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Irfan Rahman, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-6911

Research Labs

Environmental Health Sciences Center

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Research Network

Biography

Research

Oxidant and cigarette smoke-mediated lung inflammation. Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation that is not fully reversible. It is a disabling condition associated with progressive breathlessness. COPD will account for over 6 million deaths per year in 2020 (3rd major cause of death), and move from the sixth- to the third-leading cause of death worldwide. In America, COPD affects 9% of residents aged 60 years and above and it ranked fourth in the recent morbidity survey of the elderly population. It is estimated that approximately 23.4 million people in the US have COPD and the health burden is $36.1 billions per year. At present, there is no effective treatment exists to halt the decline in lung function in response to smoking. This in turn reflects a lack of understanding of the specific cellular and molecular pathways triggered in the lung by tobacco smoke/oxidants. Our laboratory is interested in understanding the redox signaling, mechanism of proinflammatory gene expression by studying the chromatin remodeling-epigenetic changes (histone acetylation/deacetylation) on pro-inflammatory genes, involvement of anti-inflammatory and anti-aging proteins sirtuins, and steroid resistance in chronic inflammatory diseases/COPD. Recent research includes in understanding the role of sirtuins in aging and accelerated decline in lung function and regulation of circadian genes. Our long-term goal is to understand the cellular and molecular mechanisms involved in pathogenesis of COPD, and the potential benefit of therapeutic interventions in this debilitating disease.

Credentials

Faculty Appointments

Education

0-0
PhD |
Biochemistry

0-0
MS |
Biochemistry

0-0
BS |
Biology and Chemistry

Awards

2006
Senior Investigator Award: The Oxygen Club of California

Publications

Journal Articles

3/3/2017
Lei W, Lerner C, Sundar IK, Rahman I. "Myofibroblast differentiation and its functional properties are inhibited by nicotine and e-cigarette via mitochondrial OXPHOS complex III." Scientific reports.. 2017 Mar 3; 7:43213. Epub 2017 Mar 03.

3/1/2017
Gerloff J, Sundar IK, Freter R, Sekera ER, Friedman AE, Robinson R, Pagano T, Rahman I. "Inflammatory Response and Barrier Dysfunction by Different e-Cigarette Flavoring Chemicals Identified by Gas Chromatography-Mass Spectrometry in e-Liquids and e-Vapors on Human Lung Epithelial Cells and Fibroblasts." Applied in vitro toxicology.. 2017 Mar 1; 3(1):28-40.

2/6/2017
Javed F, Kellesarian SV, Sundar IK, Romanos GE, Rahman I. "Recent updates on electronic cigarette aerosol and inhaled nicotine effects on periodontal and pulmonary tissues." Oral diseases.. 2017 Feb 6; Epub 2017 Feb 06.

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