Chia-Lung Wu, Ph.D.

Contact Information

Faculty Appointments

Assistant Professor - Department of Orthopaedics , Center for Musculoskeletal Research (SMD)
Assistant Professor - Department of Biomedical Engineering (SMD) - Joint

Biography

Professional Background

Dr. Chia-Lung Wu earned his bachelor's and Master’s degree in Material Science and Engineering from National Taipei University of Technology and National Taiwan University, respectively. He obtained his doctoral degree in Biomedical Engineering at Duke University in 2015. Dr. Wu then completed his post-doctoral training with Dr. Farshid Guilak in Orthopedic Surgery Department at Washington University in Saint Louis in 2020.

Research

Dr. Wu’s research focuses on identifying the molecular mechanisms by which genetic and epigenetic regulators modulate development, homeostasis and disease progression of musculoskeletal tissues, with a particular focus on cartilage and bone. His approach utilizes bioengineering, cellular biology, next-generation sequencing techniques and genome editing tools, complemented by animal and biomechanical models to uncover these fundamental principles. The long-term goal of his research program is to apply this knowledge to improve tissue engineering outcomes, regeneration and repair for musculoskeletal disorders.

Awards

2020
ON Foundation Award
Sponsor: Orthoregeneration Network Foundation

2019
NIH NIAMS K99/R00 Pathway to Independence Award – 1K99AR075899
Sponsor: National Institutes of Health

2018
The New Investigator Recognition Awards (NIRA), Post-doctoral research associate
Sponsor: Orthopaedic Research Society (ORS)

2014
The New Investigator Recognition Awards (NIRA), Graduate student
Sponsor: Orthopaedic Research Society (ORS)

2012
Taiwan Government Student Studying Aboard Scholarship (2-year funding)
Sponsor: Taiwan Government

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Publications

Journal Articles

11/22/2022
Ackerman JE, Best KT, Muscat SN, Pritchett EM, Nichols AEC, Wu CL, Loiselle AE. "Defining the spatial-molecular map of fibrotic tendon healing and the drivers of Scleraxis-lineage cell fate and function." Cell reports.. 2022 Nov 22; 41(8):111706.

3/7/2022
Kenney HM, Wu CL, Loiselle AE, Xing L, Ritchlin CT, Schwarz EM. "Single-cell transcriptomics of popliteal lymphatic vessels and peripheral veins reveals altered lymphatic muscle and immune cell populations in the TNF-Tg arthritis model." Arthritis research & therapy.. 2022 Mar 7; 24(1):64. Epub 2022 Mar 07.

1/13/2021
Wu CL, Dicks A, Steward N, Tang R, Katz DB, Choi YR, Guilak F. "Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis." Nature communications.. 2021 Jan 13; 12(1):362. Epub 2021 Jan 13.

Books & Chapters

2015
Chapter Title: Survey of Animal Models in Post-Traumatic Arthritis: Choosing the Right Model to Answer the Right Question
Book Title: Post-Traumatic Arthritis
Author List: Furman D, Kimmerling K, Wu, C.L., Little D
Edited By: Steven A. Olson, MD; Farshid Guilak, PhD
Published By: Springer 2015 in Boston, MA

2015
Chapter Title: Animal Models of Meniscal Injury in Post-Traumatic Arthritis
Book Title: Post-Traumatic Arthritis
Author List: Wu, C.L., Little D
Edited By: Steven A. Olson, MD; Farshid Guilak, PhD
Published By: Springer 2015 in Boston, MA

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