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David C. Linehan, M.D.

Contact Information

Phone Numbers

Appointment: (585) 275-1611

Office: (585) 275-2725

Fax: (585) 273-1252

URMFGA member of the University of Rochester Medical Faculty Group

groupAn Accountable Health Partner

assignmentAccepting New Patients

Faculty Appointments

  • Professor - Department of Surgery , Oncology (SMD)
  • CEO, University of Rochester Medical Center - Office of VP for Health Sciences (URMC)
  • Dean, School of Medicine & Dentistry - Dean's Office, SMD (SMD)

Patient Care Settings

Cancer, Surgery


Professional Background

Dr. Linehan is CEO of the University of Rochester Medical Center (URMC), dean of the School of Medicine and Dentistry (SMD), and senior vice president for Health Sciences at the University of Rochester. Before that, he chaired URMC’s Department of Surgery for 10 years. A surgical oncologist and an accomplished researcher, Dr. Linehan is recognized for bringing new therapies to patients with difficult-to-treat cancers, and for his compassionate approach to care. He is also internationally renowned for his research into new immunotherapy treatments for pancreatic cancer; his laboratory has been continuously funded by the National Cancer Institute for nearly two decades. He specializes in treating cancers and benign surgical conditions of the liver, pancreas, gallbladder, and bile ducts.

Dr. Linehan attended Dartmouth College, graduated from the University of Massachusetts Medical School, then completed his internship and residency at Deaconess-Harvard Surgical Service. He was a research fellow at Brigham and Women's Hospital and the Kristin Ann Carr Fellow in Surgical Oncology at Memorial Sloan-Kettering Cancer Center. He went on to become a professor of Surgery at Washington University and chief of Hepatobiliary, Pancreatic and Gastrointestinal Surgery.




    MD | University of Massachusetts Medical School

    Post-doctoral Training & Residency

    07/01/1997 - 06/30/1999
    Fellowship in Surgical Oncology at Memorial Sloan-Kettering Cancer Center

    09/01/1996 - 06/30/1997
    Fellowship in Surgery (General Surgery) at Beth Israel Deaconess Medical Center-Main Campus

    08/01/1993 - 06/01/1995
    Fellowship at Brigham & Womens Hospital

    09/01/1991 - 06/30/1996
    Residency in Surgery (General Surgery) at Beth Israel Deaconess Medical Center-Main Campus

    09/01/1990 - 06/30/1991
    Internship in Surgery (General Surgery) at Beth Israel Deaconess Medical Center-Main Campus

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    Inaugural Gerry O'Sullivan Memorial Lecturer Award
    Sponsor: University College
    Location: Cork, Ireland

    CTRF Superhero Cancer Researcher Award
    Location: Chicago, IL

    Evarts A. Graham Teaching Award
    Sponsor: Washington University School of Medicine
    Location: St. Louis, MO

    Young Investigator Award
    Sponsor: American Society of Clinical Oncology

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    Journal Articles

    Ye J, Gavras NW, Keeley DC, Hughson AL, Hannon G, Vrooman TG, Lesch ML, Johnston CJ, Lord EM, Belt BA, Linehan DC, Eyles J, Gerber SA. "CD73 and PD-L1 dual blockade amplifies antitumor efficacy of SBRT in murine PDAC models." Journal for immunotherapy of cancer.. 2023 May; 11(5)

    Williams HL, Dias Costa A, Zhang J, Raghavan S, Winter PS, Kapner KS, Ginebaugh SP, Väyrynen SA, Väyrynen JP, Yuan C, Navia AW, Wang J, Yang A, Bosse TL, Kalekar RL, Lowder KE, Lau MC, Elganainy D, Morales-Oyarvide V, Rubinson DA, Singh H, Perez K, Cleary JM, Clancy TE, Wang J, Mancias JD, Brais LK, Hill ER, Kozak MM, Linehan DC, Dunne RF, Chang DT, Koong AC, Hezel AF, Hahn WC, Shalek AK, Aguirre AJ, Nowak JA, Wolpin BM. "Spatially-resolved single-cell assessment of pancreatic cancer expression subtypes reveals co-expressor phenotypes and extensive intra-tumoral heterogeneity." Cancer research.. 2022 Dec 2; Epub 2022 Dec 02.

    Uccello TP, Lecsh ML, Ullman NA, Kintzel SA, Gradzewicz LB, Velagaleti T, Fleming FJ, Mills BN, Murphy JD, Garrett-Larsen J, Qiu H, Drage MG, Ye J, Gavras NW, Johnston CJ, Love TMT, Repasky EA, Linehan DC, Lord EM, Gerber SA. "Radiotherapy exacerbates tumor-promoting innervation and nerve signaling in rectal cancer." International journal of radiation oncology, biology, physics.. 2022 Oct 3; Epub 2022 Oct 03.

    Books & Chapters

    Book Title: Surgery of the Liver, Biliary Tract and Pancreas
    Author List: Linehan DC and Jarnagin WR
    Edited By: Blumgart LH, Editor-in-Chief
    Published By: Elsevier 2007 in Philadelphia

    Chapter Title: Thermal Ablation of Liver Tumors by Radiofrequency, Microwave, and Laser Therapy
    Book Title: Malignant Liver Tumors: Current and Emerging Therapies
    Author List: Strasberg SM and Linehan DC
    Published By: Bartlett and Barnes 2002 in Chicago

    Chapter Title: Soft Tissue Sarcoma
    Book Title: Surgical Treatment: Evidence-Based and Problem Oriented
    Author List: Linehan DC and Brennan MF
    Edited By: Holzheimer RG and Mannick JA
    Published By: W Zuckschwerdt Verlag 2001 in Munch



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