Skip to main content
Explore URMC



Michael D. Bulger, Ph.D.


Showing all 37 journal articles & 0 books available

Journal Articles

Bulger M, Palis J. "Environmentally-defined enhancer populations regulate diversity of tissue-resident macrophages." Trends in immunology.. 2015 Feb 0; 36(2):61-2. Epub 2015 Jan 07.

Cadiz-Rivera B, Fromm G, de Vries C, Fields J, McGrath KE, Fiering S, Bulger M. "The chromatin "landscape" of a murine adult ?-globin gene is unaffected by deletion of either the gene promoter or a downstream enhancer." PloS one.. 2014 9(5):e92947. Epub 2014 May 09.

Bulger M. "Maps for changing landscapes: viewing epigenomic signatures through differentiation." Cell stem cell.. 2012 Nov 2; 11(5):581-2.

Sundar IK, Chung S, Hwang JW, Lapek JD, Bulger M, Friedman AE, Yao H, Davie JR, Rahman I. "Mitogen- and stress-activated kinase 1 (MSK1) regulates cigarette smoke-induced histone modifications on NF-?B-dependent genes." PloS one.. 2012 7(2):e31378. Epub 2012 Feb 01.

Fromm G, Cadiz-Rivera B, de Vries C, Getman M, McGrath KE, Kingsley PD, Fields J, Fiering S, Bulger M. "An embryonic stage-specific enhancer within the murine ?-globin locus mediates domain-wide histone hyperacetylation." Blood.. 2011 May 12; 117(19):5207-14. Epub 2011 Feb 14.

McGrath KE, Frame JM, Fromm GJ, Koniski AD, Kingsley PD, Little J, Bulger M, Palis J. "A transient definitive erythroid lineage with unique regulation of the ?-globin locus in the mammalian embryo." Blood.. 2011 Apr 28; 117(17):4600-8. Epub 2011 Mar 04.

Bulger M, Groudine M. "Functional and mechanistic diversity of distal transcription enhancers." Cell.. 2011 Feb 4; 144(3):327-39.

Chung S, Sundar IK, Hwang JW, Yull FE, Blackwell TS, Kinnula VL, Bulger M, Yao H, Rahman I. "NF-?B inducing kinase, NIK mediates cigarette smoke/TNF?-induced histone acetylation and inflammation through differential activation of IKKs." PloS one.. 2011 6(8):e23488. Epub 2011 Aug 24.

Bulger M, Groudine M. "Enhancers: the abundance and function of regulatory sequences beyond promoters." Developmental biology.. 2010 Mar 15; 339(2):250-7. Epub 2009 Dec 16.

Fromm G, de Vries C, Byron R, Fields J, Fiering S, Groudine M, Bender MA, Palis J, Bulger M. "Histone hyperacetylation within the beta-globin locus is context-dependent and precedes high-level gene expression." Blood.. 2009 Oct 15; 114(16):3479-88. Epub 2009 Aug 18.

Fromm G, Bulger M. "A spectrum of gene regulatory phenomena at mammalian beta-globin gene loci." Biochemistry and cell biology = Biochimie et biologie cellulaire.. 2009 Oct 0; 87(5):781-90.

Yang SR, Yao H, Rajendrasozhan S, Chung S, Edirisinghe I, Valvo S, Fromm G, McCabe MJ, Sime PJ, Phipps RP, Li JD, Bulger M, Rahman I. "RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke." American journal of respiratory cell and molecular biology.. 2009 Feb 0; 40(2):147-58. Epub 2008 Aug 07.

Yang SR, Valvo S, Yao H, Kode A, Rajendrasozhan S, Edirisinghe I, Caito S, Adenuga D, Henry R, Fromm G, Maggirwar S, Li JD, Bulger M, Rahman I. "IKK alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung." American journal of respiratory cell and molecular biology.. 2008 Jun 0; 38(6):689-98. Epub 2008 Jan 31.

Hu X, Eszterhas S, Pallazzi N, Bouhassira EE, Fields J, Tanabe O, Gerber SA, Bulger M, Engel JD, Groudine M, Fiering S. "Transcriptional interference among the murine beta-like globin genes." Blood.. 2007 Mar 1; 109(5):2210-6. Epub 2006 Oct 31.

Bender MA, Byron R, Ragoczy T, Telling A, Bulger M, Groudine M. "Flanking HS-62.5 and 3' HS1, and regions upstream of the LCR, are not required for beta-globin transcription." Blood.. 2006 Aug 15; 108(4):1395-401. Epub 2006 Apr 27.

Kingsley PD, Malik J, Emerson RL, Bushnell TP, McGrath KE, Bloedorn LA, Bulger M, Palis J. ""Maturational" globin switching in primary primitive erythroid cells." Blood.. 2006 Feb 15; 107(4):1665-72. Epub 2005 Nov 01.

Hu X, Bulger M, Bender MA, Fields J, Groudine M, Fiering S. "Deletion of the core region of 5' HS2 of the mouse beta-globin locus control region reveals a distinct effect in comparison with human beta-globin transgenes." Blood.. 2006 Jan 15; 107(2):821-6. Epub 2005 Sep 27.

Yenerel MN, Sundell IB, Weese J, Bulger M, Gilligan DM. "Expression of adducin genes during erythropoiesis: a novel erythroid promoter for ADD2." Experimental hematology.. 2005 Jul 0; 33(7):758-66.

Bulger M. "Hyperacetylated chromatin domains: lessons from heterochromatin." The Journal of biological chemistry.. 2005 Jun 10; 280(23):21689-92. Epub 2005 Apr 19.

Bulger M, Schübeler D, Bender MA, Hamilton J, Farrell CM, Hardison RC, Groudine M. "A complex chromatin landscape revealed by patterns of nuclease sensitivity and histone modification within the mouse beta-globin locus." Molecular and cellular biology.. 2003 Aug 0; 23(15):5234-44.

Hu X, Bulger M, Roach JN, Eszterhas SK, Olivier E, Bouhassira EE, Groudine MT, Fiering S. "Promoters of the murine embryonic beta-like globin genes Ey and betah1 do not compete for interaction with the beta-globin locus control region." Proceedings of the National Academy of Sciences of the United States of America.. 2003 Feb 4; 100(3):1111-5. Epub 2003 Jan 13.

Bulger M, Groudine M. "TRAPping enhancer function." Nature genetics.. 2002 Dec 0; 32(4):555-6.

Bulger M, Sawado T, Schübeler D, Groudine M. "ChIPs of the beta-globin locus: unraveling gene regulation within an active domain." Current opinion in genetics & development.. 2002 Apr 0; 12(2):170-7.

Tyler JK, Collins KA, Prasad-Sinha J, Amiott E, Bulger M, Harte PJ, Kobayashi R, Kadonaga JT. "Interaction between the Drosophila CAF-1 and ASF1 chromatin assembly factors." Molecular and cellular biology.. 2001 Oct 0; 21(19):6574-84.

Nakagawa T, Bulger M, Muramatsu M, Ito T. "Multistep chromatin assembly on supercoiled plasmid DNA by nucleosome assembly protein-1 and ATP-utilizing chromatin assembly and remodeling factor." The Journal of biological chemistry.. 2001 Jul 20; 276(29):27384-91. Epub 2001 May 01.

Bulger M, Bender MA, van Doorninck JH, Wertman B, Farrell CM, Felsenfeld G, Groudine M, Hardison R. "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters." Proceedings of the National Academy of Sciences of the United States of America.. 2000 Dec 19; 97(26):14560-5.

Bender MA, Bulger M, Close J, Groudine M. "Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region." Molecular cell.. 2000 Feb 0; 5(2):387-93.

Bulger M, Groudine M. "Looping versus linking: toward a model for long-distance gene activation." Genes & development.. 1999 Oct 1; 13(19):2465-77.

Bulger M, van Doorninck JH, Saitoh N, Telling A, Farrell C, Bender MA, Felsenfeld G, Axel R, Groudine M, von Doorninck JH. "Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes." Proceedings of the National Academy of Sciences of the United States of America.. 1999 Apr 27; 96(9):5129-34.

Ito T, Bulger M, Pazin MJ, Kobayashi R, Kadonaga JT. "ACF, an ISWI-containing and ATP-utilizing chromatin assembly and remodeling factor." Cell.. 1997 Jul 11; 90(1):145-55.

Tyler JK, Bulger M, Kamakaka RT, Kobayashi R, Kadonaga JT. "The p55 subunit of Drosophila chromatin assembly factor 1 is homologous to a histone deacetylase-associated protein." Molecular and cellular biology.. 1996 Nov 0; 16(11):6149-59.

Ito T, Tyler JK, Bulger M, Kobayashi R, Kadonaga JT. "ATP-facilitated chromatin assembly with a nucleoplasmin-like protein from Drosophila melanogaster." The Journal of biological chemistry.. 1996 Oct 4; 271(40):25041-8.

Ito T, Bulger M, Kobayashi R, Kadonaga JT. "Drosophila NAP-1 is a core histone chaperone that functions in ATP-facilitated assembly of regularly spaced nucleosomal arrays." Molecular and cellular biology.. 1996 Jun 0; 16(6):3112-24.

Kamakaka RT, Bulger M, Kaufman PD, Stillman B, Kadonaga JT. "Postreplicative chromatin assembly by Drosophila and human chromatin assembly factor 1." Molecular and cellular biology.. 1996 Mar 0; 16(3):810-7.

Bulger M, Ito T, Kamakaka RT, Kadonaga JT. "Assembly of regularly spaced nucleosome arrays by Drosophila chromatin assembly factor 1 and a 56-kDa histone-binding protein." Proceedings of the National Academy of Sciences of the United States of America.. 1995 Dec 5; 92(25):11726-30.

Bulger M, Kadonaga JT. "Biochemical reconstitution of chromatin with physiological nucleosome spacing". Methods Mol. Genet. 1994; 5: 241-262.

Kamakaka RT, Bulger M, Kadonaga JT. "Potentiation of RNA polymerase II transcription by Gal4-VP16 during but not after DNA replication and chromatin assembly." Genes & development.. 1993 Sep 0; 7(9):1779-95.