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Mahin D. Maines, Ph.D.

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Office: (585) 275-5383

Fax: (585) 275-6007

Faculty Appointments



The protein kinases mediate eukaryotic cells' response to internal and external stimuli such as a growth and differentiation factors, hormones, drugs and chemicals. The cell signaling pathways that transduce stimuli depend on cascades of phosphorylation /dephosphorylation events and kinase activities. The heme metabolic pathway, which converts, sequentially, heme to biliverdin plus CO, and bilirubin, reflects activities of heme oxygenase (HO) isozymes 1,2and 3, which constitute the HSP32 (heat shock/stress protein) family of proteins, and biliverdin reductase (BVR). Our recent studies have identified the heme metabolic pathway as a component of the cell signal transduction pathways.We have described CO as a signaling molecule; HO proteins as an intracellular sink for NO and potentially an intracellular oxygen sensor, bilirubin and biliverdin as modulators of protein phosphorylation. We have recently described biliverdin reductase as a new member of the dual specificity kinase (serine/threonine/tyrosine kinase) family, a leucine zipper-type transcription factor for cAMP and AP-1 regulated genes and an inhibitor of apoptosis. We are further investigating how the HO/BVR pathway modulates cell signaling and cell cycle processes.



BS | Ball State University

MA | Ball State University

PhD | Univ of Missouri System Office


Title: Approach to Treatment of Hyperglycemia Using a Nano-Particle-Encapsulated Peptide
U.S. Serial #: 15/599,532
Filed: May 19, 2017
Invented By: Mahin Maines

Title: Use of Human Biliverdin Reductase and Fragments Thereof for the Treatment of Protein Kinase C-Delta and ERK Related Conditions
U.S. Serial #: 14/741,951
Filed: Jun 17, 2015
Invented By: Mahin Maines

Title: Use of Human Biliverdin Reductase and Fragments Thereof Protein Kinase C-Delta and ERK Related Conditions
U.S. Serial #: 12/941,883
Filed: Nov 08, 2010
Invented By: Mahin Maines

Title: Methods of Modifying Insulin Signaling Using Biliverdin Reductase
U.S. Serial #: 11/816,557
Filed: Feb 21, 2006
Invented By: Mahin Maines

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Journal Articles

Miralem T, Lerner-Marmarosh N, Gibbs PE, Jenkins JL, Heimiller C, Maines MD. "Interaction of human biliverdin reductase with Akt/protein kinase B and phosphatidylinositol-dependent kinase 1 regulates glycogen synthase kinase 3 activity: a novel mechanism of Akt activation." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2016 Aug 0; 30(8):2926-44. Epub 2016 May 10.

Vukomanovic D, Rahman MN, Maines MD, Ozolinš TR, Szarek WA, Jia Z, Nakatsu K. "Cysteine-independent activation/inhibition of heme oxygenase-2." Medical gas research. 2016 Mar 0; 6(1):10-13. Epub 2016 Apr 04.

Gibbs PE, Miralem T, Lerner-Marmarosh N, Maines MD. "Nanoparticle Delivered Human Biliverdin Reductase-Based Peptide Increases Glucose Uptake by Activating IRK/Akt/GSK3 Axis: The Peptide Is Effective in the Cell and Wild-Type and Diabetic Ob/Ob Mice." Journal of diabetes research.. 2016 2016:4712053. Epub 2016 May 17.