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Andrea Sant, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-9798

Research Labs

Lab: (585) 273-5385

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Faculty Appointments

Biography

Research

Our research seeks to understand the elements in vivo that dictate the selective specificities and effector functions of CD4 T cells during protective immune responses to pathogenic organisms, with a particular commitment overcoming the challenges associated with protective immunity to influenza virus. We are heavily focused on the role that CD4 T cells play in immunity to influenza virus because of the multiplicity of contributions that they make in protective immunity to influenza, including help for high affinity antibody production, enhancement of CD8 T cell expansion, function and memory, acceleration of the early innate response to infection and direct tissue localized cytotoxicity.

The influenza-specific CD4 T cell repertoire in humans is established through periodic exposures to infection and vaccination that each lead to distinct signatures of CD4 T cell memory. Our data suggests that the CD4 T cell repertoire specific for influenza viruses are highly variable in abundance, specificity and functionality. It is our hypothesis that deficits in particular subsets of CD4 T cells recruited into the response are associated with less robust or effective antibody responses and diminished protection mediated by the cellular components of the adaptive immune response. Accordingly, our laboratory seeks to develop and analyze improved strategies for human vaccination and to the development of molecular strategies to both foster protective immunity in the host and to dissect both predictors and correlates of protective immunity to vaccines and virus infections.

Credentials

Education

1977
BA | SUNY College at Oswego
Chemistry and Biology

1985
PhD | Washington University
Immunology

Awards

2013
AAI Awards Committee

2013
Section Editor
Sponsor: Journal of Immunology

2013
Ad Hoc reviewer
Sponsor: CMI-A study Section

2012
Ad Hoc reviewer
Sponsor: CMI-B Study Section

2012
Ad Hoc reviewer
Sponsor: NIH VMD Study Section

2005 - 2007
Chair
Sponsor: Cellular and Molecular Immunology (CMI-B) Study Section

2003 - 2005
Ad Hoc reviewer
Sponsor: NIH/NIAID Immunobiology Study Section

2002 - Present
Elected to Faculty of 1000 in Immunology

2001
Ad Hoc reviewer
Sponsor: National Institutes of Health Study Sections

2000
Breast Cancer Study Section
Sponsor: Department of Army

1999
Ad Hoc reviewer
Sponsor: National Institutes of Health Study Sections

1999
Study Section
Sponsor: Department of Defense

1998
Breast Cancer Study Section
Sponsor: Department of Army

1997
Study Section
Sponsor: Department of Defense

1996 - 1999
Study Section Co-Chair
Sponsor: American Heart Association

1996 - 1997
Chair
Sponsor: Arthritis Foundation Study Section (Co Chair 1996)

1994 - 1996
Ad Hoc reviewer
Sponsor: American Cancer Society Study Section

1994 - 1995
Ad Hoc reviewer
Sponsor: National Institutes of Health Study Sections

1989 - 1990
Zeisler Junior Faculty Scholars Award
Location: $25,000

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Publications

Journal Articles

1/31/2019
Sant AJ. "The way forward: Potentiating protective immunity to novel and pandemic influenza through engagement of memory CD4 T cells." The Journal of infectious diseases.. 2019 Jan 31; Epub 2019 Jan 31.

2019
"Editorial: Orchestration of an Immune Response to Respiratory Pathogens." Frontiers in immunology.. 2019 10:690. Epub 2019 Apr 09.

2019
"Imprinting and Editing of the Human CD4 T Cell Response to Influenza Virus." Frontiers in immunology.. 2019 10:932. Epub 2019 May 07.

Books & Chapters

2006
Chapter Title: The Mechanics of Class II Processing: Establishment of a Class II Hierarchy
Book Title: Immunodominance: The Choice of the Immune System
Author List: Drake J; Sant AJ
Edited By: J Frelinger
Published By: Wiley-VCH 2006

1994
Chapter Title: Intracellular events regulating MHC Class II restricted antigen presentation
Book Title: Antigen Processing and Presentation
Author List: Sant, AJ, Chervonsky, A, Dykhuizen, M, Katz, JF, Loss, GE, Stebbins, C, and LJ Tan
Edited By: S Pierce and R Humphreys
Published By: Academic Press 1994

1988
Chapter Title: DNA-mediated gene transfer as a tool for analyzing la structure-function relationships and antigen presentation
Book Title: Antigen Presenting Cells: Diversity, Differentiation and Regulation
Author List: Braunstein, NS, Ronchese, F, Sant, AJ, Schwartz, RH, Lechler, RI, and Germain, RN
Published By: Alan R. Liss, Inc. 1988

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