thomas JH, Nedergaard M, Kelley DH

Nature communications.. 2018 November 199 (1):4878. Epub 11/19/2018.

Glymphatic clearance controls state-dependent changes in brain lactate concentration.

Lundgaard I, Lu ML, Yang E, Peng W, Mestre H, Hitomi E, Deane R, Nedergaard M

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 2017 June 37 (6):2112-2124. Epub 01/01/2016.

Erratum to: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.

Achariyar TM, Li B, Peng W, Verghese PB, Shi Y, McConnell E, Benraiss A, Kasper T, Song W, Takano T, Holtzman DM, Nedergaard M, Deane R

Molecular neurodegeneration.. 2017 January 1212 (1):3. Epub 01/12/2017.

Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.

Achariyar TM, Li B, Peng W, Verghese PB, Shi Y, McConnell E, Benraiss A, Kasper T, Song W, Takana T, Holtzman DM, Nedergaard M, Deane R

Molecular neurodegeneration.. 2016 December 811 (1):74. Epub 12/08/2016.

Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease.

Peng W, Achariyar TM, Li B, Liao Y, Mestre H, Hitomi E, Regan S, Kasper T, Peng S, Ding F, Benveniste H, Nedergaard M, Deane R

Neurobiology of disease.. 2016 September 93 :215-25. Epub 05/24/2016.

Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system.

Plog BA, Dashnaw ML, Hitomi E, Peng W, Liao Y, Lou N, Deane R, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2015 January 1435 (2):518-26. Epub 1900 01 01.

Neuronal transgene expression in dominant-negative SNARE mice.

Fujita T, Chen MJ, Li B, Smith NA, Peng W, Sun W, Toner MJ, Kress BT, Wang L, Benraiss A, Takano T, Wang S, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2014 December 1034 (50):16594-604. Epub 1900 01 01.

Photolysis of caged Ca2+ but not receptor-mediated Ca2+ signaling triggers astrocytic glutamate release.

Wang F, Smith NA, Xu Q, Goldman S, Peng W, Huang JH, Takano T, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2013 October 3033 (44):17404-12. Epub 1900 01 01.

In vivo NADH fluorescence imaging indicates effect of aquaporin-4 deletion on oxygen microdistribution in cortical spreading depression.

Thrane AS, Takano T, Thrane VR, Wang F, Peng W, Ottersen OP, Nedergaard M, Nagelhus EA

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 2013 July 33 (7):996-9. Epub 04/24/2013.

Glutamate-dependent neuroglial calcium signaling differs between young and adult brain.

Sun W, McConnell E, Pare JF, Xu Q, Chen M, Peng W, Lovatt D, Han X, Smith Y, Nedergaard M

Science.. 2013 January 11339 (6116):197-200. Epub 1900 01 01.

A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid ?.

Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M

Science translational medicine.. 2012 August 154 (147):147ra111. Epub 1900 01 01.

Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema.

Thrane AS, Rappold PM, Fujita T, Torres A, Bekar LK, Takano T, Peng W, Wang F, Thrane VR, Enger R, Haj-Yasein NN, Skare O, Holen T, Klungland A, Ottersen OP, Nedergaard M, Nagelhus EA

Proceedings of the National Academy of Sciences of the United States of America.. 2011 January 11108 (2):846-51. Epub 12/27/2010.

Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury.

Peng W, Cotrina ML, Han X, Yu H, Bekar L, Blum L, Takano T, Tian GF, Goldman SA, Nedergaard M

Proceedings of the National Academy of Sciences of the United States of America.. 2009 July 28106 (30):12489-93. Epub 07/27/2009.

Loss of astrocytic domain organization in the epileptic brain.

Oberheim NA, Tian GF, Han X, Peng W, Takano T, Ransom B, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2008 March 2628 (13):3264-76. Epub 1900 01 01.

Cortical spreading depression causes and coincides with tissue hypoxia.

Takano T, Tian GF, Peng W, Lou N, Lovatt D, Hansen AJ, Kasischke KA, Nedergaard M

Nature neuroscience.. 2007 June 10 (6):754-62. Epub 04/29/2007.

Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo.

Wang X, Lou N, Xu Q, Tian GF, Peng WG, Han X, Kang J, Takano T, Nedergaard M

Nature neuroscience.. 2006 June 9 (6):816-23. Epub 05/14/2006.

Astrocyte-mediated control of cerebral blood flow.

Takano T, Tian GF, Peng W, Lou N, Libionka W, Han X, Nedergaard M

Nature neuroscience.. 2006 February 9 (2):260-7. Epub 12/25/2005.

An astrocytic basis of epilepsy.

Tian GF, Azmi H, Takano T, Xu Q, Peng W, Lin J, Oberheim N, Lou N, Wang X, Zielke HR, Kang J, Nedergaard M

Nature medicine.. 2005 September 11 (9):973-81. Epub 08/14/2005.

P2X7 receptor inhibition improves recovery after spinal cord injury.

Wang X, Arcuino G, Takano T, Lin J, Peng WG, Wan P, Li P, Xu Q, Liu QS, Goldman SA, Nedergaard M

Nature medicine.. 2004 August 10 (8):821-7. Epub 07/18/2004.

Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord.

Roy NS, Nakano T, Keyoung HM, Windrem M, Rashbaum WK, Alonso ML, Kang J, Peng W, Carpenter MK, Lin J, Nedergaard M, Goldman SA

Nature biotechnology.. 2004 March 22 (3):297-305. Epub 02/15/2004.

Arthroscopicology (Sun CJ and Ten XR, Eds.)

Peng W.

Hunan Science and Technology Publishing House Press, Changsha. pp. 11-19; 76-78;. 1999; : 239-241.

Serum sex hormone level in patients with osteoarthritis of knee.

Peng W, Zhou X and Caijiang, S.

China J. Modern Med. 1998; 8(3): 12.

Clinical significance of mIL-2R expression and sIL-2R level in bone tumor.

Peng W.

Chinese J. Immunol. 9(4):211. 1993; 9(4): 211.

The Atlas of Practical Orthopedic Approaches (Sun CJ and Mong JB, Eds.)

Peng W.

Hunan Science and Technology Publishing House Press, Changsha. 1993; .