BS: PUC-Rio, Brazil; Physics (1989)
MS: PUC-Rio, Brazil; Biophysics (1992)
PhD: Imperial College, UK; Biophysics (1997)
Postdoctoral Fellow - Yale University - Department of Physiology (1997-2000)
Postdoctoral Fellow - Mount Sinai School of Medicine - Department of Physiology and Biophysics (2000-2003)
2003-2004: Instructor - Mount Sinai School of Medicine - Department of Physiology and Biophysics
2004-2012: Assistant Professor - University of Rochester - Department of medicine - Cardiovascular Research Institute
2013-now: Associate Professor (Research) - University of Rochester - Department of medicine - Cardiovascular Research Institute
We are interested in understanding the regulation of ion channels by diverse G-protein signaling pathways in normal and pathological states.
One major focus of our current work involves the changes in function and regulation of cardiac ion channels that lead to the pathogenesis of the Long QTsyndrome. Our work attempts to translate channel function and dysregulation at the cellular level to patient clinical phenotype and response to treatment.
A second focus of our current research is the study of the pathological remodeling of the slow delayed rectifier-like current (IKs) in heart failure. KCNQ1 is co-assembled with the KCNE1 gene product in the heart to produce IKs, which is one of the main currents responsible for myocyte repolarization. The most commonly inherited cardiac arrhythmia, long-QT1 (LQT1), is due to mutations in the KCNQ1 potassium channel. Heart disease is also known to decrease IKs currents. Our current research focus on stress signals caused by chronic stimulation of kinase signaling pathways, and their consequence for ion channel function and membrane trafficking. We explore possible novel antiarrhythmic treatments to reverse IKs pathological remodeling during heart failure.
Ruwald MH, Parks XX, Moss AJ, Zareba W, Baman J, McNitt S, Kanters JK, Shimizu W, Wilde AA, Jons C, Lopes CM. "Stop-codon and C-terminal nonsense mutations are associated with a lower risk of cardiac events in patients with long QT syndrome type 1." Heart rhythm : the official journal of the Heart Rhythm Society. 2016 Jan; 13(1):122-31. Epub 2015 Aug 28.
2015 Sep 25
O-Uchi J, Sorenson J, Jhun BS, Mishra J, Hurst S, Williams K, Sheu SS, Lopes CM. "Isoform-specific dynamic translocation of PKC by ?1-adrenoceptor stimulation in live cells." Biochemical and biophysical research communications. 2015 Sep 25; 465(3):464-70. Epub 2015 Aug 12.
O-Uchi J, Rice JJ, Ruwald MH, Parks XX, Ronzier E, Moss AJ, Zareba W, Lopes CM. "Impaired IKs channel activation by Ca(2+)-dependent PKC shows correlation with emotion/arousal-triggered events in LQT1." Journal of molecular and cellular cardiology. 2015 Feb; 79:203-11. Epub 0/02/2014.
Mathias A, Moss AJ, Lopes CM, Barsheshet A, McNitt S, Zareba W, Robinson JL, Locati EH, Ackerman MJ, Benhorin J, Kaufman ES, Platonov PG, Qi M, Shimizu W, Towbin JA, Michael Vincent G, Wilde AA, Zhang L, Goldenberg I. "Prognostic implications of mutation-specific QTc standard deviation in congenital long QT syndrome." Heart rhythm : the official journal of the Heart Rhythm Society. 2013 May; 10(5):720-5. Epub 2013 Jan 29.
Mullally J, Goldenberg I, Moss AJ, Lopes CM, Ackerman MJ, Zareba W, McNitt S, Robinson JL, Benhorin J, Kaufman ES, Towbin JA, Barsheshet A. "Risk of life-threatening cardiac events among patients with long QT syndrome and multiple mutations." Heart rhythm : the official journal of the Heart Rhythm Society. 2013 Mar; 10(3):378-82. Epub 2012 Nov 19.