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Wilmot Cancer Institute / Research / Research Faculty

Research Faculty


M. Jacob Adams, M.D., M.P.HM. Jacob Adams, M.D., M.P.H
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Pediatric, cardiovascular and cancer epidemiology
Brian Altman, Ph.D.Brian J. Altman, Ph.D.
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Biomedical Genetics
Altman Lab

Role of Circadian Rhythm in in gene regulation and cancer cell biology and metabolism.
Jeffrey Andolina, M.D., M.S.Jeffrey R. Andolina, M.D., M.S.
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The treatment and comprehensive care for children with leukemia and lymphoma, including acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and chronic myeloid leukemia (CML), as well as the care for children with other cancers and blood diseases.
Robert Bambara, Ph.D.Robert A. Bambara, Ph.D.
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Microbiology & Immunology

Human genome stability, DNA damage response, HIV replication and evolution
Paul Barr, M.D.Paul M. Barr, M.D.
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The development of novel therapeutics for patients with chronic lymphocytic leukemia and lymphoma.
Michael Becker, M.D.Michael Becker, M.D.
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Malignant stem cell populations in myeloid neoplasms
Danielle Benoit, Ph.D.Danielle Benoit, Ph.D.
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Biomedical Engineering
Benoit Lab

Therapeutic biomaterials development for tissue engineering and drug delivery with applications ranging from bone regeneration to antioral biofilm treatments
Benoit Biteau, Ph.D.Benoit Biteau, Ph.D.
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Biomedical Genetics
Biteau Lab

Molecular and Cellular Mechanisms that Control Tissue Homeostasis and Somatic Stem Cells
Dirk Bohmann, Ph.D.Dirk Bohmann, Ph.D.
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Biomedical Genetics
Bohmann Lab

The biochemistry, molecular biology and genetics of signal-transducing transcription factors and their role in development, aging and disease
Edward Brown, Ph.D.Edward Brown, Ph.D.
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Biomedical Engineering
Brown Lab

Multiphoton Laser Scanning Microscopy, novel in vivo imaging and measurement techniques, tumor biology, angiogenesis
Marc Brown, M.D.Marc D. Brown, M.D.
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Mohs surgery, melanoma, facial reconstruction, and challenging and unusual skin cancers
W. Richard Burack, M.D., Ph.D.W. Richard Burack, M.D., Ph.D.
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Pathology & Laboratory Medicine
Burack Lab

Activation induced cytidine deaminase (AID) impact on Follicular lymphoma (FL) tumors as a prognostic factor for Diffuse Large B-cell lymphoma (DLBCL)
Laura Calvi, M.D.Laura M. Calvi, M.D.
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Calvi Lab

Cellular and Molecular Mechanisms of Microenvironmental Regulation of Hematopoietic Stem Cells in the Bone Marrow
Carla Casulo, M.D.Carla Casulo, M.D.
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Newly diagnosed and relapsed Hodgkin lymphoma, mantle cell lymphoma, diffuse large B cell lymphoma ,and peripheral T cell lymphoma
Joe Chakkalakal, Ph.D.Joe V. Chakkalakal, Ph.D.
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Pharmacology & Physiology
Chakkalakal Lab

Contribution of stem cells to the maturation, regeneration and lifelong maintenance of skeletal muscle in growth aging and cancer
Regine Choe, Ph.D.Regine Choe, Ph.D.
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Biomedical Engineering
Choe Lab

Diffuse optics for in vivo cancer detection, diagnosis and therapy monitoring
Charles Chu, Ph.D.Charles Chu, Ph.D.
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Elliott Lab
Chu Lab

Translational Research in Lymphoid Malignancies
Andrew Evans, M.D., Ph.D.Andrew Evans, M.D., Ph.D.
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Pathology & Laboratory Medicine
Calvi Lab

My current research focuses on the molecular, genetic, and immunologic mechanisms that underlie leukemia and lymphoma development. Specifically, I’m studying which bone marrow stromal interactions influence the development and persistence of these diseases. Other interests include the role of chronic viruses in lymphoma development, and the genetic characteristics that influence diagnosis and treatment of pre-myeloid leukemias or myelodysplastic syndromes.
Rudi Fasan, Ph.D.Rudi Fasan, Ph.D.
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Fasan Lab

Bioorganic chemistry, chemical biology, and biomolecular engineering and evolution
Jonathan Friedberg, M.D., M.M.Sc.Jonathan W. Friedberg, M.D., M.M.Sc.
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Development of novel therapies for patients with lymphoma
Benjamin Frisch, Ph.D.Benjamin Frisch, Ph.D.
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Calvi Lab

My research concentrates on the reciprocal interactions between the bone marrow microenvironment and hematopoietic stem cells (HSCs), under both normal and leukemic conditions. My research efforts are largely translational in focus with the ultimate goal of therapeutically targeting the bone marrow microenvironment for the treatment of hematologic malignancies.
Chunkit Fung, M.D.Chunkit Fung, M.D.
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Cancer control, particularly in the development, implementation, and dissemination of mHealth behavioral interventions to prevent and manage treatment- and cancer-related toxicities in cancer survivors, with a specific focus in cardiovascular complications from cancer treatment
Ahmed Ghazi, M.D., M.Sc.
Ahmed Ghazi, M.D., M.Sc.
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Simulation Innovation Lab

Surgical Simulation and Patient-Specific Surgical Simulation to create translational models to measure improvements in surgical training and patient outcomes.
Vera Gorbunova, Ph.D.Vera Gorbunova, Ph.D.
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Gorbunova Lab

Mechanisms of aging and the role of DNA repair and genomic instability in the aging process.
Stephen Hammes, M.D., Ph.D.Stephen R. Hammes, M.D., Ph.D.
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Hammes Lab

Androgen Effects on Reproduction and Cancer
Aram Hezel, M.D.Aram Francis Hezel, M.D.
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The molecular biology and genetics of pancreatic and biliary tract cancers
David Hicks, M.D.David G. Hicks, M.D.
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Pathology & Laboratory Medicine

Metabolic and neoplastic bone disorders; breast pathology, with particular focus on prognostic molecular markers and development of advanced tissue-based diagnostic techniques
Wei Hsu, PhDWei Hsu, PhD
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Biomedical Genetics
Hsu Lab

Cellular Signaling in Neural Development and Disease
Michelle Janelsins-Benton, Ph.D.Michelle C. Janelsins-Benton, Ph.D.
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Understanding clinical, psychological, and biological mechanisms of cognitive difficulties in cancer patients
Jean Joseph, M.D.Jean V. Joseph, M.D.
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Laparoscopic/minimally invasive urology (prostatectomy, nephrectomy), reconstructive urology, hematuria, genitourinary cancers, kidney stones, benign prostatic hypertrophy (BPH), urethral strictures, vasectomy, vasectomy reversal
Charles Kamen, Ph.D.Charles S. Kamen, Ph.D.
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Factors that lead to health disparities among sexual and gender minority populations, specifically disparities in cancer-related health outcomes and psychological distress
Sarah Kerns, Ph.D., M.P.H.Sarah L. Kerns, Ph.D., M.P.H.
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Radiation Oncology

Radiogenomics - the study of genetic factors that are associated with increased risk of developing late effects from radiotherapy used in treatment of cancer
Clara Kielkopf, Ph.D.Clara L. Kielkopf, Ph.D.
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Biochemistry & Biophysics
Kielkopf Lab

Splicing defects in hematologic malignancies; roles of human pre-mRNA splicing factors in HIV-1 infectivity; development of engineered splicing factors for correction of splicing defects; splice sites and their associated proteins as therapeutic targets.
Hartmut Land, Ph.D.Hartmut Land, Ph.D.
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Biomedical Genetics
Land Lab

Molecular mechanisms of carcinogenesis. Signaling and Cancer Cell Metabolism
Yi-Fen Lee, Ph.D.Yi-Fen Lee, Ph.D.
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Yi-Fen Lee Lab

Extracdllular vesicles (Evs), Exosomes, for their roles in cancer development, progression and response to tratment in Urology cancers.
Jane Liesveld, M.D.Jane Larae Liesveld, M.D.
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Effects of oxygen metabolites/chemokines on hematopoietic stem cell expansion and preservation
Lynne Maquat, Ph.D.Lynne Maquat, Ph.D.
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Biochemistry & Biophysics
Maquat Lab

RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.
Scott McIntosh, Ph.D.Scott McIntosh, Ph.D.
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Public Health Sciences

Smoking Cessation in special populations, Technology/Web Assisted Risk Behavior Intervention and Dissemination of effective interventions to physician practices
Stephano Mello, Ph.D.Stephano Mello, Ph.D.
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Biomedical Genetics
Mello Lab

Understanding how nuclear proteins and non-coding RNAs (ncRNAs) regulate gene transcription in pancreatic preneoplastic lesions, gaining knowledge of the process of cellular transformation and tumor initiation.
Michael Milano, M.D., Ph.D.Michael Milano, M.D., Ph.D.
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Radiation Oncology

Lung cancer and other thoracic tumors, head and neck cancer and metastatic cancer
Nimish Mohile, M.D.Nimish Mohile, M.D.
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Understanding the role of cancer stem cells in the progression of brain tumors
Richard Moore, M.D.Richard G. Moore, M.D.
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Obstetrics & Gynecology

Ovarian cancer biomarker research for the early detection and management of ovarian cancer
Craig Mullen, M.D., Ph.D.Craig Mullen, M.D., Ph.D.
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Cancer Immunobiology and Transplant Immunology
Joshua Munger, Ph.D.Joshua C. Munger, Ph.D.
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Biochemistry & Biophysics
Munger Lab

Mechanisms of metabolic network manipulation induced by viral infection and oncogenic mutation.
Patrick Murphy, Ph.D.Patrick J. Murphy, Ph.D.
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Biomedical Genetics
Murphy Lab

The genetics, genomics, and chromatin biochemistry of cell state transitions that occur during embryonic development and carcinogenesis.
Mark Noble, Ph.D.Mark Noble, Ph.D.
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Biomedical Genetics
Noble Lab

Neuro stem cell biology and medicine, developing pharmacological and cell based approaches to peripheral and spinal cord injury.
Jeanne O'Brien, M.D.Jeanne H. Sullivan O'Brien, M.D.
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Male infertility, microsurgery, varicoceles and general Urology
Catherine Ovitt, Ph.D.Catherine E. Ovitt, Ph.D.
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Biomedical Genetics
Ovitt Lab

Protective and regenerative strategies for salivary gland function and radiation therapies.
James Palis, M.D.James Palis, M.D.
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Palis Lab

Cellular and Molecular events underlying the ontogenty of the hematopoietic system.
Luke Peppone, Ph.D.Luke Peppone, Ph.D.
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The use of nutritional supplementation and exercise to treat the symptoms and side effects of cancer and its related treatment
Archibald Perkins, M.D., Ph.D.Archibald S. Perkins, M.D., Ph.D.
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Pathology & Laboratory Medicine
Perkins / Zhang Lab

Genetic mechanisms in acute myeloid leudemia and myelodyplastic syndrome with focus on the zinc finger oncoprotein EVI1
Edward Schwarz, Ph.D.Edward M. Schwarz, Ph.D.
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Schwarz Lab

Inflammatory bone loss as seen in rheumatoid arthritis, infections, tumor metasasis and wear debris induced ostolysis around prosthetic implants
Glynis Scott, M.D.Glynis A. Scott, M.D.
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Scott Lab

Investgation into signaling pathways of prostaglandins in human melanocytes and melanoma and the role of Plexin receptors in melanocyte and melanoma biology.
Paula Vertino, Ph.D.Paula M. Vertino, Ph.D.
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Biomedical Genetics

Dr. Vertino's research interests are focused on the areas of cancer epigenetics and novel mechanisms of gene silencing in cancer.
Jacqueline Williams, Ph.D.Jacqueline Patricia Williams, Ph.D.
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Environmental Medicine
Jacqueline Williams Lab

Discovering the effects of high (therapeutic) and low (environmentally-relevant) doses of radiation and their interactions with other toxic elements, such as commonly encountered infections, and better understanding differential effects of radiation in adults versus children.
Julie Wolf, Ph.D., M.P.H.Julie Wolf, Ph.D., M.P.H.
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Wolf Lab

Uncovering the biological mechanisms of radiation-induced skin toxicities
Guan Wu, M.D., Ph.D.Guan Wu, M.D., Ph.D.
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Pathology & Laboratory Medicine

Genetic defects in kidney cancer cells and how these defects cause the disease
Shu-Yuan Yeh, Ph.D.Shu-Yuan Yeh, Ph.D.
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Yeh Lab
George H. Whipple Laboratory for Cancer Research

Role of the estrogen receptor (ER) and androgen receptor (AR) in urological diseases, including prostate cancer, bladder cancer, benign prostatic hyperplasia (BPH) and male fertility.
Jiyong Zhao, Ph.D.Jiyong Zhao, Ph.D.
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Biomedical Genetics
Land Lab
Zhao Lab

Signal transduction and development of therapeutic agents in B-lymphomas; Cell cycle regulation