Research Bio
The protein kinases mediate eukaryotic cells' response to internal and external stimuli such as a growth and differentiation factors, hormones, drugs and chemicals. The cell signaling pathways that transduce stimuli depend on cascades of phosphorylation /dephosphorylation events and kinase activities. The heme metabolic pathway, which converts, sequentially, heme to biliverdin plus CO, and bilirubin, reflects activities of heme oxygenase (HO) isozymes 1,2and 3, which constitute the HSP32 (heat shock/stress protein) family of proteins, and biliverdin reductase (BVR). Our recent studies have identified the heme metabolic pathway as a component of the cell signal transduction pathways.
We have described CO as a signaling molecule; HO proteins as an intracellular sink for NO and potentially an intracellular oxygen sensor, bilirubin and biliverdin as modulators of protein phosphorylation. We have recently described biliverdin reductase as a new member of the dual specificity kinase (serine/threonine/tyrosine kinase) family, a leucine zipper-type transcription factor for cAMP and AP-1 regulated genes and an inhibitor of apoptosis. We are further investigating how the HO/BVR pathway modulates cell signaling and cell cycle processes.
Biliverdin Reductase is a Novel Cell Proliferation and Differentiation Factor
United States Serial NO.: 10/045,545
Filed Date: January 14, 2002
Title: Methods of Modifying Cell Structure and Remodeling Tissue
Invented by: Mahin Maines
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Biliverdin Reductase is a Novel Cell Proliferation and Differentiation Factor
United States Serial NO.: 11/205,562
Filed Date: August 17, 2005
Title: Methods of Modifying Cell Structure and Remodeling Tissue
Invented by: Mahin Maines
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Human Biliverdin Reductase is a New Member of the Insulin Receptor Substrate Family with Serine/Threonine/Tyrosine Kinase Activity
United States Serial NO.: 11/816,557
Filed Date: February 21, 2006
Title: Methods of Modifying Insulin Signaling Using Biliverdin Reductase
Invented by: Mahin Maines
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Trans-activation of the Human Biliverdin Rreductase and Protein Kinase C-delta: a Fragment of hBVR and Its Activity Product Are Potent Inhibitors of the PKC
United States Serial NO.: 12/941,883
Filed Date: November 8, 2010
Title: Use of Human Biliverdin Reductase and Fragments Thereof Protein Kinase C-Delta and ERK Related Conditions
Invented by: Mahin Maines
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Trans-activation of the Human Biliverdin Rreductase and Protein Kinase C-delta: a Fragment of hBVR and Its Activity Product Are Potent Inhibitors of the PKC
United States Serial NO.: 14/741,951
Filed Date: June 17, 2015
Title: Use of Human Biliverdin Reductase and Fragments Thereof for the Treatment of Protein Kinase C-Delta and ERK Related Conditions
Invented by: Mahin Maines
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2016 Aug
Miralem T, Lerner-Marmarosh N, Gibbs PE, Jenkins JL, Heimiller C, Maines MD. "Interaction of human biliverdin reductase with Akt/protein kinase B and phosphatidylinositol-dependent kinase 1 regulates glycogen synthase kinase 3 activity: a novel mechanism of Akt activation." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016 Aug; 30(8):2926-44. Epub 2016 May 10. |
2015
Gibbs PE, Miralem T, Maines MD. "Biliverdin reductase: a target for cancer therapy?" Frontiers in pharmacology. 2015 6:119. Epub 2015 Jun 03. |
2014 Jun
Gibbs PE, Lerner-Marmarosh N, Poulin A, Farah E, Maines MD. "Human biliverdin reductase-based peptides activate and inhibit glucose uptake through direct interaction with the kinase domain of insulin receptor." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2014 Jun; 28(6):2478-91. Epub 2014 Feb 25. |
2012 Jul 13
Miralem T, Lerner-Marmarosh N, Gibbs PE, Tudor C, Hagen FK, Maines MD. "The human biliverdin reductase-based peptide fragments and biliverdin regulate protein kinase C? activity: the peptides are inhibitors or substrate for the protein kinase C." The Journal of biological chemistry. 2012 Jul 13; 287(29):24698-712. Epub 2012 May 14. |
2012 Jan 6
Gibbs PE, Miralem T, Lerner-Maramarosh N, Tudor C, Maines MD. "Formation of ternary complex of human biliverdin reductase-protein kinase C?-ERK2 protein is essential for ERK2-mediated activation of Elk1 protein, nuclear factor-?B, and inducible nitric-oxidase synthase (iNOS)." The Journal of biological chemistry. 2012 Jan 6; 287(2):1066-79. Epub 2011 Nov 07. |
