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Joshua C. Munger, Ph.D.

Contact Information

Phone Numbers

Office: (585) 273-4800

Fax: (585) 275-6007

Research Labs

Faculty Appointments

Biography

Research

A major focus of our laboratory is human cytomegalovirus (HCMV), a herpes virus, which is the leading cause of congenital viral infection, occurring in approximately 1% of all live births. Congenital HCMV infection results in central nervous system damage in the majority of symptomatic newborns. HCMV infection also poses a serious health risk to immunosuppressed individuals, increasing morbidity in the elderly and in patients receiving immunosuppressive chemotherapy, including cancer patients, transplant recipients, and AIDS patients.
The majority of the projects in our lab study the interfaces between viruses and the host cell that determine the outcome of infection. Specifically, we focus on how viruses usurp cellular metabolic controls and subvert cellular anti-viral signaling to support productive infection. The goal of our laboratory is to increase our mechanistic understanding of these processes to identify novel avenues for therapeutic intervention that could prevent virally-associated pathogenesis.

Publications

Journal Articles

9/18/2019
Goodwin CM, Schafer X, Munger J. "U26 attenuates IKK?-mediated induction of ISG expression and enhanced protein ISGylation during HCMV infection." Journal of virology.. 2019 Sep 18; Epub 2019 Sep 18.

5/22/2019
"mTOR dysregulation by vaccinia virus F17 controls multiple processes with varying roles in infection." Journal of virology.. 2019 May 22; Epub 2019 May 22.

3/19/2019
Rodríguez-Sánchez I, Munger J. "Meal for Two: Human Cytomegalovirus-Induced Activation of Cellular Metabolism." Viruses.. 2019 Mar 19; 11(3)Epub 2019 Mar 19.

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