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Carl T. D'Angio, M.D.

Contact Information

Phone Numbers

Office: (585) 275-2972

Fax: (585) 461-3614

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Faculty Appointments

Patient Care Setting



Dr. D'Angio is Chief of the Division of Neonatology. He is an attending neonatologist at both URMC and Rochester General Hospital. In collaboration with other members of the neonatal team, he strives to provide compassionate, cutting-edge medical care to at-risk or critically ill newborns. Dr. D'Angio's particular clinical interests are infection and immunity in the newborn and the prevention of lung injury.

Professional Background

Dr. D’Angio attended medical school at Johns Hopkins University and received his Pediatric training at the Children’s Hospital of Philadelphia before arriving in Rochester in 1991 to complete a Fellowship in Neonatal-Perinatal Medicine. He has been a member of the University of Rochester faculty since 1994.


Dr. D'Angio's research focuses on clinical trials of therapies in the newborn. He is principal investigator for a combined University of Rochester-University of Buffalo site in the NICHD Neonatal Research Network, a 15-center consortium performing research in newborns. He has particular interest in immunizations and infections in the premature infant, lung injury, prevention of catheter-related infections, neonatal outcomes and clinical and research ethics.



  • Neonatal-Perinatal Medicine - American Board of Pediatrics
  • Pediatrics - American Board of Pediatrics


MD | Johns Hopkins University School of Medicine

Post-doctoral Training & Residency

07/01/1991 - 06/30/1994
Fellowship in Neonatology at University of Rochester Medical Center

07/01/1985 - 06/30/1987
Residency in Pediatrics at Children's Hospital of Philadelphia

07/01/1984 - 06/30/1985
Internship in Pediatrics at Children's Hospital of Philadelphia

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2011 - 2012
America's Top Doctors

2009 - 2010
Who's Who in Medicine and Healthcare

America's Top Doctors

2008 - 2009
Who's Who in America

2007 - 2010
Guide to America's Top Pediatricians

2004 - 2010
Best Doctors in America

1999 - 2000
Buswell Fellowship Award, University of Rochester

Bicentennial Unit Commendation, US Public Health Service

The PHS Citation, US Public Health Service

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Clinical Trials

Management of the Patent Ductus Arteriosus in Premature Infants Trial (PDA Trial)

Lead Researcher: Carl T D'angio

Patent ductus arteriosus (PDA) is an extra blood vessel found in babies before birth and just after birth. In most babies who have an otherwise normal heart, the PDA will shrink and close on its own in the first few days of life. If it stays open longer, it may cause extra blood to flow to the lungs. This study estimates the risks and benefits of active treatment versus expectant management of premature babies with patent ductus arteriosus.

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A Randomized Trial of Targeted Temperature Management With Whole Body Hypothermia For Moderate And Severe Hypoxic-Ischemic Encephalopathy In Premature Infants 33-35 Weeks Gestational Age.

Lead Researcher: Carl T D'angio

Encephalopathy is a general term that means brain disease, damage, or malfunction. This study is a randomized, controlled trial to assess safety and effectiveness of whole body hypothermia for 72 hours in preterm infants 33-35 weeks gestational age (GA) who present at <6 hours postnatal age with moderate to severe neonatal encephalopathy (NE). The study will enroll infants with signs of NE at 18 NICHD Neonatal Research Network sites, and randomly assign them to either receive hypothermia or participate in a non-cooled control group.

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A Randomized Controlled Trial of the Effect Of Hydrocortisone on Survival Without Bronchopulmonary Dysplasia and on Neurodevelopmental Outcomes at 22 - 26 Months of Age in Intubated Infants < 30 Weeks Gestation Age

Lead Researcher: Carl T D'angio

The Hydrocortisone and Extubation study will test if giving hydrocortisone for 10 days improves survival for premature infants who have a breathing tube. Infants will either receive hydrocortisone or placebo.

View Study Details


Journal Articles

Chalak LF, Pappas A, Tan S, Das A, Sánchez PJ, Laptook AR, Van Meurs KP, Shankaran S, Bell EF, Davis AS, Heyne RJ, Pedroza C, Poindexter BB, Schibler K, Tyson JE, Ball MB, Bara R, Grisby C, Sokol GM, D'Angio CT, Hamrick SEG, Dysart KC, Cotten CM, Truog WE, Watterberg KL, Timan CJ, Garg M, Carlo WA, Higgins RD, . "Association Between Increased Seizures During Rewarming After Hypothermia for Neonatal Hypoxic Ischemic Encephalopathy and Abnormal Neurodevelopmental Outcomes at 2-Year Follow-up: A Nested Multisite Cohort Study." JAMA neurology.. 2021 Dec 1; 78(12):1484-1493.

Basalely AM, Griffin R, Gist KM, Guillet R, Askenazi DJ, Charlton JR, Selewski DT, Fuloria M, Kaskel FJ, Reidy KJ, . "Association of early dysnatremia with mortality in the neonatal intensive care unit: results from the AWAKEN study." Journal of perinatology : official journal of the California Perinatal Association.. 2021 Nov 13; Epub 2021 Nov 13.

Blakely ML, Tyson JE, Lally KP, Hintz SR, Eggleston B, Stevenson DK, Besner GE, Das A, Ohls RK, Truog WE, Nelin LD, Poindexter BB, Pedroza C, Walsh MC, Stoll BJ, Geller R, Kennedy KA, Dimmitt RA, Carlo WA, Cotten CM, Laptook AR, Van Meurs KP, Calkins KL, Sokol GM, Sanchez PJ, Wyckoff MH, Patel RM, Frantz ID, Shankaran S, D'Angio CT, Yoder BA, Bell EF, Watterberg KL, Martin CA, Harmon CM, Rice H, Kurkchubasche AG, Sylvester K, Dunn JCY, Markel TA, Diesen DL, Bhatia AM, Flake A, Chwals WJ, Brown R, Bass KD, St Peter SD, Shanti CM, Pegoli W, Skarda D, Shilyansky J, Lemon DG, Mosquera RA, Peralta-Carcelen M, Goldstein RF, Vohr BR, Purdy IB, Hines AC, Maitre NL, Heyne RJ, DeMauro SB, McGowan EC, Yolton K, Kilbride HW, Natarajan G, Yost K, Winter S, Colaizy TT, Laughon MM, Lakshminrusimha S, Higgins RD, . "Initial Laparotomy Versus Peritoneal Drainage in Extremely Low Birthweight Infants With Surgical Necrotizing Enterocolitis or Isolated Intestinal Perforation: A Multicenter Randomized Clinical Trial." Annals of surgery.. 2021 Oct 1; 274(4):e370-e380.

Books & Chapters

Chapter Title: Burden of Chronic Lung Disease on the Care-Givers: Families, Nurses, and Physicians
Book Title: Updates on Neonatal Chronic Lung Disease
Author List: Chiafery MC, D'Angio CT.
Edited By: Kallapur SG
Published By: Elsevier 2019

Chapter Title: Perinatal Ethics
Book Title: Perinatal Palliative Care: A Clinical Guide
Author List: Wax J, D'Angio CT, Chiafery MC.
Edited By: Denney-Koelsch E, Cote-Arsenault D.
Published By: Springer 2019 in New York

Chapter Title: Biostatistics in Research
Book Title: Avery's Neonatology Review
Author List: D'Angio CT.
Edited By: Chess PR.
Published By: Elsevier 2019 in New York