Skip to main content
Explore URMC

Cesare Orlandi, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-6613

Research Labs

Faculty Appointments



The main focus of the lab research is to investigate the biology of a group of understudied G protein coupled receptors (GPCR) in brain and visual systems. Members of the large GPCR family are involved in the regulation of every aspect of human physiology. Because of their physiological relevance and localization at the plasma membrane GPCRs are ideal targets for drug development. Orphan GPCRs constitute a group of receptors whose endogenous ligands are still unknown. Nonetheless, the identification of disease-causing mutations in patients together with animal studies have established the involvement of orphan GPCRs in essential physiological processes. More broadly, the lab is interested in applying proteomics, biochemistry, microscopy imaging, and pharmacology to understand the role that orphan GPCRs play in shaping behavioral responses as well as the ways in which alterations in these complexes can lead to diseases.


Post-doctoral Training & Residency

10/01/2011 - 09/30/2018
Postdoctoral Research Associate Department of Neuroscience; The Scripps Research Institute, Jupiter, FL PI: Prof. Kirill Martemyanov New mechanisms regulating G Protein Coupled Receptor (GPCR) signaling by orphan receptors GPR158/GPR179 in complex with R7-RGS proteins in mouse brain and retina.

01/01/2010 - 09/30/2011
Postdoctoral Research Associate University of Brescia, Italy Head Professors: Prof. Sergio Barlati and Prof. Alessandro Barbon Analysis of the mechanisms that regulate the activity of Adenosine Deaminases Acting on RNA (ADAR), the enzymes responsible for the RNA editing reaction and their effect on glutamate and serotonin neurotransmission.


Journal Articles

Watkins LR, Orlandi C. "In vitro profiling of orphan G protein coupled receptor (GPCR) constitutive activity." British journal of pharmacology.. 2021 Mar 30; Epub 2021 Mar 30.

Cao Y, Wang Y, Dunn HA, Orlandi C, Shultz N, Kamasawa N, Fitzpatrick D, Li W, Zeitz C, Hauswirth W, Martemyanov KA. "Interplay between cell-adhesion molecules governs synaptic wiring of cone photoreceptors." Proceedings of the National Academy of Sciences of the United States of America.. 2020 Sep 2; Epub 2020 Sep 02.

Watkins LR, Orlandi C. "Orphan G Protein Coupled Receptors in Affective Disorders." Genes.. 2020 Jun 24; 11(6)Epub 2020 Jun 24.