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Chia-Lung Wu, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-1335

Research Labs

Faculty Appointments

  • Assistant Professor - Department of Orthopaedics , Center for Musculoskeletal Research (SMD)
  • Assistant Professor - Department of Biomedical Engineering (SMD) - Joint


Professional Background

Dr. Chia-Lung Wu earned his bachelor's and Master’s degree in Material Science and Engineering from National Taipei University of Technology and National Taiwan University, respectively. He obtained his doctoral degree in Biomedical Engineering at Duke University in 2015. Dr. Wu then completed his post-doctoral training with Dr. Farshid Guilak in Orthopedic Surgery Department at Washington University in Saint Louis in 2020.


Dr. Wu’s research focuses on identifying the molecular mechanisms by which genetic and epigenetic regulators modulate development, homeostasis and disease progression of musculoskeletal tissues, with a particular focus on cartilage and bone. His approach utilizes bioengineering, cellular biology, next-generation sequencing techniques and genome editing tools, complemented by animal and biomechanical models to uncover these fundamental principles. The long-term goal of his research program is to apply this knowledge to improve tissue engineering outcomes, regeneration and repair for musculoskeletal disorders.


ON Foundation Award
Sponsor: Orthoregeneration Network Foundation

NIH NIAMS K99/R00 Pathway to Independence Award – 1K99AR075899
Sponsor: National Institutes of Health

The New Investigator Recognition Awards (NIRA), Post-doctoral research associate
Sponsor: Orthopaedic Research Society (ORS)

The New Investigator Recognition Awards (NIRA), Graduate student
Sponsor: Orthopaedic Research Society (ORS)

Taiwan Government Student Studying Aboard Scholarship (2-year funding)
Sponsor: Taiwan Government

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Journal Articles

Wu CL, Dicks A, Steward N, Tang R, Katz DB, Choi YR, Guilak F. "Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis." Nature communications.. 2021 Jan 13; 12(1):362. Epub 2021 Jan 13.

Oestreich AK, Collins KH, Harasymowicz NS, Wu CL, Guilak F. "Is Obesity a Disease of Stem Cells?" Cell stem cell.. 2020 Jul 2; 27(1):15-18.

Wu CL, Harasymowicz NS, Klimak MA, Collins KH, Guilak F. "The role of macrophages in osteoarthritis and cartilage repair." Osteoarthritis and cartilage. 2020 May 0; 28(5):544-554. Epub 2020 Jan 08.

Books & Chapters

Chapter Title: Animal Models of Meniscal Injury in Post-Traumatic Arthritis
Book Title: Post-Traumatic Arthritis
Author List: Wu, C.L., Little D
Edited By: Steven A. Olson, MD; Farshid Guilak, PhD
Published By: Springer 2015 in Boston, MA

Chapter Title: Survey of Animal Models in Post-Traumatic Arthritis: Choosing the Right Model to Answer the Right Question
Book Title: Post-Traumatic Arthritis
Author List: Furman D, Kimmerling K, Wu, C.L., Little D
Edited By: Steven A. Olson, MD; Farshid Guilak, PhD
Published By: Springer 2015 in Boston, MA