Past Lectures
2020
Pulmonary physician and epidemiologist, Dean and Professor of the Colorado School of Public Health, Aurora, Colorado
Dr. Samet's Bio
Dr. Samet's CV
Tuesday, March 3, 2020, 12:00 pm
Auditorium of Class '62, G-9425
"Science, Policy, and the Environment: Reflections from 1970-2020"
The fifty-year span, 1970-2020, covers a half-century of science-driven progress in improving the quality of the environment. Health has benefited in the United States and beyond as a result. This presentation considers how scientific evidence has fueled the progress, covering the ways that evidence serves as the foundation for action and the roles of researchers in these translational processes. This long-standing paradigm is now under threat. In this presentation, I draw on my experience over these 50 years as a physician/researcher, using such examples as tobacco control, air pollution, and chemical risk assessment. I speak to “lessons learned” as to how a researcher may or may not “make a difference”.
Welcome by Mark Taubman, M.D.
Introduction by Mark Utell, M.D.
2021
Vera Gorbunova, Ph.D. is a Doris Johns Cherry Professor of Biology
and Medicine and is co-director of the University of Rochester Aging
Research Center. Her research is focused on understanding the
mechanisms of longevity and genome stability and on the studies of
exceptionally long-lived mammals. Her work has received awards from
the Ellison Medical Foundation, the Glenn Foundation, the American
Federation for Aging Research, and the National Institutes of Health.
Monday, December 6, 2021, 4:00 pm Auditorium of Class '62, G-9425
"Mechanisms of Longevity: Lessons from Long-Lived Mammals"
Welcome by Mark Taubman, M.D.
Introduction by Dirk Bohmann, Ph.D.
2022
Institute Professor and Professor of Biology Member, Koch Institute for Integrative Cancer
Research, MIT
“Science of RNA Biology - Advances to New Therapeutic Modalities”
Monday, March 14, 2021 - 4:00pm
Auditorium of Class '62, G-9425
Interventions targeting RNA processes and RNA-based therapeutics employing short double-stranded RNA and mRNA represent an important new class of therapeutic modalities. These were developed by translation of earlier fundamental science and engineering research, including genome sequencing, and have created new opportunities to meet major challenges in healthcare. This history will be discussed briefly, then new insights shared about another possible step in this journey—the role of RNA in regulation of transcription and gene expression.
Welcome by Mark Taubman, M.D.
Introduction by Paul Boutz, Ph.D.
Professor in the Departments of Pediatrics, Pathology and Laboratory Medicine at the University of Rochester Medical Center. Dr. Palis' research interests are:
1) Ontogeny of the mammalian hematopoietic system
2) Differentiation of the erythroid lineage,
3) Erythroid precursor self-renewal, and
4) Response of the hematopoietic system to ionizing radiation
Monday, October 10, 2022, 4:00pm
Auditorium of Class '62, G-9425
"Making blood: lessons from the mouse embryo"
Welcome by Mark Taubman, M.D.
Introduction by Rick Waugh, Ph.D.
Lynne E. Maquat, PhD
J. Lowell Orbison Endowed Chair and Professor, Departments of Biochemistry & Biophysics, Oncology, and Pediatrics, School of Medicine and Dentistry, Founding Director, UR Center for RNA Biology: From Genome to Therapeutics, Founding Chair, UR Graduate Women in Science, University of Rochester
Monday, December 12, 2022, 4:00pm
Ryan Case Method Room, 1-9576
“Nonsense-mediated mRNA Decay and Human Disease”
Despite a long appreciation for the role of nonsense-mediated mRNA decay (NMD) in destroying faulty, disease-causing mRNAs and maintaining normal, physiologic mRNA abundance, additional effectors that regulate NMD activity in mammalian cells continue to be identified. Recently, we defined a protein kinase, AKT, and the protein missing in Fragile X Syndrome, FMRP, as new NMD effectors. Our mechanistic studies of each effector have revealed two surprising mechanisms by which NMD influences normal and disease-associated metabolism, possibly opening new avenues for the development of therapeutics.
Welcome by Mark Taubman, M.D.
Introduction by Jeff Hayes, Ph.D.