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About Me

Faculty Appointments

Associate Professor - Department of Environmental Medicine (SMD)

Credentials

Post-doctoral Training & Residency

Post-doctoral Fellow, Department of Environmental Medicine, University of Rochester 1997 - 2000

Education

PhD | Univ of Cal Irvine. Environmental Toxicology. 1997

BS | Chatham College. Chemistry. 1992

Awards

Young Investigator Award, Inhalation and Respiratory Specialty Section, Society of Toxicology. 2009

Cornerstone Alumna Award in Environmental Medicine, Chatham University. 2007

Graduate Student Fellowship, U.S. Environmental Protection Agency. 1995 - 1996

College Chemistry Award, Society for Analytical Chemists of Pittsburgh. 1992

Research

Toxicology of Inhaled Ultrafine Particles and Engineered Nanomaterials

Our laboratory has focused for several years on the toxicology of inhaled ultrafine particles (UFPs), the most numerous size fraction of particulate air pollution. Interests include the impacts of age, gaseous co-pollutant...
Toxicology of Inhaled Ultrafine Particles and Engineered Nanomaterials

Our laboratory has focused for several years on the toxicology of inhaled ultrafine particles (UFPs), the most numerous size fraction of particulate air pollution. Interests include the impacts of age, gaseous co-pollutant exposure, and health status on the response(s) to inhaled UFPs. We are also interested in determining the basis for potential adverse effects of inhaled particles in the cardiovascular and central nervous systems.

This research focus has naturally led to our work with engineered nanomaterials. The research commonalities between UFP and nanomaterials are numerous, including the kinetics of tissue distribution following exposure, mechanisms of response related to oxidative stress, particle-protein interactions, and the physicochemical characteristics of the particles that determine response. Our research aims are met by using a combination of animal and cell culture models as well as detailed particle characterization.

In addition to looking for nanosized particles in tissues via chemical and microscopic means, responses are determined by measuring markers of inflammation and oxidative stress in the lung lining fluid, lung tissue, blood, circulating inflammatory cells, and extrapulmonary tissues (e.g. heart, liver, spleen, kidney, brain regions). We also have specific projects focused on cardiovascular stability and neurodegeneration following exposures to UFPs and nanomaterials.

Publications

Journal Articles

Air pollution, glymphatic impairment, and Alzheimer's disease.

Hussain R, Graham U, Elder A, Nedergaard M

Trends in neurosciences.. 2023 September 28 Epub 09/28/2023.

Inflammation as a Key Outcome Pathway in Particle Induced Effects in the Lung.

Borm PJA, Lison D, Driscoll K, Duffin R, Harkema J, Weber K, Elder A

Frontiers in public health.. 2022 10 :869041. Epub 05/25/2022.

Author Correction: Predicting dissolution and transformation of inhaled nanoparticles in the lung using abiotic flow cells: The case of barium sulphate.

Keller JG, Graham UM, Koltermann-Jülly J, Gelein R, Ma-Hock L, Landsiedel R, Wiemann M, Oberdörster G, Elder A, Wohlleben W

Scientific reports.. 2021 April 1911 (1):8813. Epub 04/19/2021.

Effects of concentrated ambient ultrafine particulate matter on hallmarks of Alzheimer's disease in the 3xTgAD mouse model.

Herr D, Jew K, Wong C, Kennell A, Gelein R, Chalupa D, Raab A, Oberdörster G, Olschowka J, O'Banion MK, Elder A

Neurotoxicology.. 2021 March 29 Epub 03/29/2021.

FutureTox IV Workshop Summary: Predictive Toxicology for Healthy Children.

Knudsen TB, Fitzpatrick SC, De Abrew KN, Birnbaum LS, Chappelle A, Daston GP, Dolinoy DC, Elder A, Euling S, Faustman EM, Fedinick KP, Franzosa JA, Haggard DE, Haws L, Kleinstreuer N, Louis GMB, Mendrick DL, Rudel R, Saili KS, Schug TT, Tanguay RL, Turley AE, Wetmore BA, White KW, Zurlinden TJ

Toxicological sciences : an official journal of the Society of Toxicology.. 2021 February 8 Epub 02/08/2021.

Diesel exhaust particle exposure reduces expression of the epithelial tight junction protein Tricellulin.

Smyth T, Veazey J, Eliseeva S, Chalupa D, Elder A, Georas SN

Particle and fibre toxicology.. 2020 October 1517 (1):52. Epub 10/15/2020.

Predicting dissolution and transformation of inhaled nanoparticles in the lung using abiotic flow cells: The case of barium sulfate.

Keller JG, Graham UM, Koltermann-Jülly J, Gelein R, Ma-Hock L, Landsiedel R, Wiemann M, Oberdörster G, Elder A, Wohlleben W

Scientific reports.. 2020 January 1610 (1):458. Epub 01/16/2020.

Selective memory and behavioral alterations after ambient ultrafine particulate matter exposure in aged 3xTgAD Alzheimer's disease mice.

Jew K, Herr D, Wong C, Kennell A, Morris-Schaffer K, Oberdörster G, O'Banion MK, Cory-Slechta DA, Elder A

Particle and fibre toxicology.. 2019 November 2616 (1):45. Epub 11/26/2019.

Correction to: Particle toxicology and health - where are we?

Riediker M, Zink D, Kreyling W, Oberdörster G, Elder A, Graham U, Lynch I, Duschl A, Ichihara G, Ichihara S, Kobayashi T, Hisanaga N, Umezawa M, Cheng TJ, Handy R, Gulumian M, Tinkle S, Cassee F

Particle and fibre toxicology.. 2019 June 2716 (1):26. Epub 06/27/2019.

Particle toxicology and health - where are we?

Riediker M, Zink D, Kreyling W, Oberdörster G, Elder A, Graham U, Lynch I, Duschl A, Ichihara G, Ichihara S, Kobayashi T, Hisanaga N, Umezawa M, Cheng TJ, Handy R, Gulumian M, Tinkle S, Cassee F

Particle and fibre toxicology.. 2019 April 2316 (1):19. Epub 04/23/2019.

Effects of neonatal inhalation exposure to ultrafine carbon particles on pathology and behavioral outcomes in C57BL/6J mice.

Morris-Schaffer K, Merrill A, Jew K, Wong C, Conrad K, Harvey K, Marvin E, Sobolewski M, Oberdörster G, Elder A, Cory-Slechta DA

Particle and fibre toxicology.. 2019 February 1816 (1):10. Epub 02/18/2019.

Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge.

Stone V, Miller MR, Clift MJD, Elder A, Mills NL, Møller P, Schins RPF, Vogel U, Kreyling WG, Alstrup Jensen K, Kuhlbusch TAJ, Schwarze PE, Hoet P, Pietroiusti A, De Vizcaya-Ruiz A, Baeza-Squiban A, Teixeira JP, Tran CL, Cassee FR

Environmental health perspectives.. 2017 October 10125 (10):106002. Epub 10/10/2017.

The roles of surface chemistry, dissolution rate, and delivered dose in the cytotoxicity of copper nanoparticles.

Shi M, de Mesy Bentley KL, Palui G, Mattoussi H, Elder A, Yang H

Nanoscale.. 2017 April 69 (14):4739-4750. Epub 1900 01 01.

From Dose to Response: In Vivo Nanoparticle Processing and Potential Toxicity.

Graham UM, Jacobs G, Yokel RA, Davis BH, Dozier AK, Birch ME, Tseng MT, Oberdörster G, Elder A, DeLouise L

Advances in experimental medicine and biology.. 2017 947 :71-100. Epub 1900 01 01.

Dung biomass smoke activates inflammatory signaling pathways in human small airway epithelial cells.

McCarthy CE, Duffney PF, Gelein R, Thatcher TH, Elder A, Phipps RP, Sime PJ

American journal of physiology. Lung cellular and molecular physiology.. 2016 December 1311 (6):L1222-L1233. Epub 11/11/2016.

Nanomaterials vs Ambient Ultrafine Particles: an Opportunity to Exchange Toxicology Knowledge.

Stone V, Miller MR, Clift MJ, Elder A, Mills NL, Møller P, Schins RP, Vogel U, Kreyling WG, Jensen KA, Kuhlbusch TA, Schwarze PE, Hoet P, Pietroiusti A, De Vizcaya-Ruiz A, Baeza-Squiban A, Tran CL, Cassee FR

Environmental health perspectives.. 2016 November 4 Epub 11/04/2016.

Biodistribution of inhaled metal oxide nanoparticles mimicking occupational exposure: a preliminary investigation using enhanced darkfield microscopy.

Guttenberg M, Bezerra L, Neu-Baker NM, Del Pilar Sosa Idelchik M, Elder A, Oberdörster G, Brenner SA

Journal of biophotonics.. 2016 October 9 (10):987-993. Epub 08/16/2016.

Electronic cigarette aerosols and copper nanoparticles induce mitochondrial stress and promote DNA fragmentation in lung fibroblasts.

Lerner CA, Rutagarama P, Ahmad T, Sundar IK, Elder A, Rahman I

Biochemical and biophysical research communications.. 2016 September 2477 (4):620-625. Epub 06/23/2016.

Environmental health hazards of e-cigarettes and their components: Oxidants and copper in e-cigarette aerosols.

Lerner CA, Sundar IK, Watson RM, Elder A, Jones R, Done D, Kurtzman R, Ossip DJ, Robinson R, McIntosh S, Rahman I

Environmental pollution.. 2015 March 198 :100-7. Epub 01/09/2015.

Workshop report: strategies for setting occupational exposure limits for engineered nanomaterials.

Gordon SC, Butala JH, Carter JM, Elder A, Gordon T, Gray G, Sayre PG, Schulte PA, Tsai CS, West J

Regulatory toxicology and pharmacology : RTP.. 2014 April 68 (3):305-11. Epub 01/23/2014.

Engineering safer-by-design, transparent, silica-coated ZnO nanorods with reduced DNA damage potential.

Sotiriou GA, Watson C, Murdaugh KM, Darrah TH, Pyrgiotakis G, Elder A, Brain JD, Demokritou P

Environmental science. Nano.. 2014 April 1 (2):144-153. Epub 1900 01 01.

Equivalent titanium dioxide nanoparticle deposition by intratracheal instillation and whole body inhalation: the effect of dose rate on acute respiratory tract inflammation.

Baisch BL, Corson NM, Wade-Mercer P, Gelein R, Kennell AJ, Oberdörster G, Elder A

Particle and fibre toxicology.. 2014 January 2411 :5. Epub 01/24/2014.

Quantification of quantum dot murine skin penetration with UVR barrier impairment.

Mortensen LJ, Jatana S, Gelein R, Debenedetto A, de Mesy Bentley KL, Beck L, Elder A, Delouise L

Nanotoxicology.. 2013 December 7 (8):1386-98. Epub 04/17/2013.

Extraction and quantification of carbon nanotubes in biological matrices with application to rat lung tissue.

Doudrick K, Corson N, Oberdörster G, Elder AC, Herckes P, Halden RU, Westerhoff P

ACS nano.. 2013 October 227 (10):8849-56. Epub 09/06/2013.

Surface characterization of nanomaterials and nanoparticles: Important needs and challenging opportunities.

Baer DR, Engelhard MH, Johnson GE, Laskin J, Lai J, Mueller K, Munusamy P, Thevuthasan S, Wang H, Washton N, Elder A, Baisch BL, Karakoti A, Kuchibhatla SV, Moon D

Journal of vacuum science & technology. A, Vacuum, surfaces, and films : an official journal of the American Vacuum Society.. 2013 September 31 (5):50820. Epub 08/27/2013.

Interlaboratory evaluation of rodent pulmonary responses to engineered nanomaterials: the NIEHS Nano GO Consortium.

Bonner JC, Silva RM, Taylor AJ, Brown JM, Hilderbrand SC, Castranova V, Porter D, Elder A, Oberdörster G, Harkema JR, Bramble LA, Kavanagh TJ, Botta D, Nel A, Pinkerton KE

Environmental health perspectives.. 2013 June 121 (6):676-82. Epub 05/06/2013.

Interlaboratory evaluation of in vitro cytotoxicity and inflammatory responses to engineered nanomaterials: the NIEHS Nano GO Consortium.

Xia T, Hamilton RF, Bonner JC, Crandall ED, Elder A, Fazlollahi F, Girtsman TA, Kim K, Mitra S, Ntim SA, Orr G, Tagmount M, Taylor AJ, Telesca D, Tolic A, Vulpe CD, Walker AJ, Wang X, Witzmann FA, Wu N, Xie Y, Zink JI, Nel A, Holian A

Environmental health perspectives.. 2013 June 121 (6):683-90. Epub 05/06/2013.

The outdoor air pollution and brain health workshop.

Block ML, Elder A, Auten RL, Bilbo SD, Chen H, Chen JC, Cory-Slechta DA, Costa D, Diaz-Sanchez D, Dorman DC, Gold DR, Gray K, Jeng HA, Kaufman JD, Kleinman MT, Kirshner A, Lawler C, Miller DS, Nadadur SS, Ritz B, Semmens EO, Tonelli LH, Veronesi B, Wright RO, Wright RJ

Neurotoxicology.. 2012 October 33 (5):972-84. Epub 09/05/2012.

Neurological impacts from inhalation of pollutants and the nose-brain connection.

Lucchini RG, Dorman DC, Elder A, Veronesi B

Neurotoxicology.. 2012 August 33 (4):838-41. Epub 12/09/2011.

Assessing the relevance of in vitro studies in nanotoxicology by examining correlations between in vitro and in vivo data.

Han X, Corson N, Wade-Mercer P, Gelein R, Jiang J, Sahu M, Biswas P, Finkelstein JN, Elder A, Oberdörster G

Toxicology.. 2012 July 16297 (1-3):1-9. Epub 04/02/2012.

Effects of surface chemistry on the generation of reactive oxygen species by copper nanoparticles.

Shi M, Kwon HS, Peng Z, Elder A, Yang H

ACS nano.. 2012 March 276 (3):2157-64. Epub 03/05/2012.

Validation of an LDH assay for assessing nanoparticle toxicity.

Han X, Gelein R, Corson N, Wade-Mercer P, Jiang J, Biswas P, Finkelstein JN, Elder A, Oberdörster G

Toxicology.. 2011 September 5287 (1-3):99-104. Epub 06/23/2011.

Correlating physico-chemical with toxicological properties of nanoparticles: the present and the future.

Rivera Gil P, Oberdörster G, Elder A, Puntes V, Parak WJ

ACS nano.. 2010 October 264 (10):5527-31. Epub 1900 01 01.

Pulmonary response after exposure to inhaled nickel hydroxide nanoparticles: short and long-term studies in mice.

Gillespie PA, Kang GS, Elder A, Gelein R, Chen L, Moreira AL, Koberstein J, Tchou-Wong KM, Gordon T, Chen LC

Nanotoxicology.. 2010 March 14 (1):106-119. Epub 1900 01 01.

A nanoparticle dispersion method for in vitro and in vivo nanotoxicity study.

Kim SC, Chen DR, Qi C, Gelein RM, Finkelstein JN, Elder A, Bentley K, Oberdörster G, Pui DY

Nanotoxicology.. 2010 March 4 (1):42-51. Epub 1900 01 01.

A nanoparticle dispersion method of in vitro and in vivo nanotoxicity study

Kim, S.C.; Chen, D.; Qi, C.; Gelein, R.M.; Finkelstein, J.N.; Elder, A.; Bentley, K.; Oberdorster, G.; Pui, D.Y.H.

Nanotoxicology. 2010; 4(1): 42-51.

Pulmonary response after exposure to inhaled nickel hydroxide nanoparticles: short and long-term studies in mice

Gillespie, P.A.; Kang, G.S.; Elder, A.; Gelein, R.; Chen, L.; Moreira, A.L.; Koberstein, J.; Tchou-Wang, K.M.; Gordon, T.; Chen, L.C.

Nanotoxicology. 2010; 4(1): 106-19.

Concept of assessing nanoparticle hazards considering nanoparticle dosemetric and chemical/biological response metrics.

Rushton EK, Jiang J, Leonard SS, Eberly S, Castranova V, Biswas P, Elder A, Han X, Gelein R, Finkelstein J, Oberdorster G

Journal of toxicology and environmental health. Part A.. 2010 73 (5):445-61. Epub 1900 01 01.

Nanoparticles and the brain: cause for concern?.

Oberdörster G, Elder A, Rinderknecht A

Journal of nanoscience and nanotechnology.. 2009 August 9 (8):4996-5007. Epub 1900 01 01.

Nanotoxicology: How do nanotubes suppress T cells?

Elder A

Nature nanotechnology.. 2009 July 4 (7):409-10. Epub 06/14/2009.

Emerging methods and tools for environmental risk assessment, decision-making, and policy for nanomaterials: summary of NATO Advanced Research Workshop.

Linkov I, Steevens J, Adlakha-Hutcheon G, Bennett E, Chappell M, Colvin V, Davis JM, Davis T, Elder A, Foss Hansen S, Hakkinen PB, Hussain SM, Karkan D, Korenstein R, Lynch I, Metcalfe C, Ramadan AB, Satterstrom FK

Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology.. 2009 April 11 (3):513-527. Epub 10/08/2008.

Nanoparticle (NP) uptake by type I alveolar epithelial cells and their oxidant stress response.

Vanwinkle BA, de Mesy Bentley KL, Malecki JM, Gunter KK, Evans IM, Elder A, Finkelstein JN, Oberdörster G, Gunter TE

Nanotoxicology.. 2009 January 13 (4):307-318. Epub 1900 01 01.

Physicochemical factors that affect metal and metal oxide nanoparticle passage across epithelial barriers.

Elder A, Vidyasagar S, DeLouise L

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.. 2009 1 (4):434-50. Epub 1900 01 01.

Does Nanoparticle Activity Depend upon Size and Crystal Phase?

Jiang J, Oberdörster G, Elder A, Gelein R, Mercer P, Biswas P

Nanotoxicology.. 2008 March 2 (1):33-42. Epub 1900 01 01.

Does nanoparticles activity depend on size and crystal phase?

Jiang, J.; Oberdorster, G.; Elder, A.; Gelein, R.; Mercer, P.; Biswas, P.

Nanotoxicology. 2008; 2(1): 33-42.

Effects of on-road highway aerosol exposures on autonomic responses in aged, spontaneously hypertensive rats.

Elder A, Couderc JP, Gelein R, Eberly S, Cox C, Xia X, Zareba W, Hopke P, Watts W, Kittelson D, Frampton M, Utell M, Oberdörster G

Inhalation toxicology.. 2007 January 19 (1):1-12. Epub 1900 01 01.

A Testing Strategy for Nanomaterials of Unknown Toxicity: An Example using Platinum Nanoparticles of Different Shapes.

Elder, A.; Yang, H.; Gwizada, R.; Teng, X.; Thurston, S.; He, H.; Oberdörster, G.

Adv. Mater. 2007; .

Nasal Toxicity in Laboratory Rats After Subchronic Inhalation Exposure to Carbon Black Nanoparticles

Santhanam, P.; J.G. Wagner; A. Elder; R. Gelein; J.M. Carter; K.E. Driscoll; G. Oberdörster; J.R. Harkema.

Int'l. J. Nanotechnol. 2007; .

A comparative dose-related response of several key pro- and antiinflammatory mediators in the lungs of rats, mice, and hamsters after subchronic inhalation of carbon black.

Carter JM, Corson N, Driscoll KE, Elder A, Finkelstein JN, Harkema JN, Gelein R, Wade-Mercer P, Nguyen K, Oberdorster G

Journal of occupational and environmental medicine. 2006 December 48 (12):1265-78. Epub 1900 01 01.

Translocation of inhaled ultrafine manganese oxide particles to the central nervous system.

Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Potter R, Maynard A, Ito Y, Finkelstein J, Oberdörster G

Environmental health perspectives.. 2006 August 114 (8):1172-8. Epub 1900 01 01.

Translocation and effects of ultrafine particles outside of the lung.

Elder A, Oberdörster G

Clinics in occupational and environmental medicine. 2006 5 (4):785-96. Epub 1900 01 01.

Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology.

Elder A, Gelein R, Finkelstein JN, Driscoll KE, Harkema J, Oberdörster G

Toxicological sciences : an official journal of the Society of Toxicology.. 2005 December 88 (2):614-29. Epub 09/21/2005.

The rat ear vein model for investigating in vivo thrombogenicity of ultrafine particles (UFP).

Silva VM, Corson N, Elder A, Oberdörster G

Toxicological sciences : an official journal of the Society of Toxicology.. 2005 June 85 (2):983-9. Epub 03/16/2005.

Lung inflammation induced by endotoxin is enhanced in rats depleted of alveolar macrophages with aerosolized clodronate.

Elder A, Johnston C, Gelein R, Finkelstein J, Wang Z, Notter R, Oberdörster G

Experimental lung research.. 2005 31 (6):527-46. Epub 1900 01 01.

Translocation of inhaled ultrafine particles to the brain.

Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Kreyling W, Cox C

Inhalation toxicology.. 2004 June 16 (6-7):437-45. Epub 1900 01 01.

Systemic effects of inhaled ultrafine particles in two compromised, aged rat strains.

Elder AC, Gelein R, Azadniv M, Frampton M, Finkelstein J, Oberdörster G

Inhalation toxicology.. 2004 June 16 (6-7):461-71. Epub 1900 01 01.

Efficient depletion of alveolar macrophages using intratracheally inhaled aerosols of liposome-encapsulated clodronate.

Elder AC, Gelein R, Oberdörster G, Finkelstein J, Notter R, Wang Z

Experimental lung research.. 2004 March 30 (2):105-20. Epub 1900 01 01.

On-road exposure to highway aerosols. 1. Aerosol and gas measurements.

Kittelson DB, Watts WF, Johnson JP, Remerowki ML, Ische EE, Oberdörster G, Gelein RM, Elder A, Hopke PK, Kim E, Zhao W, Zhou L, Jeong CH

Inhalation toxicology.. 2004 16 Suppl 1 :31-9. Epub 1900 01 01.

On-road exposure to highway aerosols. 2. Exposures of aged, compromised rats.

Elder A, Gelein R, Finkelstein J, Phipps R, Frampton M, Utell M, Kittelson DB, Watts WF, Hopke P, Jeong CH, Kim E, Liu W, Zhao W, Zhuo L, Vincent R, Kumarathasan P, Oberdörster G

Inhalation toxicology.. 2004 16 Suppl 1 :41-53. Epub 1900 01 01.

Inflammatory cell recruitment following thoracic irradiation.

Johnston CJ, Williams JP, Elder A, Hernady E, Finkelstein JN

Experimental lung research.. 2004 30 (5):369-82. Epub 1900 01 01.

Formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine in rat lung DNA following subchronic inhalation of carbon black.

Gallagher J, Sams R, Inmon J, Gelein R, Elder A, Oberdörster G, Prahalad AK

Toxicology and applied pharmacology.. 2003 August 1190 (3):224-31. Epub 1900 01 01.

Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats.

Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Lunts A, Kreyling W, Cox C

Journal of toxicology and environmental health. Part A.. 2002 October 2565 (20):1531-43. Epub 1900 01 01.

Systemic Interactions Between Inhaled Ultrafine Particles and Endotoxin

Elder, A.C.P.; Gelein, R.; Azadniv, M.; Frampton, M.; Oberdörster, G.

Ann. Occup. Hyg. 2002; 46(Suppl. 1): 231-234.

Limitations of Power Spectrum Analysis and Time-Domain Analysis of Heart Rate Variability in Short-Term ECGs Recorded using Telemetry in Unrestrained Rats

Couderc, J-P.; Elder, A.; Cox, C.; Zareba, W.; Oberdörster, G.

Comp. Cardiol. 2002; 29: 589-592.

Acute pulmonary effects of ultrafine particles in rats and mice.

Oberdörster G, Finkelstein JN, Johnston C, Gelein R, Cox C, Baggs R, Elder AC

Research report. 2000 August (96):5-74; disc. 75-86. Epub 1900 01 01.

Induction of adaptation to inhaled lipopolysaccharide in young and old rats and mice.

Elder AC, Finkelstein J, Johnston C, Gelein R, Oberdörster G

Inhalation toxicology.. 2000 March 12 (3):225-43. Epub 1900 01 01.

Endotoxin Priming Affects the Lung Response to Ultrafine Particles and Ozone in Young and Old Rats

Elder, A.C.P.; Gelein, R.; Finkelstein, J.N.; Cox, C.; Oberdörster, G.

Inhal. Toxicol. 2000; 12(Suppl. 1): 85-98.

Pulmonary inflammatory response to inhaled ultrafine particles is modified by age, ozone exposure, and bacterial toxin.

Elder AC, Gelein R, Finkelstein JN, Cox C, Oberdörster G

Inhalation toxicology.. 2000 12 Suppl 4 :227-46. Epub 1900 01 01.

Effects of ozone on macrophage adhesion in vitro and epithelial and inflammatory responses in vivo: the role of cytokines.

Pearson AC, Bhalla DK

Journal of toxicology and environmental health.. 1997 February 750 (2):143-57. Epub 1900 01 01.

Modification of macrophage adhesion by ozone: role of cytokines and cell adhesion molecules.

Bhalla DK, Hoffman LA, Pearson AC

Annals of the New York Academy of Sciences.. 1996 October 31796 :38-46. Epub 1900 01 01.

Books

Particles and Cardiovascular Disease Mechanisms (2010)

Chapter: Particles and the autonomic nervous system

Authors: Upadhyay S, Elder A, Cascio WE, Schulz H

Publisher: John Wiley & Sons, Inc., Hoboken, NJ 2010

Nanotechnology: Risks and Benefits (2009)

Chapter: Human Health Risks of Engineered Nanomaterials

Authors: Elder A, Lynch I, Grieger K, Chan-Remillard S, Gatti A, Gnewuch H, Kenawy E, Korenstein R, Kuhlbusch T, Linker F, Matias S, Monteiro-Riviere N, Pinto V, Rudnitsky R, Savoleinen K, Shvedova A

Publisher: Springer, Dordrecht 2009

Nanotechnology: Risks and Benefits (2009)

Chapter: Disposition of Nanoparticles as a Function of their Interactions with Biomolecules

Authors: Lynch I, Elder A

Publisher: Springer, Dordrecht 2009

Safety of Nanoparticles (2008)

Chapter: Breeching Epithelial Barriers – Physiochemical Factors Impacting Nanomaterial Translocation and Toxicity

Authors: DeLouise L, Mortensen L, Elder A

Publisher: Springer 2008

Effects of Air Contaminants on the Respiratory Tract - Interpretations from Mole (2004)

Chapter: Effects of inhaled fine/ultrafine particles combined with other air pollutants

Authors: Elder, A.C.P.; Gelein, R.; Finkelstein, J.; Frampton, M.; Utell, M.; Carter, J.; Driscoll, K.; Kittelson, D.; Watts, W.; Hopke, P.; Vincent, R.' Kumarathasan, P.; Oberdorster, G.

Publisher: Fraunhofer IRB Verlag, Stuttgart 2004