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Antti E. Seppo, Ph.D.


Showing all 35 journal articles & 0 books available

Journal Articles

Davis EC, Castagna VP, Sela DA, Hillard MA, Lindberg S, Mantis NJ, Seppo AE, Järvinen KM. "Gut microbiome and breast-feeding: Implications for early immune development." The Journal of allergy and clinical immunology.. 2022 Sep; 150(3):523-534.

McGuire MK, Randall AZ, Seppo AE, Järvinen KM, Meehan CL, Gindola D, Williams JE, Sellen DW, Kamau-Mbuthia EW, Kamundia EW, Mbugua S, Moore SE, Prentice AM, Foster JA, Otoo GE, Rodríguez JM, Pareja RG, Bode L, McGuire MA, Campo JJ. "Multipathogen Analysis of IgA and IgG Antigen Specificity for Selected Pathogens in Milk Produced by Women From Diverse Geographical Regions: The INSPIRE Study." Frontiers in immunology.. 2020 11:614372. Epub 2021 Feb 11.

Seppo AE, Kukkonen AK, Kuitunen M, Savilahti E, Yonemitsu C, Bode L, Järvinen KM. "Association of Maternal Probiotic Supplementation With Human Milk Oligosaccharide Composition." JAMA pediatrics.. 2019 Jan 22; Epub 2019 Jan 22.

Rajani PS, Seppo AE, Järvinen KM. "Immunologically Active Components in Human Milk and Development of Atopic Disease, With Emphasis on Food Allergy, in the Pediatric Population." Frontiers in pediatrics.. 2018 6:218. Epub 2018 Aug 07.

Järvinen KM, Wang J, Seppo AE, Zand M. "Novel multiplex assay for profiling influenza antibodies in breast milk and serum of mother-infant pairs." F1000Research.. 2018 7:1822. Epub 2018 Nov 20.

Seppo AE, Savilahti EM, Berin MC, Sampson HA, Järvinen KM. "Breast milk IgA to foods has different epitope specificity than serum IgA-Evidence for entero-mammary link for food-specific IgA?" Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.. 2017 Oct; 47(10):1275-1284. Epub 2017 May 26.

Seppo AE, Autran CA, Bode L, Järvinen KM. "Human milk oligosaccharides and development of cow's milk allergy in infants." The Journal of allergy and clinical immunology.. 2017 Feb; 139(2):708-711.e5. Epub 2016 Oct 01.

Gerdes MJ, Sevinsky CJ, Sood A, Adak S, Bello MO, Bordwell A, Can A, Corwin A, Dinn S, Filkins RJ, Hollman D, Kamath V, Kaanumalle S, Kenny K, Larsen M, Lazare M, Li Q, Lowes C, McCulloch CC, McDonough E, Montalto MC, Pang Z, Rittscher J, Santamaria-Pang A, Sarachan BD, Seel ML, Seppo A, Shaikh K, Sui Y, Zhang J, Ginty F. "Highly multiplexed single-cell analysis of formalin-fixed, paraffin-embedded cancer tissue." Proceedings of the National Academy of Sciences of the United States of America.. 2013 Jul 16; 110(29):11982-7. Epub 2013 Jul 01.

López-Expósito I, Järvinen KM, Castillo A, Seppo AE, Song Y, Li XM. "Maternal peanut consumption provides protection in offspring against peanut sensitization that is further enhanced when co-administered with bacterial mucosal adjuvant." Food research international.. 2011 Jul; 44(6):1649-1656.

Sifakis S, Ghatpande S, Seppo A, Kilpatrick MW, Tafas T, Tsipouras P, Fejgin M, Amiel A. "Prenatal diagnosis of trisomy 21 through detection of trophoblasts in cervical smears." Early human development.. 2010 May; 86(5):311-3. Epub 2010 May 14.

Seppo A, Jalali GR, Babkowski R, Symiakaki H, Rodolakis A, Tafas T, Tsipouras P, Kilpatrick MW. "Gain of 3q26: a genetic marker in low-grade squamous intraepithelial lesions (LSIL) of the uterine cervix." Gynecologic oncology.. 2009 Jul; 114(1):80-3. Epub 2009 Apr 25.

Ntouroupi TG, Ashraf SQ, McGregor SB, Turney BW, Seppo A, Kim Y, Wang X, Kilpatrick MW, Tsipouras P, Tafas T, Bodmer WF. "Detection of circulating tumour cells in peripheral blood with an automated scanning fluorescence microscope." British journal of cancer.. 2008 Sep 2; 99(5):789-95.

Seppo A, Frisova V, Ichetovkin I, Kim Y, Evans MI, Antsaklis A, Nicolaides KH, Tafas T, Tsipouras P, Kilpatrick MW. "Detection of circulating fetal cells utilizing automated microscopy: potential for noninvasive prenatal diagnosis of chromosomal aneuploidies." Prenatal diagnosis.. 2008 Sep; 28(9):815-21.

Shi S, Williams SA, Seppo A, Kurniawan H, Chen W, Ye Z, Marth JD, Stanley P. "Inactivation of the Mgat1 gene in oocytes impairs oogenesis, but embryos lacking complex and hybrid N-glycans develop and implant." Molecular and cellular biology.. 2004 Nov; 24(22):9920-9.

Seppo A, Matani P, Sharrow M, Tiemeyer M. "Induction of neuron-specific glycosylation by Tollo/Toll-8, a Drosophila Toll-like receptor expressed in non-neural cells." Development.. 2003 Apr; 130(7):1439-48.

Seppo A, Tiemeyer M. "Function and structure of Drosophila glycans." Glycobiology.. 2000 Aug; 10(8):751-60.

Seppo A, Moreland M, Schweingruber H, Tiemeyer M. "Zwitterionic and acidic glycosphingolipids of the Drosophila melanogaster embryo." European journal of biochemistry. 2000 Jun; 267(12):3549-58.

Natunen J, Seppo A, Helin J, Reinhold BB, Rabina J, Costello CE, Renkonen O. "Enzymatic transfer of a beta1,6-linked N-acetylglucosamine to the alpha-galactose of globo-N-tetraose: in vitro synthesis of a novel hybrid pentasaccharide of lacto-globo type." Glycobiology.. 1997 Jul; 7(5):711-8.

Seppo A, Turunen JP, Penttilä L, Keane A, Renkonen O, Renkonen R. "Synthesis of a tetravalent sialyl Lewis x glycan, a high-affinity inhibitor of L-selectin-mediated lymphocyte binding to endothelium." Glycobiology.. 1996 Jan; 6(1):65-71.

Turunen JP, Majuri ML, Seppo A, Tiisala S, Paavonen T, Miyasaka M, Lemström K, Penttilä L, Renkonen O, Renkonen R. "De novo expression of endothelial sialyl Lewis(a) and sialyl Lewis(x) during cardiac transplant rejection: superior capacity of a tetravalent sialyl Lewis(x) oligosaccharide in inhibiting L-selectin-dependent lymphocyte adhesion." The Journal of experimental medicine.. 1995 Oct 1; 182(4):1133-41.

Niemelä R, Penttilä L, Seppo A, Helin J, Leppänen A, Räbinä J, Uusitalo L, Maaheimo H, Taskinen J, Costello CE. "Enzyme-assisted synthesis of a bivalent high-affinity dodecasaccharide inhibitor of mouse gamete adhesion. The length of the chains carrying distal alpha 1,3-bonded galactose residues is critical." FEBS letters.. 1995 Jun 19; 367(1):67-72.

Seppo A, Penttilä L, Niemelä R, Maaheimo H, Renkonen O, Keane A. "Enzymatic synthesis of octadecameric saccharides of multiply branched blood group I-type, carrying four distal alpha 1,3-galactose or beta 1,3-GlcNAc residues." Biochemistry.. 1995 Apr 11; 34(14):4655-61.

Litscher ES, Juntunen K, Seppo A, Penttilä L, Niemelä R, Renkonen O, Wassarman PM. "Oligosaccharide constructs with defined structures that inhibit binding of mouse sperm to unfertilized eggs in vitro." Biochemistry.. 1995 Apr 11; 34(14):4662-9.

Helin J, Maaheimo H, Seppo A, Keane A, Renkonen O. "Stepwise transfer of alpha-D-Galp-(1-->3)-beta-D-Galp-(1-->4)-beta-D-GlcpNAc sequences to 3-OH and 6-OH of distal galactose residues in bi-, tri-, and tetra-antennary asialo-glycans of N-linked complex type." Carbohydrate research.. 1995 Jan 17; 266(2):191-209.

Natunen J, Niemelä R, Penttilä L, Seppo A, Ruohtula T, Renkonen O. "Enzymatic synthesis of two lacto-N-neohexaose-related Lewis x heptasaccharides and their separation by chromatography on immobilized wheat germ agglutinin." Glycobiology.. 1994 Oct; 4(5):577-83.

Seppo A, Penttilä L, Leppänen A, Maaheimo H, Niemelä R, Helin J, Wieruszeski JM, Renkonen O. "Bi-antennary oligo-(N-acetyllactosamino)glycans of I-type are galactosylated preferentially at the GlcNAc beta 1-6Gal linked arms by alpha 1,3-galactosyltransferase of bovine thymus." Glycoconjugate journal.. 1994 Jun; 11(3):217-25.

Helin J, Seppo A, Leppänen A, Penttilä L, Maaheimo H, Niemelä R, Lauri S, Renkonen O. "A novel beta-N-acetylglucosaminidase activity in hog gastric mucosal microsomes: preferential hydrolysis of terminal GlcNAc beta 1-3 linkages in GlcNAc beta 1-3(GlcNAc beta 1-6)Gal beta 1-4GlcNAc, but GlcNAc beta 1-6 linkages in GlcNAc beta 1-3(GlcNAc beta 1-6)Gal." FEBS letters.. 1993 Dec 6; 335(2):280-4.

Yagita M, Seppo A, Renkonen O, Saksela E. "Deacetylase activity of human tumor cells producing immunosuppressive aminosugars: its possible role in resistance to cell-mediated cytotoxicity." Cancer research.. 1993 Dec 1; 53(23):5600-4.

Vilkman A, Niemelä R, Penttilä L, Helin J, Leppänen A, Seppo A, Maaheimo H, Lusa S, Renkonen O. "Elongation of both branches of biantennary backbones of oligo-(N-acetyllactosamino)glycans by human serum (1----3)-N-acetyl-beta-D- glucosaminyltransferase." Carbohydrate research.. 1992 Mar 16; 226(1):155-74.

Renkonen O, Leppänen A, Niemelä R, Vilkman A, Helin J, Penttilä L, Maaheimo H, Seppo A, Suopanki J. "Enzymatic in vitro synthesis of radiolabeled pentasaccharides GlcNAc beta 1-3(Gal beta 1-4GlcNAc beta 1-6)Gal beta 1-4GlcNAc/Glc and the isomeric Gal beta 1-4GlcNAc beta 1-3(GlcNAc beta 1-6)Gal beta 1-4GlcNAc/Glc." Biochemistry and cell biology = Biochimie et biologie cellulaire.. 1992 Jan; 70(1):86-9.

Leppänen A, Penttilä L, Niemelä R, Helin J, Seppo A, Lusa S, Renkonen O. "Human serum contains a novel beta 1,6-N-acetylglucosaminyltransferase activity that is involved in midchain branching of oligo (N-acetyllactosaminoglycans)." Biochemistry.. 1991 Sep 24; 30(38):9287-96.

Renkonen O, Helin J, Penttilä L, Maaheimo H, Niemelä R, Leppänen A, Seppo A, Hård K. "Oligo-N-acetyllactosaminoglycans bearing Gal beta 1-4(Fuc alpha 1-3)GlcNAc sequences reveal lower affinities than their nonfucosylated, or alpha(1-2) fucosylated counterparts for immobilized wheat germ agglutinin." Glycoconjugate journal.. 1991 Aug; 8(4):361-7.

Renkonen O, Niemelä R, Leppänen A, Maaheimo H, Seppo A, Penttilä L, Vilkman A. "Construction of linear GlcNAc beta 1-6Gal beta 1-OR type oligosaccharides by partial cleavage of GlcNAc beta 1-3(GlcNAc beta 1-6)Gal beta 1-OR sequences with jack bean beta-N-acetylhexosaminidase." Glycoconjugate journal.. 1991 Aug; 8(4):368-75.

Renkonen O, Penttilä L, Niemelä R, Vainio A, Leppänen A, Helin J, Seppo A, Makkonen A, Maaheimo H. "N-acetyllactosaminooligosaccharides that contain the beta-D-GlcpNAc-(1----6)-D-Gal or beta-D-GlcpNAc-(1----6)-D-GalNAc sequences reveal reduction-sensitive affinities for wheat germ agglutinin." Carbohydrate research.. 1991 Jun 25; 213:169-83.

Seppo A, Penttilä L, Makkonen A, Leppänen A, Niemelä R, Jäntti J, Helin J, Renkonen O. "Wheat germ agglutinin chromatography of GlcNac beta 1-3(GlcNAc beta 1-6)Gal and GlcNAc beta 1-3(GlcNAc beta 1-6)Gal beta 1-4GlcNAc, obtained by in vitro synthesis and by partial cleavage of teratocarcinoma poly-N-acetyllactosaminoglycans." Biochemistry and cell biology = Biochimie et biologie cellulaire.. 1990 Jan; 68(1):44-53.