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Benjamin J. Frisch, Ph.D.

Contact Information

Phone Numbers

Office: (585) 276-7148

Biography

Research

Since 2007 my research career has had a translational focus, with a particular interest in microenvironmental support for the hematopoietic stem cell (HSC). Discovery of mechanisms of support for HSCs during both homeostatic and stressed hematopoiesis has evolved to the identification of novel therapeutic targets in malignant hematopoiesis, such as acute myeloid leukemia. My current research is focused on alterations of the bone marrow microenvironment induced by myeloid malignancies. This research has led to the identification of the chemokine CCL3 as a potential target for the treatment of acute myeloid leukemia. My future interests are in further characterization of the interactions between malignant hematopoiesis and the bone marrow microenvironment, with the ultimate goal of translation of novel therapeutic targets to clinical use.

Credentials

Faculty Appointments

Publications

Journal Articles

2/2013
Porter RL, Georger M, Bromberg O, McGrath KE, Frisch BJ, Becker MW, Calvi LM. "Prostaglandin E2 increases hematopoietic stem cell survival and accelerates hematopoietic recovery after radiation injury." Stem cells.. 2013 Feb 0; 31(2):372-83.

7/12/2012
Bromberg O, Frisch BJ, Weber JM, Porter RL, Civitelli R, Calvi LM. "Osteoblastic N-cadherin is not required for microenvironmental support and regulation of hematopoietic stem and progenitor cells." Blood.. 2012 Jul 12; 120(2):303-13. Epub 2012 May 17.

3/15/2012
Calvi LM, Bromberg O, Rhee Y, Weber JM, Smith JN, Basil M, Frisch BJ, Bellido T. "Osteoblastic expansion induced by parathyroid hormone receptor signaling in murine osteocytes is not sufficient to increase hematopoietic stem cells." Blood.. 2012 Mar 15; 119(11):2489-99. Epub 2012 Jan 18.

Books & Chapters

2014
Chapter Title: Hematopoietic Stem Cell Cultures and Assays
Book Title: Methods in Molecular Biology
Author List: Benjamin J Frisch, Laura M Calvi
Edited By: Mathew J Hilton
Published By: Springer2014

2013
Chapter Title: Hematopoiesis and Bone
Book Title: Primer on Metabolic Bone Diseases and Disorders of Mineral Nutrition
Author List: Benjamin J Frisch, Laura M Calvi
Edited By: Clifford J Rosen
Published By: Wiley-Blackwell2013

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