Toru Takimoto, D.V.M., Ph.D.

Toru Takimoto, D.V.M., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 672
Rochester, NY 14642

Office: (585) 273-2856
Lab: (585) 273-2894
Fax: (585) 473-9573

Research Bio

RESEARCH ACTIVITIES



Research project in progress
The major areas of research in my laboratory are as follows:
Molecular mechanism of paramyxovirus assembly: Efficient assembly and release of progeny virions from infected cells are major determinants of viral pathogenicity. Molecular mechanism of paramyxovirus assembly is not well understood. We are characterizing the trafficking of viral nucleocapsid to the site of assembly at the plasma membrane to understand the cellular machinery viruses utilize for assembly of progeny virions. URSMD Collaborators = Brian Ward, Minsoo Kim.

Assembly of Influenza A viruses: Influenza viruses replicate and form nucleocapsid core in nuclei of infected cells. The progeny nucleocapsid cores are then transported to the plasma membrane budding sites. This study analyzes cellular and viral protein interactions required for the nuclear export of nucleocapsid and budding of progeny virions. URSMD Collaborators = Brian Ward

Role of Influenza Virus Polymerase in Host Adaptation: We participate in the virology research team of the New York Influenza Center of Excellence (NYICE), which is part of the NIH Centers of Excellence for Influenza Research and Surveillance (CEIRS) network. Our focus is on the influenza virus RNA polymerase, and understanding how it contributes to host adaptation. We characterize the polymerase activities of avian and human strains, and identify residues and subunits of the polymerase complex important for the enhanced activity in mammalian hosts in vitro and in vivo. URSMD Collaborators = David Topham, John Treanor, Steve Dewhurst, Baek Kim.

Recent Journal Articles

Showing the 5 most recent journal articles. 58 available »

2015 Jun 15
Hayashi T, MacDonald LA, Takimoto T. "Influenza A Virus Protein PA-X Contributes to Viral Growth and Suppression of the Host Antiviral and Immune Responses." Journal of virology. 2015 Jun 15; 89(12):6442-52. Epub 2015 Apr 08.
2015 May 27
Hayashi T, Wills S, Bussey KA, Takimoto T. "Identification of influenza A virus PB2 residues involved in enhanced polymerase activity and virus growth in mammalian cells at low temperature." Journal of virology. 2015 May 27; Epub 2015 May 27.
2015 May 8
Fukushima K, Takahashi T, Ueyama H, Takaguchi M, Ito S, Oishi K, Minami A, Ishitsubo E, Tokiwa H, Takimoto T, Suzuki T. "Amino acid substitutions contributing to ?2,6-sialic acid linkage binding specificity of human parainfluenza virus type 3 hemagglutinin-neuraminidase." FEBS letters. 2015 May 8; 589(11):1278-82. Epub 2015 Apr 11.
2015 May
Zhan X, Slobod KS, Jones BG, Sealy RE, Takimoto T, Boyd K, Surman S, Russell CJ, Portner A, Hurwitz JL. "Sendai virus recombinant vaccine expressing a secreted, unconstrained respiratory syncytial virus fusion protein protects against RSV in cotton rats." International immunology. 2015 May; 27(5):229-36. Epub 2014 Dec 04.
2014 Feb
Bialas KM, Bussey KA, Stone RL, Takimoto T. "Specific nucleoprotein residues affect influenza virus morphology." Journal of virology. 2014 Feb; 88(4):2227-34. Epub 2013 Dec 11.

Current Appointments

Associate Professor - Department of Microbiology and Immunology (SMD) - Primary

Education

PhD | Microbiology | Japan-Hokkaido University - Sapporo1994
DVM | Veterinary Medicine | Japan-Hokkaido University - Sapporo1989
MS | Microbiology | Japan-Hokkaido University - Sapporo1988
BS | Veterinary Medicine | Japan-Hokkaido University - Sapporo1986

Post-Doctoral Training & Residency

Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 1995