Gail V W Johnson, Ph.D.

Gail V W Johnson, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 604
Rochester, NY 14642

Office: (585) 276-3740
Fax: (585) 276-2418

Journal Articles

Showing all 171 journal articles available.

Quintanilla, R.A., Matthews-Roberson, T.A., Dolan, P.J. and Johnson, G.V.W. "Caspase-cleaved tau expression results in mitochondrial dysfunction in cortical neurons. Implications for the pathogenesis of Alzheimer disease". Journal of Biological Chemistry. 2009; 284: 18754-18766.
Beagle, B.B., Mi, K. and Johnson, G.V.W. "Phosphorylation of PPP(S/T)P motif in non-membrane anchored LRP6 intracellular domain is not required to activate the Wnt/beta-Catenin pathway and attenuate GSK3beta activity". Journal of Cellular Biochemistry. 2009; 108: 886-895.
Quintanilla, R.A. and Johnson, G.V.W. "The role of mitochondrial dysfunction in Huntington disease". Brain Research Bulletin. 2009; 80: 242-247.
Gundemir, S. and Johnson, G.V.W. "Intracellular localization and conformational state of transglutaminase 2: Implications for cell death". PlosOne. 2009; 4(7): e6123.
Filiano, A.J., Bailey, C.D.C., Tucholski, J. Gundemir, S. and Johnson, G.V.W. "Transglutaminase 2 protects against ischemic insult, interacts with HIF1beta and attenuates HIF signaling". FASEB Journal. 2008; : 2662-2675.
Ding, H. and Johnson, G.V.W. "The last tangle of tau". Journal of Alzheimer Disease. 2008; : 441-447.
Ding, H. and Johnson, G.V.W. "New application of beta-galactosidase complementation to monitor tau self-association". Journal of Neurochemistry. 2008; : 1545-1551.
Ding, H. Dolan, P. and Johnson, G.V.W. "Histone deacetylase 6 interacts with tau and regulates its phosphorylation and aggregation". Journal of Neurochemistry. 2008; : 2119-2130.
Matthews-Roberson, T.A. Quintanilla, R.A., Ding, H. and Johnson, G.V.W. "Immortalized cortical neurons expressing caspase-cleaved tau are sensitized to endoplasmic reticulum stress-induced cell death". Brain Research. 2008; : 206-212.
Quintanilla, R.A., Jin, Y., Fuenzalida, K., Bronfman, M. and Johnson, G.V.W. "Rosiglitazone treatment prevents mitochondrial dysfunction in mutant huntingtin expressing cells: Possible role of PPAR? in the pathogenesis of Huntington's Disease". Journal of Biological Chemistry. 2008; : 25628-25637.
Ruan, Q., Tucholski, J., Gundemir, S. and Johnson Voll, G.V.W. "The differential effects of R580A mutation on transamidation and GTP binding activity of rat and human type transglutaminase". International Journal of Clinical and Experimental Medicine. 2008; : 248-259.
Hunter, JM; Lesort, M; Johnson, GVW. "Mutant huntingtin alterations of the proteasome system". Journal of Neuroscience Research. 2007; : 1774-1788.
Mi, K;Johnson, GVW. "Regulated proteolytic processing of LRP6 results in release of its intracellular domain". Journal of Neurochemistry. 2007; : 517-529.
Mookherjee, P; Quintanilla, R; Roh, M-S; Zmijewska, AA; Jope, RS; Johnson, GVW. "Mitochondrial-targeted active Akt protects SH-SY5Y neuroblastoma cells from staurosporine-induced apoptotic cell death". Journal of Cellular Biochemistry. 2007; 102: 196-210.
Chun, W. and Johnson, G.V.W. "The role of tau phosphorylation and cleavage in neuronal cell death". Frontiers in Bioscience. 2007; : 733-756.
Ruan, Q. and Johnson, G.V.W. "Transglutaminase 2 in neurodegenerative disorders". Frontiers in Bioscience. 2007; : 891-904.
Chun, W. and Johnson, G.V.W. "Activation of GSK3? promotes the intermolecular association of tau: the use of FRET microscopy". Journal of Biological Chemistry. 2007; : 23410-23417.
2006 Jun
Oestreich K, Jester A, Ohlbauer M, Schröter B, Germann G, Pelzer M. "[Survival strategy of burn centers in the context of the German DRG system: reimbursement]." Der Unfallchirurg. 2006 Jun; 109(6):505-10.
2006 May
Germann G, Sauerbier M, Unglaub F. "[Abdominal hernias resulting from abdominal flap harvest]." Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen. 2006 May; 77(5):424-31.
Mi, K; Dolan, PJ; Johnson, GVW. "The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity". Journal of Biological Chemistry. 2006; 284(1): 4787-4794.
Milakovic, T; Quintanilla, RA; Johnson, GVW. "Mutant huntingtin expression induces mitochondrial calcium handling defects in clonal striatal cells: functional consequences". Journal of Biological Chemistry. 2006; : 34785-34795.
Mi, K; Johnson, GVW. "The role of tau phosphorylation in the pathogenesis of Alzheimer's disease". Current Alzheimer Research. 2006; : 449-463.
Clodfelder-Miller, B.J., Zmijewska, A.A., Johnson, G.V.W. and Jope, R.S. "Tau is hyperphosphorylated at multiple sites in mouse brain in vivo after streptozotocin-induced insulin deficiency." Diabetes. 2006; : 3320-03325.
Bailey, C.D.C and Johnson, G.V.W. "The protective effects of cystamine in the R6/2 Huntington's disease mouse involve mechanisms other than the inhibition of tissue transglutaminase". Neurobiology of Aging. 2006; 27: 871-879.
Johnson, G.V.W. "Tau phosphorylation and proteolysis: insights and perspectives". Journal of Alzheimer's Disease. 2006; 9: 243-250.
Tissue transglutaminase overexpression in the brain potentiates excitotoxicity-induced hippocampal damage. "Tissue transglutaminase overexpression in the brain potentiates excitotoxicity-induced hippocampal damage". Journal of Neurochemistry. 2006; 97: 582-594.
Ding, H., Matthews, T.A. and Johnson, G.V.W. "Site-specific phosphorylation and caspase cleavage differentially impacts tau-microtubule interactions and tau aggregation". Journal of Biological Chemistry. 2006; 281: 19107-19114.
2005 Oct
Van Raamsdonk JM, Pearson J, Bailey CD, Rogers DA, Johnson GV, Hayden MR, Leavitt BR. "Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease." Journal of neurochemistry. 2005 Oct; 95(1):210-20.
2005 Sep 23
Choo YS, Mao Z, Johnson GV, Lesort M. "Increased glutathione levels in cortical and striatal mitochondria of the R6/2 Huntington's disease mouse model." Neuroscience letters. 2005 Sep 23; 386(1):63-8.
2005 Sep 2
Milakovic T, Johnson GV. "Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant huntingtin." The Journal of biological chemistry. 2005 Sep 2; 280(35):30773-82. Epub 2005 Jun 27.
2005 Aug 26
Matthews TA, Johnson GV. "14-3-3Zeta does not increase GSK3beta-mediated tau phosphorylation in cell culture models." Neuroscience letters. 2005 Aug 26; 384(3):211-6.
2005 May 15
Mi K, Johnson GV. "Role of the intracellular domains of LRP5 and LRP6 in activating the Wnt canonical pathway." Journal of cellular biochemistry. 2005 May 15; 95(2):328-38.
2005 May 15
Hunter JM, Crouse AB, Lesort M, Johnson GV, Detloff PJ. "Verification of somatic CAG repeat expansion by pre-PCR fractionation." Journal of neuroscience methods. 2005 May 15; 144(1):11-7. Epub 2004 Nov 28.
2005 Jan 7
Stoothoff WH, Cho JH, McDonald RP, Johnson GV. "FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation." The Journal of biological chemistry. 2005 Jan 7; 280(1):270-6. Epub 2004 Nov 01.
2005 Jan
Bailey CD, Johnson GV. "Tissue transglutaminase contributes to disease progression in the R6/2 Huntington's disease mouse model via aggregate-independent mechanisms." Journal of neurochemistry. 2005 Jan; 92(1):83-92.
Stoothoff, WH; Johnson, GVW. "Tau phosphorylation: physiological and pathological consequences". Biochimica Biophysica Acta. 2005; 1739: 280-297.
Bailey, C.D.C., Tucholski, J. and Johnson, G.V.W. "Transglutaminases in neurodegenerative disorders in, "Transglutaminases: the family of enzymes with diverse functions"". Progress in Experimental Tumor Research. 2005; : 139-157.
2004 Dec
Bailey CD, Johnson GV. "Developmental regulation of tissue transglutaminase in the mouse forebrain." Journal of neurochemistry. 2004 Dec; 91(6):1369-79.
2004 Nov 15
Johnson GV, Stoothoff WH. "Tau phosphorylation in neuronal cell function and dysfunction." Journal of cell science. 2004 Nov 15; 117(Pt 24):5721-9.
2004 Jul 15
Choo YS, Johnson GV, MacDonald M, Detloff PJ, Lesort M. "Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release." Human molecular genetics. 2004 Jul 15; 13(14):1407-20. Epub 2004 May 26.
2004 Apr 1
Ruan Q, Lesort M, MacDonald ME, Johnson GV. "Striatal cells from mutant huntingtin knock-in mice are selectively vulnerable to mitochondrial complex II inhibitor-induced cell death through a non-apoptotic pathway." Human molecular genetics. 2004 Apr 1; 13(7):669-81. Epub 2004 Feb 12.
2004 Apr 1
Shelton SB, Krishnamurthy P, Johnson GV. "Effects of cyclin-dependent kinase-5 activity on apoptosis and tau phosphorylation in immortalized mouse brain cortical cells." Journal of neuroscience research. 2004 Apr 1; 76(1):110-20.
2004 Mar 5
Milakovic T, Tucholski J, McCoy E, Johnson GV. "Intracellular localization and activity state of tissue transglutaminase differentially impacts cell death." The Journal of biological chemistry. 2004 Mar 5; 279(10):8715-22. Epub 2003 Dec 11.
2004 Mar
Shelton SB, Johnson GV. "Cyclin-dependent kinase-5 in neurodegeneration." Journal of neurochemistry. 2004 Mar; 88(6):1313-26.
2004 Mar
Bailey CD, Graham RM, Nanda N, Davies PJ, Johnson GV. "Validity of mouse models for the study of tissue transglutaminase in neurodegenerative diseases." Molecular and cellular neurosciences. 2004 Mar; 25(3):493-503.
2004 Feb 27
Krishnamurthy PK, Johnson GV. "Mutant (R406W) human tau is hyperphosphorylated and does not efficiently bind microtubules in a neuronal cortical cell model." The Journal of biological chemistry. 2004 Feb 27; 279(9):7893-900. Epub 2003 Dec 02.
2004 Jan
Cho JH, Johnson GV. "Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules." Journal of neurochemistry. 2004 Jan; 88(2):349-58.
Jope, RS; Johnson, GVW. "The glamour and gloom of glycogen synthase kinase-3". Trends in Biological Science. 2004; 29: 95-102.
Cho, J-H; Johnson, GVW. "Glycogen synthase kinase 3B (GSK3B) induces caspase-cleaved tau aggregation in situ,". Journal of Biological Chemistry,. 2004; 279: 54716-54723.
Suh, MD; Park, CH; Kim, SS; Kil, MO; Lee, GH; Johnson, GVW; Chun, W. "Tissue transglutaminase is not involved in the aggregate formation of stably expressed alpha-synuclein in SH-SY5Y human neuroblastoma cells". Archives of Pharmaceutical Research. 2004; 27: 850-856.
2003 Oct
Johnson GV, Bailey CD. "The p38 MAP kinase signaling pathway in Alzheimer's disease." Experimental neurology. 2003 Oct; 183(2):263-8.
2003 Jul 18
Tucholski J, Johnson GV. "Tissue transglutaminase directly regulates adenylyl cyclase resulting in enhanced cAMP-response element-binding protein (CREB) activation." The Journal of biological chemistry. 2003 Jul 18; 278(29):26838-43. Epub 2003 May 12.
2003 Feb 7
Lesort M, Lee M, Tucholski J, Johnson GV. "Cystamine inhibits caspase activity. Implications for the treatment of polyglutamine disorders." The Journal of biological chemistry. 2003 Feb 7; 278(6):3825-30. Epub 2002 Nov 27.
2003 Jan 3
Cho JH, Johnson GV. "Glycogen synthase kinase 3beta phosphorylates tau at both primed and unprimed sites. Differential impact on microtubule binding." The Journal of biological chemistry. 2003 Jan 3; 278(1):187-93. Epub 2002 Oct 29.
Johnson, GVW; LeShoure, RJr. "Immmunoblot analysis reveals that isopeptide antibodies do not specifically recognize the E-(y-glutamyl)lysine bonds formed by transglutaminase activity". Journal of Neuroscience Methods. 2003; 134: 151-158.
2002 Dec 20
Chun W, Lesort M, Lee M, Johnson GV. "Transient osmotic stress facilitates mutant huntingtin aggregation." Neuroreport. 2002 Dec 20; 13(18):2543-6.
2002 Nov
Stoothoff WH, Bailey CD, Mi K, Lin SC, Johnson GV. "Axin negatively affects tau phosphorylation by glycogen synthase kinase 3beta." Journal of neurochemistry. 2002 Nov; 83(4):904-13.
2002 Oct
Johnson GV, Bailey CD. "Tau, where are we now?" Journal of Alzheimer's disease : JAD. 2002 Oct; 4(5):375-98.
2002 May
Tucholski J, Johnson GV. "Tissue transglutaminase differentially modulates apoptosis in a stimuli-dependent manner." Journal of neurochemistry. 2002 May; 81(4):780-91.
2002 Apr
Zhang J, Krishnamurthy PK, Johnson GV. "Cdk5 phosphorylates p53 and regulates its activity." Journal of neurochemistry. 2002 Apr; 81(2):307-13.
2002 Mar 27
Chun W, Lesort M, Lee M, Johnson GV. "Mutant huntingtin aggregates do not sensitize cells to apoptotic stressors." FEBS letters. 2002 Mar 27; 515(1-3):61-5.
2002 Jan
Lesort M, Chun W, Tucholski J, Johnson GV. "Does tissue transglutaminase play a role in Huntington's disease?" Neurochemistry international. 2002 Jan; 40(1):37-52.
Zhang, J; Luan, C-H Chou, K-C; Johnson, GVW. "Identification of the N-terminal functional domains of cdk5". Proteins: Structure, Function and Genetics. 2002; 48: 447-453.
Watcharasit, P; Bijur, GN; Zmijewski, JW; Song, L; Zmijewska, A; Chen, X; Johnson, GVW; Jope, RS. "Direct, synergistic interaction of glycogen synthase kinase-3B and p53 after DNA damage". Proceedings of the National Academy of Sciences, USA. 2002; 99: 7951-7955.
2001 Dec 7
Mookherjee P, Johnson GV. "Tau phosphorylation during apoptosis of human SH-SY5Y neuroblastoma cells." Brain research. 2001 Dec 7; 921(1-2):31-43.
2001 Oct 15
Shelton SB, Johnson GV. "Tau and HMW tau phosphorylation and compartmentalization in apoptotic neuronal PC12 cells." Journal of neuroscience research. 2001 Oct 15; 66(2):203-13.
2001 Sep 15
Stoothoff WH, Johnson GV. "Hyperosmotic stress-induced apoptosis and tau phosphorylation in human neuroblastoma cells." Journal of neuroscience research. 2001 Sep 15; 65(6):573-82.
2001 Jun 15
Shen Y, Lue L, Yang L, Roher A, Kuo Y, Strohmeyer R, Goux WJ, Lee V, Johnson GV, Webster SD, Cooper NR, Bradt B, Rogers J. "Complement activation by neurofibrillary tangles in Alzheimer's disease." Neuroscience letters. 2001 Jun 15; 305(3):165-8.
2001 Jun 8
De Sarno P, Lesort M, Bijur GN, Johnson GV, Jope RS. "Cholinergic- and stress-induced signaling activities in cells overexpressing wild-type and mutant presenilin-1." Brain research. 2001 Jun 8; 903(1-2):226-30.
2001 Jun
Chun W, Lesort M, Tucholski J, Faber PW, MacDonald ME, Ross CA, Johnson GV. "Tissue transglutaminase selectively modifies proteins associated with truncated mutant huntingtin in intact cells." Neurobiology of disease. 2001 Jun; 8(3):391-404.
2001 Apr 2
Chun W, Lesort M, Tucholski J, Ross CA, Johnson GV. "Tissue transglutaminase does not contribute to the formation of mutant huntingtin aggregates." The Journal of cell biology. 2001 Apr 2; 153(1):25-34.
2001 Jan 26
Grierson AJ, Johnson GV, Miller CC. "Three different human tau isoforms and rat neurofilament light, middle and heavy chain proteins are cellular substrates for transglutaminase." Neuroscience letters. 2001 Jan 26; 298(1):9-12.
Hartigan, JA; Xiong W-C; Johnson, GVW. "Glycogen synthase kinase 3B is tyrosine phosphorylated by PYK2". Biochemical Biophysical Research Communications. 2001; 284: 485-489.
Shelton, S.B. and Johnson, G.V.W. "Tau and HMW tau phosphorylation and compartmentalization in apoptotic neuronal PC12 cells,". Journal of Neuroscience Research. 2001; : 203-213.
Tucholski J, Lesort M, Johnson GV. "Tissue transglutaminase is essential for neurite outgrowth in human neuroblastoma SH-SY5Y cells." Neuroscience. 2001 102(2):481-91.
2000 Dec
Zhang J, Johnson GV. "Tau protein is hyperphosphorylated in a site-specific manner in apoptotic neuronal PC12 cells." Journal of neurochemistry. 2000 Dec; 75(6):2346-57.
2000 Sep 1
Krishnamurthy PK, Mays JL, Bijur GN, Johnson GV. "Transient oxidative stress in SH-SY5Y human neuroblastoma cells results in caspase dependent and independent cell death and tau proteolysis." Journal of neuroscience research. 2000 Sep 1; 61(5):515-23.
2000 Apr
Jenkins SM, Johnson GV. "Microtubule/MAP-affinity regulating kinase (MARK) is activated by phenylarsine oxide in situ and phosphorylates tau within its microtubule-binding domain." Journal of neurochemistry. 2000 Apr; 74(4):1463-8.
2000 Jan 15
Jenkins SM, Zinnerman M, Garner C, Johnson GV. "Modulation of tau phosphorylation and intracellular localization by cellular stress." The Biochemical journal. 2000 Jan 15; 345 Pt 2:263-70.
Lesort, M; Tucholski, J Miller, ML; Johnson, GVW. "Tissue transglutaminase: A possible role in neurodegenerative diseases". Progess in Neurobiology. 2000; 61: 439-463.
Lesort, M; Tucholski, J; Zhang, J; Johnson, GVW. "The mitochondrial toxin 3-nitroproprionic acid results in increase tissue transglutaminase activity in situ". Journal of Neurochemistry. 2000; 75: 1954-1961.
Jenkins, S.M., Zinnerman, M., Garner, C. and Johnson, G.V.W. "Osmotic stress increases tau phosphorylation independent of stress-activated protein kinase activation". Biochemical Journal. 2000; 345: 263-270.
Lesort M, Johnson GV. "Insulin-like growth factor-1 and insulin mediate transient site-selective increases in tau phosphorylation in primary cortical neurons." Neuroscience. 2000 99(2):305-16.
1999 Dec 10
Davis PK, Johnson GV. "The microtubule binding of Tau and high molecular weight Tau in apoptotic PC12 cells is impaired because of altered phosphorylation." The Journal of biological chemistry. 1999 Dec 10; 274(50):35686-92.
1999 Nov 1
Zhang J, Tucholski J, Lesort M, Jope RS, Johnson GV. "Novel bimodal effects of the G-protein tissue transglutaminase on adrenoreceptor signalling." The Biochemical journal. 1999 Nov 1; 343 Pt 3:541-9.
1999 Nov
Jenkins SM, Johnson GV. "Modulation of tau phosphorylation within its microtubule-binding domain by cellular thiols." Journal of neurochemistry. 1999 Nov; 73(5):1843-50.
1999 Nov
Tucholski J, Kuret J, Johnson GV. "Tau is modified by tissue transglutaminase in situ: possible functional and metabolic effects of polyamination." Journal of neurochemistry. 1999 Nov; 73(5):1871-80.
1999 Nov
Lesort M, Chun W, Johnson GV, Ferrante RJ. "Tissue transglutaminase is increased in Huntington's disease brain." Journal of neurochemistry. 1999 Nov; 73(5):2018-27.
1999 Sep 10
Miller ML, Johnson GV. "Rapid, single-step procedure for the identification of transglutaminase-mediated isopeptide crosslinks in amino acid digests." Journal of chromatography. B, Biomedical sciences and applications. 1999 Sep 10; 732(1):65-72.
1999 Jul 23
Hartigan JA, Johnson GV. "Transient increases in intracellular calcium result in prolonged site-selective increases in Tau phosphorylation through a glycogen synthase kinase 3beta-dependent pathway." The Journal of biological chemistry. 1999 Jul 23; 274(30):21395-401.
1999 May 15
Davis PK, Johnson GV. "Energy metabolism and protein phosphorylation during apoptosis: a phosphorylation study of tau and high-molecular-weight tau in differentiated PC12 cells." The Biochemical journal. 1999 May 15; 340 ( Pt 1):51-8.
1999 Apr
Mashburn NA, Unlap MT, Runquist J, Alderman A, Johnson GV, Bell PD. "Altered protein kinase C activation of Na+/Ca2+ exchange in mesangial cells from salt-sensitive rats." The American journal of physiology. 1999 Apr; 276(4 Pt 2):F574-80.
1999 Feb
Lesort M, Jope RS, Johnson GV. "Insulin transiently increases tau phosphorylation: involvement of glycogen synthase kinase-3beta and Fyn tyrosine kinase." Journal of neurochemistry. 1999 Feb; 72(2):576-84.
Woolf, NJ; Zinnerman, MD; Johnson, GVW. "Hippocampal microtubule-associated protein-2 alterations with contextual memory". Brain Research. 1999; 241: 241-249.
Hensley, K., Floyd, R.A., Zheng, N.-Y., Nael, R., Robinson, K., Nguyen, X., Pye, Q.N., Stewart, C.A., Geddes, J., Markesbery, W.R., Patel, E., Johnson, G.V.W. and Bing. "p38 kinase is activated in Alzheimer's Disease brain". Journal of Neurochemistry. 1999; : 2047-2052.
Guttmann, RP; Johnson, GVW. ""Calpain-mediated proteolysis of neuronal structural proteins"." The Pharmacology and Toxicology of Calpain. 1999; : 229-249.
Lesort M, Greendorfer A, Stockmeier C, Johnson GV, Jope RS. "Glycogen synthase kinase-3beta, beta-catenin, and tau in postmortem bipolar brain." Journal of neural transmission. 1999 106(11-12):1217-22.
1998 Jul 15
Xie HQ, Johnson GV. "Calcineurin inhibition prevents calpain-mediated proteolysis of tau in differentiated PC12 cells." Journal of neuroscience research. 1998 Jul 15; 53(2):153-64.
1998 Jul 6
Xie H, Litersky JM, Hartigan JA, Jope RS, Johnson GV. "The interrelationship between selective tau phosphorylation and microtubule association." Brain research. 1998 Jul 6; 798(1-2):173-83.
1998 Jul
Zhang J, Guttmann RP, Johnson GV. "Tissue transglutaminase is an in situ substrate of calpain: regulation of activity." Journal of neurochemistry. 1998 Jul; 71(1):240-7.
1998 May 15
Lesort M, Attanavanich K, Zhang J, Johnson GV. "Distinct nuclear localization and activity of tissue transglutaminase." The Journal of biological chemistry. 1998 May 15; 273(20):11991-4.
Jenkins, SM; Johnson, GVW. "Tau interacts with phospholipase C-y ?in situ". NeuroReport. 1998; 17: 67-71.
Zhang, J; Lesort, M; Guttmann, RP; Johnson, GVW. "Modulation of the in situ activity of tissue transglutaminase by calcium and GTP". Journal of Biological Chemistry. 1998; 278: 2288-2295.
Guttmann, RP; Johnson, GVW. "Oxidative stress inhibits calpain activity in situ". Journal of Biological Chemistry. 1998; 278: 13331-13338.
Spear, N; Estevez, AG; Johnson, GVW; Breseden, DE; Thonpson, JA; Beckman, JS. "Enhancement of peroxynitrite-induced apoptosis in PC12 cells by fibroblast growth factor-1 and nerve growth factor requires p21Ras activation and is supressed by Bcl-2". Archives of Biochemistry and Biophysics. 1998; 355: 41-45.
Johnson, GVW; Hartigan, JA. "Tau protein in normal and Alzheimer's disease brain: An update". Alzheimer's Disease Reviews (Also published in Journal of Alzheimer's Disease 1:329-351, 1999). 1998; 3: 125-141.
1997 Nov
Johnson GV, Guttmann RP. "Calpains: intact and active?" BioEssays : news and reviews in molecular, cellular and developmental biology. 1997 Nov; 19(11):1011-8.
1997 Sep 5
Jenkins SM, Johnson GV. "Phosphorylation of microtubule-associated protein tau on Ser 262 by an embryonic 100 kDa protein kinase." Brain research. 1997 Sep 5; 767(2):305-13.
1997 Sep
Xie H, Johnson GV. "Ceramide selectively decreases tau levels in differentiated PC12 cells through modulation of calpain I." Journal of neurochemistry. 1997 Sep; 69(3):1020-30.
1997 Jul
Spear N, Estévez AG, Barbeito L, Beckman JS, Johnson GV. "Nerve growth factor protects PC12 cells against peroxynitrite-induced apoptosis via a mechanism dependent on phosphatidylinositol 3-kinase." Journal of neurochemistry. 1997 Jul; 69(1):53-9.
1997 Jun
Davis PK, Dudek SM, Johnson GV. "Select alterations in protein kinases and phosphatases during apoptosis of differentiated PC12 cells." Journal of neurochemistry. 1997 Jun; 68(6):2338-47.
1997 Mar 21
Johnson GV, Cox TM, Lockhart JP, Zinnerman MD, Miller ML, Powers RE. "Transglutaminase activity is increased in Alzheimer's disease brain." Brain research. 1997 Mar 21; 751(2):323-9.
1997 Jan 17
Guttmann RP, Elce JS, Bell PD, Isbell JC, Johnson GV. "Oxidation inhibits substrate proteolysis by calpain I but not autolysis." The Journal of biological chemistry. 1997 Jan 17; 272(3):2005-12.
1997 Jan
Johnson GV, Seubert P, Cox TM, Motter R, Brown JP, Galasko D. "The tau protein in human cerebrospinal fluid in Alzheimer's disease consists of proteolytically derived fragments." Journal of neurochemistry. 1997 Jan; 68(1):430-3.
Jenkins, SM; Johnson, GVW. "Involvement of the low-affinity neurotrophin receptor (p75NTR) in apoptosis of differentiated PC12 cells". Neuroscience Research Communications. 1997; 20: 137-146.
Johnson, G.V.W. and Fleming, L.M. "Analysis of the phosphorylation state of tau in situ". Function and Malfunction of the Tau Proteins: Concepts and Approaches. 1997; : 313-329.
1996 Nov 15
Arnold CS, Johnson GV, Cole RN, Dong DL, Lee M, Hart GW. "The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine." The Journal of biological chemistry. 1996 Nov 15; 271(46):28741-4.
1996 Jun 1
Litersky JM, Johnson GV, Jakes R, Goedert M, Lee M, Seubert P. "Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within its microtubule-binding domains at Ser-262 and Ser-356." The Biochemical journal. 1996 Jun 1; 316 ( Pt 2):655-60.
1996 Apr
Fleming LM, Weisgraber KH, Strittmatter WJ, Troncoso JC, Johnson GV. "Differential binding of apolipoprotein E isoforms to tau and other cytoskeletal proteins." Experimental neurology. 1996 Apr; 138(2):252-60.
Johnson, GVW; Jenkins, SM. "Tau protein in normal and Alzheimer's disease brain". Alzheimer's Disease Reviews (Also published in Journal of Alzheimer's Disease 1:307-328, 1999). 1996; 1: 38-54.
Johnson, G.V.W. and Litersky, J.M. "Phosphorylation of tau protein". Recent Research Developments in Neurochemistry. 1996; 1: 89-98.
1995 Dec 21
Dudek SM, Johnson GV. "Postnatal changes in serine/threonine protein phosphatases and their association with the microtubules." Brain research. Developmental brain research. 1995 Dec 21; 90(1-2):54-61.
1995 Oct
Greenwood JA, Johnson GV. "Localization and in situ phosphorylation state of nuclear tau." Experimental cell research. 1995 Oct; 220(2):332-7.
1995 Oct
Miller ML, Johnson GV. "Transglutaminase cross-linking of the tau protein." Journal of neurochemistry. 1995 Oct; 65(4):1760-70.
1995 Aug 11
Seubert P, Mawal-Dewan M, Barbour R, Jakes R, Goedert M, Johnson GV, Litersky JM, Schenk D, Lieberburg I, Trojanowski JQ. "Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau." The Journal of biological chemistry. 1995 Aug 11; 270(32):18917-22.
1995 Aug
Litersky JM, Johnson GV. "Phosphorylation of tau in situ: inhibition of calcium-dependent proteolysis." Journal of neurochemistry. 1995 Aug; 65(2):903-11.
1995 Jul 1
Fleming LM, Johnson GV. "Modulation of the phosphorylation state of tau in situ: the roles of calcium and cyclic AMP." The Biochemical journal. 1995 Jul 1; 309 ( Pt 1):41-7.
1995 Mar
Guttmann RP, Erickson AC, Johnson GV. "Tau self-association: stabilization with a chemical cross-linker and modulation by phosphorylation and oxidation state." Journal of neurochemistry. 1995 Mar; 64(3):1209-15.
Johnson, GVW; Greenwood, JA. "Understanding the hyperphosphorylation of tau in Alzheimer's disease: Importance of examining site-specific phosphorylation in non-disease system". Neurobiology of Aging. 1995; 16: 371-374.
Troncoso, JC; Costello, AC; Kim, JH; Johnson, GVW. "Metal-catalyzed oxidation of bovine neurofilaments in vitro". Free Radicals in Biology and Medicine. 1995; 18: 891-899.
1994 Jul 18
Dudek SM, Johnson GV. "Transglutaminase facilitates the formation of polymers of the beta-amyloid peptide." Brain research. 1994 Jul 18; 651(1-2):129-33.
1994 Feb 11
Greenwood JA, Scott CW, Spreen RC, Caputo CB, Johnson GV. "Casein kinase II preferentially phosphorylates human tau isoforms containing an amino-terminal insert. Identification of threonine 39 as the primary phosphate acceptor." The Journal of biological chemistry. 1994 Feb 11; 269(6):4373-80.
Norman, SPG; Johnson, GVW. "Compromised mitochondrial function results in dephosphorylation of tau through a calcium-dependent process in rat brain cerebral cortical slices." Neurochemical Research. 1994; 19: 1149-1156.
Woolf, NJ; Young, SL; Johnson, GVW; Fanselow, MS. "Pavlovian conditioning alters cortical patterns of microtubule-associated protein-2 immunoreactivity and cell morphometry". NeuroReports. 1994; 5: 1045-1048.
Davis, PK; Johnson, GVW. "The monoclonal antibody Alz-50 reacts with bovine and human serum albumin". Neuroscience Research. 1994; 39: 589-594.
1993 Sep
Dudek SM, Johnson GV. "Transglutaminase catalyzes the formation of sodium dodecyl sulfate-insoluble, Alz-50-reactive polymers of tau." Journal of neurochemistry. 1993 Sep; 61(3):1159-62.
1993 Jul
Greenwood JA, Troncoso JC, Costello AC, Johnson GV. "Phosphorylation modulates calpain-mediated proteolysis and calmodulin binding of the 200-kDa and 160-kDa neurofilament proteins." Journal of neurochemistry. 1993 Jul; 61(1):191-9.
1993 Jun 11
Troncoso JC, Costello A, Watson AL, Johnson GV. "In vitro polymerization of oxidized tau into filaments." Brain research. 1993 Jun 11; 613(2):313-6.
1993 Apr 15
Johnson GV, Foley VG. "Calpain-mediated proteolysis of microtubule-associated protein 2 (MAP-2) is inhibited by phosphorylation by cAMP-dependent protein kinase, but not by Ca2+/calmodulin-dependent protein kinase II." Journal of neuroscience research. 1993 Apr 15; 34(6):642-7.
1993 Mar
Erickson AC, Johnson GV. "Metal (Fe3+) affinity chromatography: differential adsorption of tau phosphoproteins." Journal of neuroscience methods. 1993 Mar; 46(3):245-9.
1993 Feb 26
Litersky JM, Scott CW, Johnson GV. "Phosphorylation, calpain proteolysis and tubulin binding of recombinant human tau isoforms." Brain research. 1993 Feb 26; 604(1-2):32-40.
1992 Dec
Johnson GV. "Differential phosphorylation of tau by cyclic AMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase II: metabolic and functional consequences." Journal of neurochemistry. 1992 Dec; 59(6):2056-62.
1992 Dec
Johnson GV, Jope RS. "The role of microtubule-associated protein 2 (MAP-2) in neuronal growth, plasticity, and degeneration." Journal of neuroscience research. 1992 Dec; 33(4):505-12.
1992 Oct
Khilko S, Greenwood JA, Johnson GV. "Brain casein kinase 2: affinity purification procedure using immobilized polyethylenimine." Protein expression and purification. 1992 Oct; 3(5):355-61.
1992 Jan 25
Litersky JM, Johnson GV. "Phosphorylation by cAMP-dependent protein kinase inhibits the degradation of tau by calpain." The Journal of biological chemistry. 1992 Jan 25; 267(3):1563-8.
Jope, RS; Johnson, GVW. "Neurotoxic effects of dietary aluminum, in Aluminum in Biology and Medicine, Cibia Foundation Symposium, No. 169". John Wiley & Sons, Inc., N.Y. 1992; : 254-267.
Kolasa K, Jope RS, Baird MS, Johnson GV. "Alterations of choline acetyltransferase, phosphoinositide hydrolysis, and cytoskeletal proteins in rat brain in response to colchicine administration." Experimental brain research. 1992 89(3):496-500.
Johnson GV, Watson AL, Lartius R, Uemura E, Jope RS. "Dietary aluminum selectively decreases MAP-2 in brains of developing and adult rats." Neurotoxicology. 1992 13(2):463-74.
1991 Nov
Johnson GV, Litersky JM, Whitaker JN. "Proteolysis of microtubule-associated protein 2 and tubulin by cathepsin D." Journal of neurochemistry. 1991 Nov; 57(5):1577-83.
1991 Aug
Johnson GV, Greenwood JA, Costello AC, Troncoso JC. "The regulatory role of calmodulin in the proteolysis of individual neurofilament proteins by calpain." Neurochemical research. 1991 Aug; 16(8):869-73.
1991 May
Johnson GV, Litersky JM, Jope RS. "Degradation of microtubule-associated protein 2 and brain spectrin by calpain: a comparative study." Journal of neurochemistry. 1991 May; 56(5):1630-8.
Jope RS, Johnson GV, Baird MS. "Seizure-induced protein tyrosine phosphorylation in rat brain regions." Epilepsia. 1991 32(6):755-60.
Johnson GV, Cogdill KW, Jope RS. "Oral aluminum alters in vitro protein phosphorylation and kinase activities in rat brain." Neurobiology of aging. 1990 11(3):209-16.
1989 Sep 29
Johnson GV, Jope RS, Binder LI. "Proteolysis of tau by calpain." Biochemical and biophysical research communications. 1989 Sep 29; 163(3):1505-11.
1989 Jul
Johnson GV, Li XH, Jope RS. "Aluminum increases agonist-stimulated cyclic AMP production in rat cerebral cortical slices." Journal of neurochemistry. 1989 Jul; 53(1):258-63.
Caputo, CB; Sygowski, LA; Scott, CW; Johnson, GVW; Brunner, WF; Salama, AI. "Changes in protein kinase activities following aluminum administration to aged rats". Brain Dysfunction. 1989; : 297-309.
1988 Aug
Johnson GV, Simonato M, Jope RS. "Dose- and time-dependent hippocampal cholinergic lesions induced by ethylcholine mustard aziridinium ion: effects of nerve growth factor, GM1 ganglioside, and vitamin E." Neurochemical research. 1988 Aug; 13(8):685-92.
1988 Jul 19
Johnson GV, Jope RS. "Phosphorylation of rat brain cytoskeletal proteins is increased after orally administered aluminum." Brain research. 1988 Jul 19; 456(1):95-103.
Johnson, GVW. "The effects of aluminum on agonist-induced alterations in cyclic AMP and cyclic GMP concentrations in rat brain regions in vivo". Toxicology 51. 1988; 51: 299-308.
1987 May
Stanton TL, Johnson GV. "In vitro measurements of cholinergic activity in brain regions of hibernating ground squirrels." Brain research bulletin. 1987 May; 18(5):663-7.
1987 Feb 10
Johnson GV, Jope RS. "Aluminum alters cyclic AMP and cyclic GMP levels but not presynaptic cholinergic markers in rat brain in vivo." Brain research. 1987 Feb 10; 403(1):1-6.
Jope, RS; Casebolt, TL; Johnson, GVW. "Modulation of carbachol-stimulated phosphoinositide hydrolysis in rat cerebral cortex". Journal of Neurochemical Research. 1987; 12: 693-700.
1986 Oct 6
Johnson GV, Jope RS. "Aluminum increases cyclic AMP in rat cerebral cortex in vivo." Life sciences. 1986 Oct 6; 39(14):1301-5.
1986 Jul
Johnson GV, Jope RS. "Aluminum impairs glucose utilization and cholinergic activity in rat brain in vitro." Toxicology. 1986 Jul; 40(1):93-102.
1986 May
Freerksen DL, Schroedl NA, Johnson GV, Hartzell CR. "Increased aerobic glucose oxidation by cAMP in cultured regenerated skeletal myotubes." The American journal of physiology. 1986 May; 250(5 Pt 1):C713-9.
1986 Jan
Jope RS, Johnson GV. "Quinacrine and 2-(4-phenylpiperidino)cyclohexanol (AH5183) inhibit acetylcholine release and synthesis in rat brain slices." Molecular pharmacology. 1986 Jan; 29(1):45-51.
1985 Jun
Johnson GV, Hartzell CR. "Halothane-induced alterations of glucose and pyruvate metabolism in rat cerebra synaptosomes." Journal of neurochemistry. 1985 Jun; 44(6):1838-44.
1985 Apr
Johnson GV, Hartzell CR. "Choline uptake, acetylcholine synthesis and release, and halothane effects in synaptosomes." Anesthesia and analgesia. 1985 Apr; 64(4):395-9.
1985 Apr
Hartzell CR, Johnson GV. "In vivo MAC values and in vitro experimentation." Anesthesia and analgesia. 1985 Apr; 64(4):386-7.
Johnson, GVW; Bailey, CDC; Tucholski, J; Lesort, M. "Tissue transglutaminase in neurodegenerative diseases". Minerva Biotechnologica. : 14171-176.
Clodfelder-Miller, BJ; Zmijewska, AA; Johnson, GVW; Jope, RS. "Tau is hyperphosphorylated at multiple sites in mouse brain in vivo after streptozotocin-induced insulin deficiency". Diabetes. .


Bailey, CDC; Tucholski, J; Johnson, GVW. "Transglutaminases in neurodegenerative disorders". Transglutaminases: the family of enzymes with diverse functions Progress in Expe. K. Mehta and R. Eckert. : Karger Publishers, 2005. 139-157
Guttmann, RP; Johnson, GVW. ""Measurement of calpain activity in vitro and in situ using a fluorescent compound and tau protein as substrates".". Calpain Methods & Protocols: Methods in Molecular Biology. : Calpain Methods & Protocols: Methods in Molecular Biology, 1999.
Guttmann, RP; Johnson, GVW. "Calpain-mediated proteolysis of neuronal structural proteins". The Pharmacology and Toxicology of Calpain. K.K.W. Wang and P. Yuen. NY: Taylor and Francis Publishers, 1999. 229-249
Guttmann, RP; Johnson, GVW. "Measurement of calpain activity in vitro and in situ using a fluorescent compound and tau protein as substrates". Calpain Methods & Protocols: Methods in Molecular Biology. J.S. Elce. Totowa, NJ: Humana Press, Inc., 1999.
Johnson, GVW; Davis, PK. "Protein phosphorylation". Neuromethods, General Techniques In Vitro, Molecular. A.A. Boulton and G.B. Baker. Totowa, NJ: Humana Press, Inc, 1998. 217-256
Johnson, GVW; Fleming, LM. "Analysis of the phosphorylation state of tau in situ". Function and Malfunction of the Tau Proteins: Concepts and Approaches. J. Avila, R. Brandt and K. Kosik. Amsterdam, The Netherlands: Harwood Academic Publishers, 1997. 313-329