Research Bio
Premature infant morbidity and mortality often results from pulmonary complications, primarily insufficient lung maturation or alveolar formation. Likewise, many adult lung diseases involve obliteration of the distal respiratory structure. With the advent of clinical means to dramatically improve pre-term infant survival, there has been a growing appreciation of a relationship between developmental complications and susceptibility to chronic lung disease. The broad objectives of Dr. Mariani's laboratory are to identify the genetic mechanisms of susceptibility to chronic lung diseases, particularly focusing upon their developmental antecedents and the influence of environmental factors. Recent efforts have also investigated biomarkers and disease mechanisms involved in infant respiratory infection. Dr. Mariani's research program focuses upon defining regulatory networks involved in lung development and maturation, and which may be perturbed in diseased states. His laboratory uses a combination of animal modeling research and studies of human subjects. He is a leader in the application of genomics methods to pulmonary biology and lung disease. Current research projects in the Mariani lab include:
1. Studying immune cell dysregulation associated with chronic respiratory morbidity following preterm birth.
2. Identifying diagnostic biomarkers and therapeutic targets defining severity of clinical responses to respiratory syncytial virus infection in infants.
3. Determining the contribution of resident cells and the extracellular matrix to normal lung development, lung homeostasis and susceptibility to respiratory disease.
4. Characterizing the cellular and pathological effects of exposure to non-traditional tobacco-related products, particularly during childhood.
This work is currently supported by the NIH.
2016 Oct
Misra RS, Bhattacharya S, Huyck HL, Wang JE, Slaunwhite CG, Slaunwhite SL, Wightman TR, Secor-Socha S, Misra SK, Bushnell TP, Reynolds AM, Ryan RM, Quataert SA, Pryhuber GS, Mariani TJ. "Flow-based sorting of neonatal lymphocyte populations for transcriptomics analysis." Journal of immunological methods. 2016 Oct; 437:13-20. Epub 2016 Jul 18. |
2016 Jul
Solleti SK, Srisuma S, Bhattacharya S, Rangel-Moreno J, Bijli KM, Randall TD, Rahman A, Mariani TJ. "Serpine2 deficiency results in lung lymphocyte accumulation and bronchus-associated lymphoid tissue formation." FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016 Jul; 30(7):2615-26. Epub 2016 Apr 08. |
2016 Jun
Karnati S, Graulich T, Oruqaj G, Pfreimer S, Seimetz M, Stamme C, Mariani TJ, Weissmann N, Mühlfeld C, Baumgart-Vogt E. "Postnatal development of the bronchiolar club cells of distal airways in the mouse lung: stereological and molecular biological studies." Cell and tissue research. 2016 Jun; 364(3):543-57. Epub 2016 Jan 21. |
2016 Jun
Ahmad A, Bhattacharya S, Sridhar A, Iqbal AM, Mariani TJ. "Recurrent copy number variants associated with bronchopulmonary dysplasia." Pediatric research. 2016 Jun; 79(6):940-5. Epub 2016 Mar 14. |
2016 May
Yee M, Gelein R, Mariani TJ, Lawrence BP, O'Reilly MA. "The Oxygen Environment at Birth Specifies the Population of Alveolar Epithelial Stem Cells in the Adult Lung." Stem cells. 2016 May; 34(5):1396-406. Epub 2016 Mar 07. |
