Skip to main content
Explore URMC

Lisa A. Delouise, Ph.D., M.P.D.

Contact Information

Phone Numbers

Administrative: (585) 275-1998

Office: (585) 275-1810

Fax: (585) 273-1346

Research Labs

We are bionanomaterials group that investigates novel biomedical devices for diagnostic and therapeutic applications.

Visit We are bionanomaterials group that investigates novel biomedical devices for diagnostic and therapeutic applications. Lab Website

Faculty Appointments

  • Associate Professor - Department of Dermatology (SMD)
  • Associate Professor - Department of Electrical & Computer Engineering (RC) - Joint



Research Interest:
The overall research area in the laboratory is the creation of Smart Bandage Biomaterial Engineering and Skin Disease. This laboratory investigates the fundamental optical, morphological, and surface chemical properties of bioengineered nanoporous silicon (PSi) in developing a platform of Smart Bandage technologies targeting biosensors for point of care diagnosis of cutaneous disease, transdermal drug delivery, and tissue engineering for wound healing. PSi is fabricated from single crystal silicon wafers using an electrochemical etch process. The pore diameter, porosity (surface area and internal void volume), bioerosion, and interferometric optical properties can be tailored over a wide range to suit the application. Ongoing projects involve developing a refractive index sensitive biosensor for detection of Candida ablicans for which we've developed methods to site direct the immobilization of phage display scFv antibody receptors. Tests are underway to evaluate detection sensitivity relative to nonspecifically immobilized whole IgG aCandida antibody receptor employing commercial antigen. Fundamental insights into the factors (pore size, steric crowding, operating frequency, device architecture, blocking agent, operation protocol, etc.) that impact detection sensitivity are being explored. Biosensor tests are typically conducted on devices attached to the silicon wafer. Recently, we developed methods to detach the sensor and mount it in a polymer support. We are conducting studies to characterize the diffusion characteristics of small molecules though hydrogel films (40 micron) cast over porous silicon sensor (4 um) by monitoring changes in the optical response that result when molecules diffuse in or out of the porous silicon layer. This work will enable us to develop models for designing transdermal drug delivery systems where the optical response can be measured, while applied to the skin, to monitor the time released delivery of therapeutics concentrated within the porous reservoir. We are interested in developing a smart bandage to deliver antifungal locally to the nail matrix where nail progenitor cells live. We are also investing the morphology and phenotype dermal human fibroblast and immortalized keratinocytes (HaCaT) cells cultured on chemically modified PSi and flat silicon wafer surfaces. The goal is systematically engineer the surface chemistry, energy and topography of biomaterial scaffolds to mimic the fetal reepithelialization process. Our hypothesis is that by controlling differential cell proliferation (keratinocyte vs. fibroblast) and cell phenotype, such as integrin and metalloproteinase expression profiles or the magnitude of actin fiber extensions, novel therapies will result that can accelerate the healing of chronic wounds (ulcers) and burns with reduced scarring. A unique aspect of this research program is the melding of cross-disciplinary skills in surface science, physical chemistry, microfluidic device engineering, optics, and biological and medical sciences. This interdisciplinary approach provides a firm basis for the investigation and fabrication of new biomedical devices, while enabling a broader perspective on quantifying biological efficacy and establishing clinical utility.



BS | Providence College

PhD | Penn State University
Physical Chemistry

MPD | Rochester Inst Technology
Product Development


Patent Title: Microfluidic Device and Method of Manufacturing the Microfluidic Device
Patent #: 9,457,497
Issue Date: Oct 04, 2016
Country: United States
Invented By: Lisa A DeLouise

Patent Title: Microfluidic Device and Method of Manufacturing the Microfluidic Device
Patent #: 9,346,197
Issue Date: May 24, 2016
Country: United States
Invented By: Lisa A DeLouise

Patent Title: Method of Enriching Stem and/or Progenitor Cells
Patent #: 8,753,880
Issue Date: Jun 17, 2014
Country: United States
Invented By: Siddarth Chandrasekaran, Lisa A DeLouise

Patent Title: Hybrid Target Analyte Responsive Polymer Sensor with Optical Amplification
Patent #: 8,841,137
Issue Date: Sep 23, 2014
Country: United States
Invented By: Lisa Bonanno, Lisa A DeLouise

VIEW ALL expand_more


Journal Articles

Phelan-Dickinson SJ, Palmer BC, Chen Y, DeLouise LA. "The UVR Filter Octinoxate Modulates Aryl Hydrocarbon Receptor Signaling in Keratinocytes via Inhibition of CYP1A1 and CYP1B1." Toxicological sciences : an official journal of the Society of Toxicology.. 2020 Jun 30; Epub 2020 Jun 30.

Palmer BC, Jatana S, Phelan-Dickinson SJ, DeLouise LA. "Amorphous silicon dioxide nanoparticles modulate immune responses in a model of allergic contact dermatitis." Scientific reports.. 2019 Mar 25; 9(1):5085. Epub 2019 Mar 25.

Palmer BC, Phelan-Dickenson SJ, DeLouise LA. "Multi-walled carbon nanotube oxidation dependent keratinocyte cytotoxicity and skin inflammation." Particle and fibre toxicology.. 2019 Jan 8; 16(1):3. Epub 2019 Jan 08.

Books & Chapters

Chapter Title: "Breeching Epithelial Barriers - Physiochemical Factors Impacting Nanoparticle Translocation and Toxicity",
Book Title: Safety of Nanoparticles: From Manufacturing to Medical Applications
Author List: DeLouise, L.A., Mortensen, L.; Elder, A.,
Edited By: Thomas J. Webster
Published By: Springer Science, Business Media 2009

Chapter Title: Biodetection Using Silicon Photonic Crystal Microcavities,
Book Title: Biophotonics
Author List: PM Fauchet, BL Miller, LA DeLouise, MR Lee, and H Ouyang,
Edited By: L Pavesi and PM Fauchet
Published By: Springer 2008

Book Title: Surface Reactions on Semiconductors Studied by Molecular Beam Reactive
Author List: Ming L. Yu and L.A. DeLouise,
Published By: Surface Science Reports 1994