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Patricia J. Simpson-Haidaris, Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 276-3000

Biography

My major academic commitment is to serve as mentor to undergraduate, graduate, medical and resident fellows wishing to pursue academic research with the goal of fostering their desires to contribute to the scholarship and knowledge of the biomedical research disciplines and health professions. I have teaching commitments in both Pathology and Microbiology & Immunology at the graduate student level at the University of Rochester. Furthermore, my commitment to mentored-training is evidenced by my service since 2001 as a reviewer on the NHLBI Special Emphasis panels for mentored training awards including the K08, K22, K23, K24, K25 and K99/R00 award mechanisms, and since 2005 as a Scientist Reviewer for Department of Defense and Komen Foundation pre-doctoral and post-doctoral training grant awards.

My research program at the University of Rochester includes both independent investigations and collaborative interactions with faculty members of the Departments of Pediatrics and Microbiology & Immunology on the pathogenic mechanisms of Pneumocystis carinii pneumonia and the host inflammatory response and wound repair in response to Photodynamic therapy of Candida infections, and in the Departments of Medicine and Biochemistry & Biophysics on the interactions of fibrinogen and fibrin at the vessel wall and the extracellular matrix. Additional collaborations with colleagues in the Cancer Center and Bioengineering are based on the role of fibrinogen in breast and prostate cancer, in the Department of Pharmacology and Physiology and the Cardiovascular Research Institute on studies examining cellular responses to heparin binding growth factors, fibrinogen, fibronectin and heparan sulfate proteoglycans in the extracellular matrix, in the Center for Oral Biology on the pathogenesis of infective endocarditis caused by Streptococcus mutans invasion of human coronary artery endothelial cells, and in the Infectious Disease Division on the the direct and indirect effects of Dengue virus infection of the vascular endothelium and the molecular pathways that may contribute to the vascular leakage syndrome associated with dengue hemorrhagic fever/dengue shock syndrome.

Research

The role of fibrinogen in the pathogenesis of disease progression and resolution in the lung, the vasculature, and in prostate and breast carcinoma.

Credentials

Faculty Appointments

Education

1973
BA, double major | Indiana University
Chemistry & Biology

1981
PhD | University of Notre Dame
Microbiology

1980
MS | University of Notre Dame
Microbiology

2000
Certificate | Rochester Institute of Technology
Deaf Studies

Awards

1981
Miles Inc., Post-doctoral Fellowship (Salary and Supplies)

1980
American Society for Microbiology Garner Award for Oral Presentation

1979 - 1981
Miles Inc., Pre-doctoral Fellowship (Stipend and Tuition)

1970 - 1973
Indiana University Merit Scholarship

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Publications

Journal Articles

1/2/2017
Freires IA, Avilés-Reyes A, Kitten T, Simpson-Haidaris PJ, Swartz M, Knight PA, Rosalen PL, Lemos JA, Abranches J. "Heterologous expression of Streptococcus mutans Cnm in Lactococcus lactis promotes intracellular invasion, adhesion to human cardiac tissues and virulence." Virulence.. 2017 Jan 2; 8(1):18-29. Epub 2016 Jun 03.

2/2014
Avilés-Reyes A, Miller JH, Simpson-Haidaris PJ, Lemos JA, Abranches J. "Cnm is a major virulence factor of invasive Streptococcus mutans and part of a conserved three-gene locus." Molecular oral microbiology.. 2014 Feb 0; 29(1):11-23. Epub 2013 Oct 30.

6/2011
Abranches J, Miller JH, Martinez AR, Simpson-Haidaris PJ, Burne RA, Lemos JA. "The collagen-binding protein Cnm is required for Streptococcus mutans adherence to and intracellular invasion of human coronary artery endothelial cells." Infection and immunity.. 2011 Jun 0; 79(6):2277-84. Epub 2011 Mar 21.

Books & Chapters

2001
Chapter Title: "Fibrinogen Structure and Physiology"
Book Title: Hemostasis and Thrombosis: Basic Principles and Clinical Practice.
Author List: Hantgan R, Simpson-Haidaris PJ, Francis CW, Marder VJ
Edited By: RW Coleman, J Hirsh, VJ Marder, AW Clowes, JN George
Published By: Lippincott Williams & Wilkins2001 in Philadelphia

2000
Chapter Title: Fibrinogen and Fibrin.
Book Title: Encyclopedic Reference of Vascular Biology & Pathology.
Author List: Bini A, Simpson-Haidaris PJ, Kudryk, B.
Edited By: A. Bikfalvi.
Published By: Springer Verlag.2000 in Berlin/Heidelberg

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