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Mark David Noble, Ph.D.


Showing all 70 journal articles & 0 books available

Journal Articles

Scott-Hewitt NJ, Folts CJ, Noble MD. "Heterozygous carriers of galactocerebrosidase mutations that cause Krabbe disease have impaired microglial function and defective repair of myelin damage." Neural regeneration research.. 2018 Mar; 13(3):393-401.

Scott-Hewitt NJ, Folts CJ, Hogestyn JM, Piester G, Mayer-Pröschel M, Noble MD. "Heterozygote galactocerebrosidase (GALC) mutants have reduced remyelination and impaired myelin debris clearance following demyelinating injury." Human molecular genetics.. 2017 Aug 1; 26(15):2825-2837.

Geary MB, Li H, Zingman A, Ketz J, Zuscik M, De Mesy Bentley KL, Noble M, Elfar JC. "Erythropoietin accelerates functional recovery after moderate sciatic nerve crush injury." Muscle & nerve.. 2017 Jul; 56(1):143-151. Epub 2017 Feb 06.

Tseng KC, Li H, Clark A, Sundem L, Zuscik M, Noble M, Elfar J. "4-Aminopyridine promotes functional recovery and remyelination in acute peripheral nerve injury." EMBO molecular medicine.. 2016 Dec; 8(12):1409-1420. Epub 2016 Dec 01.

Folts CJ, Scott-Hewitt N, Pröschel C, Mayer-Pröschel M, Noble M. "Lysosomal Re-acidification Prevents Lysosphingolipid-Induced Lysosomal Impairment and Cellular Toxicity." PLoS biology.. 2016 Dec; 14(12):e1002583. Epub 2016 Dec 15.

Sundem L, Chris Tseng KC, Li H, Ketz J, Noble M, Elfar J. "Erythropoietin Enhanced Recovery After Traumatic Nerve Injury: Myelination and Localized Effects." The Journal of hand surgery.. 2016 Oct; 41(10):999-1010. Epub 2016 Sep 01.

Campbell A, Bushman J, Munger J, Noble M, Pröschel C, Mayer-Pröschel M. "Mutation of ataxia-telangiectasia mutated is associated with dysfunctional glutathione homeostasis in cerebellar astroglia." Glia.. 2016 Feb; 64(2):227-39. Epub 2015 Oct 15.

Campbell A, Krupp B, Bushman J, Noble M, Pröschel C, Mayer-Pröschel M. "A novel mouse model for ataxia-telangiectasia with a N-terminal mutation displays a behavioral defect and a low incidence of lymphoma but no increased oxidative burden." Human molecular genetics.. 2015 Nov 15; 24(22):6331-49. Epub 2015 Aug 26.

Tanner DC, Campbell A, O'Banion KM, Noble M, Mayer-Pröschel M. "cFLIP is critical for oligodendrocyte protection from inflammation." Cell death and differentiation.. 2015 Sep; 22(9):1489-501. Epub 2015 Jan 30.

Noble M, Mayer-Pröschel M, Li Z, Dong T, Cui W, Pröschel C, Ambeskovic I, Dietrich J, Han R, Miranda Yang Y, Folts C, Stripay J, Chen HY, Stevens BM. "Redox biology in normal cells and cancer: restoring function of the redox/Fyn/c-Cbl pathway in cancer cells offers new approaches to cancer treatment." Free radical biology & medicine.. 2015 Feb; 79:300-23. Epub 2014 Dec 04.

Stevens BM, Folts CJ, Cui W, Bardin AL, Walter K, Carson-Walter E, Vescovi A, Noble M. "Cool-1-mediated inhibition of c-Cbl modulates multiple critical properties of glioblastomas, including the ability to generate tumors in vivo." Stem cells.. 2014 May; 32(5):1124-35.

Proschel C, Stripay JL, Shih CH, Munger JC, Noble MD. "Delayed transplantation of precursor cell-derived astrocytes provides multiple benefits in a rat model of Parkinsons." EMBO molecular medicine.. 2014 Apr; 6(4):504-18. Epub 2014 Jan 29.

Wang J, Bushman J, Wang X, Mayer-Proschel M, Johnson M, Noble M. "Oligodendrocyte/type-2 astrocyte progenitor cells and glial-restricted precursor cells generate different tumor phenotypes in response to the identical oncogenes." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2013 Oct 16; 33(42):16805-17.

Chen HY, Yang YM, Han R, Noble M. "MEK1/2 inhibition suppresses tamoxifen toxicity on CNS glial progenitor cells." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2013 Sep 18; 33(38):15069-74.

Noble M, Mayer-Pröschel M, Pröschel C. "iOPs: a new tool for studying myelin pathologies?" Cell stem cell.. 2013 May 2; 12(5):503-4.

Chen HY, Yang YM, Stevens BM, Noble M. "Inhibition of redox/Fyn/c-Cbl pathway function by Cdc42 controls tumour initiation capacity and tamoxifen sensitivity in basal-like breast cancer cells." EMBO molecular medicine.. 2013 May; 5(5):723-36. Epub 2013 Apr 22.

Noble M, Mayer-Pröschel M, Davies JE, Davies SJ, Pröschel C. "Cell therapies for the central nervous system: how do we identify the best candidates?" Current opinion in neurology.. 2011 Dec; 24(6):570-6.

Noble M, Davies JE, Mayer-Pröschel M, Pröschel C, Davies SJ. "Precursor cell biology and the development of astrocyte transplantation therapies: lessons from spinal cord injury." Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.. 2011 Oct; 8(4):677-93.

Davies SJ, Shih CH, Noble M, Mayer-Proschel M, Davies JE, Proschel C. "Transplantation of specific human astrocytes promotes functional recovery after spinal cord injury." PloS one.. 2011 Mar 2; 6(3):e17328. Epub 2011 Mar 02.

Noble M, Pröschel C, Mayer-Pröschel M. "Oxidative-reductionist approaches to stem and progenitor cell function." Cell stem cell.. 2011 Jan 7; 8(1):1-2.

Chen R, Hyrien O, Noble M, Mayer-Pröschel M. "A composite likelihood approach to the analysis of longitudinal clonal data on multitype cellular systems under an age-dependent branching process." Biostatistics.. 2011 Jan; 12(1):173-91. Epub 2010 Aug 23.

Hyrien O, Dietrich J, Noble M. "Mathematical and experimental approaches to identify and predict the effects of chemotherapy on neuroglial precursors." Cancer research.. 2010 Dec 15; 70(24):10051-9. Epub 2010 Nov 05.

Hyrien O, Chen R, Mayer-Pröschel M, Noble M. "Saddlepoint approximations to the moments of multitype age-dependent branching processes, with applications." Biometrics.. 2010 Jun; 66(2):567-77. Epub 2009 Jun 09.

Davies JE, Pröschel C, Zhang N, Noble M, Mayer-Pröschel M, Davies SJ. "Transplanted astrocytes derived from BMP- or CNTF-treated glial-restricted precursors have opposite effects on recovery and allodynia after spinal cord injury." Journal of biology. 2008 Sep 19; 7(7):24. Epub 2008 Sep 19.

Han R, Yang YM, Dietrich J, Luebke A, Mayer-Pröschel M, Noble M. "Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system." Journal of biology. 2008 7(4):12. Epub 2008 Apr 22.

Li Z, Dong T, Pröschel C, Noble M. "Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell function." PLoS biology.. 2007 Feb; 5(2):e35.

Jordan CT, Guzman ML, Noble M. "Cancer stem cells." The New England journal of medicine.. 2006 Sep 21; 355(12):1253-61.

Hyrien O, Ambeskovic I, Mayer-Proschel M, Noble M, Yakovlev A. "Stochastic modeling of oligodendrocyte generation in cell culture: model validation with time-lapse data." Theoretical biology & medical modelling. 2006 May 17; 3:21. Epub 2006 May 17.

Noble M. "Implications for CNS repair of redox modulation of cell survival, division and differentiation." Current Alzheimer research.. 2006 Feb; 3(1):37-47.

Davies JE, Huang C, Proschel C, Noble M, Mayer-Proschel M, Davies SJ. "Astrocytes derived from glial-restricted precursors promote spinal cord repair." Journal of biology. 2006 5(3):7. Epub 2006 Apr 27.

Dietrich J, Han R, Yang Y, Mayer-Pröschel M, Noble M. "CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo." Journal of biology. 2006 5(7):22.

Noble M. "Ethics in the trenches: a multifaceted analysis of the stem cell debate." Stem cell reviews.. 2005 Dec; 1(4):345-76.

Dietrich J, Lacagnina M, Gass D, Richfield E, Mayer-Pröschel M, Noble M, Torres C, Pröschel C. "EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy." Nature medicine.. 2005 Mar; 11(3):277-83. Epub 2005 Feb 20.

Hyrien O, Mayer-Pröschel M, Noble M, Yakovlev A. "A stochastic model to analyze clonal data on multi-type cell populations." Biometrics.. 2005 Mar; 61(1):199-207.

Hyrien O, Mayer-Pröschel M, Noble M, Yakovlev A. "Estimating the life-span of oligodendrocytes from clonal data on their development in cell culture." Mathematical biosciences.. 2005 Feb; 193(2):255-74. Epub 2005 Jan 22.

Noble, M. "Neural precursor cells and toxicant action: Addressing the analysis of low-level toxicant exposure" . Role of Glia in Neurotoxicity. 2005; 2nd Edition: 1-28.

Noble M, Mayer-Pröschel M, Pröschel C. "Redox regulation of precursor cell function: insights and paradoxes." Antioxidants & redox signaling.. 2005 7(11-12):1456-67.

Hill CE, Proschel C, Noble M, Mayer-Proschel M, Gensel JC, Beattie MS, Bresnahan JC. "Acute transplantation of glial-restricted precursor cells into spinal cord contusion injuries: survival, differentiation, and effects on lesion environment and axonal regeneration." Experimental neurology.. 2004 Dec; 190(2):289-310.

Noble M, Dietrich J. "The complex identity of brain tumors: emerging concerns regarding origin, diversity and plasticity." Trends in neurosciences.. 2004 Mar; 27(3):148-54.

Noble M, Pröschel C, Mayer-Pröschel M. "Getting a GR(i)P on oligodendrocyte development." Developmental biology.. 2004 Jan 1; 265(1):33-52.

Noble M. "The possible role of myelin destruction as a precipitating event in Alzheimer's disease." Neurobiology of aging.. 2004 Jan; 25(1):25-31.

Biran R, Noble MD, Tresco PA. "Directed nerve outgrowth is enhanced by engineered glial substrates." Experimental neurology.. 2003 Nov; 184(1):141-52.

Noble M, Smith J, Power J, Mayer-Pröschel M. "Redox state as a central modulator of precursor cell function." Annals of the New York Academy of Sciences.. 2003 Jun; 991:251-71.

Noble M, Arhin A, Gass D, Mayer-Pröschel M. "The cortical ancestry of oligodendrocytes: common principles and novel features." Developmental neuroscience.. 2003 25(2-4):217-33.

Dietrich J, Noble M, Mayer-Proschel M. "Characterization of A2B5+ glial precursor cells from cryopreserved human fetal brain progenitor cells." Glia.. 2002 Oct; 40(1):65-77.

Power J, Mayer-Pröschel M, Smith J, Noble M. "Oligodendrocyte precursor cells from different brain regions express divergent properties consistent with the differing time courses of myelination in these regions." Developmental biology.. 2002 May 15; 245(2):362-75.

Noble M, Dietrich J. "Intersections between neurobiology and oncology: tumor origin, treatment and repair of treatment-associated damage." Trends in neurosciences.. 2002 Feb; 25(2):103-7.

Gregori N, Pröschel C, Noble M, Mayer-Pröschel M. "The tripotential glial-restricted precursor (GRP) cell and glial development in the spinal cord: generation of bipotential oligodendrocyte-type-2 astrocyte progenitor cells and dorsal-ventral differences in GRP cell function." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2002 Jan 1; 22(1):248-56.

Mayer-Pröschel M, Morath D, Noble M. "Are hypothyroidism and iron deficiency precursor cell diseases?" Developmental neuroscience.. 2001 23(4-5):277-86.

Noble M. "Can neural stem cells be used to track down and destroy migratory brain tumor cells while also providing a means of repairing tumor-associated damage?" Proceedings of the National Academy of Sciences of the United States of America.. 2000 Nov 7; 97(23):12393-5.

Smith J, Ladi E, Mayer-Proschel M, Noble M. "Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell." Proceedings of the National Academy of Sciences of the United States of America.. 2000 Aug 29; 97(18):10032-7.

Yakovlev AY, Boucher K, Mayer-Proschel M, Noble M. "Quantitative insight into proliferation and differentiation of oligodendrocyte type 2 astrocyte progenitor cells in vitro." Proceedings of the National Academy of Sciences of the United States of America.. 1998 Nov 24; 95(24):14164-7.

Rao MS, Noble M, Mayer-Pröschel M. "A tripotential glial precursor cell is present in the developing spinal cord." Proceedings of the National Academy of Sciences of the United States of America.. 1998 Mar 31; 95(7):3996-4001.

Ibarrola N, Mayer-Pröschel M, Rodriguez-Peña A, Noble M. "Evidence for the existence of at least two timing mechanisms that contribute to oligodendrocyte generation in vitro." Developmental biology.. 1996 Nov 25; 180(1):1-21.

Frangiskakis JM, Ewart AK, Morris CA, Mervis CB, Bertrand J, Robinson BF, Klein BP, Ensing GJ, Everett LA, Green ED, Pröschel C, Gutowski NJ, Noble M, Atkinson DL, Odelberg SJ, Keating MT. "LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition." Cell.. 1996 Jul 12; 86(1):59-69.

Pröschel C, Blouin MJ, Gutowski NJ, Ludwig R, Noble M. "Limk1 is predominantly expressed in neural tissues and phosphorylates serine, threonine and tyrosine residues in vitro." Oncogene.. 1995 Oct 5; 11(7):1271-81.

Mayer M, Noble M. "N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro." Proceedings of the National Academy of Sciences of the United States of America.. 1994 Aug 2; 91(16):7496-500.

Bögler O, Noble M. "Measurement of time in oligodendrocyte-type-2 astrocyte (O-2A) progenitors is a cellular process distinct from differentiation or division." Developmental biology.. 1994 Apr; 162(2):525-38.

Mayer M, Bhakoo K, Noble M. "Ciliary neurotrophic factor and leukemia inhibitory factor promote the generation, maturation and survival of oligodendrocytes in vitro." Development.. 1994 Jan; 120(1):143-53.

Groves AK, Entwistle A, Jat PS, Noble M. "The characterization of astrocyte cell lines that display properties of glial scar tissue." Developmental biology.. 1993 Sep; 159(1):87-104.

Groves AK, Barnett SC, Franklin RJ, Crang AJ, Mayer M, Blakemore WF, Noble M. "Repair of demyelinated lesions by transplantation of purified O-2A progenitor cells." Nature.. 1993 Apr 1; 362(6419):453-5.

Wolswijk G, Noble M. "Cooperation between PDGF and FGF converts slowly dividing O-2Aadult progenitor cells to rapidly dividing cells with characteristics of O-2Aperinatal progenitor cells." The Journal of cell biology.. 1992 Aug; 118(4):889-900.

Wren D, Wolswijk G, Noble M. "In vitro analysis of the origin and maintenance of O-2Aadult progenitor cells." The Journal of cell biology.. 1992 Jan; 116(1):167-76.

Bögler O, Wren D, Barnett SC, Land H, Noble M. "Cooperation between two growth factors promotes extended self-renewal and inhibits differentiation of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells." Proceedings of the National Academy of Sciences of the United States of America.. 1990 Aug; 87(16):6368-72.

Wolswijk G, Noble M. "Identification of an adult-specific glial progenitor cell." Development.. 1989 Feb; 105(2):387-400.

Noble M, Murray K, Stroobant P, Waterfield MD, Riddle P. "Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor cell." Nature.. 1988 Jun 9; 333(6173):560-2.

Raff MC, Lillien LE, Richardson WD, Burne JF, Noble MD. "Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture." Nature.. 1988 Jun 9; 333(6173):562-5.

Small RK, Riddle P, Noble M. "Evidence for migration of oligodendrocyte--type-2 astrocyte progenitor cells into the developing rat optic nerve." Nature.. 1987 328(6126):155-7.

Noble M, Murray K. "Purified astrocytes promote the in vitro division of a bipotential glial progenitor cell." The EMBO journal.. 1984 Oct; 3(10):2243-7.

Raff MC, Miller RH, Noble M. "A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium." Nature.. 1983 303(5916):390-6.