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Irfan Rahman, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-6911

Research Labs

Faculty Appointments

Biography

Research

Oxidant and cigarette smoke-mediated lung inflammation.

Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation that is not fully reversible. It is a disabling condition associated with progressive breathlessness. COPD will account for over 6 million deaths per year in 2020 (3rd major cause of death), and move from the sixth- to the third-leading cause of death worldwide. In America, COPD affects 9% of residents aged 60 years and above and it ranked fourth in the recent morbidity survey of the elderly population. It is estimated that approximately 23.4 million people in the US have COPD and the health burden is $36.1 billions per year. At present, there is no effective treatment exists to halt the decline in lung function in response to smoking. This in turn reflects a lack of understanding of the specific cellular and molecular pathways triggered in the lung by tobacco smoke/oxidants.

Our laboratory is interested in understanding the redox signaling, mechanism of proinflammatory gene expression by studying the chromatin remodeling-epigenetic changes (histone acetylation/deacetylation) on pro-inflammatory genes, involvement of anti-inflammatory and anti-aging proteins sirtuins, and steroid resistance in chronic inflammatory diseases/COPD. Recent research includes in understanding the role of sirtuins in aging and accelerated decline in lung function and regulation of circadian genes. Our long-term goal is to understand the cellular and molecular mechanisms involved in pathogenesis of COPD, and the potential benefit of therapeutic interventions in this debilitating disease.

Credentials

Education

PhD |
Biochemistry

MS |
Biochemistry

BS |
Biology and Chemistry

Awards

2006
Senior Investigator Award: The Oxygen Club of California

Publications

Journal Articles

10/2019
Singh KP, Lawyer G, Muthumalage T, Maremanda KP, Khan NA, McDonough SR, Ye D, McIntosh S, Rahman I. "Systemic biomarkers in electronic cigarette users: implications for noninvasive assessment of vaping-associated pulmonary injuries." ERJ open research.. 2019 Oct 0; 5(4)Epub 2019 Dec 23.

5/3/2019
BinShabaib M, ALHarthi SS, Akram Z, Khan J, Rahman I, Romanos GE, Javed F. "Clinical periodontal status and gingival crevicular fluid cytokine profile among cigarette-smokers, electronic-cigarette users and never-smokers." Archives of oral biology.. 2019 May 3; 102:212-217. Epub 2019 May 03.

4/10/2019
Gayen Nee', Murthy S, Favara M, Fong G, Chan JSY, Addya S, Shaffer TH, Greenspan J, Bhandari V, Rahman I, Aghai ZH. "Histological Chorioamnionitis Induces Differential Gene Expression in Human Cord Blood Mononuclear Leukocytes from Term Neonates." Scientific reports.. 2019 Apr 10; 9(1):5862. Epub 2019 Apr 10.

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