CONTACT INFORMATIONBIOGRAPHYCREDENTIALSAWARDSPUBLICATIONSEthan David Cohen, Ph.D.Contact InformationPhone NumbersAdministrative: (585) 276-4994Office: (585) 276-5898Fax: (585) 275-1288LocationsUniversity of Rochester Medical CenterSchool of Medicine and Dentistry601 Elmwood Ave, Box 777Rochester, NY 14642Faculty AppointmentsResearch Assistant Professor - Department of Pediatrics , Neonatology (SMD) BiographyProfessional BackgroundDr. Cohen graduated cum laud from Lebanon Valley College before completing both his graduate and postdoctoral research at the University of Pennsylvania School of Medicine. Dr. Cohen's research is largely focused on understanding how intercellular signaling directs cardiac morphogenesis and how defect in this signaling contribute to human disease. Congenital heart defects are present in approximately 1% of newborn babies, 10% of stillborn fetuses and responsible for nearly 6% of deaths among children under one year of age. Furthermore heart disease is the leading cause of death among adults in the Western world. A better understanding of the mechanisms underlying cardiac development will aid in the discovery of new methods to detect and treat congenital heart defects. Moreover since aberrant signaling by embryonic pathways is often associated with disease, this same information will also aid in the discovery of novel treatments for adult cardiomyopathy. Many of these new treatments are likely to involve using stem/progenitor cells to replace damaged cardiac tissues. However our ability to differentiate multi-potent stem cells into functional cardiomyocytes is still limited and further insight into the molecular cues that guide cardiac development will be necessary to reach the full potential of regenerative medicine.ResearchDr. Cohen graduated cum laud from Lebanon Valley College before completing both his graduate and postdoctoral research at the University of Pennsylvania School of Medicine. Dr. Cohen's research is largely focused on understanding how intercellular signaling directs cardiac morphogenesis and how defect in this signaling contribute to human disease. Congenital heart defects are present in approximately 1% of newborn babies, 10% of stillborn fetuses and responsible for nearly 6% of deaths among children under one year of age. Furthermore heart disease is the leading cause of death among adults in the Western world. A better understanding of the mechanisms underlying cardiac development will aid in the discovery of new methods to detect and treat congenital heart defects. Moreover since aberrant signaling by embryonic pathways is often associated with disease, this same information will also aid in the discovery of novel treatments for adult cardiomyopathy. Many of these new treatments are likely to involve using stem/progenitor cells to replace damaged cardiac tissues. However our ability to differentiate multi-potent stem cells into functional cardiomyocytes is still limited and further insight into the molecular cues that guide cardiac development will be necessary to reach the full potential of regenerative medicine.CredentialsEducation1997BS | Lebanon Valley CollegeBiochemistry2004Ph.D. | University of Pennsylvania, School of MedicineBiomedical Graduate Studies2004PhD | Univ Pennsylvania Sch MedicineCell and Molecular BiologyAwards2015 - 2107American Heart Association Grant-in-Aid Award2008Holtzer Prize for outstanding postdoctoral research in cell and developmental biology at the University of PennsylvaniaLocation: University of Pennsylvania2002The Susan Heyner Award for Excellence in ResearchVIEW ALL expand_morePublicationsJournal Articles2/10/2023Burris J, Beutner G, Cohen ED, Yee M, O'Reilly MA, Porter GA. "Cyclophilin D inhibition rescues cardiac function in neonatal hypoxia." Biophysical journal.. 2023 Feb 10; 122(3S1):96a. 7/6/2021Quijada P, Trembley MA, Misra A, Myers JA, Baker CD, Pérez-Hernández M, Myers JR, Dirkx RA, Cohen ED, Delmar M, Ashton JM, Small EM. "Coordination of endothelial cell positioning and fate specification by the epicardium." Nature communications.. 2021 Jul 6; 12(1):4155. Epub 2021 Jul 06. 1/28/2021Cohen ED, Yee M, Porter GA, Ritzer EE, McDavid AN, Brookes PS, Pryhuber GS, O'Reilly MA. "Neonatal hyperoxia inhibits proliferation and survival of atrial cardiomyocytes by suppressing fatty acid synthesis." JCI insight.. 2021 Jan 28; Epub 2021 Jan 28. VIEW ALL PUBLICATIONSClose WindowSchedule an appointment with Ethan David Cohen, Ph.D.Please answer the following questions to help us find the right appointment for you.Important: If you believe that you have a medical or psychiatric emergency, please call 911 or go to the nearest hospital. 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