Dean's Lecture Series
The Dean’s Lecture Series is intended to showcase high caliber research and high impact topics in clinical medicine and related biomedical fields. The presentations will be targeted to a broad audience of investigators and trainees from multiple areas of clinical medicine, public health, and life science research, as well as for interested members of the university community and the public at large. The George D. and Freida B. Abraham Foundation are sponsoring this series.
Lynne Elizabeth Maquat, Ph.D.
J. Lowell Orbison Endowed Chair, Professor of Biochemistry & Biophysics
Founding Director of the Center for RNA Biology
Research in my lab focuses on RNA decay pathways.
One pathway, called nonsense-mediated mRNA decay (NMD) or mRNA surveillance, surveys all newly synthesized mRNAs during what we call a "pioneer" round of translation. This round of translation involves mRNA that is associated with the cap-binding heterodimer CBP80 and CBP20. It is distinct from the type of translation that supports the bulk of cellular protein synthesis and involves a different cap-binding protein, eukaryotic initiation factor (eIF) 4E. Generally, if translation terminates more than 50-55 nt upstream of an exon-exon junction that is marked by the NMD factors Upf3 or Upf3X, Upf2 and ultimately Upf1, then the mRNA will be subject to NMD. By the time CBP80 and CBP20 have been replaced by eIF4E, the Upf mark has been removed so that mRNA is largely immune to NMD.
To learn more about our research, please visit our lab website.
Dean's Lecture: TBA
Lynne Elizabeth Maquat, PhD - J. Lowell Orbison Distinguished Service Alumni Professor of Biochemistry and Biophysics, Director, Center for RNA Biology
Sep 13, 2021 @ 4:00 p.m.More info about Dr. Maquat
Atul Butte, MD, PhD - Priscilla Chan and Mark Zuckerberg Distinguished Professor of Pediatrics, Bioengineering and Therapeutic Sciences, and Epidemiology and Biostatistics at UCSF Director, Bakar Computational Health Sciences Institute, UCSF Chief Data Scientist, University of California Health System
Oct 04, 2021 @ 4:00 p.m.More info about Dr. Butte
Vera Gorbunova, PhD - Doris Johns Cherry Professor, Co-Director Rochester Aging Research Center
Dec 06, 2021 @ 4:00 p.m.More info about Dr. Gorbunova
Emery Brown, MD, PhD - Edward Hood Taplin Professor of Medical Engineering and of Computational Neuroscience; Professor of Health Sciences and Technology, Associate Director, Institute for Medical Engineering and Science Massachusetts Institute of Technology
Jan 10, 2022 @ 4:00 p.m.More info about Dr. Brown
Dean's Lecture: TBA
Phillip A. Sharp, Ph.D. - Institute Professor and Professor of Biology Member, Koch Institute for Integrative Cancer Research MIT
Mar 14, 2022 @ 4:00 p.m.More info about Dr. Sharp
Huda Yahya Zoghbi, MD - Professor in the Departments of Pediatrics, Molecular and Human Genetics, Neurology and Neuroscience at Baylor College of Medicine. She is also an Investigator at the Howard Hughes Medical Institute and the Director of the Jan and Dan Duncan Neurological Research Institute (NRI) at Texas Children's Hospital
Aug 08, 2022 @ 4:00 p.m.More info about Dr. Zoghbi