CONTACT INFORMATIONCREDENTIALSPATENTSPUBLICATIONSBenjamin J. Frisch, Ph.D.Contact InformationPhone NumbersOffice: (585) 276-7148LocationsUniversity of Rochester Medical CenterSchool of Medicine and Dentistry601 Elmwood Ave, Box 704Rochester, NY 14642Faculty AppointmentsAssistant Professor - Department of Pathology and Laboratory Medicine (SMD) Assistant Professor - Department of Biomedical Engineering (SMD) - JointBiographyResearchSince 2007 my research career has had a translational focus, with a particular interest in microenvironmental support for the hematopoietic stem cell (HSC). Discovery of mechanisms of support for HSCs during both homeostatic and stressed hematopoiesis has evolved to the identification of novel therapeutic targets in malignant hematopoiesis, such as acute myeloid leukemia. My current research is focused on alterations of the bone marrow microenvironment induced by myeloid malignancies. This research has led to the identification of the chemokine CCL3 as a potential target for the treatment of acute myeloid leukemia. My future interests are in further characterization of the interactions between malignant hematopoiesis and the bone marrow microenvironment, with the ultimate goal of translation of novel therapeutic targets to clinical use.PatentsPatent Title: Compositions and Methods for Controlled Localized Delivery of Bone Forming Therapeutic Agents Patent #: 10,195,284 Issue Date: Feb 05, 2019 Country: United States Invented By: Danielle SW Benoit, Benjamin J Frisch, Maureen Newman, J. Edward Puzas, Tzong-Jen SheuPublicationsJournal Articles2/2019Frisch BJ. "The hematopoietic stem cell niche: What's so special about bone?" Bone.. 2019 Feb; 119:8-12. Epub 2018 May 17. 10/12/2018Ayoub E, Wilson MP, McGrath KE, Li AJ, Frisch BJ, Palis J, Calvi LM, Zhang Y, Perkins AS. "EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription." Nature communications.. 2018 Oct 12; 9(1):4239. Epub 2018 Oct 12. 10/2/2018Staversky RJ, Byun DK, Georger MA, Zaffuto BJ, Goodman A, Becker MW, Calvi LM, Frisch BJ. "The Chemokine CCL3 Regulates Myeloid Differentiation and Hematopoietic Stem Cell Numbers." Scientific reports.. 2018 Oct 2; 8(1):14691. Epub 2018 Oct 02. Books & Chapters2014 Chapter Title: Hematopoietic Stem Cell Cultures and Assays Book Title: Methods in Molecular Biology Author List: Benjamin J Frisch, Laura M Calvi Edited By: Mathew J Hilton Published By: Springer 20142013 Chapter Title: Hematopoiesis and Bone Book Title: Primer on Metabolic Bone Diseases and Disorders of Mineral Nutrition Author List: Benjamin J Frisch, Laura M Calvi Edited By: Clifford J Rosen Published By: Wiley-Blackwell 2013VIEW ALL PUBLICATIONSClose WindowSchedule an appointment with Benjamin J. Frisch, Ph.D.Please answer the following questions to help us find the right appointment for you.Important: If you believe that you have a medical or psychiatric emergency, please call 911 or go to the nearest hospital. This website is not intended for emergency care.Have you seen this provider in the last 2 years?YesNoExisting Patient Schedule or request a follow up appointment online through MyChart. If you do not have a MyChart account, please close this window and call the appointment phone number. Benjamin J. Frisch, Ph.D. is currently scheduling for the following appointment type(s): Our policy does not permit patients to establish care with multiple providers within the same practice or specialty without prior approval. If you choose a new provider in the same office, we will cancel the appointment. Please contact the office directly with questions on this policy.