Dean's Lecture Series
The Dean’s Lecture Series is intended to showcase high caliber research and high impact topics in clinical medicine and related biomedical fields. The presentations will be targeted to a broad audience of investigators and trainees from multiple areas of clinical medicine, public health, and life science research, as well as for interested members of the university community and the public at large. The George D. and Freida B. Abraham Foundation are sponsoring this series.
Lynne E. Maquat, PhD
J. Lowell Orbison Endowed Chair and Professor, Departments of Biochemistry & Biophysics, Oncology, and Pediatrics, School of Medicine and Dentistry, Founding Director, UR Center for RNA Biology: From Genome to Therapeutics, Founding Chair, UR Graduate Women in Science, University of Rochester
“Nonsense-mediated mRNA Decay and Human Disease”
Despite a long appreciation for the role of nonsense-mediated mRNA decay (NMD) in destroying faulty, disease-causing mRNAs and maintaining normal, physiologic mRNA abundance, additional effectors that regulate NMD activity in mammalian cells continue to be identified. Recently, we defined a protein kinase, AKT, and the protein missing in Fragile X Syndrome, FMRP, as new NMD effectors. Our mechanistic studies of each effector have revealed two surprising mechanisms by which NMD influences normal and disease-associated metabolism, possibly opening new avenues for the development of therapeutics.
Monday, December 12, 2022 at 4:00 PM
Ryan Case Method Room (1-9576)
Welcome by Mark Taubman, M.D.
Introduction by Jeff Hayes, Ph.D.
Reception will follow the talk at Forbes Mezzanine, 1-9580