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Steven R. Gill, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-1003

Fax: (585) 473-9573

Research Labs

Our research interests are centered around microbial pathogens and the impact of human microbial flora on human health and disease.

Visit Our research interests are centered around microbial pathogens and the impact of human microbial flora on human health and disease. Lab Website

Faculty Appointments

Biography

Research

Our laboratory studies bacterial pathogens and diseases associated with the human microbiome. Active research areas in our laboratory include: 1) the study of human microbiome communities in neonates and infectious disease, and 2) pathogenesis and genomics of bacterial pathogens.

HUMAN MICROBIOME COMMUNITIES
Human life is dependent on a diverse community of symbiotic microbiota that have co-evolved with their human hosts to modulate crucial aspects of normal physiology, metabolism, immunity and neurologic function. We are engaged in multiple microbiome studies in areas of neonatal development, osteoarthritis, osteomyelitis, early childhood caries, atopic dermatitis and the tumoral microbiome of oral squamous cell carcinoma.

PATHOGENESIS AND GENOMICS OF BACTERIAL PATHOGENS
Staphylococcus aureus and Clostridioides difficile are among the most successful of human pathogens, capable of causing invasive and deadly opportunistic infections. We are using in vivo, biochemical and genomic approaches to identify genetic pathways and mechanisms associated with S. aureus responses to host innate immunity and adaptation of the clonal complex 30 lineage to a persistent lifestyle in the host. In addition, we are using genomic and phylogenetic approaches to assess emergence and transmission of new S. aureus and C. difficile clinical isolates throughout hospitals, long-term care facilities and the general community in Monroe County NY.

Credentials

Education

1981
B.S. | South Dakota State University
Microbiology and Chemistry

1983
M.S. | North Dakota State University
Bacteriology

1989
Ph.D. | Kansas State University
Microbiology

Post-doctoral Training & Residency

1996 - 1997
Research Associate, Johns Hopkins University, Cell Biology

1989 - 1995
Johns Hopkins School of Medicine, Cell Biology

Awards

2009
University at Buffalo Visionary Inventor

1989 - 1992
NIH Neuroscience Postdoctoral Fellowship

1988 - 1989
Wesley Foundation Predoctoral Fellowship

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Publications

Journal Articles

9/25/2019
Sonawane AR, Tian L, Chu CY, Qiu X, Wang L, Holden-Wiltse J, Grier A, Gill SR, Caserta MT, Falsey AR, Topham DJ, Walsh EE, Mariani TJ, Weiss ST, Silverman EK, Glass K, Liu YY. "Microbiome-Transcriptome Interactions Related to Severity of Respiratory Syncytial Virus Infection." Scientific reports.. 2019 Sep 25; 9(1):13824. Epub 2019 Sep 25.

7/31/2019
Caserta MT, Yang H, Bandyopadhyay S, Qiu X, Gill SR, Java J, McDavid A, Falsey AR, Topham DJ, Holden-Wiltse J, Scheible K, Pryhuber G. "Measuring the Severity of Respiratory Illness in the First 2 Years of Life in Preterm and Term Infants." The Journal of pediatrics.. 2019 Jul 31; Epub 2019 Jul 31.

6/24/2019
Masters EA, Salminen AT, Begolo S, Luke EN, Barrett SC, Overby CT, Gill AL, de Mesy Bentley KL, Awad HA, Gill SR, Schwarz EM, McGrath JL. "An in vitro platform for elucidating the molecular genetics of S. aureus invasion of the osteocyte lacuno-canalicular network during chronic osteomyelitis." Nanomedicine : nanotechnology, biology, and medicine.. 2019 Jun 24; :102039. Epub 2019 Jun 24.

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