Margot Mayer-Proschel, Ph.D.

Margot Mayer-Proschel, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 633
Rochester, NY 14642

Office: (585) 273-1449
Lab: (585) 273-2407
Administrative: (585) 273-1440
Fax: (585) 273-1450

Journal Articles

Showing all 73 journal articles available.

2016 Dec
Folts CJ, Scott-Hewitt N, Pröschel C, Mayer-Pröschel M, Noble M. "Lysosomal Re-acidification Prevents Lysosphingolipid-Induced Lysosomal Impairment and Cellular Toxicity." PLoS biology. 2016 Dec; 14(12):e1002583. Epub 2016 Dec 15.
2016 Feb
Campbell A, Bushman J, Munger J, Noble M, Pröschel C, Mayer-Pröschel M. "Mutation of ataxia-telangiectasia mutated is associated with dysfunctional glutathione homeostasis in cerebellar astroglia." Glia. 2016 Feb; 64(2):227-39. Epub 2015 Oct 15.
2015 Dec 22
Allen JL, Oberdorster G, Morris-Schafer K, Wong C, Klocke C, Sobolewski M, Conrad K, M MP, Cory-Slechta DA. "Developmental neurotoxicity of inhaled ambient ultrafine particle air pollution: Parallels with neuropathological and behavioral features of autism and other neurodevelopmental disorders." Neurotoxicology. 2015 Dec 22; Epub 2015 Dec 22.
2015 Nov 15
Campbell A, Krupp B, Bushman J, Noble M, Pröschel C, Mayer-Pröschel M. "A novel mouse model for ataxia-telangiectasia with a N-terminal mutation displays a behavioral defect and a low incidence of lymphoma but no increased oxidative burden." Human molecular genetics. 2015 Nov 15; 24(22):6331-49. Epub 2015 Aug 26.
2015 Sep
Tanner DC, Campbell A, O'Banion KM, Noble M, Mayer-Pröschel M. "cFLIP is critical for oligodendrocyte protection from inflammation." Cell death and differentiation. 2015 Sep; 22(9):1489-501. Epub 2015 Jan 30.
2015 Feb
Noble M, Mayer-Pröschel M, Li Z, Dong T, Cui W, Pröschel C, Ambeskovic I, Dietrich J, Han R, Miranda Yang Y, Folts C, Stripay J, Chen HY, Stevens BM. "Redox biology in normal cells and cancer: restoring function of the redox/Fyn/c-Cbl pathway in cancer cells offers new approaches to cancer treatment." Free radical biology & medicine. 2015 Feb; 79:300-23. Epub 2014 Dec 04.
Greminger AR, Mayer-Pröschel M. "Identifying the threshold of iron deficiency in the central nervous system of the rat by the auditory brainstem response." ASN neuro. 2015 7(1)
2014 Sep
Allen JL, Liu X, Pelkowski S, Palmer B, Conrad K, Oberdörster G, Weston D, Mayer-Pröschel M, Cory-Slechta DA. "Early postnatal exposure to ultrafine particulate matter air pollution: persistent ventriculomegaly, neurochemical disruption, and glial activation preferentially in male mice." Environmental health perspectives. 2014 Sep; 122(9):939-45. Epub 2014 Jun 05.
2014 Jul
Greminger AR, Lee DL, Shrager P, Mayer-Pröschel M. "Gestational iron deficiency differentially alters the structure and function of white and gray matter brain regions of developing rats." The Journal of nutrition. 2014 Jul; 144(7):1058-66. Epub 2014 Apr 17.
2013 Oct 16
Wang J, Bushman J, Wang X, Mayer-Proschel M, Johnson M, Noble M. "Oligodendrocyte/type-2 astrocyte progenitor cells and glial-restricted precursor cells generate different tumor phenotypes in response to the identical oncogenes." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 Oct 16; 33(42):16805-17.
2013 May 2
Noble M, Mayer-Pröschel M, Pröschel C. "iOPs: a new tool for studying myelin pathologies?" Cell stem cell. 2013 May 2; 12(5):503-4.
2012 Jun 15
Wang G, Dinkins M, He Q, Zhu G, Poirier C, Campbell A, Mayer-Proschel M, Bieberich E. "Astrocytes secrete exosomes enriched with proapoptotic ceramide and prostate apoptosis response 4 (PAR-4): potential mechanism of apoptosis induction in Alzheimer disease (AD)." The Journal of biological chemistry. 2012 Jun 15; 287(25):21384-95. Epub 2012 Apr 24.
2012 Apr 4
Lee DL, Strathmann FG, Gelein R, Walton J, Mayer-Pröschel M. "Iron deficiency disrupts axon maturation of the developing auditory nerve." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Apr 4; 32(14):5010-5.
2011 Dec
Noble M, Mayer-Pröschel M, Davies JE, Davies SJ, Pröschel C. "Cell therapies for the central nervous system: how do we identify the best candidates?" Current opinion in neurology. 2011 Dec; 24(6):570-6.
2011 Oct
Noble M, Davies JE, Mayer-Pröschel M, Pröschel C, Davies SJ. "Precursor cell biology and the development of astrocyte transplantation therapies: lessons from spinal cord injury." Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2011 Oct; 8(4):677-93.
2011 Apr 20
Tanner DC, Cherry JD, Mayer-Pröschel M. "Oligodendrocyte progenitors reversibly exit the cell cycle and give rise to astrocytes in response to interferon-?." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Apr 20; 31(16):6235-46.
2011 Mar 15
Mihaila C, Schramm J, Strathmann FG, Lee DL, Gelein RM, Luebke AE, Mayer-Pröschel M. "Identifying a window of vulnerability during fetal development in a maternal iron restriction model." PloS one. 2011 Mar 15; 6(3):e17483. Epub 2011 Mar 15.
2011 Mar 2
Davies SJ, Shih CH, Noble M, Mayer-Proschel M, Davies JE, Proschel C. "Transplantation of specific human astrocytes promotes functional recovery after spinal cord injury." PloS one. 2011 Mar 2; 6(3):e17328. Epub 2011 Mar 02.
2011 Feb
Latchney SE, Lioy DT, Henry EC, Gasiewicz TA, Strathmann FG, Mayer-Pröschel M, Opanashuk LA. "Neural precursor cell proliferation is disrupted through activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin." Stem cells and development. 2011 Feb; 20(2):313-26. Epub 2010 Aug 31.
2011 Jan 7
Noble M, Pröschel C, Mayer-Pröschel M. "Oxidative-reductionist approaches to stem and progenitor cell function." Cell stem cell. 2011 Jan 7; 8(1):1-2.
2011 Jan
Chen R, Hyrien O, Noble M, Mayer-Pröschel M. "A composite likelihood approach to the analysis of longitudinal clonal data on multitype cellular systems under an age-dependent branching process." Biostatistics. 2011 Jan; 12(1):173-91. Epub 2010 Aug 23.
2011 Jan
Nout YS, Culp E, Schmidt MH, Tovar CA, Pröschel C, Mayer-Pröschel M, Noble MD, Beattie MS, Bresnahan JC. "Glial restricted precursor cell transplant with cyclic adenosine monophosphate improved some autonomic functions but resulted in a reduced graft size after spinal cord contusion injury in rats." Experimental neurology. 2011 Jan; 227(1):159-71. Epub 2010 Oct 30.
2010 Jun
Hyrien O, Chen R, Mayer-Pröschel M, Noble M. "Saddlepoint approximations to the moments of multitype age-dependent branching processes, with applications." Biometrics. 2010 Jun; 66(2):567-77. Epub 2009 Jun 09.
2008 Sep 19
Davies JE, Pröschel C, Zhang N, Noble M, Mayer-Pröschel M, Davies SJ. "Transplanted astrocytes derived from BMP- or CNTF-treated glial-restricted precursors have opposite effects on recovery and allodynia after spinal cord injury." Journal of biology. 2008 Sep 19; 7(7):24. Epub 2008 Sep 19.
Han R, Yang YM, Dietrich J, Luebke A, Mayer-Pröschel M, Noble M. "Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system." Journal of biology. 2008 7(4):12. Epub 2008 Apr 22.
2007 Apr 17
Strathmann FG, Wang X, Mayer-Pröschel M. "Identification of two novel glial-restricted cell populations in the embryonic telencephalon arising from unique origins." BMC developmental biology. 2007 Apr 17; 7:33. Epub 2007 Apr 17.
2006 Dec
Mock DJ, Strathmann F, Blumberg BM, Mayer-Proschel M. "Infection of murine oligodendroglial precursor cells with Human Herpesvirus 6 (HHV-6)--establishment of a murine in vitro model." Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 2006 Dec; 37 Suppl 1:S17-23.
2006 May 17
Hyrien O, Ambeskovic I, Mayer-Proschel M, Noble M, Yakovlev A. "Stochastic modeling of oligodendrocyte generation in cell culture: model validation with time-lapse data." Theoretical biology & medical modelling. 2006 May 17; 3:21. Epub 2006 May 17.
Mock DJ; Chugh P; Kim B; Proschel C; Dietrich, J.; Strathmann F; Blumberg BM; Mayer-Proschel M. "Characterization of specific HHV-6 and cell cycle genes implicated in virus-mediated G1/S cell-cycle arrest of glial precursors". Retrovirology. 2006; 21(3 Suppl 1): S65.
Davies JE, Huang C, Proschel C, Noble M, Mayer-Proschel M, Davies SJ. "Astrocytes derived from glial-restricted precursors promote spinal cord repair." Journal of biology. 2006 5(3):7. Epub 2006 Apr 27.
Dietrich J, Han R, Yang Y, Mayer-Pröschel M, Noble M. "CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo." Journal of biology. 2006 5(7):22.
2005 Mar
Dietrich J, Lacagnina M, Gass D, Richfield E, Mayer-Pröschel M, Noble M, Torres C, Pröschel C. "EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy." Nature medicine. 2005 Mar; 11(3):277-83. Epub 2005 Feb 20.
2005 Mar
Hyrien O, Mayer-Pröschel M, Noble M, Yakovlev A. "A stochastic model to analyze clonal data on multi-type cell populations." Biometrics. 2005 Mar; 61(1):199-207.
2005 Feb
Hyrien O, Mayer-Pröschel M, Noble M, Yakovlev A. "Estimating the life-span of oligodendrocytes from clonal data on their development in cell culture." Mathematical biosciences. 2005 Feb; 193(2):255-74. Epub 2005 Jan 22.
Noble M, Mayer-Pröschel M, Pröschel C. "Redox regulation of precursor cell function: insights and paradoxes." Antioxidants & redox signaling. 2005 7(11-12):1456-67.
2004 Dec
Hill CE, Proschel C, Noble M, Mayer-Proschel M, Gensel JC, Beattie MS, Bresnahan JC. "Acute transplantation of glial-restricted precursor cells into spinal cord contusion injuries: survival, differentiation, and effects on lesion environment and axonal regeneration." Experimental neurology. 2004 Dec; 190(2):289-310.
2004 May 19
Dietrich J, Blumberg BM, Roshal M, Baker JV, Hurley SD, Mayer-Pröschel M, Mock DJ. "Infection with an endemic human herpesvirus disrupts critical glial precursor cell properties." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 May 19; 24(20):4875-83.
2004 Jan 15
Maragakis NJ, Dietrich J, Wong V, Xue H, Mayer-Proschel M, Rao MS, Rothstein JD. "Glutamate transporter expression and function in human glial progenitors." Glia. 2004 Jan 15; 45(2):133-43.
2004 Jan 1
Noble M, Pröschel C, Mayer-Pröschel M. "Getting a GR(i)P on oligodendrocyte development." Developmental biology. 2004 Jan 1; 265(1):33-52.
2003 Jun
Noble M, Smith J, Power J, Mayer-Pröschel M. "Redox state as a central modulator of precursor cell function." Annals of the New York Academy of Sciences. 2003 Jun; 991:251-71.
Noble M, Arhin A, Gass D, Mayer-Pröschel M. "The cortical ancestry of oligodendrocytes: common principles and novel features." Developmental neuroscience. 2003 25(2-4):217-33.
2002 Oct
Dietrich J, Noble M, Mayer-Proschel M. "Characterization of A2B5+ glial precursor cells from cryopreserved human fetal brain progenitor cells." Glia. 2002 Oct; 40(1):65-77.
2002 May 15
Power J, Mayer-Pröschel M, Smith J, Noble M. "Oligodendrocyte precursor cells from different brain regions express divergent properties consistent with the differing time courses of myelination in these regions." Developmental biology. 2002 May 15; 245(2):362-75.
2002 Jan 1
Gregori N, Pröschel C, Noble M, Mayer-Pröschel M. "The tripotential glial-restricted precursor (GRP) cell and glial development in the spinal cord: generation of bipotential oligodendrocyte-type-2 astrocyte progenitor cells and dorsal-ventral differences in GRP cell function." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2002 Jan 1; 22(1):248-56.
Mayer-Proschel, M.; Ying, Liu; Haipeng, Xue; Yuan Yuan, Wu; Carpenter, M.; Rao, M. "Human neural precursor cells- an in vitro characterization". Clinical Neurosci. Res. 2002; 2: 58-69. Link
Morath DJ, Mayer-Pröschel M. "Iron deficiency during embryogenesis and consequences for oligodendrocyte generation in vivo." Developmental neuroscience. 2002 24(2-3):197-207.
2001 Sep 1
Morath DJ, Mayer-Pröschel M. "Iron modulates the differentiation of a distinct population of glial precursor cells into oligodendrocytes." Developmental biology. 2001 Sep 1; 237(1):232-43.
2001 Sep
Herrera J, Yang H, Zhang SC, Proschel C, Tresco P, Duncan ID, Luskin M, Mayer-Proschel M. "Embryonic-derived glial-restricted precursor cells (GRP cells) can differentiate into astrocytes and oligodendrocytes in vivo." Experimental neurology. 2001 Sep; 171(1):11-21.
2001 Jul
Boucher K, Zorin A, Yakovlev AY, Mayer-Proschel M, Noble M. "An alternative stochastic model of generation of oligodendrocytes in cell culture." Journal of mathematical biology. 2001 Jul; 43(1):22-36.
2001 May
Mayer-Pröschel M. "Isolation and generation of oligodendrocytes by immunopanning." Current protocols in neuroscience. 2001 May; Chapter 3:Unit 3.13.
Mayer-Pröschel M, Morath D, Noble M. "Are hypothyroidism and iron deficiency precursor cell diseases?" Developmental neuroscience. 2001 23(4-5):277-86.
2000 Oct
Zorin A, Mayer-Proschel M, Noble M, Yakovlev AY. "Estimation problems associated with stochastic modeling of proliferation and differentiation of O-2A progenitor cells in vitro." Mathematical biosciences. 2000 Oct; 167(2):109-21.
2000 Aug 29
Smith J, Ladi E, Mayer-Proschel M, Noble M. "Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell." Proceedings of the National Academy of Sciences of the United States of America. 2000 Aug 29; 97(18):10032-7.
2000 Apr
Lee JC, Mayer-Proschel M, Rao MS. "Gliogenesis in the central nervous system." Glia. 2000 Apr; 30(2):105-21.
Kaas JH. "The reorganization of somatosensory and motor cortex after peripheral nerve or spinal cord injury in primates." Progress in brain research. 2000 128:173-9.
Rao MS, Mayer-Proschel M. "Precursor cells for transplantation." Progress in brain research. 2000 128:273-92.
1999 Sep 3
Stringer SE, Mayer-Proschel M, Kalyani A, Rao M, Gallagher JT. "Heparin is a unique marker of progenitors in the glial cell lineage." The Journal of biological chemistry. 1999 Sep 3; 274(36):25455-60.
1999 Jul
von Collani E, Tsodikov A, Yakovlev A, Mayer-Proschel M, Noble M. "A random walk model of oligodendrocyte generation in vitro and associated estimation problems." Mathematical biosciences. 1999 Jul; 159(2):189-204.
1999 Jun
Boucher K, Yakovlev AY, Mayer-Proschel M, Noble M. "A stochastic model of temporally regulated generation of oligodendrocytes in cell culture." Mathematical biosciences. 1999 Jun; 159(1):47-78.
Mayer-Pröschel M. "Cell differentiation in the embryonic mammalian spinal cord." Journal of neural transmission. Supplementum. 1999 55:1-8.
1998 Nov 24
Yakovlev AY, Boucher K, Mayer-Proschel M, Noble M. "Quantitative insight into proliferation and differentiation of oligodendrocyte type 2 astrocyte progenitor cells in vitro." Proceedings of the National Academy of Sciences of the United States of America. 1998 Nov 24; 95(24):14164-7.
1998 Aug 1
Mujtaba T, Mayer-Proschel M, Rao MS. "A common neural progenitor for the CNS and PNS." Developmental biology. 1998 Aug 1; 200(1):1-15.
1998 Jul
Yakovlev AY, Mayer-Proschel M, Noble M. "A stochastic model of brain cell differentiation in tissue culture." Journal of mathematical biology. 1998 Jul; 37(1):49-60.
1998 Mar 31
Rao MS, Noble M, Mayer-Pröschel M. "A tripotential glial precursor cell is present in the developing spinal cord." Proceedings of the National Academy of Sciences of the United States of America. 1998 Mar 31; 95(7):3996-4001.
1997 Dec
Noble M, Mayer-Pröschel M. "Growth factors, glia and gliomas." Journal of neuro-oncology. 1997 Dec; 35(3):193-209.
1997 Oct
Mayer-Proschel M, Kalyani AJ, Mujtaba T, Rao MS. "Isolation of lineage-restricted neuronal precursors from multipotent neuroepithelial stem cells." Neuron. 1997 Oct; 19(4):773-85.
1997 Aug 1
Rao MS, Mayer-Proschel M. "Glial-restricted precursors are derived from multipotent neuroepithelial stem cells." Developmental biology. 1997 Aug 1; 188(1):48-63.
Mayer-Pröschel M.; Rao, M.S.; Noble, M. "Progenitor cells of the central nervous system: A boon for clinical neuroscience". The Journal of NIH Research. 1997; 9: 31-36. Link
1996 Nov 25
Ibarrola N, Mayer-Pröschel M, Rodriguez-Peña A, Noble M. "Evidence for the existence of at least two timing mechanisms that contribute to oligodendrocyte generation in vitro." Developmental biology. 1996 Nov 25; 180(1):1-21.
Noble M, Mayer-Próschel M. "On the track of cell survival pharmaceuticals in the oligodendrocyte type-2 astrocyte lineage." Perspectives on developmental neurobiology. 1996 3(2):121-31.
1994 Aug 2
Mayer M, Noble M. "N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro." Proceedings of the National Academy of Sciences of the United States of America. 1994 Aug 2; 91(16):7496-500.
1994 Jan
Mayer M, Bhakoo K, Noble M. "Ciliary neurotrophic factor and leukemia inhibitory factor promote the generation, maturation and survival of oligodendrocytes in vitro." Development. 1994 Jan; 120(1):143-53.
1993 Apr 1
Groves AK, Barnett SC, Franklin RJ, Crang AJ, Mayer M, Blakemore WF, Noble M. "Repair of demyelinated lesions by transplantation of purified O-2A progenitor cells." Nature. 1993 Apr 1; 362(6419):453-5.


Noble M., Mayer-Proschel M.. "PreGlial restricted Precursors". Stem cells and CNS development. : Rao M. Humana Press Inc, 2001. 123-151
Mayer-Proschel M.. Isolation and purification of oligodendrocytes. Ron McKay. : John Wiley and Sons, 1998.