Benjamin J. Frisch, Ph.D.

Benjamin J. Frisch, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 704
Rochester, NY 14642

Office: (585) 276-7148

Research Bio

Since 2007 my research career has had a translational focus, with a particular interest in microenvironmental support for the hematopoietic stem cell (HSC). Discovery of mechanisms of support for HSCs during both homeostatic and stressed hematopoiesis has evolved to the identification of novel therapeutic targets in malignant hematopoiesis, such as acute myeloid leukemia. My current research is focused on alterations of the bone marrow microenvironment induced by myeloid malignancies. This research has led to the identification of the chemokine CCL3 as a potential target for the treatment of acute myeloid leukemia. My future interests are in further characterization of the interactions between malignant hematopoiesis and the bone marrow microenvironment, with the ultimate goal of translation of novel therapeutic targets to clinical use.

Recent Journal Articles

Showing the 5 most recent journal articles. 8 available »

2013 Feb
Porter RL, Georger M, Bromberg O, McGrath KE, Frisch BJ, Becker MW, Calvi LM. "Prostaglandin E2 increases hematopoietic stem cell survival and accelerates hematopoietic recovery after radiation injury." Stem cells. 2013 Feb; 31(2):372-83.
2012 Jul 12
Bromberg O, Frisch BJ, Weber JM, Porter RL, Civitelli R, Calvi LM. "Osteoblastic N-cadherin is not required for microenvironmental support and regulation of hematopoietic stem and progenitor cells." Blood. 2012 Jul 12; 120(2):303-13. Epub 2012 May 17.
2012 Mar 15
Calvi LM, Bromberg O, Rhee Y, Weber JM, Smith JN, Basil M, Frisch BJ, Bellido T. "Osteoblastic expansion induced by parathyroid hormone receptor signaling in murine osteocytes is not sufficient to increase hematopoietic stem cells." Blood. 2012 Mar 15; 119(11):2489-99. Epub 2012 Jan 18.
2012 Jan 12
Frisch BJ, Ashton JM, Xing L, Becker MW, Jordan CT, Calvi LM. "Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia." Blood. 2012 Jan 12; 119(2):540-50. Epub 2011 Sep 28.
Loiselle AE, Frisch BJ, Wolenski M, Jacobson JA, Calvi LM, Schwarz EM, Awad HA, O'Keefe RJ. "Bone marrow-derived matrix metalloproteinase-9 is associated with fibrous adhesion formation after murine flexor tendon injury." PloS one. 2012 7(7):e40602. Epub 2012 Jul 11.

Current Appointments

Research Assistant Professor - Department of Medicine, Hematology/Oncology (SMD) - Primary