David J. Topham, Ph.D.

David J. Topham, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 609
Rochester, NY 14642

Office: (585) 273-1403
Administrative: (585) 273-1400
Lab: (585) 273-1408
Fax: (585) 273-2452

Journal Articles

Showing all 105 journal articles available.

2016 Sep
Lambert Emo K, Hyun YM, Reilly E, Barilla C, Gerber S, Fowell D, Kim M, Topham DJ. "Live Imaging of Influenza Infection of the Trachea Reveals Dynamic Regulation of CD8+ T Cell Motility by Antigen." PLoS pathogens. 2016 Sep; 12(9):e1005881. Epub 2016 Sep 19.
2016 Jul 15
Nogales A, DeDiego ML, Topham DJ, Martínez-Sobrido L. "Rearrangement of Influenza Virus Spliced Segments for the Development of Live-Attenuated Vaccines." Journal of virology. 2016 Jul 15; 90(14):6291-302. Epub 2016 Jun 24.
2016 Jun
DeDiego ML, Anderson CS, Yang H, Holden-Wiltse J, Fitzgerald T, Treanor JJ, Topham DJ. "Directed selection of influenza virus produces antigenic variants that match circulating human virus isolates and escape from vaccine-mediated immune protection." Immunology. 2016 Jun; 148(2):160-73. Epub 2016 Mar 30.
Yang H, Baker SF, González ME, Topham DJ, Martínez-Sobrido L, Zand M, Holden-Wiltse J, Wu H. "An improved method for estimating antibody titers in microneutralization assay using green fluorescent protein." Journal of biopharmaceutical statistics. 2016 26(3):409-20. Epub 2015 May 26.
Anderson CS, DeDiego ML, Topham DJ, Thakar J. "Boolean Modeling of Cellular and Molecular Pathways Involved in Influenza Infection." Computational and mathematical methods in medicine. 2016 2016:7686081. Epub 2016 Feb 14.
Anderson CS, DeDiego ML, Thakar J, Topham DJ. "Novel Sequence-Based Mapping of Recently Emerging H5NX Influenza Viruses Reveals Pandemic Vaccine Candidates." PloS one. 2016 11(8):e0160510. Epub 2016 Aug 05.
2015 Dec
Scheible KM, Emo J, Yang H, Holden-Wiltse J, Straw A, Huyck H, Misra S, Topham DJ, Ryan RM, Reynolds AM, Mariani TJ, Pryhuber GS. "Developmentally determined reduction in CD31 during gestation is associated with CD8+ T cell effector differentiation in preterm infants." Clinical immunology : the official journal of the Clinical Immunology Society. 2015 Dec; 161(2):65-74. Epub 2015 Jul 29.
2015 Nov
Lim K, Hyun YM, Lambert-Emo K, Topham DJ, Kim M. "Visualization of integrin Mac-1 in vivo." Journal of immunological methods. 2015 Nov; 426:120-7. Epub 2015 Sep 02.
2015 Oct 15
Halliley JL, Khurana S, Krammer F, Fitzgerald T, Coyle EM, Chung KY, Baker SF, Yang H, Martínez-Sobrido L, Treanor JJ, Subbarao K, Golding H, Topham DJ, Sangster MY. "High-Affinity H7 Head and Stalk Domain-Specific Antibody Responses to an Inactivated Influenza H7N7 Vaccine After Priming With Live Attenuated Influenza Vaccine." The Journal of infectious diseases. 2015 Oct 15; 212(8):1270-8. Epub 2015 Apr 02.
2015 Sep 4
Lim K, Hyun YM, Lambert-Emo K, Capece T, Bae S, Miller R, Topham DJ, Kim M. "Neutrophil trails guide influenza-specific CD8? T cells in the airways." Science. 2015 Sep 4; 349(6252):aaa4352.
2015 Aug 1
Boule LA, Winans B, Lambert K, Vorderstrasse BA, Topham DJ, Pavelka MS, Lawrence BP. "Activation of the aryl hydrocarbon receptor during development enhances the pulmonary CD4+ T-cell response to viral infection." American journal of physiology. Lung cellular and molecular physiology. 2015 Aug 1; 309(3):L305-13. Epub 2015 Jun 12.
2015 Jul 9
Baker SF, Nogales A, Santiago FW, Topham DJ, Martínez-Sobrido L. "Competitive detection of influenza neutralizing antibodies using a novel bivalent fluorescence-based microneutralization assay (BiFMA)." Vaccine. 2015 Jul 9; 33(30):3562-70. Epub 2015 Jun 01.
2015 May 1
Wu H, Miao H, Xue H, Topham DJ, Zand M. "Quantifying Immune Response to Influenza Virus Infection via Multivariate Nonlinear ODE Models with Partially Observed State Variables and Time-Varying Parameters." Statistics in biosciences. 2015 May 1; 7(1):147-166.
2015 May
Lee AJ, Das SR, Wang W, Fitzgerald T, Pickett BE, Aevermann BD, Topham DJ, Falsey AR, Scheuermann RH. "Diversifying Selection Analysis Predicts Antigenic Evolution of 2009 Pandemic H1N1 Influenza A Virus in Humans." Journal of virology. 2015 May; 89(10):5427-40. Epub 2015 Mar 04.
2015 Mar 15
Tankam P, He Z, Chu YJ, Won J, Canavesi C, Lepine T, Hindman HB, Topham DJ, Gain P, Thuret G, Rolland JP. "Assessing microstructures of the cornea with Gabor-domain optical coherence microscopy: pathway for corneal physiology and diseases." Optics letters. 2015 Mar 15; 40(6):1113-6.
2015 Jan 15
Sundararajan A, Sangster MY, Frey S, Atmar RL, Chen WH, Ferreira J, Bargatze R, Mendelman PM, Treanor JJ, Topham DJ. "Robust mucosal-homing antibody-secreting B cell responses induced by intramuscular administration of adjuvanted bivalent human norovirus-like particle vaccine." Vaccine. 2015 Jan 15; 33(4):568-76. Epub 2014 Nov 22.
2014 Dec 15
Ramon S, Baker SF, Sahler JM, Kim N, Feldsott EA, Serhan CN, Martínez-Sobrido L, Topham DJ, Phipps RP. "The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new class of adjuvant?" The Journal of immunology : official journal of the American Association of Immunologists. 2014 Dec 15; 193(12):6031-40. Epub 2014 Nov 12.
2014 Nov 28
Babu TM, Levine M, Fitzgerald T, Luke C, Sangster MY, Jin H, Topham D, Katz J, Treanor J, Subbarao K. "Live attenuated H7N7 influenza vaccine primes for a vigorous antibody response to inactivated H7N7 influenza vaccine." Vaccine. 2014 Nov 28; 32(50):6798-804. Epub 2014 Oct 16.
2014 Oct
Guo H, Baker S, Martínez-Sobrido L, Topham DJ. "Induction of CD8 T cell heterologous protection by a single dose of single-cycle infectious influenza virus." Journal of virology. 2014 Oct; 88(20):12006-16. Epub 2014 Aug 06.
2014 Sep
Nogales A, Baker SF, Ortiz-Riaño E, Dewhurst S, Topham DJ, Martínez-Sobrido L. "Influenza A virus attenuation by codon deoptimization of the NS gene for vaccine development." Journal of virology. 2014 Sep; 88(18):10525-40. Epub 2014 Jun 25.
2014 Sep
Baker SF, Nogales A, Finch C, Tuffy KM, Domm W, Perez DR, Topham DJ, Martínez-Sobrido L. "Influenza A and B virus intertypic reassortment through compatible viral packaging signals." Journal of virology. 2014 Sep; 88(18):10778-91. Epub 2014 Jul 09.
Miao H, Sangster MY, Livingstone AM, Hilchey SP, Zhang L, Topham DJ, Mosmann TR, Holden-Wiltse J, Perelson AS, Wu H, Zand MS. "Modeling the dynamics and migratory pathways of virus-specific antibody-secreting cell populations in primary influenza infection." PloS one. 2014 9(8):e104781. Epub 2014 Aug 29.
2013 Nov
Chen J, Pompano RR, Santiago FW, Maillat L, Sciammas R, Sun T, Han H, Topham DJ, Chong AS, Collier JH. "The use of self-adjuvanting nanofiber vaccines to elicit high-affinity B cell responses to peptide antigens without inflammation." Biomaterials. 2013 Nov; 34(34):8776-85. Epub 2013 Aug 13.
2013 Sep
Overstreet MG, Gaylo A, Angermann BR, Hughson A, Hyun YM, Lambert K, Acharya M, Billroth-Maclurg AC, Rosenberg AF, Topham DJ, Yagita H, Kim M, Lacy-Hulbert A, Meier-Schellersheim M, Fowell DJ. "Inflammation-induced interstitial migration of effector CD4? T cells is dependent on integrin ?V." Nature immunology. 2013 Sep; 14(9):949-58. Epub 2013 Aug 11.
2013 Aug 9
Fouchier RA, Kawaoka Y, Cardona C, Compans RW, García-Sastre A, Govorkova EA, Guan Y, Herfst S, Orenstein WA, Peiris JS, Perez DR, Richt JA, Russell C, Schultz-Cherry SL, Smith DJ, Steel J, Tompkins SM, Topham DJ, Treanor JJ, Tripp RA, Webby RJ, Webster RG. "Gain-of-function experiments on H7N9." Science. 2013 Aug 9; 341(6146):612-3.
2013 Aug 8
Fouchier RA, Kawaoka Y, Cardona C, Compans RW, Fouchier RA, García-Sastre A, Govorkova EA, Guan Y, Herfst S, Kawaoka Y, Orenstein WA, Peiris JS, Perez DR, Richt JA, Russell C, Schultz-Cherry SL, Smith DJ, Steel J, Tompkins SM, Topham DJ, Treanor JJ, Tripp RA, Webby RJ, Webster RG. "Avian flu: Gain-of-function experiments on H7N9." Nature. 2013 Aug 8; 500(7461):150-1.
2013 Aug 7
Fouchier RA, Kawaoka Y, Cardona C, Compans RW, García-Sastre A, Govorkova EA, Guan Y, Herfst S, Orenstein WA, Peiris JS, Perez DR, Richt JA, Russell C, Schultz-Cherry SL, Smith DJ, Steel J, Tompkins SM, Topham DJ, Treanor JJ, Tripp RA, Webby RJ, Webster RG. "Gain-of-Function Experiments on H7N9." Science. 2013 Aug 7; Epub 2013 Aug 07.
2013 Aug
Baker SF, Guo H, Albrecht RA, García-Sastre A, Topham DJ, Martínez-Sobrido L. "Protection against lethal influenza with a viral mimic." Journal of virology. 2013 Aug; 87(15):8591-605. Epub 2013 May 29.
2013 Jun
Sangster MY, Baer J, Santiago FW, Fitzgerald T, Ilyushina NA, Sundararajan A, Henn AD, Krammer F, Yang H, Luke CJ, Zand MS, Wright PF, Treanor JJ, Topham DJ, Subbarao K. "B cell response and hemagglutinin stalk-reactive antibody production in different age cohorts following 2009 H1N1 influenza virus vaccination." Clinical and vaccine immunology : CVI. 2013 Jun; 20(6):867-76. Epub 2013 Apr 10.
2013 Jan 15
He XS, Sasaki S, Baer J, Khurana S, Golding H, Treanor JJ, Topham DJ, Sangster MY, Jin H, Dekker CL, Subbarao K, Greenberg HB. "Heterovariant cross-reactive B-cell responses induced by the 2009 pandemic influenza virus A subtype H1N1 vaccine." The Journal of infectious diseases. 2013 Jan 15; 207(2):288-96. Epub 2012 Oct 29.
Yang H, Topham DJ, Holden-Wiltse J, Wu H. "Statistical estimation & inference of cell counts from ELISPOT limiting dilution assays." Journal of biopharmaceutical statistics. 2013 23(4):921-36.
2012 Nov
Scheible K, Secor-Socha S, Wightman T, Wang H, Mariani TJ, Topham DJ, Pryhuber G, Quataert S. "Stability of T cell phenotype and functional assays following heparinized umbilical cord blood collection." Cytometry. Part A : the journal of the International Society for Analytical Cytology. 2012 Nov; 81(11):937-49. Epub 2012 Oct 01.
2012 Oct 5
van Helden MJ, van Kooten PJ, Bekker CP, Gröne A, Topham DJ, Easton AJ, Boog CJ, Busch DH, Zaiss DM, Sijts AJ. "Pre-existing virus-specific CD8(+) T-cells provide protection against pneumovirus-induced disease in mice." Vaccine. 2012 Oct 5; 30(45):6382-8. Epub 2012 Aug 29.
2012 Sep 1
van Helden MJ, de Graaf N, Boog CJ, Topham DJ, Zaiss DM, Sijts AJ. "The bone marrow functions as the central site of proliferation for long-lived NK cells." The Journal of immunology : official journal of the American Association of Immunologists. 2012 Sep 1; 189(5):2333-7. Epub 2012 Jul 20.
2012 Jul 15
Chapman LM, Aggrey AA, Field DJ, Srivastava K, Ture S, Yui K, Topham DJ, Baldwin WM, Morrell CN. "Platelets present antigen in the context of MHC class I." The Journal of immunology : official journal of the American Association of Immunologists. 2012 Jul 15; 189(2):916-23. Epub 2012 Jun 15.
2012 Jun 29
Li X, Miao H, Henn A, Topham DJ, Wu H, Zand MS, Mosmann TR. "Ki-67 expression reveals strong, transient influenza specific CD4 T cell responses after adult vaccination." Vaccine. 2012 Jun 29; 30(31):4581-4. Epub 2012 Apr 30.
2012 Jun 29
Santiago FW, Emo KL, Fitzgerald T, Treanor JJ, Topham DJ. "Antigenic and immunogenic properties of recombinant hemagglutinin proteins from H1N1 A/Brisbane/59/07 and B/Florida/04/06 when produced in various protein expression systems." Vaccine. 2012 Jun 29; 30(31):4606-16. Epub 2012 May 15.
Sundararajan A, Huan L, Richards KA, Marcelin G, Alam S, Joo H, Yang H, Webby RJ, Topham DJ, Sant AJ, Sangster MY. "Host differences in influenza-specific CD4 T cell and B cell responses are modulated by viral strain and route of immunization." PloS one. 2012 7(3):e34377. Epub 2012 Mar 23.
Guo H, Topham DJ. "Multiple distinct forms of CD8+ T cell cross-reactivity and specificities revealed after 2009 H1N1 influenza A virus infection in mice." PloS one. 2012 7(9):e46166. Epub 2012 Sep 27.
2011 Nov 8
Santiago FW, Fitzgerald T, Treanor JJ, Topham DJ. "Vaccination with drifted variants of avian H5 hemagglutinin protein elicits a broadened antibody response that is protective against challenge with homologous or drifted live H5 influenza virus." Vaccine. 2011 Nov 8; 29(48):8888-97. Epub 2011 Sep 28.
2011 Nov 1
Wu H, Kumar A, Miao H, Holden-Wiltse J, Mosmann TR, Livingstone AM, Belz GT, Perelson AS, Zand MS, Topham DJ. "Modeling of influenza-specific CD8+ T cells during the primary response indicates that the spleen is a major source of effectors." The Journal of immunology : official journal of the American Association of Immunologists. 2011 Nov 1; 187(9):4474-82. Epub 2011 Sep 23.
2011 Apr
de Graaf N, van Helden MJ, Textoris-Taube K, Chiba T, Topham DJ, Kloetzel PM, Zaiss DM, Sijts AJ. "PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo." European journal of immunology. 2011 Apr; 41(4):926-35. Epub 2011 Mar 01.
2011 Mar 3
Scheible K, Zhang G, Baer J, Azadniv M, Lambert K, Pryhuber G, Treanor JJ, Topham DJ. "CD8+ T cell immunity to 2009 pandemic and seasonal H1N1 influenza viruses." Vaccine. 2011 Mar 3; 29(11):2159-68. Epub 2011 Jan 04.
2011 Jan 20
Azadniv M, Bowers WJ, Topham DJ, Crispe IN. "CD4+ T cell effects on CD8+ T cell location defined using bioluminescence." PloS one. 2011 Jan 20; 6(1):e16222. Epub 2011 Jan 20.
2011 Jan 15
Mace CR, Topham DJ, Mosmann TR, Quataert SA, Treanor JJ, Miller BL. "Label-free, arrayed sensing of immune response to influenza antigens." Talanta. 2011 Jan 15; 83(3):1000-5. Epub 2010 Nov 10.
2011 Jan
Guo H, Santiago F, Lambert K, Takimoto T, Topham DJ. "T cell-mediated protection against lethal 2009 pandemic H1N1 influenza virus infection in a mouse model." Journal of virology. 2011 Jan; 85(1):448-55. Epub 2010 Oct 27.
Chapman TJ, Lambert K, Topham DJ. "Rapid reactivation of extralymphoid CD4 T cells during secondary infection." PloS one. 2011 6(5):e20493. Epub 2011 May 27.
2010 Nov 1
Richards KA, Topham D, Chaves FA, Sant AJ. "Cutting edge: CD4 T cells generated from encounter with seasonal influenza viruses and vaccines have broad protein specificity and can directly recognize naturally generated epitopes derived from the live pandemic H1N1 virus." The Journal of immunology : official journal of the American Association of Immunologists. 2010 Nov 1; 185(9):4998-5002. Epub 2010 Oct 01.
2010 Aug
Guo H, Topham DJ. "Interleukin-22 (IL-22) production by pulmonary Natural Killer cells and the potential role of IL-22 during primary influenza virus infection." Journal of virology. 2010 Aug; 84(15):7750-9. Epub 2010 May 26.
2010 Jul
Miao H, Hollenbaugh JA, Zand MS, Holden-Wiltse J, Mosmann TR, Perelson AS, Wu H, Topham DJ. "Quantifying the early immune response and adaptive immune response kinetics in mice infected with influenza A virus." Journal of virology. 2010 Jul; 84(13):6687-98. Epub 2010 Apr 21.
2010 May 10
Desmet EA, Hollenbaugh JA, Sime PJ, Wright TW, Topham DJ, Sant AJ, Takimoto T, Dewhurst S, Maggirwar SB. "Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells." Virology. 2010 May 10; 400(2):224-32. Epub 2010 Feb 25.
2010 Apr 1
Chapman TJ, Topham DJ. "Identification of a unique population of tissue-memory CD4+ T cells in the airways after influenza infection that is dependent on the integrin VLA-1." The Journal of immunology : official journal of the American Association of Immunologists. 2010 Apr 1; 184(7):3841-9. Epub 2010 Mar 03.
2010 Feb 3
Bernard MP, Bancos S, Chapman TJ, Ryan EP, Treanor JJ, Rose RC, Topham DJ, Phipps RP. "Chronic inhibition of cyclooxygenase-2 attenuates antibody responses against vaccinia infection." Vaccine. 2010 Feb 3; 28(5):1363-72. Epub 2009 Nov 24.
2010 Jan 22
Baer J, Santiago F, Yang H, Wu H, Jeanne-Holden-Wiltse , Treanor J, Topham DJ. "B cell responses to H5 influenza HA in human subjects vaccinated with a drifted variant." Vaccine. 2010 Jan 22; 28(4):907-15. Epub 2009 Nov 21.
2009 Jul
Lee HY, Topham DJ, Park SY, Hollenbaugh J, Treanor J, Mosmann TR, Jin X, Ward B, Miao H, Holden-Wiltse J, Perelson AS, Zand M, Wu H. "Simulation and prediction of the adaptive immune response to influenza A virus infection." Journal of virology. 2009 Jul; 83(14):7151-65. Epub 2009 May 13.
2009 Apr 23
Elphick GF, Sarangi PP, Hyun YM, Hollenbaugh JA, Ayala A, Biffl WL, Chung HL, Rezaie AR, McGrath JL, Topham DJ, Reichner JS, Kim M. "Recombinant human activated protein C inhibits integrin-mediated neutrophil migration." Blood. 2009 Apr 23; 113(17):4078-85. Epub 2009 Feb 24.
2009 Mar 1
Crompton PD, Mircetic M, Weiss G, Baughman A, Huang CY, Topham DJ, Treanor JJ, Sanz I, Lee FE, Durbin AP, Miura K, Narum DL, Ellis RD, Malkin E, Mullen GE, Miller LH, Martin LB, Pierce SK. "The TLR9 ligand CpG promotes the acquisition of Plasmodium falciparum-specific memory B cells in malaria-naive individuals." The Journal of immunology : official journal of the American Association of Immunologists. 2009 Mar 1; 182(5):3318-26.
2009 Jan 15
Lin GH, Sedgmen BJ, Moraes TJ, Snell LM, Topham DJ, Watts TH. "Endogenous 4-1BB ligand plays a critical role in protection from influenza-induced disease." The Journal of immunology : official journal of the American Association of Immunologists. 2009 Jan 15; 182(2):934-47.
2009 Jan 1
Kyu SY, Kobie J, Yang H, Zand MS, Topham DJ, Quataert SA, Sanz I, Lee FE. "Frequencies of human influenza-specific antibody secreting cells or plasmablasts post vaccination from fresh and frozen peripheral blood mononuclear cells." Journal of immunological methods. 2009 Jan 1; 340(1):42-7. Epub 2008 Nov 06.
Bancos S, Bernard MP, Topham DJ, Phipps RP. "Ibuprofen and other widely used non-steroidal anti-inflammatory drugs inhibit antibody production in human cells." Cellular immunology. 2009 258(1):18-28. Epub 2009 Apr 05.
2007 Dec 1
Klein I, Cornejo JC, Polakos NK, John B, Wuensch SA, Topham DJ, Pierce RH, Crispe IN. "Kupffer cell heterogeneity: functional properties of bone marrow derived and sessile hepatic macrophages." Blood. 2007 Dec 1; 110(12):4077-85. Epub 2007 Aug 09.
2007 Nov 15
Borowski AB, Boesteanu AC, Mueller YM, Carafides C, Topham DJ, Altman JD, Jennings SR, Katsikis PD. "Memory CD8+ T cells require CD28 costimulation." The Journal of immunology : official journal of the American Association of Immunologists. 2007 Nov 15; 179(10):6494-503.
2007 Oct 15
Richter MV, Topham DJ. "The alpha1beta1 integrin and TNF receptor II protect airway CD8+ effector T cells from apoptosis during influenza infection." The Journal of immunology : official journal of the American Association of Immunologists. 2007 Oct 15; 179(8):5054-63.
2007 Jul 1
Polakos NK, Klein I, Richter MV, Zaiss DM, Giannandrea M, Crispe IN, Topham DJ. "Early intrahepatic accumulation of CD8+ T cells provides a source of effectors for nonhepatic immune responses." The Journal of immunology : official journal of the American Association of Immunologists. 2007 Jul 1; 179(1):201-10.
2007 Jul
Richards KA, Chaves FA, Krafcik FR, Topham DJ, Lazarski CA, Sant AJ. "Direct ex vivo analyses of HLA-DR1 transgenic mice reveal an exceptionally broad pattern of immunodominance in the primary HLA-DR1-restricted CD4 T-cell response to influenza virus hemagglutinin." Journal of virology. 2007 Jul; 81(14):7608-19. Epub 2007 May 16.
2007 Apr 1
Richter M, Ray SJ, Chapman TJ, Austin SJ, Rebhahn J, Mosmann TR, Gardner H, Kotelianski V, deFougerolles AR, Topham DJ. "Collagen distribution and expression of collagen-binding alpha1beta1 (VLA-1) and alpha2beta1 (VLA-2) integrins on CD4 and CD8 T cells during influenza infection." The Journal of immunology : official journal of the American Association of Immunologists. 2007 Apr 1; 178(7):4506-16.
2006 Nov 17
Treanor J, Wu H, Liang H, Topham DJ. "Immune responses to vaccinia and influenza elicited during primary versus recent or distant secondary smallpox vaccination of adults." Vaccine. 2006 Nov 17; 24(47-48):6913-23. Epub 2006 Jun 21.
2006 Jul 15
Kessels HW, Schepers K, van den Boom MD, Topham DJ, Schumacher TN. "Generation of T cell help through a MHC class I-restricted TCR." The Journal of immunology : official journal of the American Association of Immunologists. 2006 Jul 15; 177(2):976-82.
2006 Apr
Polakos NK, Cornejo JC, Murray DA, Wright KO, Treanor JJ, Crispe IN, Topham DJ, Pierce RH. "Kupffer cell-dependent hepatitis occurs during influenza infection." The American journal of pathology. 2006 Apr; 168(4):1169-78; quiz 1404-5.
2006 Mar
Topham DJ, Chapman TJ, Richter M. "Lymphoid and extralymphoid CD4 T cells that orchestrate the antiviral immune response." Expert review of clinical immunology. 2006 Mar; 2(2):267-76.
2006 Feb 1
Divekar AA, Zaiss DM, Lee FE, Liu D, Topham DJ, Sijts AJ, Mosmann TR. "Protein vaccines induce uncommitted IL-2-secreting human and mouse CD4 T cells, whereas infections induce more IFN-gamma-secreting cells." The Journal of immunology : official journal of the American Association of Immunologists. 2006 Feb 1; 176(3):1465-73.
Ignatovich F.V.; Topham D.; and Novotny L. "Optical detection of single nanoparticles and viruses." Journal of Selected Topics in Quantum Electronics, Special Issue on Nanophotonics. 2006; 12(6): 1292-1300. Link
2005 Sep 30
Chapman TJ, Castrucci MR, Padrick RC, Bradley LM, Topham DJ. "Antigen-specific and non-specific CD4+ T cell recruitment and proliferation during influenza infection." Virology. 2005 Sep 30; 340(2):296-306.
2004 Dec
Aronica MA, Swaidani S, Zhang YH, Mitchell D, Mora AL, McCarthy S, O'Neal J, Topham D, Sheller JR, Boothby M. "Susceptibility to allergic lung disease regulated by recall responses of dual-receptor memory T cells." The Journal of allergy and clinical immunology. 2004 Dec; 114(6):1441-8.
2004 Feb
Ray SJ, Franki SN, Pierce RH, Dimitrova S, Koteliansky V, Sprague AG, Doherty PC, de Fougerolles AR, Topham DJ. "The collagen binding alpha1beta1 integrin VLA-1 regulates CD8 T cell-mediated immune protection against heterologous influenza infection." Immunity. 2004 Feb; 20(2):167-79.
2003 Oct 6
Sangster MY, Riberdy JM, Gonzalez M, Topham DJ, Baumgarth N, Doherty PC. "An early CD4+ T cell-dependent immunoglobulin A response to influenza infection in the absence of key cognate T-B interactions." The Journal of experimental medicine. 2003 Oct 6; 198(7):1011-21. Epub 2003 Sep 29.
2003 May
Topham DJ, Crispe IN. "Contrasting urban and rural lifestyles of memory CD8+ T cells." Immunity. 2003 May; 18(5):584-6.
2001 Dec 15
Topham DJ, Castrucci MR, Wingo FS, Belz GT, Doherty PC. "The role of antigen in the localization of naive, acutely activated, and memory CD8(+) T cells to the lung during influenza pneumonia." The Journal of immunology : official journal of the American Association of Immunologists. 2001 Dec 15; 167(12):6983-90.
2001 Aug
Topham DJ, Cardin RC, Christensen JP, Brooks JW, Belz GT, Doherty PC. "Perforin and Fas in murine gammaherpesvirus-specific CD8(+) T cell control and morbidity." The Journal of general virology. 2001 Aug; 82(Pt 8):1971-81.
2000 Feb 15
Sangster MY, Topham DJ, D'Costa S, Cardin RD, Marion TN, Myers LK, Doherty PC. "Analysis of the virus-specific and nonspecific B cell response to a persistent B-lymphotropic gammaherpesvirus." The Journal of immunology : official journal of the American Association of Immunologists. 2000 Feb 15; 164(4):1820-8.
1999 Sep 3
Marine JC, Topham DJ, McKay C, Wang D, Parganas E, Stravopodis D, Yoshimura A, Ihle JN. "SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality." Cell. 1999 Sep 3; 98(5):609-16.
1999 Sep 3
Marine JC, McKay C, Wang D, Topham DJ, Parganas E, Nakajima H, Pendeville H, Yasukawa H, Sasaki A, Yoshimura A, Ihle JN. "SOCS3 is essential in the regulation of fetal liver erythropoiesis." Cell. 1999 Sep 3; 98(5):617-27.
1999 Aug
Moriggl R, Sexl V, Piekorz R, Topham D, Ihle JN. "Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells." Immunity. 1999 Aug; 11(2):225-30.
1999 Feb
Moriggl R, Topham DJ, Teglund S, Sexl V, McKay C, Wang D, Hoffmeyer A, van Deursen J, Sangster MY, Bunting KD, Grosveld GC, Ihle JN. "Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells." Immunity. 1999 Feb; 10(2):249-59.
Moriggl R, Marine JC, Topham DJ, Teglund S, Sexl V, McKay C, Piekorz R, Wang D, Parganas E, Yoshimura A, Ihle JN. "Differential roles of cytokine signaling during T-cell development." Cold Spring Harbor symposia on quantitative biology. 1999 64:389-95.
1998 Nov 1
Topham DJ, Doherty PC. "Longitudinal analysis of the acute Sendai virus-specific CD4+ T cell response and memory." The Journal of immunology : official journal of the American Association of Immunologists. 1998 Nov 1; 161(9):4530-5.
1998 Nov
Brown MP, Topham DJ, Sangster MY, Zhao J, Flynn KJ, Surman SL, Woodland DL, Doherty PC, Farr AG, Pattengale PK, Brenner MK. "Thymic lymphoproliferative disease after successful correction of CD40 ligand deficiency by gene transfer in mice." Nature medicine. 1998 Nov; 4(11):1253-60.
1998 Oct 1
Bunting KD, Galipeau J, Topham D, Benaim E, Sorrentino BP. "Transduction of murine bone marrow cells with an MDR1 vector enables ex vivo stem cell expansion, but these expanded grafts cause a myeloproliferative syndrome in transplanted mice." Blood. 1998 Oct 1; 92(7):2269-79.
1998 May 1
Parganas E, Wang D, Stravopodis D, Topham DJ, Marine JC, Teglund S, Vanin EF, Bodner S, Colamonici OR, van Deursen JM, Grosveld G, Ihle JN. "Jak2 is essential for signaling through a variety of cytokine receptors." Cell. 1998 May 1; 93(3):385-95.
1998 Jan
Topham DJ, Doherty PC. "Clearance of an influenza A virus by CD4+ T cells is inefficient in the absence of B cells." Journal of virology. 1998 Jan; 72(1):882-5.
1997 Dec 1
Topham DJ, Tripp RA, Doherty PC. "CD8+ T cells clear influenza virus by perforin or Fas-dependent processes." The Journal of immunology : official journal of the American Association of Immunologists. 1997 Dec 1; 159(11):5197-200.
1997 Dec
Doherty PC, Hamilton-Easton AM, Topham DJ, Riberdy J, Brooks JW, Cardin RD. "Consequences of viral infections for lymphocyte compartmentalization and homeostasis." Seminars in immunology. 1997 Dec; 9(6):365-73.
1997 Oct
Doherty PC, Topham DJ, Tripp RA, Cardin RD, Brooks JW, Stevenson PG. "Effector CD4+ and CD8+ T-cell mechanisms in the control of respiratory virus infections." Immunological reviews. 1997 Oct; 159:105-17.
1997 Apr 15
Tripp RA, Topham DJ, Watson SR, Doherty PC. "Bone marrow can function as a lymphoid organ during a primary immune response under conditions of disrupted lymphocyte trafficking." The Journal of immunology : official journal of the American Association of Immunologists. 1997 Apr 15; 158(8):3716-20.
1996 Oct 1
Topham DJ, Tripp RA, Hamilton-Easton AM, Sarawar SR, Doherty PC. "Quantitative analysis of the influenza virus-specific CD4+ T cell memory in the absence of B cells and Ig." The Journal of immunology : official journal of the American Association of Immunologists. 1996 Oct 1; 157(7):2947-52.
1996 Jul
Bright JJ, Topham DJ, Nag B, Lodge PA, Sriram S. "Vaccination with peptides from MHC class II beta chain hypervariable region causes allele-specific suppression of EAE." Journal of neuroimmunology. 1996 Jul; 67(2):119-24.
1996 Apr
Doherty PC, Topham DJ, Tripp RA. "Establishment and persistence of virus-specific CD4+ and CD8+ T cell memory." Immunological reviews. 1996 Apr; 150:23-44.
1996 Feb
Topham DJ, Tripp RA, Sarawar SR, Sangster MY, Doherty PC. "Immune CD4+ T cells promote the clearance of influenza virus from major histocompatibility complex class II -/- respiratory epithelium." Journal of virology. 1996 Feb; 70(2):1288-91.
1995 Jul 1
Fabry Z, Topham DJ, Fee D, Herlein J, Carlino JA, Hart MN, Sriram S. "TGF-beta 2 decreases migration of lymphocytes in vitro and homing of cells into the central nervous system in vivo." The Journal of immunology : official journal of the American Association of Immunologists. 1995 Jul 1; 155(1):325-32.
1995 Jun 20
Ewing C, Topham DJ, Doherty PC. "Prevalence and activation phenotype of Sendai virus-specific CD4+ T cells." Virology. 1995 Jun 20; 210(1):179-85.
1994 Aug 16
Topham DJ, Nag B, Arimilli S, Sriram S. "A synthetic peptide from the third hypervariable region of major histocompatibility complex class II beta chain as a vaccine for treatment of experimental autoimmune encephalomyelitis." Proceedings of the National Academy of Sciences of the United States of America. 1994 Aug 16; 91(17):8005-9.
1991 Jul
Sriram S, Topham DJ, Carroll L, Shenoy M, Adesina A, Craighead JE. "In vivo administration of TNF-alpha prevents EMC-M virus induced viral encephalitis." International immunology. 1991 Jul; 3(7):641-5.
1991 Jun
Topham DJ, Adesina A, Shenoy M, Craighead JE, Sriram S. "Indirect role of T cells in development of polioencephalitis and encephalomyelitis induced by encephalomyocarditis virus." Journal of virology. 1991 Jun; 65(6):3238-45.
1989 Oct
Sriram S, Topham DJ, Huang SK, Rodriguez M. "Treatment of encephalomyocarditis virus-induced central nervous system demyelination with monoclonal anti-T-cell antibodies." Journal of virology. 1989 Oct; 63(10):4242-8.
1987 Sep 1
Sriram S, Topham DJ, Carroll L. "Haplotype-specific suppression of experimental allergic encephalomyelitis with anti-IA antibodies." The Journal of immunology : official journal of the American Association of Immunologists. 1987 Sep 1; 139(5):1485-9.


David J. Topham, Timothy R. Chapman, Martin Richter, and Joseph A. Hollenbaugh. "The Role of VLA-1 in Maintaining Virus-specific T cells in Peripheral Non-lymphoid Tissues". Effector Memory T cell Subsets in the Extralymphatic Tissue. Ilan Bank. Kerala, India: Research Signpost, 2009.