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Krishnan Padmanabhan, Ph.D.

Contact Information

Research Labs

Faculty Appointments

Biography

Professional Background

Dr. Padmanabhan received his BS in Biology and History and his MS in Physiological Sciences at the University of California, Los Angeles, his PhD at Carnegie Mellon University and was the Francis Crick-Irwin Jacobs Junior Fellow at the Salk Institute of Biological Studies before arriving at the University of Rochester.

Research

Dr. Padmanabhan's research aims to understand principles of neuronal function in the mammalian brain using experimental and computational methods with a focus on uncovering the biological bases of psychiatric disorders. Work in the Padmanabhan lab uses multi-electrode electrophysiology, induced-Pluripotent Stem Cell (iPSC) technology, imaging, and theoretical models to address three outstanding questions in neuroscience.

1) How does the brain represents features of the world via patterns of neuronal activity?
2) How does memory and experience shape the process of sensory perception?
3) How are these functions disrupted in neurological and psychiatric disorders?

Publications

Journal Articles

2/7/2019
Marchetto MC, Hrvoj-Mihic B, Kerman BE, Yu DX, Vadodaria KC, Linker SB, Narvaiza I, Santos R, Denli AM, Mendes AP, Oefner R, Cook J, McHenry L, Grasmick JM, Heard K, Fredlender C, Randolph-Moore L, Kshirsagar R, Xenitopoulos R, Chou G, Hah N, Muotri AR, Padmanabhan K, Semendeferi K, Gage FH. "Species-specific maturation profiles of human, chimpanzee and bonobo neural cells." eLife.. 2019 Feb 7; 8Epub 2019 Feb 07.

5/3/2018
Sarkar A, Mei A, Paquola ACM, Stern S, Bardy C, Klug JR, Kim S, Neshat N, Kim HJ, Ku M, Shokhirev MN, Adamowicz DH, Marchetto MC, Jappelli R, Erwin JA, Padmanabhan K, Shtrahman M, Jin X, Gage FH. "Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro." Cell stem cell.. 2018 May 3; 22(5):684-697.e9.

2018
Padmanabhan K, Osakada F, Tarabrina A, Kizer E, Callaway EM, Gage FH, Sejnowski TJ. "Centrifugal Inputs to the Main Olfactory Bulb Revealed Through Whole Brain Circuit-Mapping." Frontiers in neuroanatomy.. 2018 12:115. Epub 2019 Jan 07.

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