Thomas J. Mariani, Ph.D.

Thomas J. Mariani, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 651
Rochester, NY 14642

Office: (585) 276-4616
Fax: (585) 276-2642

Lab Information

Mariani Lab

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Research Bio

Premature infant morbidity and mortality often results from pulmonary complications, primarily insufficient lung maturation or alveolar formation. Likewise, many adult lung diseases involve obliteration of the distal respiratory structure. With the advent of clinical means to dramatically improve pre-term infant survival, there has been a growing appreciation of a relationship between developmental complications and susceptibility to chronic lung disease. The broad objectives of Dr. Mariani's laboratory are to identify the genetic mechanisms of susceptibility to chronic lung diseases, particularly focusing upon their developmental antecedents and the influence of environmental factors. Dr. Mariani's research program focuses upon defining regulatory networks involved in lung development and maturation, and which may be perturbed in diseased states. His laboratory uses a combination of animal modeling research and studies of human subjects. He is a leader in the application of gene expression array methods to pulmonary biology and lung disease. Current research projects in the Mariani lab include:



1. Defining genetic regulatory networks contributing to airspace morphogenesis using the FGFR3/4 mutant mouse model of abnormal alveolar formation.

2. Determining the physiological role of PPARg in lung epithelial cells during airspace formation and in lung injury/repair.

3. Investigating the cellular and molecular mechanisms by which the protease inhibitor SERPINE2 contributes to airspace formation and susceptibility to COPD.

This work is currently supported by the NIH and FAMRI.

Awards & Honors (National)

Mentored 2nd place winner - Respiratory Disease Young Investigators' Forum 2006
Mentored 1st place winner - Respiratory Disease Young Investigators' Forum 2005
Parker B. Francis Fellowship in Pulmonary Research 2000 - 2003
Novartis (Ciba) Foundation Bursar | Ciba 1994 - 1994
Individual National Research Service Award | NHLBI 1994 - 1997

Recent Journal Articles

Showing the 5 most recent journal articles. 75 available »

2016 Jul 18
Misra RS, Bhattacharya S, Huyck HL, Wang JE, Slaunwhite CG, Slaunwhite SL, Wightman TR, Secor-Socha S, Misra SK, Bushnell TP, Reynolds AM, Ryan RM, Quataert SA, Pryhuber GS, Mariani TJ. "Flow-based sorting of neonatal lymphocyte populations for transcriptomics analysis." Journal of immunological methods. 2016 Jul 18; Epub 2016 Jul 18.
2016 Jul
Solleti SK, Srisuma S, Bhattacharya S, Rangel-Moreno J, Bijli KM, Randall TD, Rahman A, Mariani TJ. "Serpine2 deficiency results in lung lymphocyte accumulation and bronchus-associated lymphoid tissue formation." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016 Jul; 30(7):2615-26. Epub 2016 Apr 08.
2016 Jun
Karnati S, Graulich T, Oruqaj G, Pfreimer S, Seimetz M, Stamme C, Mariani TJ, Weissmann N, Mühlfeld C, Baumgart-Vogt E. "Postnatal development of the bronchiolar club cells of distal airways in the mouse lung: stereological and molecular biological studies." Cell and tissue research. 2016 Jun; 364(3):543-57. Epub 2016 Jan 21.
2016 Jun
Ahmad A, Bhattacharya S, Sridhar A, Iqbal AM, Mariani TJ. "Recurrent copy number variants associated with bronchopulmonary dysplasia." Pediatric research. 2016 Jun; 79(6):940-5. Epub 2016 Mar 14.
2016 May
Yee M, Gelein R, Mariani TJ, Lawrence BP, O'Reilly MA. "The Oxygen Environment at Birth Specifies the Population of Alveolar Epithelial Stem Cells in the Adult Lung." Stem cells. 2016 May; 34(5):1396-406. Epub 2016 Mar 07.

Current Appointments

Professor - Department of Pediatrics, Neonatology (SMD) - Primary
Professor - Department of Environmental Medicine (SMD)

Education

PhD | Microbiology and Molecular Genetics | Rutgers University1993
B.S. | Biology | Rutgers University, Cook College1989

Post-Doctoral Training & Residency

Research Associate, Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 1998
Postdoctoral Fellow, Dermatology Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 1997