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Camillo Peracchia, M.D.

Contact Information

Faculty Appointments


Professional Background

Baccalaureate, Liceo Classico, "Istituto Zaccaria" (Milan, Italy), 1956
University of Milan, Milan, Italy, Doctor in Medicine and Surgery (M.D.), 1962
Istituto Provinçial de Obstetricia y Gynecologia, Madrid, Spain, Obstetrics and Gynecology, July 1961
University of Milan, Italy , Surgical Resident, Surgery, 1962-1964
University of Milan, Italy, Postdoctoral Fellow, Pharmacology, 1962-1966
Hopital Broussais, Paris, France, Visiting Surgeon, Cardiac Surgery, July 1965
McLean Hospital, (Harvard), Boston, MA, Research Fellow, Biophysics, 1966-1967
Harvard Medical School, Research Fellow, Neuropathology, 1966-1967
Duke University, Durham, NC, Research Associate, Anatomy, 1967-1970
Educational Council for Medical Graduates (ECFMG) Certificate Number 098-006, 1967


Our research has focused for several decades on the molecular mechanisms that regulate the permeability of gap junction channels. These channels mediate direct cell-to-cell exchange of small cytosolic molecules. Cell communication via gap junction channels is becoming an area of research increasingly relevant to clinical medicine. Altered cell-cell communication resulting from mutations of gap junction channel proteins (connexins), plays a key role in the X-linked Charcot-Marie-Tooth demyelinating peripheral neuropathy, hereditary non-syndromic deafness, hereditary skin disorders, and certain forms of hereditary cataract, and may be involved in the pathogenesis of cardiac arrhythmias and cancer. Recently, we have demonstrated a functional interplay between the cystic fibrosis transmembrane conductance regulator chloride channel (CFTR) and various connexin channels. The mechanism of channel regulation and gating has been studied in paired Xenopus oocytes by dual voltage-clamp electrophysiology. The molecular domains that participate in channel gating have been studied by combining molecular genetics and biophysics. The participation of calmodulin in channel gating has been suggested by data generated in oocyte pairs expressing calmodulin and connexin mutants.



Diploma di Maturita', Liceo Classico (Baccalaureate) | Insituto Zaccaria

MD | Italy-Fac Med U Milan

Post-doctoral Training & Residency

03/1967 - 09/1970
Research Associate. Dept. of Anatomy. Duke University, Durham, NC.

04/1966 - 02/1967
Research Fellow. Biophysics. McLean Hospital. Harvard Medical School, Boston, MA

04/1966 - 02/1967
Research Fellow. Neuropathology. Harvard Medical School. Boston. Mass.

07/1965 - 0
Visiting Surgeon. Cardiac Surgery. Hopital Broussais. Paris, France.

11/1962 - 03/1966
Postdoctoral Fellow. Inst. of Pharmacology. University of Milan, Italy.

1962 - 1964
Surgical Resident. University of Milan, Italy

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Commendation for Excellence in First Year Medical School Teaching

Adolph Medal for Excellence in Physiology

Commendation for Excellence in First Year Medical School Teaching

Commendation for Excellence in First Year Medical School Teaching

Manuel D. Goldman Prize for Excellence in First-Year

Commendation for Excellence in First Year Medical School Teaching

Commendation for Excellence in First Year Medical School Teaching

1987 - Present
Elected Honorary Member of the Societá di Medicina e Scienze Naturali di Parma. Universitá di Parma, Italy.

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Journal Articles

Peracchia C. "Calmodulin-Mediated Regulation of Gap Junction Channels." International journal of molecular sciences.. 2020 Jan 12; 21(2)Epub 2020 Jan 12.

Peracchia, C. "The Ca-calmodulin-cork model for chemical gating of gap junction channels". International journal of molecular sciences. 2020; In preparation.

Peracchia, C. "Chemical and voltage gating of gap junction channels expressed in Xenopus oocyte pairs". Springer Nature. 2020; .

Books & Chapters

Chapter Title: Calmodulin Role in Cell-to-Cell Channel Gating.
Book Title: Gap Junction Structure and Chemical Regulation
Author List: Peracchia, C
Published By: Academic Press – An imprint of Elsevier 2019

Chapter Title: Basic Concepts of Respiratory Physiology and Pathophysiology
Book Title: Lung Function in Health and Disease
Author List: Peracchia, C.; Anaizi, NH
Published By: Bentham Science Publishers 2014

Chapter Title: Distinct behaviors of chemical and voltage sensitive gates of gap junction channels
Book Title: Gap Junctions. Molecular Basis of cell Communication in Health and Disease
Author List: Bukauskas, F.F.; Peracchia, C.
Edited By: C. Peracchia
Published By: Academic Press 2000 in San Diego, CA