Michael A. O'Reilly, Ph.D.

Michael A. O'Reilly, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 850
Rochester, NY 14642

Office: (585) 275-5948
Lab: (585) 275-1450
Lab: (585) 273-4831
Lab: (585) 273-3118
Administrative: (585) 275-5948

Lab Information

O'Reilly Lab

Visit Lab Website »

View Research Network »

Research Bio

Dr. O¹Reilly¹s laboratory investigates mechanisms controlling lung epithelial cell survival and differentiation in response to oxidative stress caused by exposure to high oxygen (hyperoxia). Although hyperoxia is often used to treat patients with respiratory distress, it stimulates cell death in adults and permanently disrupts lung development in neonates. Research in the laboratory focuses on two major lines of investigation. First, understand how hyperoxia activates the p53-dependent expression of the cell cycle inhibitor p21 and how p21 controls cell growth, survival, and inflammation.

Second, understand how neonatal exposure to hyperoxia stimulates differentiation of alveolar epithelial progenitor cells and why this leads to long-term susceptibility to subsequent respiratory insults. These studies will allow us to develop novel therapies for treating patients requiring oxygen, as well as provide valuable information on other conditions involving persistent oxidative stress, including inflammation, neurodegeneration, cancer, and the aging process. Research funding comes from an NIH R01, the March of Dimes and participation in other NIH grants.

Awards & Honors (Local)

Dean's Research Incentive Award University of Rochester Medical Center 2005
Ruth A. Lawrence Academic Faculty Service Award Department of Pediatrics 2005
Dean's Research Incentive Award University of Rochester 2004
National Research Council NICHD, NIH 1993 - 1995
NIH Training Grant, University of Cincinnati 1986 - 1988

Recent Journal Articles

Showing the 5 most recent journal articles. 91 available »

2016 May
Yee M, Gelein R, Mariani TJ, Lawrence BP, O'Reilly MA. "The Oxygen Environment at Birth Specifies the Population of Alveolar Epithelial Stem Cells in the Adult Lung." Stem cells. 2016 May; 34(5):1396-406. Epub 2016 Mar 07.
2015 Aug
Resseguie EA, Staversky RJ, Brookes PS, O'Reilly MA. "Hyperoxia activates ATM independent from mitochondrial ROS and dysfunction." Redox biology. 2015 Aug; 5:176-85. Epub 2015 May 02.
2015 Jan 1
Reilly EC, Martin KC, Jin GB, Yee M, O'Reilly MA, Lawrence BP. "Neonatal hyperoxia leads to persistent alterations in NK responses to influenza A virus infection." American journal of physiology. Lung cellular and molecular physiology. 2015 Jan 1; 308(1):L76-85. Epub 2014 Nov 07.
Hilgendorff A, O'Reilly MA. "Bronchopulmonary dysplasia early changes leading to long-term consequences." Frontiers in medicine. 2015 2:2. Epub 2015 Feb 12.
Domm W, Misra RS, O'Reilly MA. "Affect of Early Life Oxygen Exposure on Proper Lung Development and Response to Respiratory Viral Infections." Frontiers in medicine. 2015 2:55. Epub 2015 Aug 10.

Current Appointments

Professor - Department of Pediatrics, Neonatology (SMD) - Primary
Professor - Department of Environmental Medicine (SMD)


PhD | Developmental Biology | University of Cincinnati1989
BS | Biology | SUNY at Stony Brook1984

Post-Doctoral Training & Residency

NRC Fellow, Lab. Mamm. Genes and Develop., NICHD, NIH Dr. Heiner Westphal 1995
Senior Staff Fellow, Laboratory of Chemoprevention, NCI, NIH 1993
Staff Fellow, Laboratory of Chemoprevention, NCI, NIH Drs. Michael B. Sporn and Anita B. Roberts 1992