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Cesare Orlandi, Ph.D.

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Office: (585) 275-6613

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Faculty Appointments



The main focus of the lab research is to investigate the biology of a group of understudied G protein coupled receptors (GPCR) in brain and visual systems. Members of the large GPCR family are involved in the regulation of every aspect of human physiology. Because of their physiological relevance and localization at the plasma membrane GPCRs are ideal targets for drug development. Orphan GPCRs constitute a group of receptors whose endogenous ligands are still unknown. Nonetheless, the identification of disease-causing mutations in patients together with animal studies have established the involvement of orphan GPCRs in essential physiological processes. More broadly, the lab is interested in applying proteomics, biochemistry, microscopy imaging, and pharmacology to understand the role that orphan GPCRs play in shaping behavioral responses as well as the ways in which alterations in these complexes can lead to diseases.


Journal Articles

Watkins LR, Orlandi C. "Orphan G Protein Coupled Receptors in Affective Disorders." Genes.. 2020 Jun 24; 11(6)Epub 2020 Jun 24.

Dunn HA, Orlandi C, Martemyanov KA. "Beyond the Ligand: Extracellular and Transcellular G Protein-Coupled Receptor Complexes in Physiology and Pharmacology." Pharmacological reviews.. 2019 Oct 0; 71(4):503-519.

Sutton LP, Muntean BS, Ostrovskaya O, Zucca S, Dao M, Orlandi C, Song C, Xie K, Martemyanov KA. "NF1-cAMP signaling dissociates cell type-specific contributions of striatal medium spiny neurons to reward valuation and motor control." PLoS biology.. 2019 Oct 0; 17(10):e3000477. Epub 2019 Oct 10.