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Patricia J. Simpson-Haidaris, Ph.D.

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Faculty Appointments


My major academic commitment is to serve as mentor to undergraduate, graduate, medical and resident fellows wishing to pursue academic research with the goal of fostering their desires to contribute to the scholarship and knowledge of the biomedical research disciplines and health professions. I have teaching commitments in both Pathology and Microbiology & Immunology at the graduate student level at the University of Rochester. Furthermore, my commitment to mentored-training is evidenced by my service since 2001 as a reviewer on the NHLBI Special Emphasis panels for mentored training awards including the K08, K22, K23, K24, K25 and K99/R00 award mechanisms, and since 2005 as a Scientist Reviewer for Department of Defense and Komen Foundation pre-doctoral and post-doctoral training grant awards.

My research program at the University of Rochester includes both independent investigations and collaborative interactions with faculty members of the Departments of Pediatrics and Microbiology & Immunology on the pathogenic mechanisms of Pneumocystis carinii pneumonia and the host inflammatory response and wound repair in response to Photodynamic therapy of Candida infections, and in the Departments of Medicine and Biochemistry & Biophysics on the interactions of fibrinogen and fibrin at the vessel wall and the extracellular matrix. Additional collaborations with colleagues in the Cancer Center and Bioengineering are based on the role of fibrinogen in breast and prostate cancer, in the Department of Pharmacology and Physiology and the Cardiovascular Research Institute on studies examining cellular responses to heparin binding growth factors, fibrinogen, fibronectin and heparan sulfate proteoglycans in the extracellular matrix, in the Center for Oral Biology on the pathogenesis of infective endocarditis caused by Streptococcus mutans invasion of human coronary artery endothelial cells, and in the Infectious Disease Division on the the direct and indirect effects of Dengue virus infection of the vascular endothelium and the molecular pathways that may contribute to the vascular leakage syndrome associated with dengue hemorrhagic fever/dengue shock syndrome.


The role of fibrinogen in the pathogenesis of disease progression and resolution in the lung, the vasculature, and in prostate and breast carcinoma.



BA, double major | Indiana University
Chemistry & Biology

MS | University of Notre Dame

PhD | University of Notre Dame

Certificate | Rochester Institute of Technology
Deaf Studies

Post-doctoral Training & Residency

1981 - 0
Post-doctoral Fellow. Dept of Microbiology and Immunology, University of North Carolina. Research Mentor: Kenneth Bott, Ph.D.: "Molecular cloning and expression in prokaryotes.

1979 - 1981
Graduate Research Assistant, Dept of Microbiology, University of Notre Dame. Dissertation research performed under the direction of Dr. Charles Kulpa. Ph.D. Thesis: "Characterization and evaluation of large unilamellar liposomes as carriers of synthetic, single-stranded polyribonucleotides to affect RNA virus replication in culture.

1976 - 1979
Associate Development Scientist: Miles, Inc., Ames Division. Developed and implemented quality assurance control systems to define quality of new products from raw materials through in-process production, finished product and clinical trials following GMP, GLP and FDA regulations for new clinical diagnostic products in immunochemistry test systems.

1973 - 1976
Assistant Development Scientist: Miles Inc., Ames Division. Developed quality assurance control systems to define quality of new products for thyroid function, hepatitis B and urine chemistry test systems. Elkhart, IN 46515

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Miles Inc., Post-doctoral Fellowship (Salary and Supplies)

American Society for Microbiology Garner Award for Oral Presentation

1979 - 1981
Miles Inc., Pre-doctoral Fellowship (Stipend and Tuition)

1970 - 1973
Indiana University Merit Scholarship

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Patent Title: Polypeptides and Immunogenic Conjugates Capable of Inducing Antibodies Against Pathogens, and Uses Thereof
Patent #: 7,815,918
Issue Date: Oct 19, 2010
Country: United States
Invented By: Francis Gigliotti, Constantine G Haidaris, Patricia J Simpson-Haidaris, Jesse Wells, Terry W Wright

Patent Title: Optimized Antigens of Pneumocystis and Use Thereof
Patent #: 9,512,189
Issue Date: Dec 06, 2016
Country: United States
Invented By: Francis Gigliotti, Constantine G Haidaris, Patricia J Simpson-Haidaris, Terry W Wright


Journal Articles

Lynn MA, Butcher E, Cuculick JA, Barnett S, Martina CA, Smith SR, Pollard RQ, Simpson-Haidaris PJ. "A review of mentoring deaf and hard-of-hearing scholars." Mentoring & tutoring.. 2020 28(2):211-228. Epub 2020 Apr 13.

Siebert AL, Doucette LA, Simpson-Haidaris PJ, Werren JH. "Parasitoid wasp venom elevates sorbitol and alters expression of metabolic genes in human kidney cells." Toxicon : official journal of the International Society on Toxinology.. 2019 Mar 1; Epub 2019 Mar 01.

Freires IA, Avilés-Reyes A, Kitten T, Simpson-Haidaris PJ, Swartz M, Knight PA, Rosalen PL, Lemos JA, Abranches J. "Heterologous expression of Streptococcus mutans Cnm in Lactococcus lactis promotes intracellular invasion, adhesion to human cardiac tissues and virulence." Virulence.. 2017 Jan 2; 8(1):18-29. Epub 2016 Jun 03.

Books & Chapters

Chapter Title: "Fibrinogen Structure and Physiology"
Book Title: Hemostasis and Thrombosis: Basic Principles and Clinical Practice.
Author List: Hantgan R, Simpson-Haidaris PJ, Francis CW, Marder VJ
Edited By: RW Coleman, J Hirsh, VJ Marder, AW Clowes, JN George
Published By: Lippincott Williams & Wilkins 2001 in Philadelphia

Chapter Title: Fibrinogen and Fibrin.
Book Title: Encyclopedic Reference of Vascular Biology & Pathology.
Author List: Bini A, Simpson-Haidaris PJ, Kudryk, B.
Edited By: A. Bikfalvi.
Published By: Springer Verlag. 2000 in Berlin/Heidelberg