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George J. Schwartz, M.D.

Contact Information

Phone Numbers

Appointment: (585) 275-9784

Office: (585) 275-9784

Fax: (585) 756-8054

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Faculty Appointments

Patient Care Setting

Pediatrics

Biography

Acidosis
Renal Tubular Disorders

Research

Acute pyelonephritis is a common, serious bacterial infection in children, and due to an upsurge of antibiotic resistance, clinical practice is being refocused on preventative measures that limit the use of antimicrobial therapy. Dehydration is linked to renal stress and urinary tract infection (UTI), and increased daily water is a proven effective ancillary treatment for recurrent UTI in premenopausal women. In contrast little attention has been focused on the influence of acid-base state on susceptibility to acute pyelonephritis. In preliminary studies utilizing the C3H-HeOuJ mouse strain that is prone to vesicureteral reflux (VUR), metabolic acidosis induced by ammonium chloride-loading of mice impaired clearance of UPEC-UTI. In addition to systemic metabolic acidosis, acid loading of mice with ammonium chloride induces diuresis as well as renal acidification. A second observation that acetazolamide-induced metabolic acidosis in the absence of urine acidification did not influence bacterial clearance led to our working hypothesis that urine acidification compromises the pH-dependent uroepithelium barrier function. The current proposal is designed to delineate the impact of acid-base state on the progression of acute pyelonephritis by manipulating urine acidification in the setting of systemic acidosis and diuresis and examining the effect on bacterial clearance, renal tubular inflammation, and uroepithelial barrier function as outlined in two specific aims.

Credentials

Education

1968
AB | Colgate University
Chemistry

1972
MD | Case Western Reserve University School of Medicine
Medicine

Post-doctoral Training & Residency

07/01/1974 - 06/30/1976
Fellowship in Pediatric Nephrology at Albert Einstein Medical Center

07/01/1973 - 06/30/1974
Residency in Pediatrics at Children's Hospital of Philadelphia

07/01/1972 - 06/30/1973
Internship in Pediatrics at Children's Hospital of Philadelphia

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Awards

2012 - 2013
Ruth A. Lawrence Academic Faculty Service Award in Training
Location: Golisano Children's Hospital

2006
Listed in: Guide to America's Top Pediatricians

2004 - Present
Fellow of the American Society of Nephrology

2003 - Present
Fellow of the American Heart Association (Inaugural fellow of the Council on the Kidney in Cardiovascular Disease)

2002 - Present
Best Doctors, Inc.

1999 - Present
Specialist in Clinical Hypertension
Sponsor: American Society of Hypertension

1977 - 1980
AMA Physician's Recognition Award

1968
Magna Cum Laude
Location: Colgate University

1968
Dana Scholar
Location: Colgate University

1968
Phi Beta Kappa
Location: Colgate University

1968
High Honors in Major (Chemistry)
Location: Colgate University

1966 - 1968
Honorary Journalism Society
Location: Colgate University

1966 - 1968
Honorary Mathematics Society (KME)
Location: Colgate University

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Publications

Journal Articles

6/7/2017
Fuhrman DY, Schneider MF, Dell KM, Blydt-Hansen TD, Mak R, Saland JM, Furth SL, Warady BA, Moxey-Mims MM, Schwartz GJ. "Albuminuria, Proteinuria, and Renal Disease Progression in Children with CKD." Clinical journal of the American Society of Nephrology : CJASN.. 2017 Jun 7; 12(6):912-920. Epub 2017 May 25.

5/2016
Shafi T, Michels WM, Levey AS, Inker LA, Dekker FW, Krediet RT, Hoekstra T, Schwartz GJ, Eckfeldt JH, Coresh J. "Estimating residual kidney function in dialysis patients without urine collection." Kidney international.. 2016 May 0; 89(5):1099-1110. Epub 2016 Jan 21.

2/20/2016
Lucas GM, Atta MG, Zook K, McFall AM, Mehta SH, Fine DM, Stein JH, Schwartz GJ. "Factors associated with iohexol-based glomerular filtration rate slope over 36 months in HIV-negative and HIV-positive individuals." AIDS.. 2016 Feb 20; 30(4):619-26.

Books & Chapters

2017
Chapter Title: Urinary Acidification
Book Title: Fetal and Neonatal Physiology
Author List: Wang, A.M., Schwartz, G.J.
Edited By: Polin, R.A., Abman, S.H., Rowitch, D.H., Benitz, W.E., Fox, W.W.
Published By: Elsevier 2017

2016
Chapter Title: Epidemiology of Skeletal Health in Type 1 Diabetes
Book Title: Current Osteoporosis Report
Author List: Weber, D.R., Schwartz, G.J.
Published By: Springer US 2016

2016
Book Title: Acute kidney injury in premature, very low birth-weight infants.
Author List: Mian, A.N., Guillet, R. Ruck, L., Wang, H., Schwartz, G.J.
Published By: Journal of Pediatric Intensive Care 2016

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