CONTACT INFORMATIONCREDENTIALSPATENTSPUBLICATIONSMahin D. Maines, Ph.D.Contact InformationPhone NumbersOffice: (585) 275-5383Fax: (585) 271-2683LocationsUniversity of Rochester Medical CenterSchool of Medicine and Dentistry601 Elmwood Ave, Box 712Rochester, NY 14642Faculty AppointmentsProfessor Emeritus - Department of Biochemistry and Biophysics (SMD) BiographyResearchThe protein kinases mediate eukaryotic cells' response to internal and external stimuli such as a growth and differentiation factors, hormones, drugs and chemicals. The cell signaling pathways that transduce stimuli depend on cascades of phosphorylation /dephosphorylation events and kinase activities. The heme metabolic pathway, which converts, sequentially, heme to biliverdin plus CO, and bilirubin, reflects activities of heme oxygenase (HO) isozymes 1,2and 3, which constitute the HSP32 (heat shock/stress protein) family of proteins, and biliverdin reductase (BVR). Our recent studies have identified the heme metabolic pathway as a component of the cell signal transduction pathways.We have described CO as a signaling molecule; HO proteins as an intracellular sink for NO and potentially an intracellular oxygen sensor, bilirubin and biliverdin as modulators of protein phosphorylation. We have recently described biliverdin reductase as a new member of the dual specificity kinase (serine/threonine/tyrosine kinase) family, a leucine zipper-type transcription factor for cAMP and AP-1 regulated genes and an inhibitor of apoptosis. We are further investigating how the HO/BVR pathway modulates cell signaling and cell cycle processes.CredentialsEducation1964BS | Ball State UniversityBiology1967MA | Ball State UniversityBiology1970PhD | Univ of Missouri System OfficePharmacologyPatentsPatent Title: Use of Human Biliverdin Reductase and Fragments Thereof for the Treatment of Protein Kinase C-Delta and ERK Related Conditions Patent #: 9,598,677 Issue Date: Mar 21, 2017 Country: United States Invented By: Mahin D MainesPatent Title: Use of Human Biliverdin Reductase and Fragments Thereof Protein Kinase C-Delta and ERK Related Conditions Patent #: 9,078,913 Issue Date: Jul 14, 2015 Country: United States Invented By: Mahin D MainesPatent Title: Methods of Modulating Heme Oxygenase-1 Expression and Treating Heme Oxygenase-1 Mediated Conditions Patent #: 2002360742 Issue Date: May 29, 2008 Country: Australia Invented By: Mahin D MainesPatent Title: Methods of Modifying Insulin Signaling Using Biliverdin Reductase Patent #: 8,455,427 Issue Date: Jun 04, 2013 Country: United States Invented By: Mahin D MainesPatent Title: Methods of Modifying Cell Structure and Remodeling Tissue Patent #: 6,969,610 Issue Date: Nov 29, 2005 Country: United States Invented By: Mahin D MainesPatent Title: Approach to Treatment of Hyperglycemia Using a Nano-Particle-Encapsulated Peptide Patent #: 9,907,853 Issue Date: Mar 06, 2018 Country: United States Invented By: Mahin D MainesVIEW ALL expand_morePublicationsJournal Articles8/2016Miralem T, Lerner-Marmarosh N, Gibbs PE, Jenkins JL, Heimiller C, Maines MD. "Interaction of human biliverdin reductase with Akt/protein kinase B and phosphatidylinositol-dependent kinase 1 regulates glycogen synthase kinase 3 activity: a novel mechanism of Akt activation." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2016 Aug 0; 30(8):2926-44. Epub 2016 May 10. 3/2016Vukomanovic D, Rahman MN, Maines MD, Ozolinš TR, Szarek WA, Jia Z, Nakatsu K. "Cysteine-independent activation/inhibition of heme oxygenase-2." Medical gas research. 2016 Mar 0; 6(1):10-13. Epub 2016 Apr 04. 2016Gibbs PE, Miralem T, Lerner-Marmarosh N, Maines MD. "Nanoparticle Delivered Human Biliverdin Reductase-Based Peptide Increases Glucose Uptake by Activating IRK/Akt/GSK3 Axis: The Peptide Is Effective in the Cell and Wild-Type and Diabetic Ob/Ob Mice." Journal of diabetes research.. 2016 2016:4712053. Epub 2016 May 17. VIEW ALL PUBLICATIONSClose WindowSchedule an appointment with Mahin D. Maines, Ph.D.Please answer the following questions to help us find the right appointment for you.Important: If you believe that you have a medical or psychiatric emergency, please call 911 or go to the nearest hospital. This website is not intended for emergency care.Have you seen this provider in the last 2 years?YesNoExisting Patient Schedule or request a follow up appointment online through MyChart. If you do not have a MyChart account, please close this window and call the appointment phone number. Mahin D. Maines, Ph.D. is currently scheduling for the following appointment type(s): Our policy does not permit patients to establish care with multiple providers within the same practice or specialty without prior approval. If you choose a new provider in the same office, we will cancel the appointment. Please contact the office directly with questions on this policy.