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Irfan Rahman, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-6911

Research Labs

Faculty Appointments

Biography

Research

Oxidant and cigarette smoke-mediated lung inflammation.

Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation that is not fully reversible. It is a disabling condition associated with progressive breathlessness. COPD will account for over 6 million deaths per year in 2020 (3rd major cause of death), and move from the sixth- to the third-leading cause of death worldwide. In America, COPD affects 9% of residents aged 60 years and above and it ranked fourth in the recent morbidity survey of the elderly population. It is estimated that approximately 23.4 million people in the US have COPD and the health burden is $36.1 billions per year. At present, there is no effective treatment exists to halt the decline in lung function in response to smoking. This in turn reflects a lack of understanding of the specific cellular and molecular pathways triggered in the lung by tobacco smoke/oxidants.

Our laboratory is interested in understanding the redox signaling, mechanism of proinflammatory gene expression by studying the chromatin remodeling-epigenetic changes (histone acetylation/deacetylation) on pro-inflammatory genes, involvement of anti-inflammatory and anti-aging proteins sirtuins, and steroid resistance in chronic inflammatory diseases/COPD. Recent research includes in understanding the role of sirtuins in aging and accelerated decline in lung function and regulation of circadian genes. Our long-term goal is to understand the cellular and molecular mechanisms involved in pathogenesis of COPD, and the potential benefit of therapeutic interventions in this debilitating disease.

Credentials

Education

0-0
PhD |
Biochemistry

0-0
MS |
Biochemistry

0-0
BS |
Biology and Chemistry

Awards

2006
Senior Investigator Award: The Oxygen Club of California

Publications

Journal Articles

5/15/2018
Kaur G, Muthumalage T, Rahman I. "Mechanisms of toxicity and biomarkers of flavoring and flavor enhancing chemicals in emerging tobacco and non-tobacco products." Toxicology letters.. 2018 May 15; 288:143-155. Epub 2018 Feb 23.

4/10/2018
Paquette ST, Dawes RP, Sundar IK, Rahman I, Brown EB, White PM. "Chronic cigarette smoke exposure drives spiral ganglion neuron loss in mice." Scientific reports.. 2018 Apr 10; 8(1):5746. Epub 2018 Apr 10.

4/9/2018
Sundar IK, Rashid K, Gerloff J, Rangel-Moreno J, Li D, Rahman I. "Genetic ablation of histone deacetylase 2 leads to lung cellular senescence and lymphoid follicle formation in COPD/emphysema." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2018 Apr 9; :fj201701518R. Epub 2018 Apr 09.

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