Alison Elder, Ph.D.

Alison Elder, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box EHSC
Rochester, NY 14642

Office: (585) 275-2324
Lab: (585) 275-3821
Fax: (585) 256-2631

Journal Articles

Showing all 54 journal articles available.

2016 Oct
Guttenberg M, Bezerra L, Neu-Baker NM, Del Pilar Sosa Idelchik M, Elder A, Oberdörster G, Brenner SA. "Biodistribution of inhaled metal oxide nanoparticles mimicking occupational exposure: a preliminary investigation using enhanced darkfield microscopy." Journal of biophotonics. 2016 Oct; 9(10):987-993. Epub 2016 Aug 16.
2016 Sep 2
Lerner CA, Rutagarama P, Ahmad T, Sundar IK, Elder A, Rahman I. "Electronic cigarette aerosols and copper nanoparticles induce mitochondrial stress and promote DNA fragmentation in lung fibroblasts." Biochemical and biophysical research communications. 2016 Sep 2; 477(4):620-5. Epub 2016 Jun 23.
2015 Mar
Lerner CA, Sundar IK, Watson RM, Elder A, Jones R, Done D, Kurtzman R, Ossip DJ, Robinson R, McIntosh S, Rahman I. "Environmental health hazards of e-cigarettes and their components: Oxidants and copper in e-cigarette aerosols." Environmental pollution. 2015 Mar; 198:100-7. Epub 2015 Jan 09.
2014 Apr
Gordon SC, Butala JH, Carter JM, Elder A, Gordon T, Gray G, Sayre PG, Schulte PA, Tsai CS, West J. "Workshop report: strategies for setting occupational exposure limits for engineered nanomaterials." Regulatory toxicology and pharmacology : RTP. 2014 Apr; 68(3):305-11. Epub 2014 Jan 23.
2014 Apr
Sotiriou GA, Watson C, Murdaugh KM, Darrah TH, Pyrgiotakis G, Elder A, Brain JD, Demokritou P. "Engineering safer-by-design, transparent, silica-coated ZnO nanorods with reduced DNA damage potential." Environmental science. Nano. 2014 Apr; 1(2):144-153.
2014 Jan 24
Baisch BL, Corson NM, Wade-Mercer P, Gelein R, Kennell AJ, Oberdörster G, Elder A. "Equivalent titanium dioxide nanoparticle deposition by intratracheal instillation and whole body inhalation: the effect of dose rate on acute respiratory tract inflammation." Particle and fibre toxicology. 2014 Jan 24; 11:5. Epub 2014 Jan 24.
2013 Oct 22
Doudrick K, Corson N, Oberdörster G, Elder AC, Herckes P, Halden RU, Westerhoff P. "Extraction and quantification of carbon nanotubes in biological matrices with application to rat lung tissue." ACS nano. 2013 Oct 22; 7(10):8849-56. Epub 2013 Sep 06.
2013 Sep
Baer DR, Engelhard MH, Johnson GE, Laskin J, Lai J, Mueller K, Munusamy P, Thevuthasan S, Wang H, Washton N, Elder A, Baisch BL, Karakoti A, Kuchibhatla SV, Moon D. "Surface characterization of nanomaterials and nanoparticles: Important needs and challenging opportunities." Journal of vacuum science & technology. A, Vacuum, surfaces, and films : an official journal of the American Vacuum Society. 2013 Sep; 31(5):50820. Epub 2013 Aug 27.
2013 Jun
Bonner JC, Silva RM, Taylor AJ, Brown JM, Hilderbrand SC, Castranova V, Porter D, Elder A, Oberdörster G, Harkema JR, Bramble LA, Kavanagh TJ, Botta D, Nel A, Pinkerton KE. "Interlaboratory evaluation of rodent pulmonary responses to engineered nanomaterials: the NIEHS Nano GO Consortium." Environmental health perspectives. 2013 Jun; 121(6):676-82. Epub 2013 May 06.
2013 Jun
Xia T, Hamilton RF, Bonner JC, Crandall ED, Elder A, Fazlollahi F, Girtsman TA, Kim K, Mitra S, Ntim SA, Orr G, Tagmount M, Taylor AJ, Telesca D, Tolic A, Vulpe CD, Walker AJ, Wang X, Witzmann FA, Wu N, Xie Y, Zink JI, Nel A, Holian A. "Interlaboratory evaluation of in vitro cytotoxicity and inflammatory responses to engineered nanomaterials: the NIEHS Nano GO Consortium." Environmental health perspectives. 2013 Jun; 121(6):683-90. Epub 2013 May 06.
Mortensen LJ, Jatana S, Gelein R, Debenedetto A, de Mesy Bentley KL, Beck L, Elder A, Delouise L. "Quantification of quantum dot murine skin penetration with UVR barrier impairment." Nanotoxicology. 2013 7(8):1386-98. Epub 2013 Apr 17.
2012 Oct
Block ML, Elder A, Auten RL, Bilbo SD, Chen H, Chen JC, Cory-Slechta DA, Costa D, Diaz-Sanchez D, Dorman DC, Gold DR, Gray K, Jeng HA, Kaufman JD, Kleinman MT, Kirshner A, Lawler C, Miller DS, Nadadur SS, Ritz B, Semmens EO, Tonelli LH, Veronesi B, Wright RO, Wright RJ. "The outdoor air pollution and brain health workshop." Neurotoxicology. 2012 Oct; 33(5):972-84. Epub 2012 Sep 05.
2012 Aug
Lucchini RG, Dorman DC, Elder A, Veronesi B. "Neurological impacts from inhalation of pollutants and the nose-brain connection." Neurotoxicology. 2012 Aug; 33(4):838-41. Epub 2011 Dec 09.
2012 Jul 16
Han X, Corson N, Wade-Mercer P, Gelein R, Jiang J, Sahu M, Biswas P, Finkelstein JN, Elder A, Oberdörster G. "Assessing the relevance of in vitro studies in nanotoxicology by examining correlations between in vitro and in vivo data." Toxicology. 2012 Jul 16; 297(1-3):1-9. Epub 2012 Apr 02.
2012 Mar 27
Shi M, Kwon HS, Peng Z, Elder A, Yang H. "Effects of surface chemistry on the generation of reactive oxygen species by copper nanoparticles." ACS nano. 2012 Mar 27; 6(3):2157-64. Epub 2012 Mar 05.
2011 Sep 5
Han X, Gelein R, Corson N, Wade-Mercer P, Jiang J, Biswas P, Finkelstein JN, Elder A, Oberdörster G. "Validation of an LDH assay for assessing nanoparticle toxicity." Toxicology. 2011 Sep 5; 287(1-3):99-104. Epub 2011 Jun 23.
2010 Oct 26
Rivera Gil P, Oberdörster G, Elder A, Puntes V, Parak WJ. "Correlating physico-chemical with toxicological properties of nanoparticles: the present and the future." ACS nano. 2010 Oct 26; 4(10):5527-31.
2010 Mar 1
Gillespie PA, Kang GS, Elder A, Gelein R, Chen L, Moreira AL, Koberstein J, Tchou-Wong KM, Gordon T, Chen LC. "Pulmonary response after exposure to inhaled nickel hydroxide nanoparticles: short and long-term studies in mice." Nanotoxicology. 2010 Mar 1; 4(1):106-119.
2010 Mar
Kim SC, Chen DR, Qi C, Gelein RM, Finkelstein JN, Elder A, Bentley K, Oberdörster G, Pui DY. "A nanoparticle dispersion method for in vitro and in vivo nanotoxicity study." Nanotoxicology. 2010 Mar; 4(1):42-51.
Kim, S.C.; Chen, D.; Qi, C.; Gelein, R.M.; Finkelstein, J.N.; Elder, A.; Bentley, K.; Oberdorster, G.; Pui, D.Y.H. "A nanoparticle dispersion method of in vitro and in vivo nanotoxicity study". Nanotoxicology. 2010; 4(1): 42-51.
Gillespie, P.A.; Kang, G.S.; Elder, A.; Gelein, R.; Chen, L.; Moreira, A.L.; Koberstein, J.; Tchou-Wang, K.M.; Gordon, T.; Chen, L.C. "Pulmonary response after exposure to inhaled nickel hydroxide nanoparticles: short and long-term studies in mice". Nanotoxicology. 2010; 4(1): 106-19.
Rushton EK, Jiang J, Leonard SS, Eberly S, Castranova V, Biswas P, Elder A, Han X, Gelein R, Finkelstein J, Oberdorster G. "Concept of assessing nanoparticle hazards considering nanoparticle dosemetric and chemical/biological response metrics." Journal of toxicology and environmental health. Part A. 2010 73(5):445-61.
2009 Aug
Oberdörster G, Elder A, Rinderknecht A. "Nanoparticles and the brain: cause for concern?." Journal of nanoscience and nanotechnology. 2009 Aug; 9(8):4996-5007.
2009 Jul
Elder A. "Nanotoxicology: How do nanotubes suppress T cells?" Nature nanotechnology. 2009 Jul; 4(7):409-10. Epub 2009 Jun 14.
2009 Apr
Linkov I, Steevens J, Adlakha-Hutcheon G, Bennett E, Chappell M, Colvin V, Davis JM, Davis T, Elder A, Foss Hansen S, Hakkinen PB, Hussain SM, Karkan D, Korenstein R, Lynch I, Metcalfe C, Ramadan AB, Satterstrom FK. "Emerging methods and tools for environmental risk assessment, decision-making, and policy for nanomaterials: summary of NATO Advanced Research Workshop." Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology. 2009 Apr; 11(3):513-527. Epub 2008 Oct 08.
2009 Jan 1
Vanwinkle BA, de Mesy Bentley KL, Malecki JM, Gunter KK, Evans IM, Elder A, Finkelstein JN, Oberdörster G, Gunter TE. "Nanoparticle (NP) uptake by type I alveolar epithelial cells and their oxidant stress response." Nanotoxicology. 2009 Jan 1; 3(4):307-318.
Elder A, Vidyasagar S, DeLouise L. "Physicochemical factors that affect metal and metal oxide nanoparticle passage across epithelial barriers." Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. 2009 1(4):434-50.
2008 Mar
Jiang J, Oberdörster G, Elder A, Gelein R, Mercer P, Biswas P. "Does Nanoparticle Activity Depend upon Size and Crystal Phase?" Nanotoxicology. 2008 Mar; 2(1):33-42.
Jiang, J.; Oberdorster, G.; Elder, A.; Gelein, R.; Mercer, P.; Biswas, P. "Does nanoparticles activity depend on size and crystal phase?". Nanotoxicology. 2008; 2(1): 33-42.
2007 Jan
Elder A, Couderc JP, Gelein R, Eberly S, Cox C, Xia X, Zareba W, Hopke P, Watts W, Kittelson D, Frampton M, Utell M, Oberdörster G. "Effects of on-road highway aerosol exposures on autonomic responses in aged, spontaneously hypertensive rats." Inhalation toxicology. 2007 Jan; 19(1):1-12.
Elder, A.; Yang, H.; Gwizada, R.; Teng, X.; Thurston, S.; He, H.; Oberdörster, G. "A Testing Strategy for Nanomaterials of Unknown Toxicity: An Example using Platinum Nanoparticles of Different Shapes." Adv. Mater. 2007; .
Santhanam, P.; J.G. Wagner; A. Elder; R. Gelein; J.M. Carter; K.E. Driscoll; G. Oberdörster; J.R. Harkema. "Nasal Toxicity in Laboratory Rats After Subchronic Inhalation Exposure to Carbon Black Nanoparticles". Int'l. J. Nanotechnol. 2007; .
2006 Aug
Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Potter R, Maynard A, Ito Y, Finkelstein J, Oberdörster G. "Translocation of inhaled ultrafine manganese oxide particles to the central nervous system." Environmental health perspectives. 2006 Aug; 114(8):1172-8.
Elder A, Oberdörster G. "Translocation and effects of ultrafine particles outside of the lung." Clinics in occupational and environmental medicine. 2006 5(4):785-96.
Carter JM, Corson N, Driscoll KE, Elder A, Finkelstein JN, Harkema JN, Gelein R, Wade-Mercer P, Nguyen K, Oberdorster G. "A comparative dose-related response of several key pro- and antiinflammatory mediators in the lungs of rats, mice, and hamsters after subchronic inhalation of carbon black." Journal of occupational and environmental medicine. 2006 48(12):1265-78.
2005 Jun
Silva VM, Corson N, Elder A, Oberdörster G. "The rat ear vein model for investigating in vivo thrombogenicity of ultrafine particles (UFP)." Toxicological sciences : an official journal of the Society of Toxicology. 2005 Jun; 85(2):983-9. Epub 2005 Mar 16.
Elder A, Johnston C, Gelein R, Finkelstein J, Wang Z, Notter R, Oberdörster G. "Lung inflammation induced by endotoxin is enhanced in rats depleted of alveolar macrophages with aerosolized clodronate." Experimental lung research. 2005 31(6):527-46.
Elder A, Gelein R, Finkelstein JN, Driscoll KE, Harkema J, Oberdörster G. "Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology." Toxicological sciences : an official journal of the Society of Toxicology. 2005 88(2):614-29. Epub 2005 Sep 21.
2004 Jun
Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Kreyling W, Cox C. "Translocation of inhaled ultrafine particles to the brain." Inhalation toxicology. 2004 Jun; 16(6-7):437-45.
2004 Jun
Elder AC, Gelein R, Azadniv M, Frampton M, Finkelstein J, Oberdörster G. "Systemic effects of inhaled ultrafine particles in two compromised, aged rat strains." Inhalation toxicology. 2004 Jun; 16(6-7):461-71.
2004 Mar
Elder AC, Gelein R, Oberdörster G, Finkelstein J, Notter R, Wang Z. "Efficient depletion of alveolar macrophages using intratracheally inhaled aerosols of liposome-encapsulated clodronate." Experimental lung research. 2004 Mar; 30(2):105-20.
Kittelson DB, Watts WF, Johnson JP, Remerowki ML, Ische EE, Oberdörster G, Gelein RM, Elder A, Hopke PK, Kim E, Zhao W, Zhou L, Jeong CH. "On-road exposure to highway aerosols. 1. Aerosol and gas measurements." Inhalation toxicology. 2004 16 Suppl 1:31-9.
Elder A, Gelein R, Finkelstein J, Phipps R, Frampton M, Utell M, Kittelson DB, Watts WF, Hopke P, Jeong CH, Kim E, Liu W, Zhao W, Zhuo L, Vincent R, Kumarathasan P, Oberdörster G. "On-road exposure to highway aerosols. 2. Exposures of aged, compromised rats." Inhalation toxicology. 2004 16 Suppl 1:41-53.
Johnston CJ, Williams JP, Elder A, Hernady E, Finkelstein JN. "Inflammatory cell recruitment following thoracic irradiation." Experimental lung research. 2004 30(5):369-82.
2003 Aug 1
Gallagher J, Sams R, Inmon J, Gelein R, Elder A, Oberdörster G, Prahalad AK. "Formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine in rat lung DNA following subchronic inhalation of carbon black." Toxicology and applied pharmacology. 2003 Aug 1; 190(3):224-31.
2002 Oct 25
Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Lunts A, Kreyling W, Cox C. "Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats." Journal of toxicology and environmental health. Part A. 2002 Oct 25; 65(20):1531-43.
Elder, A.C.P.; Gelein, R.; Azadniv, M.; Frampton, M.; Oberdörster, G. "Systemic Interactions Between Inhaled Ultrafine Particles and Endotoxin". Ann. Occup. Hyg. 2002; 46(Suppl. 1): 231-234.
Couderc, J-P.; Elder, A.; Cox, C.; Zareba, W.; Oberdörster, G. "Limitations of Power Spectrum Analysis and Time-Domain Analysis of Heart Rate Variability in Short-Term ECGs Recorded using Telemetry in Unrestrained Rats". Comp. Cardiol. 2002; 29: 589-592.
2000 Aug
Oberdörster G, Finkelstein JN, Johnston C, Gelein R, Cox C, Baggs R, Elder AC. "Acute pulmonary effects of ultrafine particles in rats and mice." Research report (Health Effects Institute). 2000 Aug; (96):5-74; disc. 75-86.
2000 Mar
Elder AC, Finkelstein J, Johnston C, Gelein R, Oberdörster G. "Induction of adaptation to inhaled lipopolysaccharide in young and old rats and mice." Inhalation toxicology. 2000 Mar; 12(3):225-43.
Elder, A.C.P.; Gelein, R.; Finkelstein, J.N.; Cox, C.; Oberdörster, G. "Endotoxin Priming Affects the Lung Response to Ultrafine Particles and Ozone in Young and Old Rats". Inhal. Toxicol. 2000; 12(Suppl. 1): 85-98.
Elder AC, Gelein R, Finkelstein JN, Cox C, Oberdörster G. "Pulmonary inflammatory response to inhaled ultrafine particles is modified by age, ozone exposure, and bacterial toxin." Inhalation toxicology. 2000 12 Suppl 4:227-46.
1997 Feb 7
Pearson AC, Bhalla DK. "Effects of ozone on macrophage adhesion in vitro and epithelial and inflammatory responses in vivo: the role of cytokines." Journal of toxicology and environmental health. 1997 Feb 7; 50(2):143-57.
1996 Oct 31
Bhalla DK, Hoffman LA, Pearson AC. "Modification of macrophage adhesion by ozone: role of cytokines and cell adhesion molecules." Annals of the New York Academy of Sciences. 1996 Oct 31; 796:38-46.


Upadhyay S, Elder A, Cascio WE, Schulz H. "Particles and the autonomic nervous system". Particles and Cardiovascular Disease Mechanisms. F.R. Cassee, N.L. Mills, D.E. Newby. Hoboken, NJ: John Wiley & Sons, Inc., 2010.
Elder A, Lynch I, Grieger K, Chan-Remillard S, Gatti A, Gnewuch H, Kenawy E, Korenstein R, Kuhlbusch T, Linker F, Matias S, Monteiro-Riviere N, Pinto V, Rudnitsky R, Savoleinen K, Shvedova A. "Human Health Risks of Engineered Nanomaterials". Nanotechnology: Risks and Benefits. Linkov I, Steevens J. Dordrecht: Springer, 2009. 27
Lynch I, Elder A. "Disposition of Nanoparticles as a Function of their Interactions with Biomolecules". Nanotechnology: Risks and Benefits. Linkov I, Steevens J. Dordrecht: Springer, 2009. 11
DeLouise L, Mortensen L, Elder A. "Breeching Epithelial Barriers – Physiochemical Factors Impacting Nanomaterial Translocation and Toxicity". Safety of Nanoparticles. Webster TJ. : Springer, 2008. 31
Elder, A.C.P.; Gelein, R.; Finkelstein, J.; Frampton, M.; Utell, M.; Carter, J.; Driscoll, K.; Kittelson, D.; Watts, W.; Hopke, P.; Vincent, R.' Kumarathasan, P.; Oberdorster, G.. "Effects of inhaled fine/ultrafine particles combined with other air pollutants". Effects of Air Contaminants on the Respiratory Tract - Interpretations from Mole. Heinrich, U.. Stuttgart: Fraunhofer IRB Verlag, 2004.