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Edward Brown, Ph.D.

Contact Information

University of Rochester
500 Joseph C. Wilson Blvd.
Box 270168
Rochester, NY 14611

Journal Articles

Showing all 34 journal articles available.

2012 Feb
Perry SW, Burke RM, Brown EB. "Two-photon and second harmonic microscopy in clinical and translational cancer research." Annals of biomedical engineering. 2012 Feb; 40(2):277-91. Epub 2012 Jan 19.
Sullivan, K.;Brown, E. "Diffusion and multi-photon fluorescence recovery after photobleaching in bounded systems". Physical review E. In Press. 2011; .
Perry, S.; Norman, J.; Barbieri, J.; Brown, E.; Gelbard, H. "Mitochondrial membrane potential probes and the proton gradient: a practical usage guide". BioTechniques. In Press. 2011; .
Madden KS, Szpunar MJ, Brown EB. "?-Adrenergic receptors (?-AR) regulate VEGF and IL-6 production by divergent pathways in high ?-AR-expressing breast cancer cell lines." Breast cancer research and treatment. 2011 130(3):747-58. Epub 2011 Jan 14.
2010 Aug
Kozai TD, Marzullo TC, Hooi F, Langhals NB, Majewska AK, Brown EB, Kipke DR. "Reduction of neurovascular damage resulting from microelectrode insertion into the cerebral cortex using in vivo two-photon mapping." Journal of neural engineering. 2010 Aug; 7(4):046011. Epub 2010 Jul 19.
2010 May 10
Han X, Brown E. "Measurement of the ratio of forward-propagating to back-propagating second harmonic signal using a single objective." Optics express. 2010 May 10; 18(10):10538-50.
Li, J.; Sullivan, K.; Brown, E.;Anthamatten, M. "Thermally activated diffusion in reversibly associating polymers". Soft matter. 2010; 6: 235-238.
Sullivan, K.;Brown, E. "Measuring Diffusion Coefficients via Two-Photon Fluorescence Recovery After Photobleaching". Journal of visualized experiments. 2010; 36.
Sullivan KD, Brown EB. "Measuring diffusion coefficients via two-photon fluorescence recovery after photobleaching." Journal of visualized experiments : JoVE. 2010 (36)Epub 2010 Feb 26.
2009 Jul 8
Chauhan VP, Lanning RM, Diop-Frimpong B, Mok W, Brown EB, Padera TP, Boucher Y, Jain RK. "Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo." Biophysical journal. 2009 Jul 8; 97(1):330-6.
2009 Jun 17
Sullivan KD, Sipprell WH, Brown EB, Brown EB. "Improved model of fluorescence recovery expands the application of multiphoton fluorescence recovery after photobleaching in vivo." Biophysical journal. 2009 Jun 17; 96(12):5082-94.
2008 Feb 4
Han X, Burke RM, Zettel ML, Tang P, Brown EB. "Second harmonic properties of tumor collagen: determining the structural relationship between reactive stroma and healthy stroma." Optics express. 2008 Feb 4; 16(3):1846-59.
2007 Feb
Schmidt H, Arendt O, Brown EB, Schwaller B, Eilers J. "Parvalbumin is freely mobile in axons, somata and nuclei of cerebellar Purkinje neurones." Journal of neurochemistry. 2007 Feb; 100(3):727-35.
2005 Nov
Tyrrell JA, Mahadevan V, Tong RT, Brown EB, Jain RK, Roysam B. "A 2-D/3-D model-based method to quantify the complexity of microvasculature imaged by in vivo multiphoton microscopy." Microvascular research. 2005 Nov; 70(3):165-78. Epub 2005 Oct 18.
2005 Jun
Stroh M, Zimmer JP, Duda DG, Levchenko TS, Cohen KS, Brown EB, Scadden DT, Torchilin VP, Bawendi MG, Fukumura D, Jain RK. "Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo." Nature medicine. 2005 Jun; 11(6):678-82. Epub 2005 May 08.
2004 Sep 1
Duda DG, Fukumura D, Munn LL, Booth MF, Brown EB, Huang P, Seed B, Jain RK. "Differential transplantability of tumor-associated stromal cells." Cancer research. 2004 Sep 1; 64(17):5920-4.
2004 May
Brown EB, Boucher Y, Nasser S, Jain RK. "Measurement of macromolecular diffusion coefficients in human tumors." Microvascular research. 2004 May; 67(3):231-6.
2004 Mar 18
Garkavtsev I, Kozin SV, Chernova O, Xu L, Winkler F, Brown E, Barnett GH, Jain RK. "The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis." Nature. 2004 Mar 18; 428(6980):328-32.
2004 Feb
Alexandrakis G, Brown EB, Tong RT, McKee TD, Campbell RB, Boucher Y, Jain RK. "Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors." Nature medicine. 2004 Feb; 10(2):203-7. Epub 2004 Jan 11.
2003 Nov 15
Znati CA, Rosenstein M, McKee TD, Brown E, Turner D, Bloomer WD, Watkins S, Jain RK, Boucher Y. "Irradiation reduces interstitial fluid transport and increases the collagen content in tumors." Clinical cancer research : an official journal of the American Association for Cancer Research. 2003 Nov 15; 9(15):5508-13.
2003 Sep
Abdul-Karim MA, Al-Kofahi K, Brown EB, Jain RK, Roysam B. "Automated tracing and change analysis of angiogenic vasculature from in vivo multiphoton confocal image time series." Microvascular research. 2003 Sep; 66(2):113-25.
2003 Jun
Brown E, McKee T, diTomaso E, Pluen A, Seed B, Boucher Y, Jain RK. "Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation." Nature medicine. 2003 Jun; 9(6):796-800. Epub 2003 May 18.
2003 Apr
Schmidt H, Brown EB, Schwaller B, Eilers J. "Diffusional mobility of parvalbumin in spiny dendrites of cerebellar Purkinje neurons quantified by fluorescence recovery after photobleaching." Biophysical journal. 2003 Apr; 84(4):2599-608.
2003 Feb
Wei X, Henke VG, StrĂ¼bing C, Brown EB, Clapham DE. "Real-time imaging of nuclear permeation by EGFP in single intact cells." Biophysical journal. 2003 Feb; 84(2 Pt 1):1317-27.
2002 Oct
Migliorini C, Qian Y, Chen H, Brown EB, Jain RK, Munn LL. "Red blood cells augment leukocyte rolling in a virtual blood vessel." Biophysical journal. 2002 Oct; 83(4):1834-41.
2002 Sep
Ramanujan S, Pluen A, McKee TD, Brown EB, Boucher Y, Jain RK. "Diffusion and convection in collagen gels: implications for transport in the tumor interstitium." Biophysical journal. 2002 Sep; 83(3):1650-60.
2002 Jun 7
Padera TP, Kadambi A, di Tomaso E, Carreira CM, Brown EB, Boucher Y, Choi NC, Mathisen D, Wain J, Mark EJ, Munn LL, Jain RK. "Lymphatic metastasis in the absence of functional intratumor lymphatics." Science. 2002 Jun 7; 296(5574):1883-6. Epub 2002 Apr 25.
Campbell RB, Fukumura D, Brown EB, Mazzola LM, Izumi Y, Jain RK, Torchilin VP, Munn LL. "Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors." Cancer research. 2002 62(23):6831-6.
2001 Jul
Brown EB, Campbell RB, Tsuzuki Y, Xu L, Carmeliet P, Fukumura D, Jain RK. "In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy." Nature medicine. 2001 Jul; 7(7):864-8.
2001 Apr 10
Pluen A, Boucher Y, Ramanujan S, McKee TD, Gohongi T, di Tomaso E, Brown EB, Izumi Y, Campbell RB, Berk DA, Jain RK. "Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors." Proceedings of the National Academy of Sciences of the United States of America. 2001 Apr 10; 98(8):4628-33. Epub 2001 Mar 27.
2000 Mar 1
Majewska A, Brown E, Ross J, Yuste R. "Mechanisms of calcium decay kinetics in hippocampal spines: role of spine calcium pumps and calcium diffusion through the spine neck in biochemical compartmentalization." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2000 Mar 1; 20(5):1722-34.
1999 Nov
Brown EB, Wu ES, Zipfel W, Webb WW. "Measurement of molecular diffusion in solution by multiphoton fluorescence photobleaching recovery." Biophysical journal. 1999 Nov; 77(5):2837-49.
1999 Jan
Brown EB, Shear JB, Adams SR, Tsien RY, Webb WW. "Photolysis of caged calcium in femtoliter volumes using two-photon excitation." Biophysical journal. 1999 Jan; 76(1 Pt 1):489-99.
1996 May 15
Shear JB, Brown EB, Webb WW. "Multiphoton-excited fluorescence of fluorogen-labeled neurotransmitters." Analytical chemistry. 1996 May 15; 68(10):1778-83.


Sullivan K, Majewska A, Brown E. "Single and Multiphoton Fluorescence Recovery After Photobleaching". Imaging: A Laboratory Manual. Yuste R. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 2011. 655-666
Madden K, Zettel M, Majewska A, Brown E. "Imaging Tumors in the Brain". Imaging in Neuroscience: A Laboratory Manual. Helmchen F, Konnerth A. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, In Press, 2011.
Han X, Perry S, Brown E. "Second Harmonic Imaging of Tumors". Second Harmonic Generation Imaging. Campagnola P, Pavone F. : Taylor and Francis Press, In Preparation, 2011.
Brown E, Majewska A, Jain RK. "Photobleaching and Recovery with Nonlinear Microscopy". Handbook of Biological Nonlinear Optical Microscopy. So P., Masters B. Oxford: Oxford University Press, 2008. 673-688
Jain RK, Booth M, Padera T, Munn L, Fukumura D, Brown E. "Applications of Nonlinear Intravital Microscopy in Tumor Biology". Handbook of Biological Nonlinear Optical Microscopy. So P., Masters B. Oxford: Oxford University Press, 2008. 735-756
Jain RK, Fukumura D, Munn L, Brown E. "Optical Microscopy in Small Animal Research". Textbook of in vivo Imaging of Vertebrates. Tavitian B., Leroy-Willig A., Ntziachristos V. London: Wiley & Sons, 2007. 183-189
Jain RK, Fukumura D, Munn L, Brown E. "Tumor Angiogenesis and Blood Flow". Textbook of in vivo Imaging of Vertebrates. Tavitian B., Leroy-Willig A., Ntziachristos V. London: Wiley & Sons, 2007. 299-301
Brown E, Majewska A, Jain RK. "FRAP and Multiphoton FRAP". Imaging in Neuroscience and Development: A Laboratory Manual. Yuste R, Konnerth A. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 2005. 429-438
Brown E, Munn L, Fukumura D, Jain RK. "A Practical Guide to in vivo Imaging of Tumors". Imaging in Neuroscience and Development: A Laboratory Manual. Yuste R, Konnerth A. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 2005. 695-700
Jain RK, Brown E, Munn L, Fukumura D. "Intravital Microscopy of Normal and Diseased Tissue in the Mouse". Live Cell Imaging: A Laboratory Manual. Spector D, Goldman R. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 2004. 435-466
Brown E, Webb W. "Two-Photon Activation of Caged Calcium with Submicron, Submillisecond Resolution". Methods of Enzymology. Mariott G. San Diego: Academic Press, 1998. 356-380