Lynne Elizabeth Maquat, Ph.D.

Lynne Elizabeth Maquat, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester, NY 14642

Office: (585) 273-5640
Fax: (585) 271-2683

Journal Articles

Showing all 137 journal articles available.

2016 Jun 2
Popp MW, Maquat LE. "Leveraging Rules of Nonsense-Mediated mRNA Decay for Genome Engineering and Personalized Medicine." Cell. 2016 Jun 2; 165(6):1319-22.
2016 Apr
Maquat LE. "Eukaryotic antisense ahead of its time." Nature reviews. Molecular cell biology. 2016 Apr; 17(4):204. Epub 2016 Feb 24.
2016 Mar 1
Elbarbary RA, Maquat LE. "Coupling pre-mRNA splicing and 3' end formation to mRNA export: alternative ways to punch the nuclear export clock." Genes & development. 2016 Mar 1; 30(5):487-8.
2016 Feb 12
Elbarbary RA, Lucas BA, Maquat LE. "Retrotransposons as regulators of gene expression." Science. 2016 Feb 12; 351(6274):aac7247. Epub 2016 Feb 11.
2016 Feb 1
Kurosaki T, Maquat LE. "Nonsense-mediated mRNA decay in humans at a glance." Journal of cell science. 2016 Feb 1; 129(3):461-7. Epub 2016 Jan 19.
2015 Apr 1
Elbarbary RA, Maquat LE. "CARMing down the SINEs of anarchy: two paths to freedom from paraspeckle detention." Genes & development. 2015 Apr 1; 29(7):687-9.
2015 Apr
Maquat LE. "The amazing web of post-transcriptional gene control: the sum of small changes can make for significant consequences." RNA. 2015 Apr; 21(4):488-9.
2015 Mar 26
Popp MW, Maquat LE. "Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics." Nature communications. 2015 Mar 26; 6:6632. Epub 2015 Mar 26.
2015 Mar 20
Popp MW, Maquat LE. "RNA. A TRICK'n way to see the pioneer round of translation." Science. 2015 Mar 20; 347(6228):1316-7.
2015 Jan
Jackson KL, Dayton RD, Orchard EA, Ju S, Ringe D, Petsko GA, Maquat LE, Klein RL. "Preservation of forelimb function by UPF1 gene therapy in a rat model of TDP-43-induced motor paralysis." Gene therapy. 2015 Jan; 22(1):20-8. Epub 2014 Nov 06.
Gong C, Maquat LE. "Affinity purification of long noncoding RNA-protein complexes from formaldehyde cross-linked mammalian cells." Methods in molecular biology. 2015 1206:81-6.
2014 Sep 1
Kurosaki T, Li W, Hoque M, Popp MW, Ermolenko DN, Tian B, Maquat LE. "A post-translational regulatory switch on UPF1 controls targeted mRNA degradation." Genes & development. 2014 Sep 1; 28(17):1900-16.
2014 Jul
Gleghorn ML, Maquat LE. "'Black sheep' that don't leave the double-stranded RNA-binding domain fold." Trends in biochemical sciences. 2014 Jul; 39(7):328-40. Epub 2014 Jun 19.
2014 Apr
Popp MW, Maquat LE. "Defective secretory-protein mRNAs take the RAPP." Trends in biochemical sciences. 2014 Apr; 39(4):154-6. Epub 2014 Mar 03.
2014 Jan
Popp MW, Maquat LE. "The dharma of nonsense-mediated mRNA decay in mammalian cells." Molecules and cells. 2014 Jan; 37(1):1-8. Epub 2014 Jan 27.
Elbarbary RA, Maquat LE. "Dodging two bullets with one dsRNA-binding protein." Cell cycle. 2014 13(3):345-6. Epub 2013 Dec 13.
Belfort M, Marraffini L, Macfarlan T, Boeke J, Slotkin K, Malik H, Maquat L. "Mobile DNA: an evolving field." Mobile DNA. 2014 5:16. Epub 2014 Jun 05.
2013 Oct
Gong C, Tang Y, Maquat LE. "mRNA-mRNA duplexes that autoelicit Staufen1-mediated mRNA decay." Nature structural & molecular biology. 2013 Oct; 20(10):1214-20. Epub 2013 Sep 22.
2013 Jul 1
Elbarbary RA, Li W, Tian B, Maquat LE. "STAU1 binding 3' UTR IRAlus complements nuclear retention to protect cells from PKR-mediated translational shutdown." Genes & development. 2013 Jul 1; 27(13):1495-510.
2013 May 24
Wang J, Lucas BA, Maquat LE. "New gene expression pipelines gush lncRNAs." Genome biology. 2013 May 24; 14(5):117. Epub 2013 May 24.
2013 Apr 1
Wang J, Gong C, Maquat LE. "Control of myogenesis by rodent SINE-containing lncRNAs." Genes & development. 2013 Apr 1; 27(7):793-804. Epub 2013 Apr 04.
2013 Apr
Gleghorn ML, Gong C, Kielkopf CL, Maquat LE. "Staufen1 dimerizes through a conserved motif and a degenerate dsRNA-binding domain to promote mRNA decay." Nature structural & molecular biology. 2013 Apr; 20(4):515-24. Epub 2013 Mar 24.
2013 Mar 1
Trcek T, Sato H, Singer RH, Maquat LE. "Temporal and spatial characterization of nonsense-mediated mRNA decay." Genes & development. 2013 Mar 1; 27(5):541-51. Epub 2013 Feb 21.
2013 Feb 26
Kurosaki T, Maquat LE. "Rules that govern UPF1 binding to mRNA 3' UTRs." Proceedings of the National Academy of Sciences of the United States of America. 2013 Feb 26; 110(9):3357-62. Epub 2013 Feb 12.
2013 Jan 8
Park E, Gleghorn ML, Maquat LE. "Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity." Proceedings of the National Academy of Sciences of the United States of America. 2013 Jan 8; 110(2):405-12. Epub 2012 Dec 20.
Park E, Maquat LE. "Staufen-mediated mRNA decay." Wiley interdisciplinary reviews. RNA. 2013 4(4):423-35. Epub 2013 May 16.
Wei-Lin Popp M, Maquat LE. "Organizing principles of mammalian nonsense-mediated mRNA decay." Annual review of genetics. 2013 47:139-65.
2012 Oct
Gong C, Popp MW, Maquat LE. "Biochemical analysis of long non-coding RNA-containing ribonucleoprotein complexes." Methods : a companion to Methods in enzymology. 2012 Oct; 58(2):88-93. Epub 2012 Jul 10.
2012 Mar 6
Schoenberg DR, Maquat LE. "Regulation of cytoplasmic mRNA decay." Nature reviews. Genetics. 2012 Mar 6; 13(4):246-59. Epub 2012 Mar 06.
2011 Aug
Hwang J, Maquat LE. "Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question." Current opinion in genetics & development. 2011 Aug; 21(4):422-30.
2011 Jun 15
Gong C, Maquat LE. ""Alu"strious long ncRNAs and their role in shortening mRNA half-lives." Cell cycle. 2011 Jun 15; 10(12):1882-3. Epub 2011 Jun 15.
2011 Apr
Ju S, Tardiff DF, Han H, Divya K, Zhong Q, Maquat LE, Bosco DA, Hayward LJ, Brown RH, Lindquist S, Ringe D, Petsko GA. "A yeast model of FUS/TLS-dependent cytotoxicity." PLoS biology. 2011 Apr; 9(4):e1001052. Epub 2011 Apr 26.
2011 Mar 18
Gleghorn ML, Maquat LE. "UPF1 learns to relax and unwind." Molecular cell. 2011 Mar 18; 41(6):621-3.
2011 Feb 10
Gong C, Maquat LE. "lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3' UTRs via Alu elements." Nature. 2011 Feb 10; 470(7333):284-8.
2010 Aug 13
Hwang J, Sato H, Tang Y, Matsuda D, Maquat LE. "UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps." Molecular cell. 2010 Aug 13; 39(3):396-409. Epub 2010 Aug 05.
2010 Aug 6
Maquat LE, Tarn WY, Isken O. "The pioneer round of translation: features and functions." Cell. 2010 Aug 6; 142(3):368-74.
Maquat LE, Hwang J, Sato H, Tang Y. "CBP80-promoted mRNP rearrangements during the pioneer round of translation, nonsense-mediated mRNA decay, and thereafter." Cold Spring Harbor symposia on quantitative biology. 2010 75:127-34. Epub 2011 Mar 29.
2009 Dec
Maquat LE, Gong C. "Gene expression networks: competing mRNA decay pathways in mammalian cells." Biochemical Society transactions. 2009 Dec; 37(Pt 6):1287-92.
2009 Nov 1
Sato H, Maquat LE. "Remodeling of the pioneer translation initiation complex involves translation and the karyopherin importin beta." Genes & development. 2009 Nov 1; 23(21):2537-50.
2009 Sep
Schoenberg DR, Maquat LE. "Re-capping the message." Trends in biochemical sciences. 2009 Sep; 34(9):435-42. Epub 2009 Sep 02.
2009 Jan 1
Gong C, Kim YK, Woeller CF, Tang Y, Maquat LE. "SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs." Genes & development. 2009 Jan 1; 23(1):54-66. Epub 2008 Dec 18.
Isken O, Maquat LE. "Telomeric RNAs as a novel player in telomeric integrity." F1000 biology reports. 2009 1:90. Epub 2009 Nov 26.
2008 Sep
Isken O, Maquat LE. "The multiple lives of NMD factors: balancing roles in gene and genome regulation." Nature reviews. Genetics. 2008 Sep; 9(9):699-712.
2008 Jul
Saltzman AL, Kim YK, Pan Q, Fagnani MM, Maquat LE, Blencowe BJ. "Regulation of multiple core spliceosomal proteins by alternative splicing-coupled nonsense-mediated mRNA decay." Molecular and cellular biology. 2008 Jul; 28(13):4320-30. Epub 2008 Apr 28.
2008 May
Woeller CF, Gaspari M, Isken O, Maquat LE. "NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA." EMBO reports. 2008 May; 9(5):446-51. Epub 2008 Mar 28.
2008 Apr 18
Isken O, Kim YK, Hosoda N, Mayeur GL, Hershey JW, Maquat LE. "Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay." Cell. 2008 Apr 18; 133(2):314-27.
2008 Feb 1
Sato H, Hosoda N, Maquat LE. "Efficiency of the pioneer round of translation affects the cellular site of nonsense-mediated mRNA decay." Molecular cell. 2008 Feb 1; 29(2):255-62.
Maquat LE, Kiledjian M. "RNA turnover in eukaryotes: nucleases, pathways and analysis of mRNA decay. Preface." Methods in enzymology. 2008 448:xxi-xxii.
Maquat LE, Arraiano CM. "RNA turnover in prokaryotes, archaea and organelles. Preface." Methods in enzymology. 2008 447:xxiii-xxiv.
Maquat LE, Kiledjian M. "RNA turnover in eukaryotes: analysis of specialized and quality control RNA decay pathways. Preface." Methods in enzymology. 2008 449:xvii-xviii.
Matsuda D, Sato H, Maquat LE. "Chapter 9. Studying nonsense-mediated mRNA decay in mammalian cells." Methods in enzymology. 2008 449:177-201.
2007 Oct
Matsuda D, Hosoda N, Kim YK, Maquat LE. "Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA." Nature structural & molecular biology. 2007 Oct; 14(10):974-9. Epub 2007 Sep 16.
2007 Aug 1
Isken O, Maquat LE. "Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function." Genes & development. 2007 Aug 1; 21(15):1833-56.
2007 Jun 6
Kim YK, Furic L, Parisien M, Major F, DesGroseillers L, Maquat LE. "Staufen1 regulates diverse classes of mammalian transcripts." The EMBO journal. 2007 Jun 6; 26(11):2670-81. Epub 2007 May 17.
2006 Jul
Kuzmiak HA, Maquat LE. "Applying nonsense-mediated mRNA decay research to the clinic: progress and challenges." Trends in molecular medicine. 2006 Jul; 12(7):306-16. Epub 2006 Jun 16.
2006 Apr
Hosoda N, Lejeune F, Maquat LE. "Evidence that poly(A) binding protein C1 binds nuclear pre-mRNA poly(A) tails." Molecular and cellular biology. 2006 Apr; 26(8):3085-97.
2006 Jan 15
Pan Q, Saltzman AL, Kim YK, Misquitta C, Shai O, Maquat LE, Frey BJ, Blencowe BJ. "Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression." Genes & development. 2006 Jan 15; 20(2):153-8.
2005 Oct
Hosoda N, Kim YK, Lejeune F, Maquat LE. "CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells." Nature structural & molecular biology. 2005 Oct; 12(10):893-901. Epub 2005 Sep 25.
2005 Jun
Lejeune F, Maquat LE. "Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells." Current opinion in cell biology. 2005 Jun; 17(3):309-15.
2005 May 1
Maquat LE. "Nonsense-mediated mRNA decay in mammals." Journal of cell science. 2005 May 1; 118(Pt 9):1773-6.
2005 Mar 22
Gao Q, Das B, Sherman F, Maquat LE. "Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast." Proceedings of the National Academy of Sciences of the United States of America. 2005 Mar 22; 102(12):4258-63. Epub 2005 Mar 07.
2005 Jan 28
Kim YK, Furic L, Desgroseillers L, Maquat LE. "Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay." Cell. 2005 Jan 28; 120(2):195-208.
2004 Nov
Valencia-Sánchez MA, Maquat LE. "An enemy within: fly reconnaissance deploys an endonuclease to destroy nonsense-containing mRNA." Trends in cell biology. 2004 Nov; 14(11):594-7.
2004 Oct
Lejeune F, Ranganathan AC, Maquat LE. "eIF4G is required for the pioneer round of translation in mammalian cells." Nature structural & molecular biology. 2004 Oct; 11(10):992-1000. Epub 2004 Sep 07.
2004 Jun 4
Brumbaugh KM, Otterness DM, Geisen C, Oliveira V, Brognard J, Li X, Lejeune F, Tibbetts RS, Maquat LE, Abraham RT. "The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells." Molecular cell. 2004 Jun 4; 14(5):585-98.
2004 Apr 1
Chiu SY, Lejeune F, Ranganathan AC, Maquat LE. "The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex." Genes & development. 2004 Apr 1; 18(7):745-54. Epub 2004 Apr 01.
2004 Feb
Maquat LE. "Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics." Nature reviews. Molecular cell biology. 2004 Feb; 5(2):89-99.
Lejeune F, Maquat LE. "Immunopurification and analysis of protein and RNA components of mRNP in mammalian cells." Methods in molecular biology. 2004 257:115-24.
2003 Sep
Lejeune F, Li X, Maquat LE. "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities." Molecular cell. 2003 Sep; 12(3):675-87.
2003 Jul
Arraiano CM, Maquat LE. "Post-transcriptional control of gene expression: effectors of mRNA decay." Molecular microbiology. 2003 Jul; 49(1):267-76.
2003 Jan
Chiu SY, Serin G, Ohara O, Maquat LE. "Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1." RNA. 2003 Jan; 9(1):77-87.
2002 Oct 1
Stevens A, Wang Y, Bremer K, Zhang J, Hoepfner R, Antoniou M, Schoenberg DR, Maquat LE. "Beta -Globin mRNA decay in erythroid cells: UG site-preferred endonucleolytic cleavage that is augmented by a premature termination codon." Proceedings of the National Academy of Sciences of the United States of America. 2002 Oct 1; 99(20):12741-6. Epub 2002 Sep 19.
2002 Jul 15
Maquat LE. "NASty effects on fibrillin pre-mRNA splicing: another case of ESE does it, but proposals for translation-dependent splice site choice live on." Genes & development. 2002 Jul 15; 16(14):1743-53.
2002 Jul 1
Lejeune F, Ishigaki Y, Li X, Maquat LE. "The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling." The EMBO journal. 2002 Jul 1; 21(13):3536-45.
2002 Mar 22
Maquat LE. "Molecular biology. Skiing toward nonstop mRNA decay." Science. 2002 Mar 22; 295(5563):2221-2.
2002 Mar 19
Maquat LE. "Nonsense-mediated mRNA decay." Current biology : CB. 2002 Mar 19; 12(6):R196-7.
2002 Feb
Maquat LE. "RNA-protein interactions: insight into gene function." Methods : a companion to Methods in enzymology. 2002 Feb; 26(2):93-4.
Sun, X.; Maquat, L.E. ;. "Nonsense-Mediated Decay: Assaying for Effects on Selenoprotein mRNAs". In Methods in Enzymology. Protein Sensors of Reactive Oxygen Species: Selenoproteins, Thioredoxin, Thiol Enzymes, and Proteins, eds. H. Sies, L. Packer, Academic Press. 2002; 347(3): 49-57. Link
Sun X, Maquat LE. "Nonsense-mediated decay: assaying for effects on selenoprotein mRNAs." Methods in enzymology. 2002 347:49-57.
2001 Dec
Schneider R, Agol VI, Andino R, Bayard F, Cavener DR, Chappell SA, Chen JJ, Darlix JL, Dasgupta A, Donzé O, Duncan R, Elroy-Stein O, Farabaugh PJ, Filipowicz W, Gale M, Gehrke L, Goldman E, Groner Y, Harford JB, Hatzglou M, He B, Hellen CU, Hentze MW, Hershey J, Hershey P, Hohn T, Holcik M, Hunter CP, Igarashi K, Jackson R, Jagus R, Jefferson LS, Joshi B, Kaempfer R, Katze M, Kaufman RJ, Kiledjian M, Kimball SR, Kimchi A, Kirkegaard K, Koromilas AE, Krug RM, Kruys V, Lamphear BJ, Lemon S, Lloyd RE, Maquat LE, Martinez-Salas E, Mathews MB, Mauro VP, Miyamoto S, Mohr I, Morris DR, Moss EG, Nakashima N, Palmenberg A, Parkin NT, Pe'ery T, Pelletier J, Peltz S, Pestova TV, Pilipenko EV, Prats AC, Racaniello V, Read GS, Rhoads RE, Richter JD, Rivera-Pomar R, Rouault T, Sachs A, Sarnow P, Scheper GC, Schiff L, Schoenberg DR, Semler BL, Siddiqui A, Skern T, Sonenberg N, Sossin W, Standart N, Tahara SM, Thomas AA, Toulmé JJ, Wilusz J, Wimmer E, Witherell G, Wormington M. "New ways of initiating translation in eukaryotes." Molecular and cellular biology. 2001 Dec; 21(23):8238-46.
2001 Sep 7
Ishigaki Y, Li X, Serin G, Maquat LE. "Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20." Cell. 2001 Sep 7; 106(5):607-17.
2001 Jun 22
Denning G, Jamieson L, Maquat LE, Thompson EA, Fields AP. "Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein." The Journal of biological chemistry. 2001 Jun 22; 276(25):22709-14. Epub 2001 Apr 30.
2001 Apr
Sun X, Li X, Moriarty PM, Henics T, LaDuca JP, Maquat LE. "Nonsense-mediated decay of mRNA for the selenoprotein phospholipid hydroperoxide glutathione peroxidase is detectable in cultured cells but masked or inhibited in rat tissues." Molecular biology of the cell. 2001 Apr; 12(4):1009-17.
2001 Mar
Maquat LE, Li X. "Mammalian heat shock p70 and histone H4 transcripts, which derive from naturally intronless genes, are immune to nonsense-mediated decay." RNA. 2001 Mar; 7(3):445-56.
2001 Jan 26
Maquat LE, Carmichael GG. "Quality control of mRNA function." Cell. 2001 Jan 26; 104(2):173-6.
2001 Jan
Serin G, Gersappe A, Black JD, Aronoff R, Maquat LE. "Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)." Molecular and cellular biology. 2001 Jan; 21(1):209-23.
2001 Jan
Maquat LE. "The power of point mutations." Nature genetics. 2001 Jan; 27(1):5-6.
2001 Jan
Pal M, Ishigaki Y, Nagy E, Maquat LE. "Evidence that phosphorylation of human Upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathway." RNA. 2001 Jan; 7(1):5-15.
Maquat LE. "Evidence that selenium deficiency results in the cytoplasmic decay of GPx1 mRNA dependent on pre-mRNA splicing proteins bound to the mRNA exon-exon junction." BioFactors (Oxford, England). 2001 14(1-4):37-42.
Maquat LE, Serin G. "Nonsense-mediated mRNA decay: insights into mechanism from the cellular abundance of human Upf1, Upf2, Upf3, and Upf3X proteins." Cold Spring Harbor symposia on quantitative biology. 2001 66:313-20.
2000 Dec 15
Le Hir H, Izaurralde E, Maquat LE, Moore MJ. "The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions." The EMBO journal. 2000 Dec 15; 19(24):6860-9.
2000 Sep 1
Sun X, Moriarty PM, Maquat LE. "Nonsense-mediated decay of glutathione peroxidase 1 mRNA in the cytoplasm depends on intron position." The EMBO journal. 2000 Sep 1; 19(17):4734-44.
2000 May 1
Le Hir H, Moore MJ, Maquat LE. "Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions." Genes & development. 2000 May 1; 14(9):1098-108.
2000 Mar
Valentin C, Cohen-Solal M, Maquat L, Horányi M, Inselt-Kovács M, Hollán S. "Identical germ-line mutations in the triosephosphate isomerase alleles of two brothers are associated with distinct clinical phenotypes." Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie. 2000 Mar; 323(3):245-50.
2000 Jan
Sun X, Maquat LE. "mRNA surveillance in mammalian cells: the relationship between introns and translation termination." RNA. 2000 Jan; 6(1):1-8.
1998 Sep
Zhang J, Sun X, Qian Y, LaDuca JP, Maquat LE. "At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation." Molecular and cellular biology. 1998 Sep; 18(9):5272-83.
1998 Aug 18
Sun X, Perlick HA, Dietz HC, Maquat LE. "A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells." Proceedings of the National Academy of Sciences of the United States of America. 1998 Aug 18; 95(17):10009-14.
1998 Jul
Zhang J, Sun X, Qian Y, Maquat LE. "Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm." RNA. 1998 Jul; 4(7):801-15.
1998 Jun
Nagy E, Maquat LE. "A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance." Trends in biochemical sciences. 1998 Jun; 23(6):198-9.
1998 May
Moriarty PM, Reddy CC, Maquat LE. "Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase 1 by a UGA-dependent mechanism likely to be nonsense codon-mediated decay of cytoplasmic mRNA." Molecular and cellular biology. 1998 May; 18(5):2932-9.
1997 Dec
Moriarty PM, Reddy CC, Maquat LE. "The presence of an intron within the rat gene for selenium-dependent glutathione peroxidase 1 is not required to protect nuclear RNA from UGA-mediated decay." RNA. 1997 Dec; 3(12):1369-73.
1997 Feb 17
Zhang J, Maquat LE. "Evidence that translation reinitiation abrogates nonsense-mediated mRNA decay in mammalian cells." The EMBO journal. 1997 Feb 17; 16(4):826-33.
1996 Aug
Maquat LE. "Defects in RNA splicing and the consequence of shortened translational reading frames." American journal of human genetics. 1996 Aug; 59(2):279-86.
1996 Mar
Zhang J, Maquat LE. "Evidence that the decay of nucleus-associated nonsense mRNA for human triosephosphate isomerase involves nonsense codon recognition after splicing." RNA. 1996 Mar; 2(3):235-43.
Stephenson LS, Maquat LE. "Cytoplasmic mRNA for human triosephosphate isomerase is immune to nonsense-mediated decay despite forming polysomes." Biochimie. 1996 78(11-12):1043-7.
1995 Jul
Maquat LE. "When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells." RNA. 1995 Jul; 1(5):453-65.
1995 Jan
Nesic D, Zhang J, Maquat LE. "Lack of an effect of the efficiency of RNA 3'-end formation on the efficiency of removal of either the final or the penultimate intron in intact cells." Molecular and cellular biology. 1995 Jan; 15(1):488-96.
1994 Dec
Belgrader P, Cheng J, Zhou X, Stephenson LS, Maquat LE. "Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life." Molecular and cellular biology. 1994 Dec; 14(12):8219-28.
1994 Sep
Cheng J, Belgrader P, Zhou X, Maquat LE. "Introns are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundance." Molecular and cellular biology. 1994 Sep; 14(9):6317-25.
1994 Sep
Belgrader P, Maquat LE. "Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping." Molecular and cellular biology. 1994 Sep; 14(9):6326-36.
1994 Feb 1
Nesic D, Maquat LE. "Upstream introns influence the efficiency of final intron removal and RNA 3'-end formation." Genes & development. 1994 Feb 1; 8(3):363-75.
1993 Jun
Nesic D, Cheng J, Maquat LE. "Sequences within the last intron function in RNA 3'-end formation in cultured cells." Molecular and cellular biology. 1993 Jun; 13(6):3359-69.
1993 Jun
Chang ML, Artymiuk PJ, Wu X, Hollán S, Lammi A, Maquat LE. "Human triosephosphate isomerase deficiency resulting from mutation of Phe-240." American journal of human genetics. 1993 Jun; 52(6):1260-9.
1993 Mar
Cheng J, Maquat LE. "Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA." Molecular and cellular biology. 1993 Mar; 13(3):1892-902.
1993 Jan 15
Belgrader P, Cheng J, Maquat LE. "Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA." Proceedings of the National Academy of Sciences of the United States of America. 1993 Jan 15; 90(2):482-6.
1992 Sep
Lim SK, Maquat LE. "Human beta-globin mRNAs that harbor a nonsense codon are degraded in murine erythroid tissues to intermediates lacking regions of exon I or exons I and II that have a cap-like structure at the 5' termini." The EMBO journal. 1992 Sep; 11(9):3271-8.
1992 Mar
Lim SK, Sigmund CD, Gross KW, Maquat LE. "Nonsense codons in human beta-globin mRNA result in the production of mRNA degradation products." Molecular and cellular biology. 1992 Mar; 12(3):1149-61.
1991 Dec
Maquat LE. "Nuclear mRNA export." Current opinion in cell biology. 1991 Dec; 3(6):1004-12.
1991 Jul 15
Boyer TG, Maquat LE. "Modulation of human triosephosphate isomerase gene transcription by serum." The Journal of biological chemistry. 1991 Jul 15; 266(20):13350-4.
1990 Nov 25
Boyer TG, Maquat LE. "Minimal sequence and factor requirements for the initiation of transcription from an atypical, TATATAA box-containing housekeeping promoter." The Journal of biological chemistry. 1990 Nov 25; 265(33):20524-32.
1990 Oct
Cheng J, Fogel-Petrovic M, Maquat LE. "Translation to near the distal end of the penultimate exon is required for normal levels of spliced triosephosphate isomerase mRNA." Molecular and cellular biology. 1990 Oct; 10(10):5215-25.
1990 Jul 25
Cheng J, Mielnicki LM, Pruitt SC, Maquat LE. "Nucleotide sequence of murine triosephosphate isomerase cDNA." Nucleic acids research. 1990 Jul 25; 18(14):4261.
1989 Sep
Lim S, Mullins JJ, Chen CM, Gross KW, Maquat LE. "Novel metabolism of several beta zero-thalassemic beta-globin mRNAs in the erythroid tissues of transgenic mice." The EMBO journal. 1989 Sep; 8(9):2613-9.
1989 Mar 25
Boyer TG, Krug JR, Maquat LE. "Transcriptional regulatory sequences of the housekeeping gene for human triosephosphate isomerase." The Journal of biological chemistry. 1989 Mar 25; 264(9):5177-87.
1988 Feb
Daar IO, Maquat LE. "Premature translation termination mediates triosephosphate isomerase mRNA degradation." Molecular and cellular biology. 1988 Feb; 8(2):802-13.
1986 Oct
Daar IO, Artymiuk PJ, Phillips DC, Maquat LE. "Human triose-phosphate isomerase deficiency: a single amino acid substitution results in a thermolabile enzyme." Proceedings of the National Academy of Sciences of the United States of America. 1986 Oct; 83(20):7903-7.
1986 Jul
Baumann H, Maquat LE. "Localization of DNA sequences involved in dexamethasone-dependent expression of the rat alpha 1-acid glycoprotein gene." Molecular and cellular biology. 1986 Jul; 6(7):2551-61.
1985 Jul
Brown JR, Daar IO, Krug JR, Maquat LE. "Characterization of the functional gene and several processed pseudogenes in the human triosephosphate isomerase gene family." Molecular and cellular biology. 1985 Jul; 5(7):1694-706.
1985 Apr 25
Maquat LE, Kinniburgh AJ. "A beta zero-thalassemic beta-globin RNA that is labile in bone marrow cells is relatively stable in HeLa cells." Nucleic acids research. 1985 Apr 25; 13(8):2855-67.
1985 Mar 25
Maquat LE, Chilcote R, Ryan PM. "Human triosephosphate isomerase cDNA and protein structure. Studies of triosephosphate isomerase deficiency in man." The Journal of biological chemistry. 1985 Mar 25; 260(6):3748-53.
1982 Sep 25
Kinniburgh AJ, Maquat LE, Schedl T, Rachmilewitz E, Ross J. "mRNA-deficient beta o-thalassemia results from a single nucleotide deletion." Nucleic acids research. 1982 Sep 25; 10(18):5421-7.
1981 Dec
Maquat LE, Kinniburgh AJ, Rachmilewitz EA, Ross J. "Unstable beta-globin mRNA in mRNA-deficient beta o thalassemia." Cell. 1981 Dec; 27(3 Pt 2):543-53.
1980 Jul
Maquat LE, Kinniburgh AJ, Beach LR, Honig GR, Lazerson J, Ershler WB, Ross J. "Processing of human beta-globin mRNA precursor to mRNA is defective in three patients with beta+-thalassemia." Proceedings of the National Academy of Sciences of the United States of America. 1980 Jul; 77(7):4287-91.
1980 May 25
Maquat LE, Reznikoff WS. "lac Promoter mutation Pr115 generates a new transcription initiation point." Journal of molecular biology. 1980 May 25; 139(3):551-6.
1980 May 25
Maquat LE, Thornton K, Reznikoff WS. "lac Promoter mutations located downstream from the transcription start site." Journal of molecular biology. 1980 May 25; 139(3):537-49.
1979 Jun 25
Patient RK, Hardies SC, Larson JE, Inman RB, Maquat LE, Wells RD. "Influence of A-T content on the fractionation of DNA restriction fragments by RPC-5 column chromatography." The Journal of biological chemistry. 1979 Jun 25; 254(12):5548-54.
1978 Nov 15
Maquat LE, Reznikoff WS. "In vitro analysis of the Escherichia coli RNA polymerase interaction with wild-type and mutant lactose promoters." Journal of molecular biology. 1978 Nov 15; 125(4):467-90.