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Camillo Peracchia, M.D.

Contact Information

Phone Numbers

Appointment: (585) 276-3000

Biography

Professional Background

Baccalaureate, Liceo Classico, "Istituto Zaccaria" (Milan, Italy), 1956
University of Milan, Milan, Italy, Doctor in Medicine and Surgery (M.D.), 1962
Istituto Provinçial de Obstetricia y Gynecologia, Madrid, Spain, Obstetrics and Gynecology, July 1961
University of Milan, Italy , Surgical Resident, Surgery, 1962-1964
University of Milan, Italy, Postdoctoral Fellow, Pharmacology, 1962-1966
Hopital Broussais, Paris, France, Visiting Surgeon, Cardiac Surgery, July 1965
McLean Hospital, (Harvard), Boston, MA, Research Fellow, Biophysics, 1966-1967
Harvard Medical School, Research Fellow, Neuropathology, 1966-1967
Duke University, Durham, NC, Research Associate, Anatomy, 1967-1970
Educational Council for Medical Graduates (ECFMG) Certificate Number 098-006, 1967

Research

Our research has focused for several decades on the molecular mechanisms that regulate the permeability of gap junction channels. These channels mediate direct cell-to-cell exchange of small cytosolic molecules. Cell communication via gap junction channels is becoming an area of research increasingly relevant to clinical medicine. Altered cell-cell communication resulting from mutations of gap junction channel proteins (connexins), plays a key role in the X-linked Charcot-Marie-Tooth demyelinating peripheral neuropathy, hereditary non-syndromic deafness, hereditary skin disorders, and certain forms of hereditary cataract, and may be involved in the pathogenesis of cardiac arrhythmias and cancer. Recently, we have demonstrated a functional interplay between the cystic fibrosis transmembrane conductance regulator chloride channel (CFTR) and various connexin channels. The mechanism of channel regulation and gating has been studied in paired Xenopus oocytes by dual voltage-clamp electrophysiology. The molecular domains that participate in channel gating have been studied by combining molecular genetics and biophysics. The participation of calmodulin in channel gating has been suggested by data generated in oocyte pairs expressing calmodulin and connexin mutants.

Credentials

Faculty Appointments

Education

1956
Diploma di Maturita', Liceo Classico (Baccalaureate) | Insituto Zaccaria

1962
MD | Italy-Fac Med U Milan
Medicine

Awards

2005
Commendation for Excellence in First Year Medical School Teaching

2004
Adolph Medal for Excellence in Physiology

2002
Commendation for Excellence in First Year Medical School Teaching

1999
Commendation for Excellence in First Year Medical School Teaching

1998
Manuel D. Goldman Prize for Excellence in First-Year

1996
Commendation for Excellence in First Year Medical School Teaching

1995
Commendation for Excellence in First Year Medical School Teaching

1987 - Present
Elected Honorary Member of the Societá di Medicina e Scienze Naturali di Parma. Universitá di Parma, Italy.

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Publications

Journal Articles

2/2007
Peracchia C, Salim M, Peracchia LL. "Unusual slow gating of gap junction channels in oocytes expressing connexin32 or its COOH-terminus truncated mutant." The Journal of membrane biology.. 2007 Feb 0; 215(2-3):161-8. Epub 2007 Jun 14.

2007
Chanson, M.; Kotsias, B.A.; Peracchia, C.; O'Grady, S.M. "Interaction of connexins with other membrane channels and transporters". Biochim. Biophys. Acta. 2007; .

2007
Peracchia, C.; Salim, M.; L.L. Peracchia. "Unusulal slow gating of gap junction channels in oocytes expressing connexin32 or its COOH-terminus truncated mutant". J, Membr. Biol. 2007; .

Books & Chapters

2000
Book Title: Molecular Basis of Cell Communication in Health and Disease
Author List: Peracchia, C.
Edited By: Peracchia, C.
Published By: Academic Press, Inc.2000 in San Diego, CA.

2000
Chapter Title: Behavior of chemical and slow voltage-gates of connexin channels. The cork gating hypothesis
Book Title: Gap Junctions - Molecular Basis of Cell Communication in Health and Disease
Author List: Peracchia, C.; Wang, X.G.; Peracchia, L.M.
Edited By: C. Peracchia
Published By: Academic Press2000 in San Diego, CA

2000
Chapter Title: Distinct behaviors of chemical and voltage sensitive gates of gap junction channels
Book Title: Gap Junctions. Molecular Basis of cell Communication in Health and Disease
Author List: Bukauskas, F.F.; Peracchia, C.
Edited By: C. Peracchia
Published By: Academic Press2000 in San Diego, CA

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