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Craig Morrell, D.V.M., Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 276-7698

Office: (585) 276-7693

Fax: (585) 276-1530

Research Labs

Faculty Appointments

Biography

Professional Background

Dr. Morrell earned his undergraduate degree from Brown University in 1995. He then graduated from Tufts University School of Veterinary Medicine in 2000 before beginning a comparative pathology fellowship at The Johns Hopkins University School of Medicine. While at Hopkins Dr. Morrell concurrently completed a PhD in the laboratory of Dr. Charles Lowenstein in 2005 where he investigated molecular mechanisms of nitric oxide inhibition of platelet degranulation and received a K08 award. Dr. Morrell then established an \ independent laboratory in the Department of Molecular and Comparative Pathobiology at Hopkins from 2005-2009, before moving to the University of Rochester's Aab Cardiovascular Research Institute. His current research interests include platelets and vascular inflammation.

Research

Research in our lab is focused on the complex interface between platelets, the vasculature, and immune cells. Platelets are not only the cellular mediators of thrombosis, but also have important roles in inflammatory and immune cell responses. Ongoing and past studies by our group have examined platelet, and platelet derived inflammatory mediator interactions with both vascular and immune cells, and the impact of these interactions on tissue injury responses in disease relevant contexts. These studies demonstrated that platelets are regulators of all aspects of inflammatory responses, including the induction of acute phase responses, innate immune cell activation and trafficking, T helper cell differentiation, and B cell development. Our lab regularly uses advanced mouse models to dissect molecular interactions and vascular inflammatory signaling pathways both in vitro and in vivo, establishing our lab as leaders in understanding how platelets regulate vascular and immune cell homeostatic and inflammatory responses. Our work continues to define many novel implications for platelet immune regulation in vascular and inflammatory disease processes.

Credentials

Education

1995
Sc.B | Brown University
Biology

2000
DVM | Tufts University School of Veterinary Medicine
Veterinary Medicine

2005
PhD | The Johns Hopkins U Sch Medicine
Pathobiology

Post-doctoral Training & Residency

2000 - 2005
Department of Comparative Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD

2000 - 2005
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD

Awards

2008
Kenneth M. Brinkous Young Investigators Prize in Thrombosis Research
Location: Atherosclerosis Thrombosis and Vascular

2006
Deans Gift, A monetary research award given to new investigators of outstanding potential
Location: The Johns Hopkins University School of Medicine

2005
Travel Scholarship
Location: American Society of Clinical Investigation Annual Meeting

2005
Travel Scholarship
Location: Keystone Symposia, Cellular Biology of Atherosclerosis

2004
Young Investigator Award, Basic Science
Location: Johns Hopkins Department of Pathology Young Investigators Day

2003 - 2004
Cheif Fellow, Comparative Pathology
Location: Johns Hopkins University Department of Comparative Medicine

2003
Young Investigators Award, First Place, Experimental Disease
Location: American College of Veterinary Pathologists Annual Meeting

2000
Pathology Award-Excellence in Pathology
Location: Tufts University School of Veterinary Medicine

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Patents

Patent Title: Antigen Presenting Platelets and Methods of Eliciting an Immune Response
Patent #: 9,340,773
Issue Date: May 17, 2016
Country: United States
Invented By: Craig N Morrell

Publications

Journal Articles

12/18/2019
Hilt ZT, Ture SK, Mohan A, Arne A, Morrell CN. "Platelet-derived ?2m regulates age related monocyte/macrophage functions." Aging.. 2019 Dec 18; 11Epub 2019 Dec 18.

8/16/2019
Morrell CN, Hilt ZT, Pariser DN, Maurya P. "PAD4 and von Willebrand Factor Link Inflammation and Thrombosis." Circulation research.. 2019 Aug 16; 125(5):520-522. Epub 2019 Aug 15.

6/17/2019
Dugbartey GJ, Quinn B, Luo L, Mickelsen DM, Ture SK, Morrell CN, Czyzyk J, Doyley MM, Yan C, Berk BC, Korshunov VA. "The Protective Role of Natriuretic Peptide Receptor 2 against High Salt Injury in the Renal Papilla." The American journal of pathology.. 2019 Jun 17; Epub 2019 Jun 17.

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