CONTACT INFORMATIONBIOGRAPHYCREDENTIALSPUBLICATIONSZhenzhi Tang, Ph.D.Contact InformationPhone NumbersLocationsUniversity of Rochester Medical CenterSchool of Medicine and Dentistry601 Elmwood Ave, Box 673Rochester, NY 14642Faculty AppointmentsResearch Assistant Professor - Department of Neurology , NMD (SMD) BiographyProfessional BackgroundFeb 2014-Present Research Assistant Professor, University of Rochester, Department of Neurology Project advisor: Dr. Charles Thornton July 2009-Jan 2014 Postdoctoral fellow, University of Rochester, Department of Neurology Project title: The pathological mechanism in myotonic dystrophy Project advisor: Dr. Charles Thornton July 2006-July 2009 Postdoctoral Research Associate, Howard Hughes Medical Institute, University of California, Los Angeles (HHMI at UCLA) Project title: Molecular mechanism in regulating alternative splicing of Cav1.2 L-type voltage-gated calcium channel Project advisor: Dr. Douglas Black 2001-June 2006 Ph.D. (January 2006) National University of Singapore, Department of Physiology Dissertation: Molecular and functional study of splice variations of the L-type voltage-gated calcium channel Cav1.2 ??-subunit Supervisor: Dr. Tuck Wah Soong 1993 - 2000 Registered Pharmacist, Xiamen Pharmaceutical Corporation, Fujian, China 1993 B.Sc. (Hons) Shanghai Medical University, China Department of PharmacologyResearchMy current study aims to investigate whether aberrant splicing in calcium signaling relevant genes may play roles in muscle wasting and weakness in Myotonic Dystrophy (DM) patients. I am also working on the projects to generate novel DM1 and DM2 transgenic mice expressing 440-CTG repeats and 1100-CCTG repeats in skeletal muscles. In addition, I am trying to generate a novel mouse model for the devastating motor neuron disease, Amyotrophic lateral sclerosis (ALS).CredentialsEducation1993BSc | China-Shanghai Medical UnivPharmacology2006PhD | Singapore-National Univ of SingaporePhysiologyPublicationsJournal Articles1/27/2021Tanner MK, Tang Z, Thornton CA. "Targeted splice sequencing reveals RNA toxicity and therapeutic response in myotonic dystrophy." Nucleic acids research.. 2021 Jan 27; Epub 2021 Jan 27. 11/5/2020Angelbello AJ, Benhamou RI, Rzuczek SG, Choudhary S, Tang Z, Chen JL, Roy M, Wang KW, Yildirim I, Jun AS, Thornton CA, Disney MD. "A Small Molecule that Binds an RNA Repeat Expansion Stimulates Its Decay via the Exosome Complex." Cell chemical biology.. 2020 Nov 5; Epub 2020 Nov 05. 4/29/2020Ketley A, Wojciechowska M, Ghidelli-Disse S, Bamborough P, Ghosh TK, Morato ML, Sedehizadeh S, Malik NA, Tang Z, Powalowska P, Tanner M, Billeter-Clark R, Trueman RC, Geiszler PC, Agostini A, Othman O, Bösche M, Bantscheff M, Rüdiger M, Mossakowska DE, Drewry DH, Zuercher WJ, Thornton CA, Drewes G, Uings I, Hayes CJ, Brook JD. "CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model." Science translational medicine.. 2020 Apr 29; 12(541)VIEW ALL PUBLICATIONSClose WindowSchedule an appointment with Zhenzhi Tang, Ph.D.Please answer the following questions to help us find the right appointment for you.Important: If you believe that you have a medical or psychiatric emergency, please call 911 or go to the nearest hospital. This website is not intended for emergency care.Have you seen this provider in the last 2 years?YesNoExisting Patient Schedule or request a follow up appointment online through MyChart. If you do not have a MyChart account, please close this window and call the appointment phone number. Zhenzhi Tang, Ph.D. is currently scheduling for the following appointment type(s): Our policy does not permit patients to establish care with multiple providers within the same practice or specialty without prior approval. If you choose a new provider in the same office, we will cancel the appointment. Please contact the office directly with questions on this policy.