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Thomas Diekwisch, D.M.D., Ph.D., Ph.D.

Thomas Diekwisch, D.M.D., Ph.D., Ph.D.

Contact

Call Center (585) 276-3000

Research Lab

About Me

Faculty Appointments

Professor - Department of Dentistry (SMD)

Chair - Center for Oral and Craniofacial Sciences

Margaret and Cy Welcher Professorship in Dental Research - Center for Oral and Craniofacial Sciences

Professor - Department of Periodontology (EIOH) - Joint

Professor - Department of Pharmacology and Physiology (SMD) - Joint

Research

Publications

Journal Articles

Editorial: Tooth enamel research: Enamel 10 and beyond.

Den Besten PK, Diekwisch TGH

Frontiers in physiology.. 2023 14 :1323504. Epub 11/07/2023.

Long-acting PFI-2 small molecule release and multilayer scaffold design achieve extensive new formation of complex periodontal tissues with unprecedented fidelity.

Lyu H, Zhou X, Qian Y, Liu X, Gopinathan G, Pandya M, Qin C, Luan X, Diekwisch TGH

Biomaterials.. 2022 November 290 :121819. Epub 09/22/2022.

Epigenetics and Early Development.

Gopinathan G, Diekwisch TGH

Journal of developmental biology.. 2022 June 1610 (2)Epub 06/16/2022.

MicroRNAs: Harbingers and shapers of periodontal inflammation.

Luan X, Zhou X, Fallah P, Pandya M, Lyu H, Foyle D, Burch D, Diekwisch TGH

Seminars in cell & developmental biology.. 2022 April 124 :85-98. Epub 06/10/2021.

The Hippo Pathway Effectors YAP/TAZ Are Essential for Mineralized Tissue Homeostasis in the Alveolar Bone/Periodontal Complex.

Pandya M, Gopinathan G, Tillberg C, Wang J, Luan X, Diekwisch TGH

Journal of developmental biology.. 2022 March 110 (1)Epub 03/01/2022.

Amelogenesis: Transformation of a protein-mineral matrix into tooth enamel.

Pandya M, Diekwisch TGH

Journal of structural biology.. 2021 December 213 (4):107809. Epub 11/06/2021.

Pseudogenized Amelogenin Reveals Early Tooth Loss in True Toads (Anura: Bufonidae).

Shaheen J, Mudd AB, Diekwisch TGH, Abramyan J

Integrative and comparative biology.. 2021 November 1761 (5):1933-1945. Epub 1900 01 01.

Successful Application of a Galanin-Coated Scaffold for Periodontal Regeneration.

Ma W, Lyu H, Pandya M, Gopinathan G, Luan X, Diekwisch TGH

Journal of dental research.. 2021 September 100 (10):1144-1152. Epub 07/30/2021.

Polarized, Amelogenin Expressing Ameloblast-Like Cells from Cervical Loop/Dental Pulp Cocultures in Bioreactors.

Pandya M, Lyu H, Luan X, Diekwisch TGH

Stem cells and development.. 2021 August 1530 (16):797-805. Epub 07/19/2021.

Propagation of Dental and Respiratory Cells and Organs in Microgravity.

Pandya M, Ma W, Lyu H, Luan X, Diekwisch TGH

Journal of visualized experiments : JoVE.. 2021 May 25 (171)Epub 05/25/2021.

The Glycoprotein/Cytokine Erythropoietin Promotes Rapid Alveolar Ridge Regeneration In Vivo by Promoting New Bone Extracellular Matrix Deposition in Conjunction with Coupled Angiogenesis/Osteogenesis.

Pandya M, Saxon M, Bozanich J, Tillberg C, Luan X, Diekwisch TGH

International journal of molecular sciences.. 2021 March 1022 (6)Epub 03/10/2021.

Enamel Defects Associated With Dentin Sialophosphoprotein Mutation in Mice.

Liang T, Xu Q, Zhang H, Wang S, Diekwisch TGH, Qin C, Lu Y

Frontiers in physiology.. 2021 12 :724098. Epub 09/24/2021.

SETD1 and NF-?B Regulate Periodontal Inflammation through H3K4 Trimethylation.

Francis M, Gopinathan G, Salapatas A, Nares S, Gonzalez M, Diekwisch TGH, Luan X

Journal of dental research.. 2020 December 99 (13):1486-1493. Epub 08/07/2020.

Histone Methylation: Achilles Heel and Powerful Mediator of Periodontal Homeostasis.

Francis M, Gopinathan G, Foyle D, Fallah P, Gonzalez M, Luan X, Diekwisch TGH

Journal of dental research.. 2020 November 99 (12):1332-1340. Epub 08/07/2020.

Evolution: Herbivore-Type Teeth in a Cretaceous Tuatara Relative.

Diekwisch TGH

Current biology : CB.. 2020 May 430 (9):R395-R397. Epub 1900 01 01.

Microporous Bio-orthogonally Annealed Particle Hydrogels for Tissue Engineering and Regenerative Medicine.

Isaac A, Jivan F, Xin S, Hardin J, Luan X, Pandya M, Diekwisch TGH, Alge DL

ACS biomaterials science & engineering.. 2019 December 95 (12):6395-6404. Epub 11/11/2019.

The Wnt Antagonist SFRP1: A Key Regulator of Periodontal Mineral Homeostasis.

Gopinathan G, Foyle D, Luan X, Diekwisch TGH

Stem cells and development.. 2019 August 128 (15):1004-1014. Epub 07/22/2019.

Periodontal Homeostasis: From Vienna to Texas-A Century of Periodontal Research in the Spirit of Bernhard Gottlieb.

Diekwisch TGH

Stem cells and development.. 2019 August 128 (15):961-962. Epub 07/22/2019.

Particle-Attachment-Mediated and Matrix/Lattice-Guided Enamel Apatite Crystal Growth.

Jokisaari JR, Wang C, Qiao Q, Hu X, Reed DA, Bleher R, Luan X, Klie RF, Diekwisch TGH

ACS nano.. 2019 March 2613 (3):3151-3161. Epub 02/25/2019.

Titanium particles generated during ultrasonic scaling of implants.

Harrel SK, Wilson TG, Pandya M, Diekwisch TGH

Journal of periodontology.. 2019 March 90 (3):241-246. Epub 11/14/2018.

Enamel biomimetics-fiction or future of dentistry.

Pandya M, Diekwisch TGH

International journal of oral science.. 2019 January 511 (1):8. Epub 01/05/2019.

MicroRNAs and immunity in periodontal health and disease.

Luan X, Zhou X, Naqvi A, Francis M, Foyle D, Nares S, Diekwisch TGH

International journal of oral science.. 2018 August 610 (3):24. Epub 08/06/2018.

Meeting report: a hard look at the state of enamel research.

Klein OD, Duverger O, Shaw W, Lacruz RS, Joester D, Moradian-Oldak J, Pugach MK, Wright JT, Millar SE, Kulkarni AB, Bartlett JD, Diekwisch TG, DenBesten P, Simmer JP

International journal of oral science.. 2017 November 229 (11):e3. Epub 11/22/2017.

MicroRNAs and Periodontal Homeostasis.

Luan X, Zhou X, Trombetta-eSilva J, Francis M, Gaharwar AK, Atsawasuwan P, Diekwisch TGH

Journal of dental research.. 2017 May 96 (5):491-500. Epub 01/09/2017.

Enamel Research: Priorities and Future Directions.

Kirkham J, Brookes SJ, Diekwisch TGH, Margolis HC, Berdal A, Hubbard MJ

Frontiers in physiology.. 2017 8 :513. Epub 07/20/2017.

Posttranslational Amelogenin Processing and Changes in Matrix Assembly during Enamel Development.

Pandya M, Lin T, Li L, Allen MJ, Jin T, Luan X, Diekwisch TGH

Frontiers in physiology.. 2017 8 :790. Epub 10/17/2017.

Intravesicular Phosphatase PHOSPHO1 Function in Enamel Mineralization and Prism Formation.

Pandya M, Rosene L, Farquharson C, Millán JL, Diekwisch TGH

Frontiers in physiology.. 2017 8 :805. Epub 10/17/2017.

Integrative Temporo-Spatial, Mineralogic, Spectroscopic, and Proteomic Analysis of Postnatal Enamel Development in Teeth with Limited Growth.

Pandya M, Liu H, Dangaria SJ, Zhu W, Li LL, Pan S, Abufarwa M, Davis RG, Guggenheim S, Keiderling T, Luan X, Diekwisch TGH

Frontiers in physiology.. 2017 8 :793. Epub 10/24/2017.

Novel approaches toward managing the micromanagers: 'non-toxic' but effective.

Diekwisch TG

Gene therapy.. 2016 October 23 (10):697-698. Epub 07/07/2016.

Daughters of the Enamel Organ: Development, Fate, and Function of the Stratum Intermedium, Stellate Reticulum, and Outer Enamel Epithelium.

Liu H, Yan X, Pandya M, Luan X, Diekwisch TG

Stem cells and development.. 2016 October 25 (20):1580-1590. Epub 09/09/2016.

Ameloblastin, an Extracellular Matrix Protein, Affects Long Bone Growth and Mineralization.

Lu X, Fukumoto S, Yamada Y, Evans CA, Diekwisch TG, Luan X

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2016 June 31 (6):1235-46. Epub 02/26/2016.

Our periodontal tissue: a masterpiece of evolution.

Diekwisch TG

Journal of clinical periodontology.. 2016 April 43 (4):320-2. Epub 03/29/2016.

MicroRNA-138 Inhibits Periodontal Progenitor Differentiation under Inflammatory Conditions.

Zhou X, Luan X, Chen Z, Francis M, Gopinathan G, Li W, Lu X, Li S, Wu C, Diekwisch TG

Journal of dental research.. 2016 February 95 (2):230-7. Epub 10/30/2015.

SM50 repeat-polypeptides self-assemble into discrete matrix subunits and promote appositional calcium carbonate crystal growth during sea urchin tooth biomineralization.

Mao Y, Satchell PG, Luan X, Diekwisch TG

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft.. 2016 January 203 :38-46. Epub 07/06/2015.

Oral Biology and Chicago.

Diekwisch TG

Evolution & development.. 2016 18 (1):3-6. Epub 1900 01 01.

A three dimensional free body analysis describing variation in the musculoskeletal configuration of the cynodont lower jaw.

Reed DA, Iriarte-Diaz J, Diekwisch TG

Evolution & development.. 2016 18 (1):41-53. Epub 1900 01 01.

The ameloblastin extracellular matrix molecule enhances bone fracture resistance and promotes rapid bone fracture healing.

Lu X, Li W, Fukumoto S, Yamada Y, Evans CA, Diekwisch T, Luan X

Matrix biology : journal of the International Society for Matrix Biology.. 2016 52-54 :113-126. Epub 02/18/2016.

Varanoid Tooth Eruption and Implantation Modes in a Late Cretaceous Mosasaur.

Liu M, Reed DA, Cecchini GM, Lu X, Ganjawalla K, Gonzales CS, Monahan R, Luan X, Diekwisch TG

Frontiers in physiology.. 2016 7 :145. Epub 05/17/2016.

Cyclic stretch and compression forces alter microRNA-29 expression of human periodontal ligament cells.

Chen Y, Mohammed A, Oubaidin M, Evans CA, Zhou X, Luan X, Diekwisch TG, Atsawasuwan P

Gene.. 2015 July 15566 (1):13-7. Epub 03/28/2015.

Activation of ?-catenin signalling leads to temporomandibular joint defects.

Wang M, Li S, Xie W, Shen J, Im HJ, Holz JD, Wang M, Diekwisch TG, Chen D

European cells & materials.. 2014 October 2328 :223-35. Epub 10/23/2014.

The use of light/chemically hardened polymethylmethacrylate, polyhydroxylethylmethacrylate, and calcium hydroxide graft material in combination with polyanhydride around implants and extraction sockets in minipigs: Part II: histologic and micro-CT evaluations.

Hasturk H, Kantarci A, Ghattas M, Dangaria SJ, Abdallah R, Morgan EF, Diekwisch TG, Ashman A, Van Dyke T

Journal of periodontology.. 2014 September 85 (9):1230-9. Epub 02/06/2014.

Lyophilized platelet-rich fibrin (PRF) promotes craniofacial bone regeneration through Runx2.

Li Q, Reed DA, Min L, Gopinathan G, Li S, Dangaria SJ, Li L, Geng Y, Galang MT, Gajendrareddy P, Zhou Y, Luan X, Diekwisch TG

International journal of molecular sciences.. 2014 May 1415 (5):8509-25. Epub 05/14/2014.

Case study: polycystic livers in a transgenic mouse line.

Lovaglio J, Artwohl JE, Ward CJ, Diekwisch TG, Ito Y, Fortman JD

Comparative medicine.. 2014 April 64 (2):115-20. Epub 1900 01 01.

Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation.

Goodwin AF, Tidyman WE, Jheon AH, Sharir A, Zheng X, Charles C, Fagin JA, McMahon M, Diekwisch TG, Ganss B, Rauen KA, Klein OD

Human molecular genetics.. 2014 February 123 (3):682-92. Epub 09/20/2013.

The expanded amelogenin polyproline region preferentially binds to apatite versus carbonate and promotes apatite crystal elongation.

Gopinathan G, Jin T, Liu M, Li S, Atsawasuwan P, Galang MT, Allen M, Luan X, Diekwisch TG

Frontiers in physiology.. 2014 5 :430. Epub 11/11/2014.

Expression and function of enamel-related gene products in calvarial development.

Atsawasuwan P, Lu X, Ito Y, Chen Y, Gopinathan G, Evans CA, Kulkarni AB, Gibson CW, Luan X, Diekwisch TG

Journal of dental research.. 2013 July 92 (7):622-8. Epub 04/26/2013.

Epigenetic marks define the lineage and differentiation potential of two distinct neural crest-derived intermediate odontogenic progenitor populations.

Gopinathan G, Kolokythas A, Luan X, Diekwisch TG

Stem cells and development.. 2013 June 1522 (12):1763-78. Epub 03/15/2013.

Combinatorial Design of Hydrolytically Degradable, Bone-like Biocomposites Based on PHEMA and Hydroxyapatite.

Huang J, Zhao D, Dangaria SJ, Luan X, Diekwisch TG, Jiang G, Saiz E, Liu G, Tomsia AP

Polymer.. 2013 January 2454 (2):909-919. Epub 12/13/2012.

Alternative Splicing of the Amelogenin Gene in a Caudate Amphibian, Plethodon cinereus.

Wang X, Xing Z, Zhang X, Zhu L, Diekwisch TG

PloS one.. 2013 8 (6):e68965. Epub 06/26/2013.

Ameloblastin-rich enamel matrix favors short and randomly oriented apatite crystals.

Lu X, Ito Y, Kulkarni A, Gibson C, Luan X, Diekwisch TG

European journal of oral sciences.. 2011 December 119 Suppl 1 :254-60. Epub 1900 01 01.

Structure and function of ameloblastin as an extracellular matrix protein: adhesion, calcium binding, and CD63 interaction in human and mouse.

Zhang X, Diekwisch TG, Luan X

European journal of oral sciences.. 2011 December 119 Suppl 1 :270-9. Epub 1900 01 01.

Evolution and ameloblastin.

Diekwisch T

European journal of oral sciences.. 2011 December 119 Suppl 1 :293-7. Epub 1900 01 01.

Enamel VIII foreword.

Wright T, Diekwisch T

European journal of oral sciences.. 2011 December 119 Suppl 1 :x-xi. Epub 1900 01 01.

Successful periodontal ligament regeneration by periodontal progenitor preseeding on natural tooth root surfaces.

Dangaria SJ, Ito Y, Luan X, Diekwisch TG

Stem cells and development.. 2011 October 20 (10):1659-68. Epub 03/09/2011.

The use of light/chemically hardened polymethylmethacrylate, polyhydroxyethylmethacrylate, and calcium hydroxide graft material in combination with polyanhydride around implants in minipigs: part I: immediate stability and function.

Hasturk H, Kantarci A, Ghattas M, Schmidt M, Giordano RA, Ashman A, Diekwisch TG, Van Dyke T

Journal of periodontology.. 2011 September 82 (9):1339-52. Epub 02/22/2011.

NF-Y and USF1 transcription factor binding to CCAAT-box and E-box elements activates the CP27 promoter.

Ito Y, Zhang Y, Dangaria S, Luan X, Diekwisch TG

Gene.. 2011 March 1473 (2):92-9. Epub 11/13/2010.

Apatite microtopographies instruct signaling tapestries for progenitor-driven new attachment of teeth.

Dangaria SJ, Ito Y, Yin L, Valdré G, Luan X, Diekwisch TG

Tissue engineering. Part A.. 2011 February 17 (3-4):279-90. Epub 10/08/2010.

Amelogenin supramolecular assembly in nanospheres defined by a complex helix-coil-PPII helix 3D-structure.

Zhang X, Ramirez BE, Liao X, Diekwisch TG

PloS one.. 2011 6 (10):e24952. Epub 10/03/2011.

beta-Catenin initiates tooth neogenesis in adult rodent incisors.

Liu F, Dangaria S, Andl T, Zhang Y, Wright AC, Damek-Poprawa M, Piccolo S, Nagy A, Taketo MM, Diekwisch TG, Akintoye SO, Millar SE

Journal of dental research.. 2010 September 89 (9):909-14. Epub 06/08/2010.

BMP-2 regulates the formation of oral sulcus in mouse tongue by altering the balance between TIMP-1 and MMP-13.

Fukui T, Suga T, Iida RH, Morito M, Luan X, Diekwisch TG, Nakamura Y, Yamane A

The anatomical record : advances in integrative anatomy and evolutionary biology.. 2010 August 293 (8):1408-15. Epub 1900 01 01.

Characterization of the mouse CP27 promoter and NF-Y mediated gene regulation.

Luan X, Ito Y, Zhang Y, Diekwisch TG

Gene.. 2010 July 15460 (1-2):8-19. Epub 04/11/2010.

Elongated polyproline motifs facilitate enamel evolution through matrix subunit compaction.

Jin T, Ito Y, Luan X, Dangaria S, Walker C, Allen M, Kulkarni A, Gibson C, Braatz R, Liao X, Diekwisch TG

PLoS biology.. 2009 December 7 (12):e1000262. Epub 12/22/2009.

Extracellular matrix-mediated differentiation of periodontal progenitor cells.

Dangaria SJ, Ito Y, Walker C, Druzinsky R, Luan X, Diekwisch TG

Differentiation; research in biological diversity.. 2009 78 (2-3):79-90. Epub 05/09/2009.

Amelogenin evolution and tetrapod enamel structure.

Diekwisch TGH, Jin T, Wang X, Ito Y, Schmidt M, Druzinsky R, Yamane A, Luan X

Frontiers of oral biology.. 2009 13 :74-79. Epub 09/21/2009.

RANKL, osteopontin, and osteoclast homeostasis in a hyperocclusion mouse model.

Walker CG, Ito Y, Dangaria S, Luan X, Diekwisch TG

European journal of oral sciences.. 2008 August 116 (4):312-8. Epub 1900 01 01.

Vienna-Chicago: the cultural transformation of the model system of the un-opposed molar.

Luan X, Diekwisch TG

BioEssays : news and reviews in molecular, cellular and developmental biology.. 2007 August 29 (8):819-30. Epub 1900 01 01.

BMP2, BMP4, and their receptors are expressed in the differentiating muscle tissues of mouse embryonic tongue.

Suga T, Fukui T, Shinohara A, Luan X, Diekwisch TG, Morito M, Yamane A

Cell and tissue research.. 2007 July 329 (1):103-17. Epub 04/12/2007.

Extracellular matrix-mediated tissue remodeling following axial movement of teeth.

Luan X, Ito Y, Holliday S, Walker C, Daniel J, Galang TM, Fukui T, Yamane A, Begole E, Evans C, Diekwisch TG

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.. 2007 February 55 (2):127-40. Epub 10/02/2006.

Dental follicle progenitor cell heterogeneity in the developing mouse periodontium.

Luan X, Ito Y, Dangaria S, Diekwisch TG

Stem cells and development.. 2006 August 15 (4):595-608. Epub 1900 01 01.

Identification and characterization of a squamate reptilian amelogenin gene: Iguana iguana.

Wang X, Fan JL, Ito Y, Luan X, Diekwisch TG

Journal of experimental zoology. Part B, Molecular and developmental evolution.. 2006 July 15306 (4):393-406. Epub 1900 01 01.

Evolution and development of Hertwig's epithelial root sheath.

Luan X, Ito Y, Diekwisch TG

Developmental dynamics : an official publication of the American Association of Anatomists.. 2006 May 235 (5):1167-80. Epub 1900 01 01.

Expression and characterization of a Rana pipiens amelogenin protein.

Diekwisch TG, Wang X, Fan JL, Ito Y, Luan X

European journal of oral sciences.. 2006 May 114 Suppl 1 :86-92; discussion 93-5, 379-80. Epub 1900 01 01.

Satellite cells and utrophin are not directly correlated with the degree of skeletal muscle damage in mdx mice.

Yamane A, Akutsu S, Diekwisch TG, Matsuda R

American journal of physiology. Cell physiology.. 2005 July 289 (1):C42-8. Epub 02/09/2005.

Amelogenin sequence and enamel biomineralization in Rana pipiens.

Wang X, Ito Y, Luan X, Yamane A, Diekwisch TG

Journal of experimental zoology. Part B, Molecular and developmental evolution.. 2005 March 15304 (2):177-86. Epub 1900 01 01.

Bones, teeth, and genes: a genomic homage to Harry Sicher's "Axial Movement of Teeth".

Holliday S, Schneider B, Galang MT, Fukui T, Yamane A, Luan X, Diekwisch TG

World journal of orthodontics.. 2005 6 (1):61-70. Epub 1900 01 01.

Exogenous hepatocyte growth factor inhibits myoblast differentiation by inducing myf5 expression and suppressing myoD expression in an organ culture system of embryonic mouse tongue.

Yamane A, Amano O, Urushiyama T, Nagata J, Akutsu S, Fukui T, Diekwisch TG

European journal of oral sciences.. 2004 April 112 (2):177-81. Epub 1900 01 01.

Change from a hard to soft diet alters the expression of insulin-like growth factors, their receptors, and binding proteins in association with atrophy in adult mouse masseter muscle.

Urushiyama T, Akutsu S, Miyazaki J, Fukui T, Diekwisch TG, Yamane A

Cell and tissue research.. 2004 January 315 (1):97-105. Epub 10/25/2003.

Membranes, minerals, and proteins of developing vertebrate enamel.

Diekwisch TG, Berman BJ, Anderton X, Gurinsky B, Ortega AJ, Satchell PG, Williams M, Arumugham C, Luan X, McIntosh JE, Yamane A, Carlson DS, Sire JY, Shuler CF

Microscopy research and technique.. 2002 December 159 (5):373-95. Epub 1900 01 01.

Caiman periodontium as an intermediate between basal vertebrate ankylosis-type attachment and mammalian "true" periodontium.

McIntosh JE, Anderton X, Flores-De-Jacoby L, Carlson DS, Shuler CF, Diekwisch TG

Microscopy research and technique.. 2002 December 159 (5):449-59. Epub 1900 01 01.

Roles of insulin-like growth factors and their binding proteins in the differentiation of mouse tongue myoblasts.

Yamane A, Urushiyama T, Diekwisch TG

The International journal of developmental biology.. 2002 September 46 (6):807-16. Epub 1900 01 01.

Conservation and variation in enamel protein distribution during vertebrate tooth development.

Satchell PG, Anderton X, Ryu OH, Luan X, Ortega AJ, Opamen R, Berman BJ, Witherspoon DE, Gutmann JL, Yamane A, Zeichner-David M, Simmer JP, Shuler CF, Diekwisch TG

The Journal of experimental zoology.. 2002 August 15294 (2):91-106. Epub 1900 01 01.

CP27 affects viability, proliferation, attachment and gene expression in embryonic fibroblasts.

Luan X, Diekwisch TG

Cell proliferation.. 2002 August 35 (4):207-19. Epub 1900 01 01.

Pathways and fate of migratory cells during late tooth organogenesis.

Diekwisch TG

Connective tissue research.. 2002 43 (2-3):245-56. Epub 1900 01 01.