Axel W. E. Wismueller, M.D., M.Sc., Ph.D.

Axel W. E. Wismueller, M.D., M.Sc., Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 648
Rochester, NY 14642

Office: (585) 613-2399

Professional Bio

Dr. Wismueller is Professor of Radiology and Biomedical Engineering at the University of Rochester Medical Center, where he directs the Computational Radiology Laboratory at the Department of Imaging Sciences. He received his M.D. (Dr. med.) degree from the Technical University of Munich, School of Medicine, in 1992, which included a scientific dissertation in neurology. In addition, he received a M.Sc. degree (Dipl.-Phys. Univ.) in Physics from the Ludwig Maximilians University Munich in 1996 for a scientific thesis on pattern recognition. From 1997 to 2005, he completed his radiology residency and a fellowship in Diagnostic Radiology at the Ludwig Maximilians University Medical Center in Munich, where he founded and established an interdisciplinary research team on digital image processing in radiology. In 2006, he received a Ph.D. degree (Dr. rer. nat.) from the Department of Electrical and Computer Engineering at the Technical University of Munich for a scientific dissertation on a novel pattern recognition algorithm invented by him (Exploratory Observation Machine - XOM), for which he holds several national and international patents.

Dr. Wismueller is author of more than 170 peer-reviewed scientific publications, holds U.S. and European medical licenses, multiple national and international patents, American and German Board Certifications in Diagnostic Radiology, a state doctorate (Habilitation) and an adjunct professorship (Privatdozent) with venia legendi for radiology at the Ludwig Maximilians University Munich.

Dr. Wismueller is the Principal Investigator of a recently granted active National Institutes of Health (NIH) R01 Award on "Brain connectivity in HIV-related cognitive impairment." Supported by NIDA and its AIDS research program and co-funded by the German Ministry of Research, this project focuses on developing a novel analysis approach for exploring information transfer in the human brain based on functional MRI neuro-imaging studies.

Based on his dual professional qualification in both science and medicine, Dr. Wismueller's main research interest is focused on innovative strategies for computational radiology. He is internationally known for his accomplishments in developing novel data exploration, pattern recognition, visualization, and machine learning methods for biomedical imaging. He introduced unsupervised learning techniques to image sequence processing with numerous clinical applications to functional MRI neuroimaging for human brain mapping, breast cancer workup, molecular imaging analysis, and the diagnosis of stroke.

Dr. Wismueller is an active member of multiple national and international professional societies in both medicine and engineering, such as RSNA and SPIE. He has organized multiple scientific conferences and special focus sessions at major international research conventions, has been active in numerous scientific program committees and as a scientific reviewer for highly renowned journals and conferences, and has served on numerous academic and administrative committees in both the U.S and Europe.

Dr. Wismueller has successfully supervised scientific theses of more than 30 Ph.D. and M.Sc. degree students from engineering, computer science, mathematics, biology, and academic medicine at both leading U.S. and European universities, and has advised three post-doctoral fellows. He has led multiple research studies on big data analysis in computational radiology, including a comprehensive research, publication, and funding track record. Besides several NIH-funded awards, he has served as Principal Investigator in a multi-center Translational Research Network Award of the Clinical and Translational Science Institute and in several NYSTAR-funded public-private research projects on biomedical imaging with leading industry partners.

Awards & Honors (National)

Principal Investigator, National Institutes of Health (NIH)/NIDA R01 Award | Brain Connectivity in HIV-Related Cognitive Impairment | Supported by NIDA and co-funded by German Ministry of Research 2012 - Present

Awards & Honors (Local)

Harry W. Fischer Funds Award, University of Rochester Medical Center | Imaging for Oncoplastic Resections of Breast Cancer 2012
Upstate New York Translational Research Network (UNYTRN) Award | Clinical and Translational Sciences Institute (CTSI) | Multidimensional Imaging for Breast Cancer Diagnosis 2011
Center for Emerging and Innovative Sciences (CEIS) Research Award | Funded by NYSTAR | Computer-Aided Analysis of Interstitial Lung Disease Patterns 2010
Charles and Janet Forbes Entrepreneurial Award for Biomedical Engineering Senior Design Project | Department of Biomedical Engineering, University of Rochester | Transportation Device for Urinalysis by Raman Spectroscopy 2008
Ludwig Maximilians University Munich Research Grant | Intelligent MRI Data Analysis 2003 - 2005
German Research Council (DFG) Graduate Research Program Award | Speech, Mimics and Motion in Technical Information Systems 2000 - 2003
Max Planck Institute of Psychiatry Grant Award | Segmentation of White Matter Lesions from Multispectral MRI Data 2000 - 2001
Institute of Phonetics Grant Award | Ludwig Maximilians University Munich | MRI of the Human Vocal Tract 1999
Novartis Pharmaceutical Corporation Grant Award | Segmentation of Lower Extremity Edema in MRI Data 1999
Max Planck Institute of Psychiatry Grant Award | Explorative Analysis of Functional MRI Data of the Human Brain 1998
Marconi Corporation Grant Award | MRI Segmentation and Registration 1998 - 1999
Hanns Seidel Foundation, Senior Laureate Fellow 1997 - Present
Wacker Chemical Corporation Research Grant Award | Intelligent control of chemical waste combustion plants 1996
Hanns Seidel Foundation Postgraduate Fellowship Award 1996 - 1997
Hanns Seidel Foundation Scientific Conference Organization Grant Award | Symp. on Biological Information Processing and Neural Networks 1995
Sun Microsystems Corporation Scientific Conference Organization Grant Award | Symp. on Biological Information Processing and Neural Networks 1995
Hanns Seidel Foundation Undergraduate Fellowship Award 1985 - 1989
State of Bavaria Scholarship Award for Outstanding Achievements 1982 - 1986

Recent Journal Articles

Showing the 5 most recent journal articles. 202 available »

Schmidt C, Pester B, Schmid-Hertel N, Witte H, Wismüller A, Leistritz L. "A Multivariate Granger Causality Concept towards Full Brain Functional Connectivity." PloS one. 2016 11(4):e0153105. Epub 2016 Apr 11.
2015 Nov
Nagarajan MB, Coan P, Huber MB, Diemoz PC, Wismüller A. "Volumetric quantitative characterization of human patellar cartilage with topological and geometrical features on phase-contrast X-ray computed tomography." Medical & biological engineering & computing. 2015 Nov; 53(11):1211-20. Epub 2015 Jul 04.
Mahesh B. Nagarajan; Paola Coan; Markus B. Huber; Paul C. Diemoz; Axel Wismüller. "Integrating dimension reduction and out-of-sample extension in automated classification of ex vivo human patellar cartilage on phase contrast X-ray computed tomography". PLOS One. 2015; D-14-25225R1. Link
Axel Wismüller; Xixi Wang; Adora M. DSouza; Susan K. Hobbs; Lutz Leistritz; Mahesh B. Nagarajan. "Nonlinear Functional Connectivity Network Recovery in the Human Brain with Mutual Connectivity Analysis (MCA): Convergent Cross-Mapping and Non-Metric Clustering". Proc. of SPIE. 2015; 9417(doi:10.1117/12.2082124). Link
Axel Wismüller; Adora M. DSouza; Anas Z. Abidin; Xixi Wang; Susan K. Hobbs; Mahesh B. Nagarajan. "Functional Connectivity Analysis in Resting State fMRI with Echo-State Networks and Non-Metric Clustering for Network Structure Recovery". Proc. of SPIE. 2015; 9417(doi:10.1117/12.2082106). Link

Current Appointments

Professor - Department of Imaging Sciences (SMD) - Primary
Professor - Department of Electrical & Computer Engineering (RC)


Diagnostic Radiology - American Board of Radiology


American Board of Radiology | Diagnostic Radiology2013
Venia legendi (Privatdozent) | Radiology | Germany - Ludwig Maximilians University Munich2010
Habilitation | Radiology | Germany - Ludwig Maximilians University Munich2009
Educational Commission for Foreign Medical Graduates (ECFMG) Certificate | Medicine | U.S.A.2008
PhD | Electrical and Computer Engineering | Germany - Technical University of Munich2006
Board Certification | Radiology (Facharzt für Radiologie) | Germany - Bavarian Council of Physicians2005
MSc | Physics | Germany - Ludwig Maximilians University Munich1996
MD | Medicine | Germany - Technical University of Munich1992

Post-Doctoral Training & Residency

Fellowship in Radiology at University Hospitals04/01/2005 - 01/31/2007
Residency in Radiology at University Hospitals01/01/1997 - 03/31/2005
Residency in Internal Medicine at University Hospitals07/01/1989 - 12/31/1990