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Hartmut K. Land, Ph.D.


Showing all 71 journal articles & 0 books available

Journal Articles

McMurray HR, Stern HA, Ambeskovic A, Land H, McCall MN. "Protocol to use TopNet for gene regulatory network modeling using gene expression data from perturbation experiments." STAR protocols.. 2022 Sep 30; 3(4):101737. Epub 2022 Sep 30.

Mammola S, Malumbres-Olarte J, Arabesky V, Barrales-Alcalá DA, Barrion-Dupo AL, Benamú MA, Bird TL, Bogomolova M, Cardoso P, Chatzaki M, Cheng RC, Chu TA, Classen-Rodríguez LM, ?upi? I, Dhiya'ulhaq NU, Drapeau Picard AP, El-Hennawy HK, Elverici M, Fukushima CS, Ganem Z, Gavish-Regev E, Gonnye NT, Hacala A, Haddad CR, Hesselberg T, Tian Ho TA, Into T, Isaia M, Jayaraman D, Karuaera N, Khalap R, Khalap K, Kim D, Korhonen T, Kralj-Fišer S, Land H, Lin SW, Loboda S, Lowe E, Lubin Y, Martínez A, Mbo Z, Mili?i? M, Kioko GM, Nanni V, Norma-Rashid Y, Nwankwo D, Painting CJ, Pang A, Pantini P, Pavlek M, Pearce R, Petcharad B, Pétillon J, Raberahona OC, Russo P, Saarinen JA, Segura-Hernández L, Sentenská L, Uhl G, Walker L, Warui CM, Wi?niewski K, Zamani A, Chuang A, Scott C. "The global spread of misinformation on spiders." Current biology : CB.. 2022 Aug 22; 32(16):R871-R873.

McMurray HR, Ambeskovic A, Newman LA, Aldersley J, Balakrishnan V, Smith B, Stern HA, Land H, McCall MN. "Gene network modeling via TopNet reveals functional dependencies between diverse tumor-critical mediator genes." Cell reports.. 2021 Dec 21; 37(12):110136.

Sherina V, McMurray HR, Powers W, Land H, Love TMT, McCall MN. "Multiple imputation and direct estimation for qPCR data with non-detects." BMC bioinformatics.. 2020 Nov 26; 21(1):545. Epub 2020 Nov 26.

Komisarof J, McCall M, Newman L, Bshara W, Mohler JL, Morrison C, Land H. "A four gene signature predictive of recurrent prostate cancer." Oncotarget.. 2017 Jan 10; 8(2):3430-3440.

Smith B, Schafer XL, Ambeskovic A, Spencer CM, Land H, Munger J. "Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells." Cell reports.. 2016 Oct 11; 17(3):821-836.

Pulvino M, Chen L, Oleksyn D, Li J, Compitello G, Rossi R, Spence S, Balakrishnan V, Jordan C, Poligone B, Casulo C, Burack R, Shapiro JL, Bernstein S, Friedberg JW, Deshaies RJ, Land H, Zhao J. "Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline." Oncotarget.. 2015 Jun 20; 6(17):14796-813.

McCall MN, McMurray H, Land H, Almudevar A. "On non-detects in qPCR data." Bioinformatics.. 2014 Aug 15; 30(16):2310-6. Epub 2014 Apr 23.

Kinsey C, Balakrishnan V, O'Dell MR, Huang JL, Newman L, Whitney-Miller CL, Hezel AF, Land H. "Plac8 links oncogenic mutations to regulation of autophagy and is critical to pancreatic cancer progression." Cell reports.. 2014 May 22; 7(4):1143-55. Epub 2014 May 01.

Sampson ER, McMurray HR, Hassane DC, Newman L, Salzman P, Jordan CT, Land H. "Gene signature critical to cancer phenotype as a paradigm for anticancer drug discovery." Oncogene.. 2013 Aug 15; 32(33):3809-18. Epub 2012 Sep 10.

Hu X, Dutta P, Tsurumi A, Li J, Wang J, Land H, Li WX. "Unphosphorylated STAT5A stabilizes heterochromatin and suppresses tumor growth." Proceedings of the National Academy of Sciences of the United States of America.. 2013 Jun 18; 110(25):10213-8. Epub 2013 Jun 03.

Gaur K, Li J, Wang D, Dutta P, Yan SJ, Tsurumi A, Land H, Wu G, Li WX. "The Birt-Hogg-Dubé tumor suppressor Folliculin negatively regulates ribosomal RNA synthesis." Human molecular genetics.. 2013 Jan 15; 22(2):284-99. Epub 2012 Oct 16.

Smith B, Land H. "Anticancer activity of the cholesterol exporter ABCA1 gene." Cell reports.. 2012 Sep 27; 2(3):580-90. Epub 2012 Sep 13.

Ashton JM, Balys M, Neering SJ, Hassane DC, Cowley G, Root DE, Miller PG, Ebert BL, McMurray HR, Land H, Jordan CT. "Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells." Cell stem cell.. 2012 Sep 7; 11(3):359-72. Epub 2012 Aug 02.

O'Dell MR, Huang JL, Whitney-Miller CL, Deshpande V, Rothberg P, Grose V, Rossi RM, Zhu AX, Land H, Bardeesy N, Hezel AF. "Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinoma." Cancer research.. 2012 Mar 15; 72(6):1557-67. Epub 2012 Jan 20.

Almudevar A, McCall MN, McMurray H, Land H. "Fitting Boolean networks from steady state perturbation data." Statistical applications in genetics and molecular biology. 2011 Oct 5; 10(1)Epub 2011 Oct 05.

McMurray HR, Sampson ER, Compitello G, Kinsey C, Newman L, Smith B, Chen SR, Klebanov L, Salzman P, Yakovlev A, Land H. "Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype." Nature.. 2008 Jun 19; 453(7198):1112-6. Epub 2008 May 25.

Xia M, Land H. "Tumor suppressor p53 restricts Ras stimulation of RhoA and cancer cell motility." Nature structural & molecular biology.. 2007 Mar; 14(3):215-23. Epub 2007 Feb 18.

Klebanov, L.; Gordon, A.; Xiao, Y.; Land, H.; Yakovlev, A. "A permutation test motivated by microarray data analysis". Computational Statistics and Data Analysis. 2005; 50: 3619-3628.

Deleu L, Shellard S, Alevizopoulos K, Amati B, Land H. "Recruitment of TRRAP required for oncogenic transformation by E1A." Oncogene.. 2001 Dec 13; 20(57):8270-5.

Roper E, Weinberg W, Watt FM, Land H. "p19ARF-independent induction of p53 and cell cycle arrest by Raf in murine keratinocytes." EMBO reports.. 2001 Feb; 2(2):145-50.

Perez-Roger I, Kim SH, Griffiths B, Sewing A, Land H. "Cyclins D1 and D2 mediate myc-induced proliferation via sequestration of p27(Kip1) and p21(Cip1)." The EMBO journal.. 1999 Oct 1; 18(19):5310-20.

Sewing A, Wiseman B, Lloyd AC, Land H. "High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1." Molecular and cellular biology.. 1997 Sep; 17(9):5588-97.

Pérez-Roger I, Solomon DL, Sewing A, Land H. "Myc activation of cyclin E/Cdk2 kinase involves induction of cyclin E gene transcription and inhibition of p27(Kip1) binding to newly formed complexes." Oncogene.. 1997 May 22; 14(20):2373-81.

Lloyd AC, Obermüller F, Staddon S, Barth CF, McMahon M, Land H. "Cooperating oncogenes converge to regulate cyclin/cdk complexes." Genes & development.. 1997 Mar 1; 11(5):663-77.

Bhakoo KK, Williams SR, Florian CL, Land H, Noble MD. "Immortalization and transformation are associated with specific alterations in choline metabolism." Cancer research.. 1996 Oct 15; 56(20):4630-5.

Solomon DL, Philipp A, Land H, Eilers M. "Expression of cyclin D1 mRNA is not upregulated by Myc in rat fibroblasts." Oncogene.. 1995 Nov 2; 11(9):1893-7.

Land H. "Transformation of primary rat embryo cells." Methods in enzymology.. 1995 254:37-41.

Evan G, Harrington E, Fanidi A, Land H, Amati B, Bennett M. "Integrated control of cell proliferation and cell death by the c-myc oncogene." Philosophical transactions of the Royal Society of London. Series B, Biological sciences.. 1994 Aug 30; 345(1313):269-75.

Amati B, Land H. "Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation and death." Current opinion in genetics & development.. 1994 Feb; 4(1):102-8.

Evan,G.; Harrington,E.; Fanidi,A.; Land,H.; Amati,B.; Bennett,M.;. "Integrated control of cell proliferation and cell death by the c-myc oncogene". Philosophical transactions of the Royal Society of London. Series B: Biological sciences. 1994; 345(1313): 269-275.

Amati B, Littlewood TD, Evan GI, Land H. "The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max." The EMBO journal.. 1993 Dec 15; 12(13):5083-7.

Solomon DL, Amati B, Land H. "Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers." Nucleic acids research.. 1993 Nov 25; 21(23):5372-6.

Amati B, Brooks MW, Levy N, Littlewood TD, Evan GI, Land H. "Oncogenic activity of the c-Myc protein requires dimerization with Max." Cell.. 1993 Jan 29; 72(2):233-45.

Amati B, Dalton S, Brooks MW, Littlewood TD, Evan GI, Land H. "Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max." Nature.. 1992 Oct 1; 359(6394):423-6.

Littlewood TD, Amati B, Land H, Evan GI. "Max and c-Myc/Max DNA-binding activities in cell extracts." Oncogene.. 1992 Sep; 7(9):1783-92.

Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ, Hancock DC. "Induction of apoptosis in fibroblasts by c-myc protein." Cell.. 1992 Apr 3; 69(1):119-28.

Morgenstern JP, Land H. "Choice and manipulation of retroviral vectors." Methods in molecular biology.. 1991 7:181-206.

Penn LJ, Brooks MW, Laufer EM, Littlewood TD, Morgenstern JP, Evan GI, Lee WM, Land H. "Domains of human c-myc protein required for autosuppression and cooperation with ras oncogenes are overlapping." Molecular and cellular biology.. 1990 Sep; 10(9):4961-6.

Bögler O, Wren D, Barnett SC, Land H, Noble M. "Cooperation between two growth factors promotes extended self-renewal and inhibits differentiation of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells." Proceedings of the National Academy of Sciences of the United States of America.. 1990 Aug; 87(16):6368-72.

Morgenstern JP, Land H. "Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line." Nucleic acids research.. 1990 Jun 25; 18(12):3587-96.

Wiehle RD, Helftenbein G, Land H, Neumann K, Beato M. "Establishment of rat endometrial cell lines by retroviral mediated transfer of immortalizing and transforming oncogenes." Oncogene.. 1990 Jun; 5(6):787-94.

Penn LJ, Brooks MW, Laufer EM, Land H. "Negative autoregulation of c-myc transcription." The EMBO journal.. 1990 Apr; 9(4):1113-21.

Morgenstern JP, Land H. "A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells." Nucleic acids research.. 1990 Feb 25; 18(4):1068.

Penn LJ, Laufer EM, Land H. "C-MYC: evidence for multiple regulatory functions." Seminars in cancer biology.. 1990 Feb; 1(1):69-80.

von Deimling A, Aguzzi A, Kleihues P, Land H, Wiestler OD. "[Induction of primitive neuroectodermal tumors by oncogene complementation]." Verhandlungen der Deutschen Gesellschaft für Pathologie. 1990 74:432-6.

Noble M, Barnett SC, Bögler O, Land H, Wolswijk G, Wren D. "Control of division and differentiation in oligodendrocyte-type-2 astrocyte progenitor cells." Ciba Foundation symposium.. 1990 150:227-43; discussion 244-9.

Ridley AJ, Davis JB, Stroobant P, Land H. "Transforming growth factors-beta 1 and beta 2 are mitogens for rat Schwann cells." The Journal of cell biology.. 1989 Dec; 109(6 Pt 2):3419-24.

Beddington RS, Morgernstern J, Land H, Hogan A. "An in situ transgenic enzyme marker for the midgestation mouse embryo and the visualization of inner cell mass clones during early organogenesis." Development.. 1989 May; 106(1):37-46.

Compere SJ, Baldacci P, Sharpe AH, Thompson T, Land H, Jaenisch R. "The ras and myc oncogenes cooperate in tumor induction in many tissues when introduced into midgestation mouse embryos by retroviral vectors." Proceedings of the National Academy of Sciences of the United States of America.. 1989 Apr; 86(7):2224-8.

Thompson TC, Southgate J, Kitchener G, Land H. "Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ." Cell.. 1989 Mar 24; 56(6):917-30.

Ridley AJ, Paterson HF, Noble M, Land H. "Ras-mediated cell cycle arrest is altered by nuclear oncogenes to induce Schwann cell transformation." The EMBO journal.. 1988 Jun; 7(6):1635-45.

Land H, Chen AC, Morgenstern JP, Parada LF, Weinberg RA. "Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts." Molecular and cellular biology.. 1986 Jun; 6(6):1917-25.

Parada LF, Land H, Chen A, Morganstern J, Weinberg RA. "Cooperation between cellular oncogenes in the transformation of primary rat embryo fibroblasts." Progress in medical virology. Fortschritte der medizinischen Virusforschung. Progrès en virologie médicale. 1985 32:115-28.

Lenoir GM, Land H, Parada LF, Cunningham JM, Weinberg RA. "Activated oncogenes in Burkitt's lymphoma." Current topics in microbiology and immunology.. 1984 113:6-14.

Parada LF, Land H, Weinberg RA, Wolf D, Rotter V. "Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation." Nature.. 1984 312(5995):649-51.

Land H, Parada LF, Weinberg RA. "Cellular oncogenes and multistep carcinogenesis." Science.. 1983 Nov 18; 222(4625):771-8.

Land H, Grez M, Hauser H, Lindenmaier W, Schütz G. "Synthesis of ds-cDNA involving addition of dCMP tails to allow cloning of 5'-terminal m RNA sequences." Methods in enzymology.. 1983 100:285-92.

Land H, Parada LF, Weinberg RA. "Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes." Nature.. 1983 304(5927):596-602.

Land H, Grez M, Ruppert S, Schmale H, Rehbein M, Richter D, Schütz G. "Deduced amino acid sequence from the bovine oxytocin-neurophysin I precursor cDNA." Nature.. 1983 302(5906):342-4.

Land H, Schütz G, Schmale H, Richter D. "Nucleotide sequence of cloned cDNA encoding bovine arginine vasopressin-neurophysin II precursor." Nature.. 1982 Jan 28; 295(5847):299-303.

Grez M, Land H, Giesecke K, Schütz G, Jung A, Sippel AE. "Multiple mRNAs are generated from the chicken lysozyme gene." Cell.. 1981 Sep; 25(3):743-52.

Land H, Grez M, Hauser H, Lindenmaier W, Schütz G. "5'-Terminal sequences of eucaryotic mRNA can be cloned with high efficiency." Nucleic acids research.. 1981 May 25; 9(10):2251-66.

Hauser H, Graf T, Beug H, Greiser-Wilke I, Lindenmaier W, Grez M, Land H, Giesecke K, Schütz G. "Structure of the lysozyme gene and expression in the oviduct and macrophages." Haematology and blood transfusion.. 1981 26:175-8.

Lindenmaier W, Nguyen-Huu MC, Stratmann LM, Blin N, Wurtz T, Hauser HJ, Giesecke K, Land H, Jeep S, Grez M, Sippel AE, Schütz G. "The isolation and characterization of the chicken lysozyme and ovomucoid gene." Journal of steroid biochemistry.. 1980 Jan; 12:211-8.

Lindenmaier W, Nguyen-Huu MC, Lurz R, Blin N, Stratmann M, Land H, Jeep S, Sippel AE, Schütz G. "Isolation and characterization of the chicken ovomucoid gene." Nucleic acids research.. 1979 Nov 10; 7(5):1221-32.

Nguyen-Huu MC, Stratmann M, Groner B, Wurtz T, Land H, Giesecke K, Sippel AE, Schütz G. "Chicken lysozyme gene contains several intervening sequences." Proceedings of the National Academy of Sciences of the United States of America.. 1979 Jan; 76(1):76-80.

Hofer E, Land H, Sekeris CE, Morris HP. "Messenger RNA activities for two liver enzymes, tyrosine aminotransferase and tryptophan oxygenase, in Morris hepatoma 5123C and 9618A and in HTC cells. Correlation with enzyme activities." European journal of biochemistry. 1978 Nov 2; 91(1):223-9.

Sippel AE, Land H, Lindenmaier W, Nguyen-Huu MC, Wurtz T, Timmis KN, Giesecke K, Schütz G. "Cloning of chicken lysozyme structural gene sequences synthesized in vitro." Nucleic acids research.. 1978 Sep; 5(9):3275-94.

Land H, Hofer E, Sekeris CE. "Differential behavior of two dexamethasone induced mRNA activities in HTC cells in response to cordycepin and to withdrawal of hormone." Biochemical and biophysical research communications.. 1978 Jul 28; 83(2):607-15.

Land H, Schäfer KP. "In vitro synthesis and stability of RNA in isolated nuclei from bovine lymphocytes." Biochemical and biophysical research communications.. 1977 Dec 7; 79(3):947-57.