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George J. Schwartz, M.D.

Pediatrics

Clinical Interests

Nephrology, Hypertension; Nephrology, Kidney

Contact Information

Phone Numbers

Appointment: (585) 275-9784

Office: (585) 275-9784

Fax: (585) 756-8054

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Biography

Acidosis
Renal Tubular Disorders

Research

Dr. Schwartz' research interests are:
1) Molecular physiology of acid-base disturbances
2) Kidney tubular acidosis
3) Disorders of sodium, potassium, and magnesium transport
4) Carbonic anhydrase deficiency diseases
5) Assessment of kidney function (glomerular filtration rate)

The long term goal is to determine how intercalated cells of the kidney cortical collecting duct (CCD) sense a change in extracellular pH and adapt by reversing their polarity of H+/HCO3 transporters. After exposure to a 3 h incubation at pH 6.8, rabbit CCDs, which normally secrete HCO3, reverse polarity, secrete H+ and endocytically remove apical Cl/HCO3 exchangers to stop HCO3 secretion. The novel protein hensin is expressed in the extracellular matrix (ECM) surrounding adapting HCO3-secreting intercalated cells (B-ICs) and plays a key role in this adaptation.

Aim 1 determines the mechanisms by which polymerized hensin is deposited in the ECM and how hensin signals the adaptation of B-ICs during metabolic acidosis. Other proteins interacting with hensin include integrins, galectin 3, and cyclophilin A (cyp A); these proteins may be regulated by acid-base disturbances and hensin polymerization. Cyclosporin (CsA) causes renal tubular acidosis and inhibits cyp A peptidyl prolyl isomerase activity. To assess CsA's effect, cultured intercalated cells are plated at high density in the presence of CsA and examined for hensin polymerization in the media and ECM. A cyp A "knockdown" model using siRNAs will be examined similarly; to determine if hensin fails to polymerize without this isomerase activity.

Aim 2 examines the adaptation of CCD ICs to metabolic alkalosis regarding proteins of the hensin pathway and investigates if in vitro alkalosis can reverse the adaptation occurring in response to in vivo metabolic acidosis.

Aim 3 addresses early events in response to metabolic acidosis. Our data suggest that low cell pH is the signal to initiate the adaptation; the role of the adjacent principal cell in this signaling will be determined. We will show whether low pH stimulates endothelin-1 and nitric oxide, and whether they mediate changes in HCO3 transport during acidosis. The early steps of tyrosine phosphorylation and c-Src activation in response to low pH will also be examined.

These studies will illustrate how ICs respond to acid-base perturbations and change functional polarity.

Credentials

Faculty Appointments

Specialties

  • Pediatrics - American Board of Pediatrics
  • Pediatric Nephrology - American Board of Pediatrics

Education

1968
AB | Colgate University
Chemistry

1972
MD | Case Western Reserve University School of Medicine
Medicine

Post-doctoral Training & Residency

07/01/1974 - 06/30/1976
Fellowship in Pediatric Nephrology at Albert Einstein Medical Center

07/01/1973 - 06/30/1974
Residency in Pediatrics at Children's Hospital of Philadelphia

07/01/1974 - 06/30/1976
Fellowship in Pediatric Nephrology at Albert Einstein Medical Center

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Awards

2012 - 2013
Ruth A. Lawrence Academic Faculty Service Award in Training
Location: Golisano Children's Hospital

2006
Listed in: Guide to America's Top Pediatricians

2004 - Present
Fellow of the American Society of Nephrology

2003 - Present
Fellow of the American Heart Association (Inaugural fellow of the Council on the Kidney in Cardiovascular Disease)

2002 - Present
Best Doctors, Inc.

1999 - Present
Specialist in Clinical Hypertension
Sponsor: American Society of Hypertension

1977 - 1980
AMA Physician's Recognition Award

1968
Magna Cum Laude
Location: Colgate University

1968
Dana Scholar
Location: Colgate University

1968
Phi Beta Kappa
Location: Colgate University

1968
High Honors in Major (Chemistry)
Location: Colgate University

1966 - 1968
Honorary Journalism Society
Location: Colgate University

1966 - 1968
Honorary Mathematics Society (KME)
Location: Colgate University

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Publications

Journal Articles

6/7/2017
Fuhrman DY, Schneider MF, Dell KM, Blydt-Hansen TD, Mak R, Saland JM, Furth SL, Warady BA, Moxey-Mims MM, Schwartz GJ. "Albuminuria, Proteinuria, and Renal Disease Progression in Children with CKD." Clinical journal of the American Society of Nephrology : CJASN.. 2017 Jun 7; 12(6):912-920. Epub 2017 May 25.

5/2016
Shafi T, Michels WM, Levey AS, Inker LA, Dekker FW, Krediet RT, Hoekstra T, Schwartz GJ, Eckfeldt JH, Coresh J. "Estimating residual kidney function in dialysis patients without urine collection." Kidney international.. 2016 May 0; 89(5):1099-1110. Epub 2016 Jan 21.

2/20/2016
Lucas GM, Atta MG, Zook K, McFall AM, Mehta SH, Fine DM, Stein JH, Schwartz GJ. "Factors associated with iohexol-based glomerular filtration rate slope over 36 months in HIV-negative and HIV-positive individuals." AIDS.. 2016 Feb 20; 30(4):619-26.

Books & Chapters

2017
Chapter Title: Urinary Acidification
Book Title: Fetal and Neonatal Physiology
Author List: Wang, A.M., Schwartz, G.J.
Edited By: Polin, R.A., Abman, S.H., Rowitch, D.H., Benitz, W.E., Fox, W.W.
Published By: Elsevier2017

2016
Chapter Title: Epidemiology of Skeletal Health in Type 1 Diabetes
Book Title: Current Osteoporosis Report
Author List: Weber, D.R., Schwartz, G.J.
Published By: Springer US2016

2016
Book Title: Acute kidney injury in premature, very low birth-weight infants.
Author List: Mian, A.N., Guillet, R. Ruck, L., Wang, H., Schwartz, G.J.
Published By: Journal of Pediatric Intensive Care2016

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