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Chia-Lung Wu, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-1335

Research Labs

Faculty Appointments


Professional Background

Dr. Chia-Lung Wu earned his bachelor's and Master’s degree in Material Science and Engineering from National Taipei University of Technology and National Taiwan University, respectively. He obtained his doctoral degree in Biomedical Engineering at Duke University in 2015. Dr. Wu then completed his post-doctoral training with Dr. Farshid Guilak in Orthopedic Surgery Department at Washington University in Saint Louis in 2020.


Dr. Wu’s research focuses on identifying the molecular mechanisms by which genetic and epigenetic regulators modulate development, homeostasis and disease progression of musculoskeletal tissues, with a particular focus on cartilage and bone. His approach utilizes bioengineering, cellular biology, next-generation sequencing techniques and genome editing tools, complemented by animal and biomechanical models to uncover these fundamental principles. The long-term goal of his research program is to apply this knowledge to improve tissue engineering outcomes, regeneration and repair for musculoskeletal disorders.


ON Foundation Award
Sponsor: Orthoregeneration Network Foundation

NIH NIAMS K99/R00 Pathway to Independence Award – 1K99AR075899
Sponsor: National Institutes of Health

The New Investigator Recognition Awards (NIRA), Post-doctoral research associate
Sponsor: Orthopaedic Research Society (ORS)

The New Investigator Recognition Awards (NIRA), Graduate student
Sponsor: Orthopaedic Research Society (ORS)

Taiwan Government Student Studying Aboard Scholarship (2-year funding)
Sponsor: Taiwan Government

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Journal Articles

Ackerman JE, Best KT, Muscat SN, Pritchett EM, Nichols AEC, Wu CL, Loiselle AE. "Defining the spatial-molecular map of fibrotic tendon healing and the drivers of Scleraxis-lineage cell fate and function." Cell reports.. 2022 Nov 22; 41(8):111706.

Kenney HM, Wu CL, Loiselle AE, Xing L, Ritchlin CT, Schwarz EM. "Single-cell transcriptomics of popliteal lymphatic vessels and peripheral veins reveals altered lymphatic muscle and immune cell populations in the TNF-Tg arthritis model." Arthritis research & therapy.. 2022 Mar 7; 24(1):64. Epub 2022 Mar 07.

Wu CL, Dicks A, Steward N, Tang R, Katz DB, Choi YR, Guilak F. "Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis." Nature communications.. 2021 Jan 13; 12(1):362. Epub 2021 Jan 13.

Books & Chapters

Chapter Title: Survey of Animal Models in Post-Traumatic Arthritis: Choosing the Right Model to Answer the Right Question
Book Title: Post-Traumatic Arthritis
Author List: Furman D, Kimmerling K, Wu, C.L., Little D
Edited By: Steven A. Olson, MD; Farshid Guilak, PhD
Published By: Springer 2015 in Boston, MA

Chapter Title: Animal Models of Meniscal Injury in Post-Traumatic Arthritis
Book Title: Post-Traumatic Arthritis
Author List: Wu, C.L., Little D
Edited By: Steven A. Olson, MD; Farshid Guilak, PhD
Published By: Springer 2015 in Boston, MA