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Robert T. Dirksen, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-4824

Fax: (585) 273-2652

Research Labs

Faculty Appointments

Biography

Research

Dr. Dirksen directs a multi-disciplinary research program focused on elucidating disease mechanisms and advancing treatment for muscular dystrophy and heart disease. The laboratory investigates the pathophysiological mechanisms by which defects in the proper control of intracellular calcium signaling lead to muscle dysfunction and disease. Current projects involve elucidating the cellular mechanisms by which muscle function is controlled by proteins involved in coordinating: 1) excitation-contraction coupling, 2) store-operated calcium entry, and 3) mitochondrial calcium uptake and energy production, as well as 4) the molecular mechanisms for skeletal and cardiac muscle dysfunction in myotonic dystrophy.

Credentials

Education

1985
BS | University of Notre Dame
Biology

1988
MS | University of Rochester
Pharmacology

1991
PhD | University of Rochester
Pharmacology

Post-doctoral Training & Residency

1991 - 1996
Postdoctoral Fellow, Colorado State University, Fort Collins, CO (Mentor: Kurt G. Beam, Ph. D.)

Awards

2015
Chair
Sponsor: Muscle: Excitation-Contraction Coupling Gordon Conference

2012
Vice-Chair
Sponsor: Muscle: Excitation-Contraction Coupling Gordon Conference

2002
Graduate Student Society Faculty Mentoring Award

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Publications

Journal Articles

9/5/2022
O'Connor TN, Kallenbach JG, Chakkalakal JV, Dirksen RT. "Exercise attenuates juvenile irradiation-induced skeletal muscle decline by improving calcium handling and decreasing mitochondrial stress." The Journal of general physiology.. 2022 Sep 5; 154(9)Epub 2021 Nov 12.

9/5/2022
Wei-LaPierre L, Groom L, Dirksen RT. "Acute exposure to extracellular BTP2 does not inhibit Ca2+ release during EC coupling in intact skeletal muscle fibers." The Journal of general physiology.. 2022 Sep 5; 154(9)Epub 2021 Dec 15.

6/28/2021
Michelucci A, Liang C, Protasi F, Dirksen RT. "Altered Ca Handling and Oxidative Stress Underlie Mitochondrial Damage and Skeletal Muscle Dysfunction in Aging and Disease." Metabolites.. 2021 Jun 28; 11(7)Epub 2021 Jun 28.

Books & Chapters

2006
Chapter Title: Malignant hyperthermia Susceptibility is: GeneReviews at GeneTests.
Book Title: Medical Genetics Information Resource [database online]
Author List: Rosenberg, H; and Dirksen, RT
Published By: University of Washington 2006 in Seattle

2005
Chapter Title: Pathophysiology of muscle disorders linked to mutations in the skeletal muscle ryanodine receptor.
Book Title: Ryanodine Receptors: Structure, Function and Dysfunction in Clinical Disease
Author List: Dirksen RT and Avila G
Edited By: XH Wehrens and AR Marks
Published By: Springer 2005

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