Zhenzhi Tang, Ph.D.

Zhenzhi Tang, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 673
Rochester, NY 14642

Lab: (585) 275-7108

Professional Bio

Feb 2014-Present Research Assistant Professor,
University of Rochester, Department of Neurology
Project advisor: Dr. Charles Thornton

July 2009-Jan 2014 Postdoctoral fellow,
University of Rochester, Department of Neurology
Project title: The pathological mechanism in myotonic dystrophy
Project advisor: Dr. Charles Thornton

July 2006-July 2009 Postdoctoral Research Associate,
Howard Hughes Medical Institute,
University of California, Los Angeles (HHMI at UCLA)
Project title: Molecular mechanism in regulating alternative splicing of Cav1.2 L-type voltage-gated calcium channel
Project advisor: Dr. Douglas Black

2001-June 2006 Ph.D. (January 2006)
National University of Singapore, Department of Physiology
Dissertation: Molecular and functional study of splice variations of the L-type voltage-gated calcium channel Cav1.2 ??-subunit
Supervisor: Dr. Tuck Wah Soong

1993 - 2000 Registered Pharmacist,
Xiamen Pharmaceutical Corporation,
Fujian, China

1993 B.Sc. (Hons)
Shanghai Medical University, China Department of Pharmacology

Research Bio

My current study aims to investigate whether aberrant splicing in calcium signaling relevant genes may play roles in muscle wasting and weakness in Myotonic Dystrophy (DM) patients. I am also working on the projects to generate novel DM1 and DM2 transgenic mice expressing 440-CTG repeats and 1100-CCTG repeats in skeletal muscles. In addition, I am trying to generate a novel mouse model for the devastating motor neuron disease, Amyotrophic lateral sclerosis (ALS).

Recent Journal Articles

Showing the 5 most recent journal articles. 10 available »

2013 Oct 18
Rzuczek SG, Gao Y, Tang ZZ, Thornton CA, Kodadek T, Disney MD. "Features of modularly assembled compounds that impart bioactivity against an RNA target." ACS chemical biology. 2013 Oct 18; 8(10):2312-21. Epub 2013 Sep 13.
2012 Mar 15
Tang ZZ, Yarotskyy V, Wei L, Sobczak K, Nakamori M, Eichinger K, Moxley RT, Dirksen RT, Thornton CA. "Muscle weakness in myotonic dystrophy associated with misregulated splicing and altered gating of Ca(V)1.1 calcium channel." Human molecular genetics. 2012 Mar 15; 21(6):1312-24. Epub 2011 Dec 02.
2011 Nov
Groom L, Muldoon SM, Tang ZZ, Brandom BW, Bayarsaikhan M, Bina S, Lee HS, Qiu X, Sambuughin N, Dirksen RT. "Identical de novo mutation in the type 1 ryanodine receptor gene associated with fatal, stress-induced malignant hyperthermia in two unrelated families." Anesthesiology. 2011 Nov; 115(5):938-45.
2011 Mar 25
Tang ZZ, Sharma S, Zheng S, Chawla G, Nikolic J, Black DL. "Regulation of the mutually exclusive exons 8a and 8 in the CaV1.2 calcium channel transcript by polypyrimidine tract-binding protein." The Journal of biological chemistry. 2011 Mar 25; 286(12):10007-16. Epub 2011 Jan 31.
2009 Oct 1
Lee JA, Tang ZZ, Black DL. "An inducible change in Fox-1/A2BP1 splicing modulates the alternative splicing of downstream neuronal target exons." Genes & development. 2009 Oct 1; 23(19):2284-93. Epub 2009 Sep 17.

Current Appointments

Research Assistant Professor - Department of Neurology, NMD (SMD) - Primary
Research Assistant Professor - Center for Neural Development & Disease


PhD | Physiology | Singapore-National Univ of Singapore2006
BSc | Pharmacology | China-Shanghai Medical Univ1993