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Michael A. O'Reilly, Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 275-5948

Office: (585) 275-5948

Research Labs

Faculty Appointments

Biography

Research

The O'Reilly lab consists of an interactive group of senior scientists, graduate students, technicians, and undergraduate scholars interested in understanding how the oxygen environment at birth influences children's health and disease. Premature exposure to oxygen is a major risk factor for neonatal lung disease and can cause bronchopulmonary dysplasia (BPD), a chronic form of lung disease frequently seen in preterm infants with very low birth weight. While better clinical care has reduced mortality, children born prematurely are at risk for having reduced lung function, increased airway wheezing, increased severity of pulmonary morbidity following a respiratory viral infection, and development of pulmonary hypertension. Hence, there is an urgent need to better understand how early-life exposure to oxygen and failure to gain weight adversely affects health of children born preterm. Using the mouse as a model system, our studies are focused on defining how the oxygen environment at birth influences growth and differentiation of progenitor cells critical for development and regeneration of the cardiopulmonary system. We also investigate how oxygen-induced damage to mitochondrial and nuclear genomes activates molecular pathways that control whether oxidized cells live or die. We then collaborate with physicians who study health outcomes and treat children born prematurely. By integrating research findings in cells, mice, and humans, we hope to ultimately identify therapeutic opportunities for improving the long-term health of children born prematurely.

Credentials

Education

1984
BS | SUNY at Stony Brook
Biology

1989
PhD | University of Cincinnati
Developmental Biology

Post-doctoral Training & Residency

1993 - 1995
NRC Fellow, Lab. Mamm. Genes and Develop., NICHD, NIH Dr. Heiner Westphal

1992 - 1993
Senior Staff Fellow, Laboratory of Chemoprevention, NCI, NIH

1989 - 1992
Staff Fellow, Laboratory of Chemoprevention, NCI, NIH Drs. Michael B. Sporn and Anita B. Roberts

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Awards

2005
Ruth A. Lawrence Academic Faculty Service Award
Sponsor: Department of Pediatrics

2004 - 2008
Dean's Incentive Award
Location: University of Rochester Research

1993 - 1995
National Research Council
Sponsor: NICHD, NIH Research

1988 - 1989
Albert B. Ryan
Location: University of Cincinnati Ph.D Studies

1986 - 1988
NIH Training Grant
Location: University of Cincinnati

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Publications

Journal Articles

10/9/2019
Dylag AM, Brookes PS, O'Reilly MA. "Swapping mitochondria: A key to understanding susceptibility to neonatal chronic lung disease." American journal of physiology. Lung cellular and molecular physiology.. 2019 Oct 9; Epub 2019 Oct 09.

9/11/2019
Warren R, Domm W, Yee M, Campbell A, Malone J, Wright T, Mayer-Proschel M, O'Reilly MA. "Ataxia-telangiectasia mutated is required for the development of protective immune memory after influenza A virus infection." American journal of physiology. Lung cellular and molecular physiology.. 2019 Sep 11; Epub 2019 Sep 11.

5/7/2019
Mai N, Miller-Rhodes K, Prifti V, Kim M, O'Reilly MA, Halterman MW. "Lung-Derived SOD3 Attenuates Neurovascular Injury After Transient Global Cerebral Ischemia." Journal of the American Heart Association.. 2019 May 7; 8(9):e011801.

Books & Chapters

2015
Chapter Title: Perinatal disruptions of lung development: Mechanisms and implications for chronic lung diseases.
Book Title: Lung Development, Clinical Correlates and Technologies for the Future
Author List: O'Reilly, MA.
Edited By: Whitsett J, Jobe A, and Abman, S
Published By: New York, Cambridge University Press 2015

2014
Chapter Title: The impact of DNA damage on epithelial cell maintenance of the lung.
Book Title: Mitochondrial Function in Lung Health and Disease.
Author List: Kalifa L and O'Reilly MA.
Edited By: Natargajan V and Parinandi NL
Published By: Springer Science+Business Media 2014

2005
Chapter Title: Cell and Animal Models of Lung Injury
Book Title: Lung Injury: Mechanisms, Pathophysiology, and Therapy
Author List: Finkelstein JN, O'Reilly MA, Holm BA, Chess PC, Notter RH
Published By: Marcel Dekker 2005 in New York, NY

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Videos

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Many 'Adult' Diseases Trace Back to Baby's Earliest Days