Gloria Pryhuber, M.D.

Contact Information

Phone Numbers

Office: (585) 275-2972

Fax: (585) 461-3614

A member of the University of Rochester Medical Faculty Group

An Accountable Health Partner

Accepting New Patients

Research Labs

Pryhuber Lab

Visit Pryhuber Lab Lab Website

Locations

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 850
Rochester, NY 14642

Faculty Appointments

Professor - Department of Pediatrics , Neonatology (SMD)

Patient Care Setting

Pediatrics

Biography

Acute and Chronic Lung Disease in Neonates

Professional Background

Dr. Pryhuber trained in Cincinnati, Ohio and in addition to her research work, serves as an attending neonatologist at URMC In collaboration with other members of the neonatal team. She passionately enjoys providing thoughtful, detailed, cutting-edge medical care to at-risk or critically ill newborns and their families. She embraces the team-approach to medicine involving nurses, mid-level providers, social workers and care coordinators, as well as the family in decision making as much as possible. Dr. Pryhuber's particular clinical interests are care of infants with pulmonary hypertension, lung injury, growth and developmental failure, often complicated by chronic and inflammatory disease. She leads the neonatal pulmonary hypertension consultation team.

Research

Research interests:
1) Chronic Lung Disease of Prematurity
2) Lung Development

Dr. Pryhuber trained as a post-doctoral Proctor Research Scholar and participant in the University of Cincinnati Program of Excellence in Molecular Biology of the Heart and Lung. She has since accumulated > 20 years as independent researcher and author in lung injury and immunology. She serves on NIH study sections and as reviewer for journals in her area of expertise, manages an active laboratory, supervises students in pulmonary biology and epithelial cell research and has received awards recognizing both teaching and original research accomplishments. She teaches regularly for the UofR Toxicology graduate program, Medical School and Pediatric Residency.

An NIH-funded physician-scientist with expertise in human perinatal lung injury and repair, Dr. Pryhuber also served nine years as Perinatal-Neonatal Fellowship Associate Director and mentors undergraduate, graduate and post-doctoral students. She is honored to be a member of the American Pediatric Society, the Perinatal Research Society, and the Society for Pediatric Research, the American Thoracic Society, the American Academy of Pediatrics, the International Cytokine Society and the American Physiological Society. As Professor in the Departments of Pediatrics and Environmental Medicine, Dr. Pryhuber also acts as communicating PI for the UofR / University at Buffalo Center for the Prematurity and Respiratory Outcomes Program (PROP, NHLBI U01), as Lead Site Investigator for the UR-Respiratory Pathogens Research Center Clinical Study I (NIAID / DMID Contract), PI for the Lung Molecular Atlas Program Human Tissue Core (NHLBI U01) and remains active as clinical academic Neonatologist and Pulmonary Hypertension Team member. Dr. Pryhuber directs the UofR Pediatric and Environmental Health Sciences Center Histology Facility since 2009 and Pediatric Processing Lab since 2011, providing, through the work of talented technicians and University resources, technical support and training for preparation and analysis of tissues and cells of organisms ranging from human to drosophila. Dr. Pryhuber has also provided access to an archive of neonatal lung tissue acquired by expedited autopsy at gestational ages varying from 24 to 43 weeks. In collaboration with investigators in multiple centers, subsets of the archive are published, contributing novel observations pertaining to vascular development, epithelial cell abnormalities and inflammation in bronchopulmonary dysplasia. This repository is expanded by the LungMAP to collect donated human lung across the developmental spectrum from pseudoglandular through alveologenesis. These successful clinical and research programs demonstrate particular interests and strengths in creating multi-disciplinary teams of investigators, coordinators, nurses, technicians, and information specialists. They create and foster active collaborations of investigators and clinicians in neonatology, pulmonology, infectious disease, obstetrics/perinatology, immunology, microbiology, pathology, toxicology and genomics, as well as extramural collaborations around perinatal development and disease.

Clinically, preterm infant cohorts are enrolled in longitudinal studies. In the laboratory, fresh isolated cells, cell lines and whole animal models are utilized to understand cellular interactions during development and inflammation. Specific studies determined parenchymal TNF receptor signaling mechanisms that regulate gene expression, inflammation and apoptosis in the lung. More recently, high-dimensional flow cytometry, cell sorting, transcriptomic and genomic techniques are applied to understand the effects of in utero environment, premature birth and microbial colonization on the adaptive immune system and lung. The impact on respiratory morbidity and mortality of alterations in CD4 and CD8 lymphocyte responses to stimuli are the focus of active studies.

Credentials

Specialties

Neonatal-Perinatal Medicine - American Board of Pediatrics

Education

1985
MD | SUNY Upstate College of Health Professions

Post-doctoral Training & Residency

07/01/1988 - 06/30/1991
Fellowship in Neonatology at University of Cincinnati College of Medicine

07/01/1986 - 06/30/1988
Residency in Pediatrics at University Hospital-SUNY Health Science Center

07/01/1985 - 06/30/1986
Internship in Pediatrics at University Hospital-SUNY Health Science Center

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Awards

2014
Ruth A. Lawrence Academic Faculty Service Award for Excellence in Research
Location: Department of Pediatrics, Univ of Rochester

2013
American Pediatric Society Membe

2011 - 2014
George Washington Goler Professor of Pediatrics
Location: University of Rochester

2011
Perinatal Research Society Member

2006 - Present
Best Doctors in America Database
Sponsor: America's Best Doctors

2005
Ruth A. Lawrence Academic Faculty Service Award for Excellence in Training, Department of Pediatrics, University of Rochester, R

2001
University of Rochester Environmental Health Sciences Center, Pulmonary Core - Member

1999
Society for Pediatric Research - Member

1995
Buswell Fellowship Award University of Rochester

1989
Chief Fellow in Neonatology, University of Cincinnati, Cincinnati, OH

1986 - 1987
Resident Teaching Award

1985 - 1986
Resident Teaching Award

1985
Janet M. Glascow Memorial Achievement Award
Sponsor: American Medical Women's Association
Location: SUNY Health Science Center at Syracuse

1985
Alpha Omega Alpha Medical Honor Society

1984
Annual Clinical Campus Pediatric Award
Sponsor: SUNY Health Science Center at Syracuse

1978 - 1981
Cornell University, College Honor Society

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Clinical Trials

Safety of Sildenafil in Premature Infants With Severe Bronchopulmonary Dysplasia

Lead Researcher: Gloria Pryhuber

This is a multicenter study of sildenafil in premature infants in Neonatal Intensive Care Units (NICUs) with severe bronchopulmonary dysplasia (BPD). Infants must be receiving respiratory support at enrollment.

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Developmental Impact of Neonatal Intensive Care Unit (NICU) Exposures: Environmental Influences on Child Health Outcomes (ECHO)

Lead Researcher: Gloria Pryhuber

Entry into the DINE study requires prior enrollment in the Prematurity and Respiratory Outcomes Program (PROP) or the Impact of Respiratory Virus Infections and Bacterial Microbiome Shifts/PRISM study. If you have not participated in these studies in the past you will not be eligible for this trial. The DINE study will test the hypothesis that potentially avoidable NICU-based exposures contribute to the neuro-cognitive and somatic impairments prevalent among NICU graduates. This hypothesis is drawn from the documented impact of phthalate exposure on early development in term-born children, and the acknowledged presence of these toxic chemicals in the NICU. Third trimester in utero exposure to phthalates have been linked to poorer childhood performance in cognition, motor function, attention, hyperactivity and social behavior. Phthalate exposure is also associated with altered onset of puberty and asthma. The multi-site cohort and approach will clarify the role of NICU-based phthalate exposure on high-prevalence clinical outcomes.

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Publications

Journal Articles

4/15/2022
McDavid A, Laniewski N, Grier A, Gill AL, Kessler HA, Huyck H, Carbonell E, Holden-Wiltse J, Bandyopadhyay S, Carnahan J, Dylag AM, Topham DJ, Falsey AR, Caserta MT, Pryhuber GS, Gill SR, Scheible KM. "Aberrant newborn T cell and microbiota developmental trajectories predict respiratory compromise during infancy." iScience.. 2022 Apr 15; 25(4):104007. Epub 2022 Mar 01.

4/7/2022
Xu X, Jin K, Bais AS, Zhu W, Yagi H, Feinstein TN, Nguyen PK, Criscione JD, Liu X, Beutner G, Karunakaran KB, Rao KS, He H, Adams P, Kuo CK, Kostka D, Pryhuber GS, Shiva S, Ganapathiraju MK, Porter GA, Lin JI, Aronow B, Lo CW. "Uncompensated mitochondrial oxidative stress underlies heart failure in an iPSC-derived model of congenital heart disease." Cell stem cell.. 2022 Apr 7; Epub 2022 Apr 07.

3/11/2022
Xu J, Xu L, Sui P, Chen J, Moya EA, Hume P, Janssen WJ, Duran JM, Thistlethwaite P, Carlin A, Gulleman P, Banaschewski B, Goldy MK, Yuan JX, Malhotra A, Pryhuber G, Crotty-Alexander L, Deutsch G, Young LR, Sun X. "Excess neuropeptides in lung signal through endothelial cells to impair gas exchange." Developmental cell.. 2022 Mar 11; Epub 2022 Mar 11.

Books & Chapters

2019
Book Title: Updates on Neonatal Chronic Lung Disease
Author List: S.Abman;N.Ambalavanan;M.ArdiniPoleske;J.Aschner;J.Baatz;C.Baker;E.Baker;V.Bhandari;D.Bush;J.Cheong;M.Chiafery;J.Collaco;C.DAngio;P.Davis;G.Deutsch;K.Dolma;L.Doyle;A.Dylag;O.Ekhaguere;S.Garantziotis;W.Hay;N.Higano;J.Ibrahim;E.Jensen;M. Keszler;H.Kirpalani;K.LimKua; Lakshminrusimha;C.Lal;S.Leary;S.Lynch;D.Malleske;E.Mandell;T.Mariani;R.Martin;C.McEvoy;S.McGrathMorrow;R.McKinney;R.Misra;L.Nelin;E.Patel;C.Richardson;R.Ryan;R.Savani; K.Scheible;B.Schmidt;E.Shepherd;L.Strueby;B.Thébaud;P.Vali;J.Woods
Edited By: Kallapur, S.G. and Pryhuber, G.S.,
Published By: Elsevier 2019

2015
Chapter Title: Acute Respiratory Disorders of the Newborn
Book Title: Neonatology: Pathophysiology and Management of the Newborn.
Author List: Whitsett JA, Rice WR, Pryhuber GS and Wert SE.
Edited By: Mhairi G. MacDonald, MD Mullett and MMK Seshia.
Published By: Lippencott, Williams and Wilkins 2015 in New York, New York

2015
Chapter Title: Postnatal Infections and Immunology Affecting Chronic Lung Disease of Prematurity.
Book Title: Bronchopulmonary Dysplasia: An Update.
Author List: Pryhuber, G.
Published By: Clin Perinatol 2015

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