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Cesare Orlandi, Ph.D.

(Pronouns: he/him)

Contact Information

Phone Numbers

Office: (585) 275-6613

Research Labs



The main focus of the lab research is to investigate the biology of a group of understudied G protein coupled receptors (GPCR) in brain and visual systems. Members of the large GPCR family are involved in the regulation of every aspect of human physiology. Because of their physiological relevance and localization at the plasma membrane GPCRs are ideal targets for drug development. Orphan GPCRs constitute a group of receptors whose endogenous ligands are still unknown. Nonetheless, the identification of disease-causing mutations in patients together with animal studies have established the involvement of orphan GPCRs in essential physiological processes. More broadly, the lab is interested in applying proteomics, biochemistry, microscopy imaging, and pharmacology to understand the role that orphan GPCRs play in shaping behavioral responses as well as the ways in which alterations in these complexes can lead to diseases.


Post-doctoral Training & Residency

10/01/2011 - 09/30/2018
Postdoctoral Research Associate Department of Neuroscience; The Scripps Research Institute, Jupiter, FL PI: Prof. Kirill Martemyanov New mechanisms regulating G Protein Coupled Receptor (GPCR) signaling by orphan receptors GPR158/GPR179 in complex with R7-RGS proteins in mouse brain and retina.

01/01/2010 - 09/30/2011
Postdoctoral Research Associate University of Brescia, Italy Head Professors: Prof. Sergio Barlati and Prof. Alessandro Barbon Analysis of the mechanisms that regulate the activity of Adenosine Deaminases Acting on RNA (ADAR), the enzymes responsible for the RNA editing reaction and their effect on glutamate and serotonin neurotransmission.


Journal Articles

Alabdali R, Franchini L, Orlandi C. "." Molecular pharmacology.. 2023 Aug 11; Epub 2023 Aug 11.

Franchini L, Orlandi C. "Probing the orphan receptors: Tools and directions." Progress in molecular biology and translational science.. 2023 195:47-76. Epub 2022 Jul 13.

Fu W, Franchini L, Orlandi C. "Comprehensive Spatial Profile of the Orphan G Protein Coupled Receptor GPRC5B Expression in Mouse Brain." Frontiers in neuroscience.. 2022 16:891544. Epub 2022 Jun 23.

Books & Chapters

Chapter Title: Probing the orphan receptors: Tools and directions
Book Title: Progress in Molecular Biology and Translational Science
Author List: Luca Franchini Cesare Orlandi
Published By: Elsevier 2022