Research Bio
Normal function of the salivary glands is critical for the maintenance of oral health. Radiation treatment of patients with head and neck cancers, as well as autoimmune diseases such as Sjögren's syndrome cause cellular damage in the salivary glands that is usually severe, irreversible, and impairs normal function. The long-range goal of this laboratory is to establish therapeutic strategies for repair or regeneration of the salivary glands. Basic research projects in our laboratory include the identification and characterization of progenitor cells involved in salivary gland development and regeneration, and the factors required for differentiation of secretory cells. Applied projects address strategies for protection of the salivary glands from radiation-induced damage, and for promoting regeneration of damaged glands.
2013 Jun
Arany S, Benoit DS, Dewhurst S, Ovitt CE. "Nanoparticle-mediated gene silencing confers radioprotection to salivary glands in vivo." Molecular therapy : the journal of the American Society of Gene Therapy. 2013 Jun; 21(6):1182-94. Epub 2013 Mar 19. |
2012 Jun
Arany S, Xu Q, Hernady E, Benoit DS, Dewhurst S, Ovitt CE. "Pro-apoptotic gene knockdown mediated by nanocomplexed siRNA reduces radiation damage in primary salivary gland cultures." Journal of cellular biochemistry. 2012 Jun; 113(6):1955-65. |
2012 May
Rugel-Stahl A, Elliott ME, Ovitt CE. "Ascl3 marks adult progenitor cells of the mouse salivary gland." Stem cell research. 2012 May; 8(3):379-87. Epub 2012 Jan 31. |
2011 May 15
Arany S, Catalán MA, Roztocil E, Ovitt CE. "Ascl3 knockout and cell ablation models reveal complexity of salivary gland maintenance and regeneration." Developmental biology. 2011 May 15; 353(2):186-93. Epub 2011 Mar 04. |
2011 May
Lan Y, Liu H, Ovitt CE, Jiang R. "Generation of Osr1 conditional mutant mice." Genesis : the journal of genetics and development. 2011 May; 49(5):419-22. Epub 2011 Apr 02. |
