Coagulation, Critical Care & Ultrasound Research
Dr. Michael Eaton’s general area of interest is the interaction of cardiopulmonary bypass with human blood, and the minimization of the adverse effects of this interaction. This is of particular importance in pediatric and neonatal cardiac surgery, where available knowledge is significantly less and patients are at higher risk due to an immature hemostatic system and the greater degree of hemodilution involved. Currently Dr. Eaton is investigating exploring a novel combination anticoagulant strategy for cardiopulmonary bypass without heparin using closed loop cardiopulmonary bypass models. He has a clinical trial underway randomizing infants undergoing cardiac surgery with cardiopulmonary bypass to supplementation with antithrombin III or placebo. He is also completing a study investigating the ability of traditional tube-based ACT testing compared with cartridge-based ACT devices to measure thrombin generation during bypass.
The Division of Critical Care Medicine has a 20 year history of research on Mechanical Ventilation, ARDS, and Lung Physiology Research. Dr. Peter Papadakos has been actively collaborating with investigators throughout the US and Europe on a number of multicenter funded projects. Over the last 2 years he and his colleagues have been investigating how mechanical ventilation impacts on atelectasis and Surfactant dysfunction. Basic science collaboration with Professor Dr. Burkhard Lachmann at the Charite of the University of Berlin is currently looking at Surfactant dysfunction in an animal model. The group is also looking at cytokine modulation in the lung and how it is affected by sedative agents. Dr. Papadakos is also working on several research projects with several national organizations such as the ASA and the AORN to improve human to technology interfacing and prevent electronic distraction.
Dr. Jacek Wojtczak’s research interests are focused on craniofacial phenotyping/upper airway imaging and biophysical mechanisms of lung B-lines. He is using new ultrasonic imaging techniques including compression elastography and acoustic radiation force imaging and he has also developed a new imaging technique - nanoparticle imaging. This technique allows quantification and monitoring of local anesthetic spread in tissues. He is collaborating with Dr. David Cattano (UT Houston) on the ultrasonic imaging of airway devices in situ and with Dr. Pavel Andruszkiewicz (University of Warsaw) on the prediction of unanticipated difficult airway and emergency airway procedures including ultrasound-guided